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Torzilli PA, Bhargava M, Chen CT. Mechanical Loading of Articular Cartilage Reduces IL-1-Induced Enzyme Expression. Cartilage. 2011;2(4):364–73. This study shows that applying mechanical load in combination with IL-1 can reduce the mRNA expression of matrix-degrading enzymes that would normally be upregulated in response to IL-1.
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Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes
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PID: 20509944, This study revealed a mechanism of differential kinase activation upstream of ERK1/2 phosphorylation that may regulate the effects of inflammation during mechanical loading in chondrocytes
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Perera PM, Wypasek E, Madhavan S, et al. Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes. Arthritis Res Ther. 2010;12(3):R106. This study revealed a mechanism of differential kinase activation upstream of ERK1/2 phosphorylation that may regulate the effects of inflammation during mechanical loading in chondrocytes.
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Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo
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PID: 22307759, COI: 1:CAS:528:DC%2BC38XptFCnsrw%3D, This study shows a strong link between OA progression and mechanical loading in a mouse model
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Burleigh A, Chanalaris A, Gardiner MD, et al. Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo. Arthritis Rheum. 2012;64(7):2278–88. This study shows a strong link between OA progression and mechanical loading in a mouse model.
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Aviezer D, Hecht D, Safran M, et al. Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell. 1994;79(6):1005–13.
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Allen JL, Cooke ME, Alliston T. ECM stiffness primes the TGFbeta pathway to promote chondrocyte differentiation. Mol Biol Cell. 2012;23(18):3731–42. This study shows that substrate stiffness and growth factors can have a synergistic response on chondrogenesis.
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