메뉴 건너뛰기




Volumn 13, Issue 2, 2015, Pages 116-124

The Immunological Contribution to Heterotopic Ossification Disorders

Author keywords

Chemokines; Complement; Cytokines; Fibrodysplasia ossificans progressiva; Heterotopic ossification; Immune system; Lymphocytes; Macrophages; Mast cells; Progressive osseous heteroplasia

Indexed keywords

APREPITANT; BONE MORPHOGENETIC PROTEIN 2; CHEMOKINE; CLODRONIC ACID; CROMOGLYCATE DISODIUM; CYTOKINE; GAMMA INTERFERON; IMATINIB; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84925534285     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-015-0258-z     Document Type: Review
Times cited : (67)

References (105)
  • 1
    • 84888211613 scopus 로고    scopus 로고
    • Blast injuries and heterotopic ossification
    • PID: 23610689
    • Alfieri KA, Forsberg JA, Potter BK. Blast injuries and heterotopic ossification. Bone Joint Res. 2012;1(8):192–7.
    • (2012) Bone Joint Res , vol.1 , Issue.8 , pp. 192-197
    • Alfieri, K.A.1    Forsberg, J.A.2    Potter, B.K.3
  • 2
    • 84859502282 scopus 로고    scopus 로고
    • The incidence of heterotopic ossification after hip arthroscopy
    • PID: 22268230
    • Bedi A, Zbeda RM, Bueno VF, et al. The incidence of heterotopic ossification after hip arthroscopy. Am J Sports Med. 2012;40(4):854–63.
    • (2012) Am J Sports Med , vol.40 , Issue.4 , pp. 854-863
    • Bedi, A.1    Zbeda, R.M.2    Bueno, V.F.3
  • 3
    • 84862260518 scopus 로고    scopus 로고
    • Heterotopic ossification after total hip arthroplasty
    • Cohn RM, Schwarzkopf R, Jaffe F. Heterotopic ossification after total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2011;40(11):E232–5.
    • (2011) Am J Orthop (Belle Mead NJ) , vol.40 , Issue.11 , pp. 232-235
    • Cohn, R.M.1    Schwarzkopf, R.2    Jaffe, F.3
  • 4
    • 47349087316 scopus 로고    scopus 로고
    • Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification
    • PID: 18553568
    • Adegbite NS, Xu M, Kaplan FS, et al. Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification. Am J Med Genet A. 2008;146A(14):1788–96.
    • (2008) Am J Med Genet A , vol.146A , Issue.14 , pp. 1788-1796
    • Adegbite, N.S.1    Xu, M.2    Kaplan, F.S.3
  • 5
    • 61649084689 scopus 로고    scopus 로고
    • Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1
    • PID: 19085907
    • Kaplan FS, Xu M, Seemann P, et al. Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1. Hum Mutat. 2009;30(3):379–90.
    • (2009) Hum Mutat , vol.30 , Issue.3 , pp. 379-390
    • Kaplan, F.S.1    Xu, M.2    Seemann, P.3
  • 6
    • 25844492010 scopus 로고    scopus 로고
    • Nonhereditary heterotopic ossification: implications for injury, arthroplasty, and aging
    • Pignolo RJ, Foley KL. Nonhereditary heterotopic ossification: implications for injury, arthroplasty, and aging. Clin Rev Bone Miner Metab. 2005;3(3–4):261–6.
    • (2005) Clin Rev Bone Miner Metab , vol.3 , Issue.3-4 , pp. 261-266
    • Pignolo, R.J.1    Foley, K.L.2
  • 7
    • 77956261580 scopus 로고    scopus 로고
    • The genetics of heterotopic ossification: insight into the bone remodeling pathway
    • PID: 20736788
    • Mitchell EJ, Canter J, Norris P, et al. The genetics of heterotopic ossification: insight into the bone remodeling pathway. J Orthop Trauma. 2010;24(9):530–3.
    • (2010) J Orthop Trauma , vol.24 , Issue.9 , pp. 530-533
    • Mitchell, E.J.1    Canter, J.2    Norris, P.3
  • 8
    • 70350044926 scopus 로고    scopus 로고
    • Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors
    • PID: 19411456
    • Forsberg JA, Pepek JM, Wagner S, et al. Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors. J Bone Joint Surg Am. 2009;91(5):1084–91.
    • (2009) J Bone Joint Surg Am , vol.91 , Issue.5 , pp. 1084-1091
    • Forsberg, J.A.1    Pepek, J.M.2    Wagner, S.3
  • 9
    • 2942750256 scopus 로고    scopus 로고
    • Influenza-like viral illnesses and flare-ups of fibrodysplasia ossificans progressiva
    • PID: 15232462
    • Scarlett RF, Rocke DM, Kantanie S, et al. Influenza-like viral illnesses and flare-ups of fibrodysplasia ossificans progressiva. Clin Orthop Relat Res. 2004;423:275–9.
    • (2004) Clin Orthop Relat Res , vol.423 , pp. 275-279
    • Scarlett, R.F.1    Rocke, D.M.2    Kantanie, S.3
  • 10
    • 80053034418 scopus 로고    scopus 로고
    • Sensory nerve induced inflammation contributes to heterotopic ossification
    • PID: 21678472
    • Salisbury E, Rodenberg E, Sonnet C, et al. Sensory nerve induced inflammation contributes to heterotopic ossification. J Cell Biochem. 2011;112(10):2748–58.
    • (2011) J Cell Biochem , vol.112 , Issue.10 , pp. 2748-2758
    • Salisbury, E.1    Rodenberg, E.2    Sonnet, C.3
  • 11
    • 57349171954 scopus 로고    scopus 로고
    • BMP type I receptor inhibition reduces heterotopic [corrected] ossification
    • PID: 19029982
    • Yu PB, Deng DY, Lai CS, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008;14(12):1363–9.
