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Volumn 49, Issue , 2016, Pages 30-36

Granting immunity to FOP and catching heterotopic ossification in the Act

Author keywords

Activin A; ACVR1; Bone morphogenetic protein (BMP); Bone morphogenetic protein signaling; Fibrodysplasia ossificans progressiva (FOP); Heterotopic ossification; Innate immune system; Toll like receptor (TLR)

Indexed keywords

ACTIVIN; ACTIVIN A; ACTIVIN RECEPTOR 1; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; MUTANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ACVR1 PROTEIN, HUMAN;

EID: 84958104294     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2015.12.013     Document Type: Review
Times cited : (54)

References (93)
  • 1
    • 77956275161 scopus 로고    scopus 로고
    • Inherited human diseases of heterotopic bone formation
    • Shore E.M., Kaplan F.S. Inherited human diseases of heterotopic bone formation. Nat. Rev. Rheumatol. 2010, 6:518-527.
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 518-527
    • Shore, E.M.1    Kaplan, F.S.2
  • 4
    • 70649090107 scopus 로고    scopus 로고
    • The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling
    • Kaplan F.S., Pignolo R.J., Shore E.M. The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling. Cytokine Growth Factor Rev. 2009, 20:399-407.
    • (2009) Cytokine Growth Factor Rev. , vol.20 , pp. 399-407
    • Kaplan, F.S.1    Pignolo, R.J.2    Shore, E.M.3
  • 7
    • 84857033273 scopus 로고    scopus 로고
    • When versatility matters: activins/inhibins as key regulators of immunity
    • Aleman-Muench G.R., Soldevila G. When versatility matters: activins/inhibins as key regulators of immunity. Immunol. Cell Biol. 2012, 90:137-148.
    • (2012) Immunol. Cell Biol. , vol.90 , pp. 137-148
    • Aleman-Muench, G.R.1    Soldevila, G.2
  • 9
    • 84906883828 scopus 로고    scopus 로고
    • Fibrodysplasia ossificans progressiva: clinical course, genetic mutations and genotype-phenotype correlation
    • Hüning I., Gillessen-Kaesbach G. Fibrodysplasia ossificans progressiva: clinical course, genetic mutations and genotype-phenotype correlation. Mol. Syndromol. 2014, 5:201-211.
    • (2014) Mol. Syndromol. , vol.5 , pp. 201-211
    • Hüning, I.1    Gillessen-Kaesbach, G.2
  • 11
    • 0028287031 scopus 로고
    • Age and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva
    • Rocke D.M., Zasloff M., Peeper J., Cohen R.B., Kaplan F.S. Age and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. Clin. Orthop. Rel. Res. 1994, 301:243-248.
    • (1994) Clin. Orthop. Rel. Res. , vol.301 , pp. 243-248
    • Rocke, D.M.1    Zasloff, M.2    Peeper, J.3    Cohen, R.B.4    Kaplan, F.S.5
  • 13
    • 25844529319 scopus 로고    scopus 로고
    • Developmental anomalies of the cervical spine in patients with fibrodysplasia ossificans progressiva are distinctly different from those in patients with Klippel-Feil syndrome
    • Schaffer A.A., Kaplan F.S., Tracy M.R., O'Brien M.L., Dormans J.P., Shore E.M., Harland R.M., Kusumi K. Developmental anomalies of the cervical spine in patients with fibrodysplasia ossificans progressiva are distinctly different from those in patients with Klippel-Feil syndrome. Spine 2005, 30:1379-1385.
    • (2005) Spine , vol.30 , pp. 1379-1385
    • Schaffer, A.A.1    Kaplan, F.S.2    Tracy, M.R.3    O'Brien, M.L.4    Dormans, J.P.5    Shore, E.M.6    Harland, R.M.7    Kusumi, K.8
  • 15
    • 0033142884 scopus 로고    scopus 로고
    • Conductive hearing loss in individuals with fibrodysplasia ossificans progressiva
    • Levy C.E., Lash A.T., Janoff H.B., Kaplan F.S. Conductive hearing loss in individuals with fibrodysplasia ossificans progressiva. Am. J. Audiol. 1999, 8:29-33.
