Signal transduction pathways involving p38 MAPK, JNK, NFκB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1β and dynamic compression

Inflammation Research

Volumn 57, Issue 7, 2008, Pages 306-313

  Chowdhury, T T ^a   Salter, D M ^b   Bader, D L ^a   Lee, D A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cartilage; MAPK; Mechanotransduction; Nitric oxide; PGE2

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AGAROSE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRITE; OZONE; PROSTAGLANDIN E2; PYRROLIDINE DITHIOCARBAMATE; SULFATE; THYMIDINE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; NONHUMAN; OSTEOARTHRITIS; SIGNAL TRANSDUCTION;

ANIMALS; BIOREACTORS; CARTILAGE; CATTLE; CHONDROCYTES; ENZYME INHIBITORS; INTERLEUKIN-1BETA; MAP KINASE KINASE 4; MODELS, BIOLOGICAL; NF-KAPPA B; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSCRIPTION FACTOR AP-1;

EID: 51849144630     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-7126-y     Document Type: Article

References (62)

1. Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002; 39: 237-46.
2. Malemud CJ. Cytokines as therapeutic targets for osteoarthritis. BioDrugs 2004; 18: 23-35.
3. Blom AB, van der Kraan PM, van den Berg WB. Cytokine targeting in osteoarthrits. Curr Drug Targets 2007; 8(2): 283-92.
4. Lotz M, Blanco FJ, von Kempis J, Dudler J, Maier R, Villiger PM, Geng Y. Cytokine regulation of chondrocyte functions. J Rheumatology 1995; Suppl 43: 104-8.
5. Clancy RM, Abramson SB, Kohne C, Rediske J. Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury. J Cell Physiol 1997; 172: 183-91.
6. Lotz M. The role of nitric oxide in articular cartilage damage. Rheum Dis Clin North Am 1999; 25: 269-82.
7. Terkeltaub R, Johnson K, Murphy A, Ghosh S. Invited review: the mitochondrion in osteoarthritis. Mitochondrion 2002; 1: 301-19.
8. Verbruggen G. Chondroprotective drugs in degenerative joint diseases. Rheumatology (Oxford) 2006; 45: 129-38.
9. Blom AB, van der Kraan PM, van den Berg WB. Cytokine targeting in osteoarthritis. Curr Drug Targets 2007; 8: 283-92.
10. Fajardo M, Di Cesare PE. Disease-modifying therapies for OA: current status. Drugs Aging 2005; 22: 141-61.
11. Stadler J, Stefanoviv-Racic M, Billiar TR, Curran RD, McIntyre LA, Georgescue HI, Simmons RL, Evans CH. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991; 147: 391-320.
12. Stefanovic-Racic M, Morales TI, Taskiran D, McIntyre LA, Evans CH. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J Immunol 1996; 156: 1213-20.
13. Stefanovic-Racic M, Mollers MO, Miller LA, Evans CH. Nitric oxide and proteoglycan turnover in rabbit articular cartilage. J Orthop Res 1997; 15: 442-9.
14. Taskiran D, Stefanovic-Racic M, Georgescu H, Evans C. Nitric oxide suppression of cartilage proteoglycan synthesis by IL-1. Biochem Biophys Res Commun 1994; 200: 142-8.
15. 2 by IL-1β stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun 2001; 285: 1168-74.
16. 2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage 2003; 11: 688-96.
17. Blain EJ, Mason DJ, Duance VC. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 2001; 40: 111-7
18. Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Banes AJ, Guilak F. The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. J Orthop Res 2001; 19: 729-37.
19. Fermor B, Weinburg JB, Pisetsky DS, Misukonis MA, Fink C, Guilak F. Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. Osteoarthritis Cartilage 2002; 10: 792-8.
20. De Croos JN, Dhaliwal SS, Grynpas MD, Pilliar RM, Kandel RA. Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation. Matrix Biol 2006; 25: 323-31.
21. Mio K, Saito S, Tomatsu T, Toyama Y. Intermittent compressive strain may reduce aggrecanase expression in cartilage: a study of chondrocytes in agarose gel. Clin Orthop Relat Res 2005; 433: 225-32.
22. 2 synthesis in cartilage explants under compression: mPGES1 is a mechanosensitive gene. Arthritis Res Ther 2006; 8: R135
23. Fanning PJ, Emkey G, Smith RJ, Grodzinsky AJ, Szasz N, Trippel SB. Mechanical regulation of MAPK signalling in articular cartilage. J Biol Chem 2003; 278: 50940-8.
24. Deschner J, Hofman CR, Piesco NP, Agarwal S. Signal transduction by mechanical strain in chondrocytes. Curr Opin Clin Nutr Metab Care 2003; 6: 289-93.
25. Fitzgerald JB, Jin M, Dean D, Wood DJ, Zheng MH, Grodzinsky AJ. Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem 2004; 279: 19502-11.
26. Agarwal S, Deschner J, Long P, Verma A, Hofman C, Evans CH, Piesco N. Role of NF-kappaB transcription factors in anti-inflammatory and pro-inflammatory actions of mechanical signals. Arthritis Rheum 2004; 50: 3541-8.
27. Liacini A, Sylvester J, Li WQ, Zafarullah M. Inhibition of IL-1 stimulated MAP kinases, AP-1 and NF-kappa B transcription factors down-regulates MMP gene expression in articular chondrocytes. Matrix Biol 2002; 21: 251-62.
28. Malemud CJ. Protein kinases in chondrocyte signalling and osteoarthritis. Clin Orthop Relat Res 2004; Suppl 427: 145-51.
29. Badger AM, Cook MN, Lark MW, Newman-Tarr TM, Swift BA, Nelson AH, Barone FC, Kumar S. SB203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes. J Immunol 1998; 161: 467-73.