    • (2008) Nat Med , vol.14 , Issue.12 , pp. 1363-1369
    • Yu, P.B.1    Deng, D.Y.2    Lai, C.S.3
  • 12
    • 84877039859 scopus 로고    scopus 로고
    • Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans
    • PID: 23571050
    • Hoff P, Rakow A, Gaber T, et al. Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans. Bone. 2013;55(1):93–101.
    • (2013) Bone , vol.55 , Issue.1 , pp. 93-101
    • Hoff, P.1    Rakow, A.2    Gaber, T.3
  • 13
    • 84876093457 scopus 로고    scopus 로고
    • Inflammatory cytokine and chemokine expression is associated with heterotopic ossification in high-energy penetrating war injuries
    • PID: 22588530
    • Evans KN, Forsberg JA, Potter BK, et al. Inflammatory cytokine and chemokine expression is associated with heterotopic ossification in high-energy penetrating war injuries. J Orthop Trauma. 2012;26(11):e204–13.
    • (2012) J Orthop Trauma , vol.26 , Issue.11 , pp. 204-213
    • Evans, K.N.1    Forsberg, J.A.2    Potter, B.K.3
  • 14
    • 25844469044 scopus 로고    scopus 로고
    • Immunological features of fibrodysplasia ossificans progressiva and the dysregulated BMP4 pathway
    • Kaplan FS, Shore EM, Gupta R, et al. Immunological features of fibrodysplasia ossificans progressiva and the dysregulated BMP4 pathway. Clin Rev Bone Miner Metab. 2005;3(3–4):189–93.
    • (2005) Clin Rev Bone Miner Metab , vol.3 , Issue.3-4 , pp. 189-193
    • Kaplan, F.S.1    Shore, E.M.2    Gupta, R.3
  • 15
    • 84905976527 scopus 로고    scopus 로고
    • Do inflammatory markers portend heterotopic ossification and wound failure in combat wounds?
    • PID: 24879568
    • Forsberg JA, Potter BK, Polfer EM, et al. Do inflammatory markers portend heterotopic ossification and wound failure in combat wounds? Clin Orthop Relat Res. 2014;472(9):2845–54.
    • (2014) Clin Orthop Relat Res , vol.472 , Issue.9 , pp. 2845-2854
    • Forsberg, J.A.1    Potter, B.K.2    Polfer, E.M.3
  • 16
    • 0029012733 scopus 로고
    • Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva
    • PID: 7752003
    • Lanchoney TF, Cohen RB, Rocke DM, et al. Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva. J Pediatr. 1995;126(5 Pt 1):762–4.
    • (1995) J Pediatr , vol.126 , pp. 762-764
    • Lanchoney, T.F.1    Cohen, R.B.2    Rocke, D.M.3
  • 17
    • 77956275161 scopus 로고    scopus 로고
    • Inherited human diseases of heterotopic bone formation
    • PID: 20703219
    • Shore EM, Kaplan FS. Inherited human diseases of heterotopic bone formation. Nat Rev Rheumatol. 2010;6(9):518–27.
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.9 , pp. 518-527
    • Shore, E.M.1    Kaplan, F.S.2
  • 18
    • 0037050365 scopus 로고    scopus 로고
    • Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia
    • Shore EM, Ahn J, Jan de Beur S, et al. Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia. N Engl J Med. 2002;346(2):99–106.
    • (2002) N Engl J Med , vol.346 , Issue.2 , pp. 99-106
    • Shore, E.M.1    Ahn, J.2    Jan de Beur, S.3
  • 19
    • 33646348736 scopus 로고    scopus 로고
    • A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
    • PID: 16642017
    • Shore EM, Xu M, Feldman GJ, et al. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet. 2006;38(5):525–7.
    • (2006) Nat Genet , vol.38 , Issue.5 , pp. 525-527
    • Shore, E.M.1    Xu, M.2    Feldman, G.J.3
  • 20
    • 0034735792 scopus 로고    scopus 로고
    • Bone versus immune system
    • PID: 11117729
    • Arron JR, Choi Y. Bone versus immune system. Nature. 2000;408(6812):535–6.
    • (2000) Nature , vol.408 , Issue.6812 , pp. 535-536
    • Arron, J.R.1    Choi, Y.2
  • 21
    • 79959508609 scopus 로고    scopus 로고
    • Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model
    • PID: 21305607
    • Alexander KA, Chang MK, Maylin ER, et al. Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Miner Res. 2011;26(7):1517–32.
    • (2011) J Bone Miner Res , vol.26 , Issue.7 , pp. 1517-1532
    • Alexander, K.A.1    Chang, M.K.2    Maylin, E.R.3
  • 22
    • 84894144846 scopus 로고    scopus 로고
    • Complement C3 and C5 deficiency affects fracture healing
    • PID: 24260573
    • Ehrnthaller C, Huber-Lang M, Nilsson P, et al. Complement C3 and C5 deficiency affects fracture healing. PLoS One. 2013;8(11):e81341.
    • (2013) PLoS One , vol.8 , Issue.11 , pp. 81341
    • Ehrnthaller, C.1    Huber-Lang, M.2    Nilsson, P.3
  • 23
    • 84879879893 scopus 로고    scopus 로고
    • The role of complement in trauma and fracture healing
    • PID: 23768898
    • Huber-Lang M, Kovtun A, Ignatius A. The role of complement in trauma and fracture healing. Semin Immunol. 2013;25(1):73–8.
