ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation

Journal of Bone and Mineral Research

Volumn 25, Issue 6, 2010, Pages 1208-1215

  Van Dinther, Maarten ^a   Visser, Nils ^a   De Gorter, David J J ^a   Doorn, Joyce ^b   Goumans, Marie José ^a   De Boer, Jan ^b   Ten Dijke, Peter ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Bone morphogenetic protein; Ectopic bone formation; Fibrodysplasia ossificans progressiva; Osteoblast differentiation; SMAD

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ACTIVIN RECEPTORM LIKE KINASE 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; CALCIUM PHOSPHATE; SMAD1 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; GENE MUTATION; GENETIC TRANSCRIPTION; IMPLANTATION; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHOSPHORYLATION; WILD TYPE;

ACTIVIN RECEPTORS, TYPE I; AMINO ACID SUBSTITUTION; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONE MORPHOGENETIC PROTEINS; CALCIUM PHOSPHATES; CATTLE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHORISTOMA; HUMANS; MESENCHYMAL STEM CELLS; MICE; MUTANT PROTEINS; MUTATION; MYOSITIS OSSIFICANS; OSTEOBLASTS; OSTEOGENESIS; TISSUE SCAFFOLDS;

EID: 77953497987     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.091110     Document Type: Article

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