    • (1999) Am. J. Audiol. , vol.8 , pp. 29-33
    • Levy, C.E.1    Lash, A.T.2    Janoff, H.B.3    Kaplan, F.S.4
  • 17
    • 25844523629 scopus 로고    scopus 로고
    • Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva
    • Kitterman J.A., Kantanie S., Rocke D.M., Kaplan F.S. Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva. Pediatrics 2005, 116:654-661.
    • (2005) Pediatrics , vol.116 , pp. 654-661
    • Kitterman, J.A.1    Kantanie, S.2    Rocke, D.M.3    Kaplan, F.S.4
  • 21
    • 25844510176 scopus 로고    scopus 로고
    • Thoracic insufficiency syndrome in patients with fibrodysplasia ossificans progressiva
    • Kaplan F.S., Glaser D.L. Thoracic insufficiency syndrome in patients with fibrodysplasia ossificans progressiva. Clin. Rev. Bone Miner. Metab. 2005, 3:213-216.
    • (2005) Clin. Rev. Bone Miner. Metab. , vol.3 , pp. 213-216
    • Kaplan, F.S.1    Glaser, D.L.2
  • 24
    • 84865652361 scopus 로고    scopus 로고
    • The medical management of fibrodysplasia ossificans progressiva: current treatment considerations
    • The International Clinical Consortium on FOP, F.S. Kaplan, E.M. Shore, R.J. Pignolo (Eds.)
    • The medical management of fibrodysplasia ossificans progressiva: current treatment considerations. Clinical Proceedings of International Clinical Consortium on FOP, 4 2011, 1-100. The International Clinical Consortium on FOP. F.S. Kaplan, E.M. Shore, R.J. Pignolo (Eds.).
    • (2011) Clinical Proceedings of International Clinical Consortium on FOP, 4 , pp. 1-100
  • 25
    • 82355182537 scopus 로고    scopus 로고
    • Fibrodysplasia ossificans progressiva: clinical and genetic aspects
    • Pignolo R.J., Shore E.M., Kaplan F.S. Fibrodysplasia ossificans progressiva: clinical and genetic aspects. Orphanet J. Rare Dis. 2011, 6:80.
    • (2011) Orphanet J. Rare Dis. , vol.6 , pp. 80
    • Pignolo, R.J.1    Shore, E.M.2    Kaplan, F.S.3
  • 26
    • 84881346430 scopus 로고    scopus 로고
    • Fibrodysplasia ossificans progressiva: diagnosis management, and therapeutic horizons. Emerging concepts in pediatric bone disease
    • Pignolo R.J., Shore E.M., Kaplan F.S. Fibrodysplasia ossificans progressiva: diagnosis management, and therapeutic horizons. Emerging concepts in pediatric bone disease. Pediatr. Endocrinol. Rev 2013, 10(S-2):437-448.
    • (2013) Pediatr. Endocrinol. Rev , vol.10 , pp. 437-448
    • Pignolo, R.J.1    Shore, E.M.2    Kaplan, F.S.3
  • 27
    • 84896710829 scopus 로고    scopus 로고
    • From mysteries to medicines: drug development for fibrodysplasia ossificans progressiva
    • Kaplan F.S., Pignolo R.J., Shore E.M. From mysteries to medicines: drug development for fibrodysplasia ossificans progressiva. Expert Opin. Orphan Drugs 2013, 1:637-649.
    • (2013) Expert Opin. Orphan Drugs , vol.1 , pp. 637-649
    • Kaplan, F.S.1    Pignolo, R.J.2    Shore, E.M.3
  • 31
    • 34548457296 scopus 로고    scopus 로고
    • Functional modeling of the ACVR1 (R206H) mutation in FOP
    • Groppe J.C., Shore E.M., Kaplan F.S. Functional modeling of the ACVR1 (R206H) mutation in FOP. Clin. Orthop. Rel. Res. 2007, 462:87-92.
    • (2007) Clin. Orthop. Rel. Res. , vol.462 , pp. 87-92
    • Groppe, J.C.1    Shore, E.M.2    Kaplan, F.S.3
  • 33
    • 77954588190 scopus 로고    scopus 로고
    • Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva
    • Song G.A., Kim H.J., Woo K.M., Baek J.H., Kim G.S., Choi J.Y., Ryoo H.M. Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva. J. Biol. Chem. 2010, 285:22542-22553.