    • (2013) Semin Immunol , vol.25 , Issue.1 , pp. 73-78
    • Huber-Lang, M.1    Kovtun, A.2    Ignatius, A.3
  • 24
    • 84912550880 scopus 로고    scopus 로고
    • Unraveling macrophage contributions to bone repair
    • Wu AC, Raggatt LJ, Alexander KA, et al. Unraveling macrophage contributions to bone repair. Bonekey Rep. 2013;2:373.
    • (2013) Bonekey Rep , vol.2 , pp. 373
    • Wu, A.C.1    Raggatt, L.J.2    Alexander, K.A.3
  • 25
    • 84893205545 scopus 로고    scopus 로고
    • Bone and the innate immune system
    • PID: 24500569
    • Charles JF, Nakamura MC. Bone and the innate immune system. Curr Osteoporos Rep. 2014;12(1):1–8.
    • (2014) Curr Osteoporos Rep , vol.12 , Issue.1 , pp. 1-8
    • Charles, J.F.1    Nakamura, M.C.2
  • 26
    • 33750953842 scopus 로고    scopus 로고
    • Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system
    • PID: 17075861
    • De Benedetti F, Rucci N, Del Fattore A, et al. Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum. 2006;54(11):3551–63.
    • (2006) Arthritis Rheum , vol.54 , Issue.11 , pp. 3551-3563
    • De Benedetti, F.1    Rucci, N.2    Del Fattore, A.3
  • 27
    • 84860475314 scopus 로고    scopus 로고
    • Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice
    • PID: 22558291
    • Bonar SL, Brydges SD, Mueller JL, et al. Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice. PLoS One. 2012;7(4):e35979.
    • (2012) PLoS One , vol.7 , Issue.4 , pp. 35979
    • Bonar, S.L.1    Brydges, S.D.2    Mueller, J.L.3
  • 28
    • 67849119581 scopus 로고    scopus 로고
    • Bone loss in inflammatory disorders
    • PID: 19443863
    • Hardy R, Cooper MS. Bone loss in inflammatory disorders. J Endocrinol. 2009;201(3):309–20.
    • (2009) J Endocrinol , vol.201 , Issue.3 , pp. 309-320
    • Hardy, R.1    Cooper, M.S.2
  • 29
    • 66449088641 scopus 로고    scopus 로고
    • Pathogen recognition and inflammatory signaling in innate immune defenses
    • PID: 19366914, Table of Contents
    • Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22(2):240–73. Table of Contents.
    • (2009) Clin Microbiol Rev , vol.22 , Issue.2 , pp. 240-273
    • Mogensen, T.H.1
  • 30
    • 79955483094 scopus 로고    scopus 로고
    • Design principles of adaptive immune systems
    • PID: 21475308
    • Boehm T. Design principles of adaptive immune systems. Nat Rev Immunol. 2011;11(5):307–17.
    • (2011) Nat Rev Immunol , vol.11 , Issue.5 , pp. 307-317
    • Boehm, T.1
  • 32
    • 40449127195 scopus 로고    scopus 로고
    • Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function
    • Ishida Y, Gao JL, Murphy PM. Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. J Immunol. 2007;180(1):569–79.
    • (2007) J Immunol , vol.180 , Issue.1 , pp. 569-579
    • Ishida, Y.1    Gao, J.L.2    Murphy, P.M.3
  • 33
    • 12344259549 scopus 로고    scopus 로고
    • Inflammatory processes in muscle injury and repair
    • PID: 15637171
    • Tidball JG. Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol. 2005;288(2):R345–53.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288 , Issue.2 , pp. 345-353
    • Tidball, J.G.1
  • 34
    • 80053028119 scopus 로고    scopus 로고
    • Kan L, Lounev VY, Pignolo RJ, et al. Substance P signaling mediates BMP-dependent heterotopic ossification. J Cell Biochem. 2011;112(10):2759–72. This study is the first to show that chemical inhibition of mast cells and Substance P signaling significantly reduces HO formation in vivo and provides a link between elevated Substance P levels in FOP patients and HO development
    • Kan L, Lounev VY, Pignolo RJ, et al. Substance P signaling mediates BMP-dependent heterotopic ossification. J Cell Biochem. 2011;112(10):2759–72. This study is the first to show that chemical inhibition of mast cells and Substance P signaling significantly reduces HO formation in vivo and provides a link between elevated Substance P levels in FOP patients and HO development.
  • 35
    • 84894460361 scopus 로고    scopus 로고
    • Kan L, Mutso AA, McGuire TL, et al. Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification. Inflamm Res. 2014;63(3):207–15. This study further elucidated the role of mast cells and their signaling pathways in the development of HO
    • Kan L, Mutso AA, McGuire TL, et al. Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification. Inflamm Res. 2014;63(3):207–15. This study further elucidated the role of mast cells and their signaling pathways in the development of HO.
  • 36
    • 59849119987 scopus 로고    scopus 로고
    • Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification
    • PID: 18832590
    • Kan L, Liu Y, McGuire TL, et al. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells. 2009;27(1):150–6.
    • (2009) Stem Cells , vol.27 , Issue.1 , pp. 150-156
    • Kan, L.1    Liu, Y.2    McGuire, T.L.3
  • 37
    • 0036137896 scopus 로고    scopus 로고
    • Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2
    • PID: 11792561
    • Champagne CM, Takebe J, Offenbacher S, et al. Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2. Bone. 2002;30(1):26–31.
    • (2002) Bone , vol.30 , Issue.1 , pp. 26-31
    • Champagne, C.M.1    Takebe, J.2    Offenbacher, S.3
  • 38
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • PID: 19029990
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8(12):958–69.
    • (2008) Nat Rev Immunol , vol.8 , Issue.12 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 39
    • 0035916929 scopus 로고    scopus 로고
    • Bone formation and inflammation in cardiac valves
    • PID: 11257079
    • Mohler ER, Gannon F, Reynolds C, et al. Bone formation and inflammation in cardiac valves. Circulation. 2001;103(11):1522–8.
