Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

FASEB Journal

Volumn 27, Issue 8, 2013, Pages 3239-3248

  Takeda, Shuko ^a   Hashimoto, Tadafumi ^a   Roe, Allyson D ^a   Hori, Yukiko ^a   Spires Jones, Tara L ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apolipoprotein E; In vivo microdialysis

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE INHIBITOR; OLIGOMER; 2-(((3,5-DIFLUOROPHENYL)ACETYL)AMINO)-N-(1-METHYL-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-1,4-BENZODIAZEPIN-3-YL)PROPANAMIDE; AMYLOID PRECURSOR PROTEIN; BENZODIAZEPINE DERIVATIVE; PRESENILIN 1; SECRETASE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GEL PERMEATION CHROMATOGRAPHY; IN VIVO STUDY; INTERSTITIAL FLUID; MALE; METABOLISM; MICRODIALYSIS; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; AGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; EXTRACELLULAR FLUID; GENETICS; HUMAN; IMMUNOBLOTTING; MOLECULAR WEIGHT; PROCEDURES; PROTEIN MULTIMERIZATION;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BENZODIAZEPINONES; BRAIN; DISEASE MODELS, ANIMAL; EXTRACELLULAR FLUID; HUMANS; IMMUNOBLOTTING; MICE; MICE, TRANSGENIC; MICRODIALYSIS; MOLECULAR WEIGHT; PRESENILIN-1; PROTEIN MULTIMERIZATION;

EID: 84881151330     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-229666     Document Type: Article

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