Hyperactive BMP signaling induced by ALK2 R206H requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva

Developmental Dynamics

Volumn 241, Issue 1, 2012, Pages 200-214

  Le, Viet Q ^a   Wharton, Kristi A ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

ACVR1; ALK2; BMP signaling; Dpp; Drosophila; FOP; Gbb; Receptor kinase activation; Sax; Type I receptor; Type II receptor

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 2; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; OSTEOGENIC PROTEIN 1; PROTEIN; PROTEIN SERINE THREONINE KINASE; SAX PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; GENE INDUCTION; GENE MUTATION; GENE OVEREXPRESSION; HETEROZYGOSITY; LIGAND BINDING; NONHUMAN; ORTHOLOGY; OSSIFYING MYOSITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; MYOSITIS OSSIFICANS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; WING;

EID: 83655203094     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22779     Document Type: Article

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