    • (2001) Circulation , vol.103 , Issue.11 , pp. 1522-1528
    • Mohler, E.R.1    Gannon, F.2    Reynolds, C.3
  • 40
    • 0034878150 scopus 로고    scopus 로고
    • Mast cell involvement in fibrodysplasia ossificans progressiva
    • PID: 11521229
    • Gannon FH, Glaser D, Caron R, et al. Mast cell involvement in fibrodysplasia ossificans progressiva. Hum Pathol. 2001;32(8):842–8.
    • (2001) Hum Pathol , vol.32 , Issue.8 , pp. 842-848
    • Gannon, F.H.1    Glaser, D.2    Caron, R.3
  • 41
    • 7444254949 scopus 로고    scopus 로고
    • Ossification of the peritoneal membrane
    • PID: 15490988
    • Di Paolo N, Sacchi G, Lorenzoni P, et al. Ossification of the peritoneal membrane. Perit Dial Int. 2004;24(5):471–7.
    • (2004) Perit Dial Int , vol.24 , Issue.5 , pp. 471-477
    • Di Paolo, N.1    Sacchi, G.2    Lorenzoni, P.3
  • 42
    • 0031201054 scopus 로고    scopus 로고
    • Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation
    • PID: 9250144
    • Smith RS, Smith TJ, Blieden TM, et al. Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol. 1997;151(2):317–22.
    • (1997) Am J Pathol , vol.151 , Issue.2 , pp. 317-322
    • Smith, R.S.1    Smith, T.J.2    Blieden, T.M.3
  • 43
    • 77955883153 scopus 로고    scopus 로고
    • Complement: a key system for immune surveillance and homeostasis
    • PID: 20720586
    • Ricklin D, Hajishengallis G, Yang K, et al. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11(9):785–97.
    • (2010) Nat Immunol , vol.11 , Issue.9 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3
  • 44
    • 84860389426 scopus 로고    scopus 로고
    • Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1beta
    • PID: 21598302
    • Ignatius A, Schoengraf P, Kreja L, et al. Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1beta. J Cell Biochem. 2011;112(9):2594–605.
    • (2011) J Cell Biochem , vol.112 , Issue.9 , pp. 2594-2605
    • Ignatius, A.1    Schoengraf, P.2    Kreja, L.3
  • 45
    • 0141996516 scopus 로고    scopus 로고
    • A living case of pulmonary ossification associated with osteoclast formation from alveolar macrophage in the presence of T-cell cytokines
    • PID: 14518672
    • Tsuji T, Nakamura S, Komuro I, et al. A living case of pulmonary ossification associated with osteoclast formation from alveolar macrophage in the presence of T-cell cytokines. Intern Med. 2003;42(9):834–8.
    • (2003) Intern Med , vol.42 , Issue.9 , pp. 834-838
    • Tsuji, T.1    Nakamura, S.2    Komuro, I.3
  • 46
    • 84864115359 scopus 로고    scopus 로고
    • Chakkalakal SA, Zhang D, Culbert AL, et al. An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva. J Bone Miner Res. 2012;27(8):1746–56. The first publication of an Alk2 (R206H) knock-in mouse model of HO, resulting in very strong recapitulation of the human disease
    • Chakkalakal SA, Zhang D, Culbert AL, et al. An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva. J Bone Miner Res. 2012;27(8):1746–56. The first publication of an Alk2 (R206H) knock-in mouse model of HO, resulting in very strong recapitulation of the human disease.
  • 47
    • 0141626663 scopus 로고    scopus 로고
    • Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification?
    • PID: 12950027
    • Hegyi L, Gannon FH, Glaser DL, et al. Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification? J Pathol. 2003;201(1):141–8.
    • (2003) J Pathol , vol.201 , Issue.1 , pp. 141-148
    • Hegyi, L.1    Gannon, F.H.2    Glaser, D.L.3
  • 48
    • 4644264945 scopus 로고    scopus 로고
    • Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype
    • PID: 15466378
    • Kan L, Hu M, Gomes WA, et al. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am J Pathol. 2004;165(4):1107–15.
    • (2004) Am J Pathol , vol.165 , Issue.4 , pp. 1107-1115
    • Kan, L.1    Hu, M.2    Gomes, W.A.3
  • 49
    • 84873743410 scopus 로고    scopus 로고
    • M1 and M2 macrophages: oracles of health and disease
    • PID: 23428224
    • Mills CD. M1 and M2 macrophages: oracles of health and disease. Crit Rev Immunol. 2012;32(6):463–88.
    • (2012) Crit Rev Immunol , vol.32 , Issue.6 , pp. 463-488
    • Mills, C.D.1
  • 50
    • 33846581108 scopus 로고    scopus 로고
    • Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
    • PID: 17259966
    • Bischoff SC. Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol. 2007;7(2):93–104.
    • (2007) Nat Rev Immunol , vol.7 , Issue.2 , pp. 93-104
    • Bischoff, S.C.1
  • 51
    • 84872596950 scopus 로고    scopus 로고
    • Mast cell activation syndrome: a review
    • PID: 23179866
    • Frieri M, Patel R, Celestin J. Mast cell activation syndrome: a review. Curr Allergy Asthma Rep. 2013;13(1):27–32.
    • (2013) Curr Allergy Asthma Rep , vol.13 , Issue.1 , pp. 27-32
    • Frieri, M.1    Patel, R.2    Celestin, J.3
  • 52
    • 84893344124 scopus 로고    scopus 로고
    • Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing
    • PID: 24507159
    • Douaiher J, Succar J, Lancerotto L, et al. Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing. Adv Immunol. 2014;122:211–52.