    • (2010) J. Biol. Chem. , vol.285 , pp. 22542-22553
    • Song, G.A.1    Kim, H.J.2    Woo, K.M.3    Baek, J.H.4    Kim, G.S.5    Choi, J.Y.6    Ryoo, H.M.7
  • 34
    • 77953497987 scopus 로고    scopus 로고
    • ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation
    • van Dinther M., Visser N., de Gorter D.J., Doorn J., Goumans M.J., de Boer J., ten Dijke P. ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation. J. Bone Miner. Res. 2010, 25:1208-1215.
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 1208-1215
    • van Dinther, M.1    Visser, N.2    de Gorter, D.J.3    Doorn, J.4    Goumans, M.J.5    de Boer, J.6    ten Dijke, P.7
  • 35
    • 78049256780 scopus 로고    scopus 로고
    • Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type I receptor that causes fibrodysplasia ossificans progressiva
    • Kaplan F.S., Seemann P., Haupt J., Xu M., Mullins M., Shore E.M. Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type I receptor that causes fibrodysplasia ossificans progressiva. Methods Enzymol. 2010, 484:357-373.
    • (2010) Methods Enzymol. , vol.484 , pp. 357-373
    • Kaplan, F.S.1    Seemann, P.2    Haupt, J.3    Xu, M.4    Mullins, M.5    Shore, E.M.6
  • 37
    • 0031059563 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2/4 in early fibromatous lesions of fibrodysplasia ossificans progressiva
    • Gannon F.H., Kaplan F.S., Olmsted E., Finkel G., Zasloff M.A., Shore E.M. Bone morphogenetic protein 2/4 in early fibromatous lesions of fibrodysplasia ossificans progressiva. Hum. Pathol. 1997, 28:339-343.
    • (1997) Hum. Pathol. , vol.28 , pp. 339-343
    • Gannon, F.H.1    Kaplan, F.S.2    Olmsted, E.3    Finkel, G.4    Zasloff, M.A.5    Shore, E.M.6
  • 38
    • 0038035670 scopus 로고    scopus 로고
    • Paresis of a bone morphogenetic protein-antagonist response in a genetic disorder of heterotopic skeletogenesis
    • Ahn J., Serrano de la Peña L., Shore E.M., Kaplan F.S. Paresis of a bone morphogenetic protein-antagonist response in a genetic disorder of heterotopic skeletogenesis. J. Bone Joint Surg. 2003, 85-A:667-674.
    • (2003) J. Bone Joint Surg. , pp. 667-674
    • Ahn, J.1    Serrano de la Peña, L.2    Shore, E.M.3    Kaplan, F.S.4
  • 39
    • 20844450082 scopus 로고    scopus 로고
    • Fibrodysplasia ossificans progressiva (FOP), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA
    • Serrano de la Peña L., Billings P.C., Fiori J.L., Ahn J., Shore E.M., Kaplan F.S. Fibrodysplasia ossificans progressiva (FOP), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA. J. Bone Miner. Res. 2005, 20:1168-1176.
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 1168-1176
    • Serrano de la Peña, L.1    Billings, P.C.2    Fiori, J.L.3    Ahn, J.4    Shore, E.M.5    Kaplan, F.S.6
  • 40
    • 33646865518 scopus 로고    scopus 로고
    • Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva (FOP)
    • Fiori J.L., Billings P.C., Serrano de la Peña L., Kaplan F.S., Shore E.M. Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva (FOP). J. Bone Miner. Res. 2006, 21:902-909.
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 902-909
    • Fiori, J.L.1    Billings, P.C.2    Serrano de la Peña, L.3    Kaplan, F.S.4    Shore, E.M.5
  • 41
    • 37249016863 scopus 로고    scopus 로고
    • Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva
    • Billings P.C., Fiori J.L., Bentwood J.L., O'Connell M.P., Jiao X., Nussbaum B., Caron R.J., Shore E.M., Kaplan F.S. Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva. J. Bone Miner. Res. 2008, 23:305-313.
