Biomechanical thresholds regulate inflammation through the NF-κB pathway: Experiments and modeling

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Nam, Jin ^a   Aguda, Baltazar D ^a,b   Rath, Bjoern ^c   Agarwal, Sudha ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR RELA; I KAPPA B; MESSENGER RNA; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BIOMECHANICS; CARTILAGE CELL; CARTILAGE DEGENERATION; COMPRESSION; CONTROLLED STUDY; EXERCISE; GENE EXPRESSION REGULATION; INFLAMMATION; MATHEMATICAL MODEL; MECHANOTRANSDUCTION; NONHUMAN; PHYSICAL ACTIVITY; POSITIVE FEEDBACK; PROTEIN PHOSPHORYLATION; BIOLOGICAL MODEL; CARTILAGE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; GENETICS; HUMAN; MECHANICAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

BIOMECHANICS; CARTILAGE; CELL LINE; CHONDROCYTES; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-1BETA; MODELS, BIOLOGICAL; NF-KAPPA B; NITRIC OXIDE SYNTHASE; PROTEIN TRANSPORT; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 65349083779     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005262     Document Type: Article

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