    • (2014) Adv Immunol , vol.122 , pp. 211-252
    • Douaiher, J.1    Succar, J.2    Lancerotto, L.3
  • 53
    • 84885469901 scopus 로고    scopus 로고
    • A snapshot of direct cell-cell communications in wound healing and scarring
    • Ehrlich HP. A snapshot of direct cell-cell communications in wound healing and scarring. Adv Wound Care (New Rochelle). 2013;2(4):113–21.
    • (2013) Adv Wound Care (New Rochelle) , vol.2 , Issue.4 , pp. 113-121
    • Ehrlich, H.P.1
  • 54
    • 84864299611 scopus 로고    scopus 로고
    • Widespread immunological functions of mast cells: fact or fiction?
    • PID: 22840840
    • Rodewald HR, Feyerabend TB. Widespread immunological functions of mast cells: fact or fiction? Immunity. 2012;37(1):13–24.
    • (2012) Immunity , vol.37 , Issue.1 , pp. 13-24
    • Rodewald, H.R.1    Feyerabend, T.B.2
  • 55
    • 84887331111 scopus 로고    scopus 로고
    • Mast cell activation contributes to sickle cell pathobiology and pain in mice
    • PID: 23775718
    • Vincent L, Vang D, Nguyen J, et al. Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood. 2013;122(11):1853–62.
    • (2013) Blood , vol.122 , Issue.11 , pp. 1853-1862
    • Vincent, L.1    Vang, D.2    Nguyen, J.3
  • 56
    • 84925464029 scopus 로고    scopus 로고
    • Mast cells as targets for immunotherapy of solid tumors, Mol Immunol:
    • Oldford SA, Marshall JS. Mast cells as targets for immunotherapy of solid tumors. Mol Immunol. 2014.
    • (2014) Marshall JS
    • Oldford, S.A.1
  • 57
    • 84886784908 scopus 로고    scopus 로고
    • A focus on mast cells and pain
    • PID: 24125568
    • Heron A, Dubayle D. A focus on mast cells and pain. J Neuroimmunol. 2013;264(1–2):1–7.
    • (2013) J Neuroimmunol , vol.264 , Issue.1-2 , pp. 1-7
    • Heron, A.1    Dubayle, D.2
  • 58
    • 84890175534 scopus 로고    scopus 로고
    • The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan
    • PID: 24246646
    • Farrugia BL, Whitelock JM, Jung M, et al. The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan. Biomaterials. 2014;35(5):1462–77.
    • (2014) Biomaterials , vol.35 , Issue.5 , pp. 1462-1477
    • Farrugia, B.L.1    Whitelock, J.M.2    Jung, M.3
  • 59
    • 80052967617 scopus 로고    scopus 로고
    • The pivotal role of fibrocytes and mast cells in mediating fibrotic reactions to biomaterials
    • PID: 21864899
    • Thevenot PT, Baker DW, Weng H, et al. The pivotal role of fibrocytes and mast cells in mediating fibrotic reactions to biomaterials. Biomaterials. 2011;32(33):8394–403.
    • (2011) Biomaterials , vol.32 , Issue.33 , pp. 8394-8403
    • Thevenot, P.T.1    Baker, D.W.2    Weng, H.3
  • 60
    • 44349101991 scopus 로고    scopus 로고
    • Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
    • PID: 18483499
    • Galli SJ, Grimbaldeston M, Tsai M. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol. 2008;8(6):478–86.
    • (2008) Nat Rev Immunol , vol.8 , Issue.6 , pp. 478-486
    • Galli, S.J.1    Grimbaldeston, M.2    Tsai, M.3
  • 61
    • 54549103514 scopus 로고    scopus 로고
    • New developments in mast cell biology
    • PID: 18936782
    • Kalesnikoff J, Galli SJ. New developments in mast cell biology. Nat Immunol. 2008;9(11):1215–23.
    • (2008) Nat Immunol , vol.9 , Issue.11 , pp. 1215-1223
    • Kalesnikoff, J.1    Galli, S.J.2
  • 62
    • 84871435201 scopus 로고    scopus 로고
    • Mast cell: an emerging partner in immune interaction
    • PID: 22654879
    • Gri G, Frossi B, D’Inca F, et al. Mast cell: an emerging partner in immune interaction. Front Immunol. 2012;3:120.
    • (2012) Front Immunol , vol.3 , pp. 120
    • Gri, G.1    Frossi, B.2    D’Inca, F.3
  • 63
    • 40849094518 scopus 로고    scopus 로고
    • Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons
    • PID: 18079356
    • Bucelli RC, Gonsiorek EA, Kim WY, et al. Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. J Pharmacol Exp Ther. 2008;324(3):1172–80.
    • (2008) J Pharmacol Exp Ther , vol.324 , Issue.3 , pp. 1172-1180
    • Bucelli, R.C.1    Gonsiorek, E.A.2    Kim, W.Y.3
  • 65
    • 84893745158 scopus 로고    scopus 로고
    • Are mast cells instrumental for fibrotic diseases?
    • PID: 24478701
    • Overed-Sayer C, Rapley L, Mustelin T, et al. Are mast cells instrumental for fibrotic diseases? Front Pharmacol. 2013;4:174.
    • (2013) Front Pharmacol , vol.4 , pp. 174
    • Overed-Sayer, C.1    Rapley, L.2    Mustelin, T.3
  • 66
    • 84863097573 scopus 로고    scopus 로고
    • The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures
    • PID: 22173279
    • Monument MJ, Hart DA, Befus AD, et al. The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures. Inflamm Res. 2012;61(4):285–92.