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 305-313
    • Billings, P.C.1    Fiori, J.L.2    Bentwood, J.L.3    O'Connell, M.P.4    Jiao, X.5    Nussbaum, B.6    Caron, R.J.7    Shore, E.M.8    Kaplan, F.S.9
  • 43
    • 84899008454 scopus 로고    scopus 로고
    • Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification
    • Culbert A.L., Chakkalakal S.A., Theosmy E.G., Brennan T.A., Kaplan F.S., Shore E.M. Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells 2014, 32:1289-1300.
    • (2014) Stem Cells , vol.32 , pp. 1289-1300
    • Culbert, A.L.1    Chakkalakal, S.A.2    Theosmy, E.G.3    Brennan, T.A.4    Kaplan, F.S.5    Shore, E.M.6
  • 44
    • 83655203094 scopus 로고    scopus 로고
    • Hyperactive BMP signaling induced by ALK2 (R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva
    • Le V.Q., Wharton K.A. Hyperactive BMP signaling induced by ALK2 (R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva. Dev. Dyn. 2012, 241:200-214.
    • (2012) Dev. Dyn. , vol.241 , pp. 200-214
    • Le, V.Q.1    Wharton, K.A.2
  • 46
    • 80051799654 scopus 로고    scopus 로고
    • In vitro analysis of dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP
    • Groppe J.C., Wu J., Shore E.M., Kaplan F.S. In vitro analysis of dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP. Cells Tissues Organs 2011, 194:291-295.
    • (2011) Cells Tissues Organs , vol.194 , pp. 291-295
    • Groppe, J.C.1    Wu, J.2    Shore, E.M.3    Kaplan, F.S.4
  • 47
    • 2542507301 scopus 로고    scopus 로고
    • The immunophilin FKBP12: a molecular guardian of the TGF-beta family type I receptors
    • Wang T., Donahoe P.K. The immunophilin FKBP12: a molecular guardian of the TGF-beta family type I receptors. Front. Biosci. 2004, 9:619-631.
    • (2004) Front. Biosci. , vol.9 , pp. 619-631
    • Wang, T.1    Donahoe, P.K.2
  • 48
    • 0033524943 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12
    • Huse M., Chen Y.G., Massagué J., Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell 1999, 96:425-436.
    • (1999) Cell , vol.96 , pp. 425-436
    • Huse, M.1    Chen, Y.G.2    Massagué, J.3    Kuriyan, J.4
  • 49
    • 0034796457 scopus 로고    scopus 로고
    • The TGF beta receptor activation process: an inhibitor- to substrate-binding switch
    • Huse M., Muir T.W., Xu L., Chen Y.G., Kuriyan J., Massagué J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol. Cell 2001, 8:671-682.
    • (2001) Mol. Cell , vol.8 , pp. 671-682
    • Huse, M.1    Muir, T.W.2    Xu, L.3    Chen, Y.G.4    Kuriyan, J.5    Massagué, J.6
  • 50
    • 70849128432 scopus 로고    scopus 로고
    • Applications of small molecule BMP inhibitors in physiology and disease
    • Hong C.C., Yu P.B. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine Growth Factor Rev. 2009, 20:409-418.
    • (2009) Cytokine Growth Factor Rev. , vol.20 , pp. 409-418
    • Hong, C.C.1    Yu, P.B.2
  • 51
    • 70649097373 scopus 로고    scopus 로고
    • Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVR1 and ACVR1/ALK2
    • Twombly V., Bangi E., Le V., Malnic B., Singer M.A., Wharton K.A. Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVR1 and ACVR1/ALK2. Genetics 2009, 183:563-579.
    • (2009) Genetics , vol.183 , pp. 563-579
    • Twombly, V.1    Bangi, E.2    Le, V.3    Malnic, B.4    Singer, M.A.5    Wharton, K.A.6
  • 52
    • 67349187409 scopus 로고    scopus 로고
    • Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis
    • Little S.C., Mullins M.C. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol. 2009, 11:637-643.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 637-643
    • Little, S.C.1    Mullins, M.C.2
  • 54
    • 0029012733 scopus 로고
    • Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva
    • Lanchoney T.F., Cohen R.B., Rocke D.M., Zasloff M.A., Kaplan F.S. Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva. J. Pediatr. 1995, 126:762-764.
