Nanoscale synaptic membrane mimetic allows unbiased high throughput screen that targets binding sites for Alzheimer's-associated Aβ oligomers

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Wilcox, Kyle C ^a   Marunde, Matthew R ^a   Das, Aditi ^b,c   Velasco, Pauline T ^a   Kuhns, Benjamin D ^a   Marty, Michael T ^b   Jiang, Haoming ^a   Luan, Chi Hao ^a   Sligar, Stephen G ^b,c   Klein, William L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; NANOMATERIAL; OLIGOMER; PROTEIN BINDING;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; LIGAND BINDING; LIPID BILAYER; MOLECULAR WEIGHT; NONHUMAN; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; SYNAPTIC MEMBRANE; SYNAPTOSOME; ANIMAL; IN VITRO STUDY; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BINDING SITES; IN VITRO TECHNIQUES; PROTEIN BINDING; RATS; SYNAPTIC MEMBRANES; SYNAPTOSOMES;

EID: 84957927877     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125263     Document Type: Article

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