    • (2012) Inflamm Res , vol.61 , Issue.4 , pp. 285-292
    • Monument, M.J.1    Hart, D.A.2    Befus, A.D.3
  • 67
    • 77954933984 scopus 로고    scopus 로고
    • The origins of vertebrate adaptive immunity
    • PID: 20651744
    • Litman GW, Rast JP, Fugmann SD. The origins of vertebrate adaptive immunity. Nat Rev Immunol. 2010;10(8):543–53.
    • (2010) Nat Rev Immunol , vol.10 , Issue.8 , pp. 543-553
    • Litman, G.W.1    Rast, J.P.2    Fugmann, S.D.3
  • 68
    • 79952279446 scopus 로고    scopus 로고
    • Evolutionary divergence and functions of the human interleukin (IL) gene family
    • PID: 21106488
    • Brocker C, Thompson D, Matsumoto A, et al. Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum Genomics. 2010;5(1):30–55.
    • (2010) Hum Genomics , vol.5 , Issue.1 , pp. 30-55
    • Brocker, C.1    Thompson, D.2    Matsumoto, A.3
  • 69
    • 65549165903 scopus 로고    scopus 로고
    • Interferons and viral infections
    • PID: 19319841
    • Fensterl V, Sen GC. Interferons and viral infections. Biofactors. 2009;35(1):14–20.
    • (2009) Biofactors , vol.35 , Issue.1 , pp. 14-20
    • Fensterl, V.1    Sen, G.C.2
  • 70
    • 0031984796 scopus 로고    scopus 로고
    • Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva
    • PID: 9577406
    • Gannon FH, Valentine BA, Shore EM, et al. Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva. Clin Orthop Relat Res. 1998;346:19–25.
    • (1998) Clin Orthop Relat Res , vol.346 , pp. 19-25
    • Gannon, F.H.1    Valentine, B.A.2    Shore, E.M.3
  • 71
    • 33846839273 scopus 로고    scopus 로고
    • Hematopoietic stem-cell contribution to ectopic skeletogenesis
    • PID: 17272450
    • Kaplan FS, Glaser DL, Shore EM, et al. Hematopoietic stem-cell contribution to ectopic skeletogenesis. J Bone Joint Surg Am. 2007;89(2):347–57.
    • (2007) J Bone Joint Surg Am , vol.89 , Issue.2 , pp. 347-357
    • Kaplan, F.S.1    Glaser, D.L.2    Shore, E.M.3
  • 72
    • 81755173571 scopus 로고    scopus 로고
    • Role for circulating osteogenic precursor cells in aortic valvular disease
    • PID: 21903944
    • Egan KP, Kim JH, Mohler 3rd ER, et al. Role for circulating osteogenic precursor cells in aortic valvular disease. Arterioscler Thromb Vasc Biol. 2011;31(12):2965–71.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.12 , pp. 2965-2971
    • Egan, K.P.1    Kim, J.H.2    Mohler, E.R.3
  • 73
    • 33745631250 scopus 로고    scopus 로고
    • T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization
    • PID: 16619272
    • Rifas L. T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization. J Cell Biochem. 2006;98(4):706–14.
    • (2006) J Cell Biochem , vol.98 , Issue.4 , pp. 706-714
    • Rifas, L.1
  • 74
    • 0028270481 scopus 로고
    • Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant
    • PID: 8170963
    • Carr MW, Roth SJ, Luther E, et al. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994;91(9):3652–6.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.9 , pp. 3652-3656
    • Carr, M.W.1    Roth, S.J.2    Luther, E.3
  • 75
    • 66149172257 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 (MCP-1): an overview
    • PID: 19441883
    • Deshmane SL, Kremlev S, Amini S, et al. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res. 2009;29(6):313–26.
    • (2009) J Interferon Cytokine Res , vol.29 , Issue.6 , pp. 313-326
    • Deshmane, S.L.1    Kremlev, S.2    Amini, S.3
  • 76
    • 60849136593 scopus 로고    scopus 로고
    • Mesenchymal stem cell homing: the devil is in the details
    • PID: 19265660
    • Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell. 2009;4(3):206–16.
    • (2009) Cell Stem Cell , vol.4 , Issue.3 , pp. 206-216
    • Karp, J.M.1    Leng Teo, G.S.2
  • 77
    • 51849086413 scopus 로고    scopus 로고
    • Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human
    • PID: 18698345
    • Chamberlain G, Wright K, Rot A, et al. Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. PLoS One. 2008;3(8):e2934.
    • (2008) PLoS One , vol.3 , Issue.8 , pp. 2934
    • Chamberlain, G.1    Wright, K.2    Rot, A.3
  • 78
    • 22144491551 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets
    • PID: 15784733
    • Sordi V, Malosio ML, Marchesi F, et al. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood. 2005;106(2):419–27.
    • (2005) Blood , vol.106 , Issue.2 , pp. 419-427
    • Sordi, V.1    Malosio, M.L.2    Marchesi, F.3
  • 79
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • PID: 18161745
    • Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214(2):199–210.
    • (2008) J Pathol , vol.214 , Issue.2 , pp. 199-210
    • Wynn, T.A.1
  • 80
    • 4644225081 scopus 로고    scopus 로고
    • IL-13 activates a mechanism of tissue fibrosis that is completely TGF-independent
    • PID: 15356151
    • Kaviratne M, Hesse M, Leusink M, et al. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-independent. J Immunol. 2004;173(6):4020–9.
    • (2004) J Immunol , vol.173 , Issue.6 , pp. 4020-4029
    • Kaviratne, M.1    Hesse, M.2    Leusink, M.3
  • 81
    • 84899008454 scopus 로고    scopus 로고
    • Culbert AL, Chakkalakal SA, Theosmy EG, et al. Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells. 2014;32(5):1289–300. This study utilized in vitro and in vivo approaches to demonstrate the molecular role of Alk2 in the chondrogenesis stage of HO in FOP
    • Culbert AL, Chakkalakal SA, Theosmy EG, et al. Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells. 2014;32(5):1289–300. This study utilized in vitro and in vivo approaches to demonstrate the molecular role of Alk2 in the chondrogenesis stage of HO in FOP.