    • (1995) J. Pediatr. , vol.126 , pp. 762-764
    • Lanchoney, T.F.1    Cohen, R.B.2    Rocke, D.M.3    Zasloff, M.A.4    Kaplan, F.S.5
  • 56
    • 0031964498 scopus 로고    scopus 로고
    • Catastrophic falls in patients who have fibrodysplasia ossificans progressiva
    • Glaser D.L., Rocke D.M., Kaplan F.S. Catastrophic falls in patients who have fibrodysplasia ossificans progressiva. Clin. Orthop. Rel. Res. 1998, 346:110-116.
    • (1998) Clin. Orthop. Rel. Res. , vol.346 , pp. 110-116
    • Glaser, D.L.1    Rocke, D.M.2    Kaplan, F.S.3
  • 59
    • 0031984796 scopus 로고    scopus 로고
    • Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva
    • Gannon F.H., Valentine B.A., Shore E.M., Zasloff M.A., Kaplan F.S. Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva. Clin. Orthop. Rel. Res. 1998, 346:19-25.
    • (1998) Clin. Orthop. Rel. Res. , vol.346 , pp. 19-25
    • Gannon, F.H.1    Valentine, B.A.2    Shore, E.M.3    Zasloff, M.A.4    Kaplan, F.S.5
  • 61
    • 0141626663 scopus 로고    scopus 로고
    • Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification
    • Hegyi L., Gannon F.H., Glaser D.L., Shore E.M., Kaplan F.S., Shanahan C.M. Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification. J. Pathol. 2003, 201:141-148.
    • (2003) J. Pathol. , vol.201 , pp. 141-148
    • Hegyi, L.1    Gannon, F.H.2    Glaser, D.L.3    Shore, E.M.4    Kaplan, F.S.5    Shanahan, C.M.6
  • 63
    • 0029915544 scopus 로고    scopus 로고
    • Submandibular swelling in patients with fibrodysplasia ossificans progressiva
    • Janoff H.B., Zasloff M.A., Kaplan F.S. Submandibular swelling in patients with fibrodysplasia ossificans progressiva. Otolaryngol. Head Neck Surg. 1996, 114:599-604.
    • (1996) Otolaryngol. Head Neck Surg. , vol.114 , pp. 599-604
    • Janoff, H.B.1    Zasloff, M.A.2    Kaplan, F.S.3
  • 64
    • 57349171954 scopus 로고    scopus 로고
    • BMP type receptor inhibition reduces heterotopic ossification
    • Yu P.B., et al. BMP type receptor inhibition reduces heterotopic ossification. Nat. Med. 2008, 14:1363-1369.
    • (2008) Nat. Med. , vol.14 , pp. 1363-1369
    • Yu, P.B.1
  • 67
    • 84870041193 scopus 로고    scopus 로고
    • Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis
    • Kaplan F.S., Chakkalakal S.A., Shore E.M. Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis. Dis. Model Mech. 2012, 5:756-762.
    • (2012) Dis. Model Mech. , vol.5 , pp. 756-762
    • Kaplan, F.S.1    Chakkalakal, S.A.2    Shore, E.M.3
  • 68
    • 59849119987 scopus 로고    scopus 로고
    • Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification
    • Kan L., Liu Y., McGuire T.L., Berger D.M., Awatramani R.B., Dymecki S.M., Kessler J.A. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells 2009, 27:150-156.
    • (2009) Stem Cells , vol.27 , pp. 150-156
    • Kan, L.1    Liu, Y.2    McGuire, T.L.3    Berger, D.M.4    Awatramani, R.B.5    Dymecki, S.M.6    Kessler, J.A.7
  • 72
    • 77953796760 scopus 로고    scopus 로고
    • Understanding immunity requires more than immunology
    • Tracey K.J. Understanding immunity requires more than immunology. Nat. Immunol. 2010, 11:561-564.
    • (2010) Nat. Immunol. , vol.11 , pp. 561-564
    • Tracey, K.J.1
  • 74
    • 77951473740 scopus 로고    scopus 로고
    • Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration
    • Clever J.L., Sakai Y., Wang R.A., Schneider D.B. Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration. Am. J. Physiol. Cell Physiol. 2010, 298:C1087-C1099.
