Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva

Journal of Biological Chemistry

Volumn 284, Issue 11, 2009, Pages 7149-7156

  Fukuda, Toru ^a   Kohda, Masakazu ^a   Kanomata, Kazuhiro ^a   Nojima, Junya ^a   Nakamura, Atsushi ^a   Kamizono, Jyunji ^b   Noguchi, Yasuo ^c   Iwakiri, Kiyofumi ^d   Kondo, Takeo ^e   Kurose, Junichi ^f   Endo, Ken Ichi ^g   Awakura, Takeshi ^h   Fukushi, Junichi ⁱ   Nakashima, Yasuharu ^i,j   Chiyonobu, Tomohiro ^k   Kawara, Akira ^l   Nishida, Yoshihiro ^m   Wada, Ikuo ⁿ   Akita, Masumi ^a   Komori, Tetsuo ^a   Nakayama, Konosuke ^a   Nanba, Akira ^a   Maruki, Yuichi ^a,o   Yoda, Tetsuya ^a   Tomoda, Hiroshi ^a,p   Yu, Paul B ^q   Kaplan, Frederick S ^r   Miyazono, Kohei ^a,s   Matsuoka, Masaru ^a   Ikebuchi, Kenji ^a   Ohtake, Akira ^a   Oda, Hiromi ^a   Jimi, Eijiro ^a,t   Owan, Ichiro ^a,u   Okazaki, Yasushi ^a   Katagiri, Takenobu ^a   more..

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b KITAKYUSHU CITY YAHATA HOSPITAL   (Japan)

^c Saga Prefectural Hospital Koseikan   (Japan)

^d Nagayoshi Orthopedic Clinic   (Japan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f Senjyudo Hospital   (Japan)

^g Endo Clinic   (Japan)

^h Awakura Clinic   (Japan)

ⁱ KYUSHU UNIVERSITY   (Japan)

^j Japan Ministry of Health Labour and Welfare   (Japan)

^k Akashi Municipal Hospital   (Japan)

^l Kawara Clinic   (Japan)

^m NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁿ NAGOYA CITY UNIVERSITY HOSPITAL   (Japan)

^o Saitama Neuropyschiatric Institute   (Japan)

^p KITASATO UNIVERSITY   (Japan)

^q MASSACHUSETTS GENERAL HOSPITAL   (United States)

^r UNIVERSITY OF PENNSYLVANIA   (United States)

^s UNIVERSITY OF TOKYO   (Japan)

^t KYUSHU DENTAL COLLEGE   (Japan)

^u UNIVERSITY OF THE RYUKYUS SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GENE TRANSFER;

AMINO ACID SUBSTITUTION; AUTOSOMAL DOMINANTS; BONE MORPHOGENETIC PROTEINS; CONGENITAL MALFORMATIONS; HETEROTOPIC BONE; LIGAND BINDING; MUSCLE TISSUES; OSTEOBLASTIC DIFFERENTIATION;

PROTEINS;

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; MUTANT PROTEIN; PROTEIN ALK2; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD7 PROTEIN; UNCLASSIFIED DRUG; (6 (4 (2 PIPERIDIN 1 YLETHOXY)PHENYL)) 3 PYRIDIN 4 YLPYRAZOLO(1,5 A)PYRIMIDINE; (6-(4-(2-PIPERIDIN-1-YLETHOXY)PHENYL))-3-PYRIDIN-4-YLPYRAZOLO(1,5-A)PYRIMIDINE; ACTIVIN RECEPTOR 1; ACVR1 PROTEIN, HUMAN; ACVR1 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; MATRIX METALLOPROTEINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SMAD1 PROTEIN, HUMAN; SMAD1 PROTEIN, MOUSE; SMAD5 PROTEIN, HUMAN; SMAD5 PROTEIN, MOUSE; SMAD7 PROTEIN, HUMAN; SMAD7 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENE TRANSFER; HETEROTOPIC OSSIFICATION; HUMAN; JAPANESE; LIGAND BINDING; MOUSE; MUSCLE INJURY; NONHUMAN; OSSIFYING MYOSITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; UPREGULATION; AMINO ACID SUBSTITUTION; ANIMAL; BONE DEVELOPMENT; CELL LINE; FEMALE; GENETICS; MALE; METABOLISM; MISSENSE MUTATION; OSTEOBLAST; PATHOLOGY;

ACTIVIN RECEPTORS, TYPE I; AMINO ACID SUBSTITUTION; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; CELL DIFFERENTIATION; CELL LINE; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASES, SECRETED; MICE; MUTATION, MISSENSE; MYOSITIS OSSIFICANS; OSTEOBLASTS; OSTEOGENESIS; PYRAZOLES; PYRIMIDINES; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD7 PROTEIN;

EID: 65449139561     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801681200     Document Type: Article

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