  • 82
    • 79952291528 scopus 로고    scopus 로고
    • Akdis M, Burgler S, Crameri R, et al. Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2011;127(3):701–21. e1-70
    • Akdis M, Burgler S, Crameri R, et al. Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2011;127(3):701–21. e1-70.
  • 83
    • 0345689338 scopus 로고    scopus 로고
    • BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis
    • PID: 12920023
    • Tsai PT, Lee RA, Wu H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003;102(12):3947–53.
    • (2003) Blood , vol.102 , Issue.12 , pp. 3947-3953
    • Tsai, P.T.1    Lee, R.A.2    Wu, H.3
  • 84
    • 0033380772 scopus 로고    scopus 로고
    • Lineage-restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines
    • PID: 10660478
    • Detmer K, Steele TA, Shoop MA, et al. Lineage-restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines. Blood Cells Mol Dis. 1999;25(5–6):310–23.
    • (1999) Blood Cells Mol Dis , vol.25 , Issue.5-6 , pp. 310-323
    • Detmer, K.1    Steele, T.A.2    Shoop, M.A.3
  • 85
    • 35348827881 scopus 로고    scopus 로고
    • Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells
    • PID: 17899540
    • Sivertsen EA, Huse K, Hystad ME, et al. Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells. Eur J Immunol. 2007;37(10):2937–48.
    • (2007) Eur J Immunol , vol.37 , Issue.10 , pp. 2937-2948
    • Sivertsen, E.A.1    Huse, K.2    Hystad, M.E.3
  • 86
    • 77649158924 scopus 로고    scopus 로고
    • Exaggerated inflammatory response after use of recombinant bone morphogenetic protein in recurrent unicameral bone cysts
    • PID: 20179570
    • MacDonald KM, Swanstrom MM, McCarthy JJ, et al. Exaggerated inflammatory response after use of recombinant bone morphogenetic protein in recurrent unicameral bone cysts. J Pediatr Orthop. 2010;30(2):199–205.
    • (2010) J Pediatr Orthop , vol.30 , Issue.2 , pp. 199-205
    • MacDonald, K.M.1    Swanstrom, M.M.2    McCarthy, J.J.3
  • 87
    • 0027074882 scopus 로고
    • Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression
    • PID: 1334547
    • Cunningham NS, Paralkar V, Reddi AH. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Proc Natl Acad Sci U S A. 1992;89(24):11740–4.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.24 , pp. 11740-11744
    • Cunningham, N.S.1    Paralkar, V.2    Reddi, A.H.3
  • 88
    • 58149253167 scopus 로고    scopus 로고
    • Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)
    • PID: 18979151
    • Kaplan FS, Shen Q, Lounev V, et al. Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP). J Bone Miner Metab. 2008;26(6):521–30.
    • (2008) J Bone Miner Metab , vol.26 , Issue.6 , pp. 521-530
    • Kaplan, F.S.1    Shen, Q.2    Lounev, V.3
  • 89
    • 79953736346 scopus 로고    scopus 로고
    • Shimono K, Tung WE, Macolino C, et al. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists. Nat Med. 2011;17(4):454–60. This study documents potent in vivo inhibition of HO by administration with retinoic acid receptor-gamma agonists, identifying a new potential therapeutic target for the treatment of HO disorders
    • Shimono K, Tung WE, Macolino C, et al. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists. Nat Med. 2011;17(4):454–60. This study documents potent in vivo inhibition of HO by administration with retinoic acid receptor-gamma agonists, identifying a new potential therapeutic target for the treatment of HO disorders.
  • 90
    • 70449528507 scopus 로고    scopus 로고
    • Prophylaxis of heterotopic ossification of the hip: systematic review and meta-analysis
    • PID: 19517202
    • Vavken P, Castellani L, Sculco TP. Prophylaxis of heterotopic ossification of the hip: systematic review and meta-analysis. Clin Orthop Relat Res. 2009;467(12):3283–9.
    • (2009) Clin Orthop Relat Res , vol.467 , Issue.12 , pp. 3283-3289
    • Vavken, P.1    Castellani, L.2    Sculco, T.P.3
  • 91
    • 0030696015 scopus 로고    scopus 로고
    • The in vivo anabolic actions of prostaglandins in bone
    • PID: 9315332
    • Jee WS, Ma YF. The in vivo anabolic actions of prostaglandins in bone. Bone. 1997;21(4):297–304.
    • (1997) Bone , vol.21 , Issue.4 , pp. 297-304
    • Jee, W.S.1    Ma, Y.F.2
  • 92
    • 34147155238 scopus 로고    scopus 로고
    • Selective COX-2 inhibitor versus indomethacin for the prevention of heterotopic ossification after hip replacement: a double-blind randomized trial of 100 patients with 1-year follow-up
    • PID: 17453399
    • Grohs JG, Schmidt M, Wanivenhaus A. Selective COX-2 inhibitor versus indomethacin for the prevention of heterotopic ossification after hip replacement: a double-blind randomized trial of 100 patients with 1-year follow-up. Acta Orthop. 2007;78(1):95–8.
    • (2007) Acta Orthop , vol.78 , Issue.1 , pp. 95-98
    • Grohs, J.G.1    Schmidt, M.2    Wanivenhaus, A.3
  • 93
    • 0024428780 scopus 로고
    • The liposome-mediated macrophage ‘suicide’ technique
    • PID: 2530286
    • Van Rooijen N. The liposome-mediated macrophage ‘suicide’ technique. J Immunol Methods. 1989;124(1):1–6.