    • (2010) Am. J. Physiol. Cell Physiol. , vol.298 , pp. C1087-C1099
    • Clever, J.L.1    Sakai, Y.2    Wang, R.A.3    Schneider, D.B.4
  • 76
    • 34250019537 scopus 로고
    • Bone: formation by autoinduction
    • Urist M.R. Bone: formation by autoinduction. Science 1965, 150:893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 78
    • 0027074882 scopus 로고
    • Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression
    • Cunningham N.S., Paralkar V., Reddi A.H. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:11740-11744.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 11740-11744
    • Cunningham, N.S.1    Paralkar, V.2    Reddi, A.H.3
  • 79
    • 34047221709 scopus 로고    scopus 로고
    • Immunohistochemical localization of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation
    • McCullough K.A., Waits C.A., Garimella R., Tague S.E., Sipe J.B., Anderson H.C. Immunohistochemical localization of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation. J. Orthop. Res. 2007, 25:465-472.
    • (2007) J. Orthop. Res. , vol.25 , pp. 465-472
    • McCullough, K.A.1    Waits, C.A.2    Garimella, R.3    Tague, S.E.4    Sipe, J.B.5    Anderson, H.C.6
  • 81
    • 4644264945 scopus 로고    scopus 로고
    • Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype
    • Kan L., Hu M., Gomes W.A., Kessler J.A. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am. J. Pathol. 2004, 165:1107-1110.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1107-1110
    • Kan, L.1    Hu, M.2    Gomes, W.A.3    Kessler, J.A.4
  • 82
    • 0033567388 scopus 로고    scopus 로고
    • ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    • Kopp E., Medzhitov R., Carothers J., Xiao C., Douglas I., Janeway C.A., Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 1999, 13:2059-2071.
    • (1999) Genes Dev. , vol.13 , pp. 2059-2071
    • Kopp, E.1    Medzhitov, R.2    Carothers, J.3    Xiao, C.4    Douglas, I.5    Janeway, C.A.6    Ghosh, S.7
  • 84
    • 0348014691 scopus 로고    scopus 로고
    • Ecsit-ement on the crossroads of Toll and BMP signal transduction
    • Moustakas A., Heldin C.H. Ecsit-ement on the crossroads of Toll and BMP signal transduction. Genes Dev. 2003, 17:2855-2859.
    • (2003) Genes Dev. , vol.17 , pp. 2855-2859
    • Moustakas, A.1    Heldin, C.H.2
  • 85
    • 84919494829 scopus 로고    scopus 로고
    • TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB
    • Wi S.M., Moon G., Kim J., Kim S.T., Shim J.H., Chun E., Lee K.Y. TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB. J. Biol. Chem. 2014, 289:35205-35214.
    • (2014) J. Biol. Chem. , vol.289 , pp. 35205-35214
    • Wi, S.M.1    Moon, G.2    Kim, J.3    Kim, S.T.4    Shim, J.H.5    Chun, E.6    Lee, K.Y.7
  • 90
    • 33646560934 scopus 로고    scopus 로고
    • Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2
    • Fukuda T., Scott G., Komatsu Y., Araya R., Kawano M., Ray M.K., Yamada M., Mishina Y. Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis 2006, 44:159-167.
    • (2006) Genesis , vol.44 , pp. 159-167
    • Fukuda, T.1    Scott, G.2    Komatsu, Y.3    Araya, R.4    Kawano, M.5    Ray, M.K.6    Yamada, M.7    Mishina, Y.8
  • 91
    • 84859912590 scopus 로고    scopus 로고
    • Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification
    • Wosczyna M.N., Biswas A.A., Cogswell C.A., Goldhamer D.J. Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification. J. Bone Miner. Res. 2012, 27:1004-1017.
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 1004-1017
    • Wosczyna, M.N.1    Biswas, A.A.2    Cogswell, C.A.3    Goldhamer, D.J.4
  • 93
    • 25844522195 scopus 로고    scopus 로고
    • A few hundred people turned to bone
    • Maeder T. A few hundred people turned to bone. Atl. Mon. 1998, 281:81-89.
    • (1998) Atl. Mon. , vol.281 , pp. 81-89
    • Maeder, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.