30. Mendes AF, Carvalho AP, Caramona MM, Lopes MC. Role of nitric oxide in the activation of NF-kappaB, AP-1 and NOS II expression in articular chondrocytes. Inflamm Res 2002; 51: 369-75.
31. Lee DA, Bader DL. Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res 1997; 15: 18-8.
32. Lee DA, Knight MM. Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med 2004; 100: 307-24
33. Cuenda A, Rose J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC. SB203580 is a specific inhibitor of a MAPK homologue which is stimulated by cellular stresses and IL-1. FEBS Lett 1995; 364: 229-33
34. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001;108:73-81.
35. 2 and antioxidants have opposite effects on activation of NF-kB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 1993; 12: 2005-15.
36. Marks-Konczalik J, Chu SC, Moss J. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both AP-1 and NF-κB binding sites. J Biol Chem 1998; 273: 22201-8.
37. Chen YR, Tan TH: Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 1998; 17: 173-8
38. Chowdhury TT, Bader DL, Shelton JC, Lee DA. Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys 2003; 417: 105-11.
39. Rao J, Otto WR. Fluorimetric DNA assay for cell growth estimation. Analytical Biochem 1991; 207: 186-92.
40. Hung CT, Henshaw DR, Wang CC, Mauck RL, Raia F, Palmer G, Chao PH, Mow VC, Ratcliffe A, Valhmu WB. Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization. J Biomech 2000; 33: 73-80.
41. Lee DA, Frean SP, Lees P, Bader DL. Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose. Biochem Biophys Res Commun 1998; 251: 580-5.
42. Murata M, Bonassar LJ, Wright M, Mankin HJ, Towle CA. A role for the interleukin-1 receptor in the pathway linking static mechanical compression to decreased proteoglycan synthesis in surface articular cartilage. Arch Biochem Biophys 2003; 413: 229-35.
43. Millward-Sadler SJ, Salter DM. Integrin-dependent signal cascades in chondrocyte mechanotransduction. Ann Biomed Eng 2004; 32: 435-46.
44. Badger AM, Roshak AK, Cook MN, Newman-Tarr TM, Swift BA, Carlson K, et al. Differential effects of SB242235, a selective inhibitor of p38 MAPK on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis cartilage 2000; 8: 434-43
45. Studer RK, Bergman R, Stubbs T, Decker K. Chondrocyte response to growth factors is modulated by p38 MAPK inhibition. Arthritis Research Therapy 2004; 6: R56-R64.
46. Scherle PA, Pratta MA, Feeser WS, Tancula EJ, Arner EC. The effects of IL-1 on mitogen-activated protein kinases in rabbit articular chondrocytes. Biochem Biophys Res Commun 1997; 230: 573-7.
47. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. IL-1 induction of MMP-13 gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum, 2000; 43: 801-11.
48. Zhou Y, Millward-Sadler SJ, Lin H, Robinson H, Goldring M, Salter DM, Nuki G. Evidence for JNK-dependent up-regulation of proteoglycan synthesis and for activation of JNK1 following cyclical mechanical stimulation in a human chondrocyte culture model. Osteoarthritis Cartilage, 2007 15(8):884-93
49. Lee DA, Bader DL. The development and characterisation of an in vitro system to study strain induced cell deformation in isolated chondrocytes. In vitro Cell Deve Animal Biol 1995; 31: 828-35.
50. Nieminen R, Leinonen S, Lahti A, Vuolteenaho K, Jalonen U, Kankaanranta H, Goldring MB, Moilanen E. Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. Mediators Inflamm 2005; 5: 249-55.
51. Gassner R, Buckley MJ, Georgescu H, Studer R, Stefanovic-Racic M, Piesco NP, Evans CH, Agarwal S. Cyclic tensile stress exerts anti-inflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase. J Immunol 1999; 163: 2187-92.
52. Xu Z, Buckley MJ, Evans CH, Agarwal S. Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes. J Immunol 2000; 165: 453-60.
53. Chowdhury TT, Bader DL, Lee DA. Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology 2006; 43: 413-29.
54. Ragan PM, Badger AM, Cook M, Chin VI, Gowen M, Grodzinsky AJ, Lark MW. Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration. J Orthop Res 1999; 17: 836-42.
55. 2 synthesis by bovine chondrocytes. Osteoarthritis Cartilage 2005; 13: 74-9.
56. 2 by mechanical stress in articular cartilage. Osteoarthritis Cartilage 2005; 13: 935-41.
57. Saklatvala J. Inflammatory signalling in cartilage. MAPK and NFκB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of OA. Curr Drug Targets 2007; 8: 305-13.
58. Fernandes J, Tardif G, Martel-Pelletier J, Lascau-Coman V, Dupuis M, Moldovan F, Sheppard M, Krishnan BR, Pelletier JP. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am J Pathol1999; 154: 1159-69.
59. van den Berg WB, van de Loo F, Joosten LA, Arntz OJ.. Animal models of arthritis in NOS2-deficient mice. Osteoarthritis Cartilage 1999; 7: 413-5.
60. Pelletier JP, Lascau-Coman V, Jovanovic D, Fernandes JC, Manning P, Connor JR, Currie MG, Martel-Pelletier J. Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol. 1999 Sep;26(9):2002-14.
61. Van den Berg WB. Lessons from animal models of osteoarthritis. Curr Opin Rheumatol 2001; 13:452-6.
62. Kumar S, Boehm J, Lee JC. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003 2;717-26.