    • (1989) J Immunol Methods , vol.124 , Issue.1 , pp. 1-6
    • Van Rooijen, N.1
  • 94
    • 84867073684 scopus 로고    scopus 로고
    • Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice
    • PID: 22673886
    • Ferenbach DA, Sheldrake TA, Dhaliwal K, et al. Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice. Kidney Int. 2012;82(8):928–33.
    • (2012) Kidney Int , vol.82 , Issue.8 , pp. 928-933
    • Ferenbach, D.A.1    Sheldrake, T.A.2    Dhaliwal, K.3
  • 95
    • 33744821877 scopus 로고    scopus 로고
    • Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study
    • PID: 16424086
    • Summan M, Warren GL, Mercer RR, et al. Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study. Am J Physiol Regul Integr Comp Physiol. 2006;290(6):R1488–95.
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.290 , Issue.6 , pp. 1488-1495
    • Summan, M.1    Warren, G.L.2    Mercer, R.R.3
  • 96
    • 0030009240 scopus 로고    scopus 로고
    • Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid
    • PID: 8621159
    • Van Rooijen N, Sanders A. Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid. Hepatology. 1996;23(5):1239–43.
    • (1996) Hepatology , vol.23 , Issue.5 , pp. 1239-1243
    • Van Rooijen, N.1    Sanders, A.2
  • 97
    • 0033711724 scopus 로고    scopus 로고
    • Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis
    • PID: 11014344
    • Barrera P, Blom A, van Lent PL, et al. Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. Arthritis Rheum. 2000;43(9):1951–9.
    • (2000) Arthritis Rheum , vol.43 , Issue.9 , pp. 1951-1959
    • Barrera, P.1    Blom, A.2    van Lent, P.L.3
  • 98
    • 4644275017 scopus 로고    scopus 로고
    • The role of substance P in inflammatory disease
    • PID: 15334652
    • O’Connor TM, O’Connell J, O’Brien DI, et al. The role of substance P in inflammatory disease. J Cell Physiol. 2004;201(2):167–80.
    • (2004) J Cell Physiol , vol.201 , Issue.2 , pp. 167-180
    • O’Connor, T.M.1    O’Connell, J.2    O’Brien, D.I.3
  • 99
    • 78549255861 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals
    • PID: 20975512
    • Manak MM, Moshkoff DA, Nguyen LT, et al. Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals. AIDS. 2010;24(18):2789–96.
    • (2010) AIDS , vol.24 , Issue.18 , pp. 2789-2796
    • Manak, M.M.1    Moshkoff, D.A.2    Nguyen, L.T.3
  • 100
    • 23444462473 scopus 로고    scopus 로고
    • Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis
    • PID: 16014680
    • Juurikivi A, Sandler C, Lindstedt KA, et al. Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann Rheum Dis. 2005;64(8):1126–31.
    • (2005) Ann Rheum Dis , vol.64 , Issue.8 , pp. 1126-1131
    • Juurikivi, A.1    Sandler, C.2    Lindstedt, K.A.3
  • 101
    • 84880512177 scopus 로고    scopus 로고
    • Werner CM, Zimmermann SM, Wurgler-Hauri CC, et al. Use of imatinib in the prevention of heterotopic ossification. HSS J. 2013;9(2):166–70. Administration of imatinib, resulting in blockage of PDGF signaling, reduced HO volume by 85% in an Achilles tenotomy mouse model of HO, documenting an additional approach by which to therapeutically intervene in cases of HO
    • Werner CM, Zimmermann SM, Wurgler-Hauri CC, et al. Use of imatinib in the prevention of heterotopic ossification. HSS J. 2013;9(2):166–70. Administration of imatinib, resulting in blockage of PDGF signaling, reduced HO volume by 85% in an Achilles tenotomy mouse model of HO, documenting an additional approach by which to therapeutically intervene in cases of HO.
  • 102
    • 84875720612 scopus 로고    scopus 로고
    • Challenges and approaches for the development of safer immunomodulatory biologics
    • PID: 23535934
    • Sathish JG, Sethu S, Bielsky MC, et al. Challenges and approaches for the development of safer immunomodulatory biologics. Nat Rev Drug Discov. 2013;12(4):306–24.
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.4 , pp. 306-324
    • Sathish, J.G.1    Sethu, S.2    Bielsky, M.C.3
  • 103
    • 34548657310 scopus 로고    scopus 로고
    • Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection
    • PID: 17641054
    • Zalevsky J, Secher T, Ezhevsky SA, et al. Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J Immunol. 2007;179(3):1872–83.
    • (2007) J Immunol , vol.179 , Issue.3 , pp. 1872-1883
    • Zalevsky, J.1    Secher, T.2    Ezhevsky, S.A.3
  • 104
    • 0036839225 scopus 로고    scopus 로고
    • Adalimumab (a fully human anti-tumour necrosis factor alpha monoclonal antibody) in the treatment of active rheumatoid arthritis: the initial results of five trials
    • PID: 12379628
    • Rau R. Adalimumab (a fully human anti-tumour necrosis factor alpha monoclonal antibody) in the treatment of active rheumatoid arthritis: the initial results of five trials. Ann Rheum Dis. 2002;61(2):ii70–3.
    • (2002) Ann Rheum Dis , vol.61 , Issue.2 , pp. 70-73
    • Rau, R.1
  • 105
    • 84907939471 scopus 로고    scopus 로고
    • Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants
    • Mohedas A, Wang Y, Sanvitale CE, et al. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014.
    • (2014) J Med Chem
    • Mohedas, A.1    Wang, Y.2    Sanvitale, C.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.