Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model

Journal of Orthopaedic Research

Volumn 31, Issue 3, 2013, Pages 385-391

  Ashwell, Melissa S ^a   Gonda, Michael G ^a,d   Gray, Kent ^a,e   Maltecca, Christian ^a   O'Nan, Audrey T ^a   Cassady, Joseph P ^a   Mente, Peter L ^b,c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b Biomedical Research Imaging Center   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d SOUTH DAKOTA STATE UNIVERSITY   (United States)

^e Smithfield Premium Genetics   (United States)

Author keywords

articular cartilage; chondrocyte; gene expression; joint injury; osteoarthritis

Indexed keywords

RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOSYNTHESIS; CARTILAGE CELL; CARTILAGE INJURY; CATABOLISM; CELL CULTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION REGULATION; IN VITRO STUDY; INFLAMMATION; NONHUMAN; PATELLA; PHENOTYPE; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; UPREGULATION;

ANIMALS; CARTILAGE, ARTICULAR; CHONDROCYTES; FEMALE; KNEE INJURIES; KNEE JOINT; MODELS, GENETIC; ORGAN CULTURE TECHNIQUES; OSTEOARTHRITIS, KNEE; PATELLA; REAL-TIME POLYMERASE CHAIN REACTION; SUS SCROFA; TRANSCRIPTOME;

EID: 84872761673     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22239     Document Type: Article

References (59)

1. Hootman JM, Helmick CG,. 2006. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum 54: 226-229.
2. Buckwalter JA,. 1995. Osteoarthritis and articular cartilage use, disuse, and abuse: experimental studies. J Rheumatol Suppl 43: 13-15.
3. Buckwalter JA, Mankin HJ,. 1998. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47: 487-504.
4. Kraus VB,. 1997. Pathogenesis and treatment of osteoarthritis. Med Clin North Am 81: 85-112.
5. Mankin HJ,. 1982. The response of articular cartilage to mechanical injury. J Bone Joint Surg Am 64: 460-466.
6. Altman RD, Tenenbaum J, Latta L, et al. 1984. Biomechanical and biochemical properties of dog cartilage in experimentally induced osteoarthritis. Ann Rheum Dis 43: 83-90.
7. Brandt KD, Schauwecker DS, Dansereau S, et al. 1997. Bone scintigraphy in the canine cruciate deficiency model of osteoarthritis. Comparison of the unstable and contralateral knee. J Rheumatol 24: 140-145.
8. Dedrick DK, Goldstein SA, Brandt KD, et al. 1993. A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rheum 36: 1460-1467.
9. Johnson RG, Poole AR,. 1990. The early response of articular cartilage to ACL transection in a canine model. Exp Pathol 38: 37-52.
10. McDevitt C, Gilbertson E, Muir H,. 1977. An experimental model of osteoarthritis; early morphological and biochemical changes. J Bone Joint Surg Br 59: 24-35.
11. Pidd JG, Gardner DL, Adams ME,. 1988. Ultrastructural changes in the femoral condylar cartilage of mature American foxhounds following transection of the anterior cruciate ligament. J Rheumatol 15: 663-669.
12. Donohue JM, Buss D, Oegema TR Jr, et al. 1983. The effects of indirect blunt trauma on adult canine articular cartilage. J Bone Joint Surg Am 65: 948-957.
13. Haut RC, Ide TM, De Camp CE,. 1995. Mechanical responses of the rabbit patello-femoral joint to blunt impact. J Biomech Eng 117: 402-408.
14. Mente PL, Lewis JL, Oegema TR Jr, et al. 1995. Damage after blunt trauma to a joint surface. Transactions of the 2nd combined meeting of the Orthopaedic Research Societies of USA, Japan, Canada, and Europe, 1995, p. 125.
15. Mente PL, Lossing JA, Dinola NE, et al. 2005. Chondrocyte necrosis and proliferation in mechanically impacted articular cartilage. Transactions of the 51st annual meeting of the Orthopaedic Research Society.
16. Newberry WN, Zukosky DK, Haut RC,. 1997. Subfracture insult to a knee joint causes alterations in the bone and in the functional stiffness of overlying cartilage. J Orthop Res 15: 450-455.
17. Thompson RC Jr, Oegema TR Jr, Lewis JL, et al. 1991. Osteoarthrotic changes after acute transarticular load. An animal model. J Bone Joint Surg Am 73: 990-1001.
18. Radin EL, Martin RB, Burr DB, et al. 1984. Effects of mechanical loading on the tissues of the rabbit knee. J Orthop Res 2: 221-234.
19. Serink MT, Nachemson A, Hansson G,. 1977. The effect of impact loading on rabbit knee joints. Acta Orthop Scand 48: 250-262.
20. Clements KM, Bee ZC, Crossingham GV, et al. 2001. How severe must repetitive loading be to kill chondrocytes in articular cartilage? Osteoarthritis Cartilage 9: 499-507.
21. Ewers BJ, Dvoracek-Driksna D, Orth MW, et al. 2001. The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading. J Orthop Res 19: 779-784.
22. Jeffrey JE, Gregory DW, Aspden RM,. 1995. Matrix damage and chondrocyte viability following a single impact load on articular cartilage. Arch Biochem Biophys 322: 87-96.
23. Jeffrey JE, Thomson LA, Aspden RM,. 1997. Matrix loss and synthesis following a single impact load on articular cartilage in vitro. Biochim Biophys Acta 1334: 223-232.
24. Quinn TM, Allen RG, Schalet BJ, et al. 2001. Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stress. J Orthop Res 19: 242-249.
25. Quinn TM, Grodzinsky AJ, Hunziker EB, et al. 1998. Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants. J Orthop Res 16: 490-499.
26. Repo RU, Finlay JB,. 1977. Survival of articular cartilage after controlled impact. J Bone Joint Surg Am 59: 1068-1076.
27. Tew SR, Kwan AP, Hann A, et al. 2000. The reactions of articular cartilage to experimental wounding: role of apoptosis. Arthritis Rheum 43: 215-225.
28. Torzilli PA, Grigiene R, Borrelli J Jr, et al. 1999. Effect of impact load on articular cartilage: cell metabolism and viability, and matrix water content. J Biomech Eng 121: 433-441.
29. Wilson W, van Burken C, van Donkelaar C, et al. 2006. Causes of mechanically induced collagen damage in articular cartilage. J Orthop Res 24: 220-228.
30. Ashwell MS, O'Nan AT, Gonda MG, et al. 2008. Gene expression profiling of chondrocytes from a porcine impact injury model. Osteoarthritis Cartilage 16: 936-946.
31. Burton-Wurster N, Mateescu RG, Todhunter RJ, et al. 2005. Genes in canine articular cartilage that respond to mechanical injury: gene expression studies with Affymetrix canine GeneChip. J Hered 96: 821-828.
32. Chan PS, Schlueter AE, Coussens PM, et al. 2005. Gene expression profile of mechanically impacted bovine articular cartilage explants. J Orthop Res 23: 1146-1151.
33. Lee JH, Fitzgerald JB, Dimicco MA, et al. 2005. Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Arthritis Rheum 52: 2386-2395.
34. Kumar S, Connor JR, Dodds RA, et al. 2001. Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. Osteoarthritis Cartilage 9: 641-653.
35. Monfort J, Garcia-Giralt N, Lopez-Armada MJ, et al. 2006. Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation. Arthritis Res Ther 8: R149.
36. Blain EJ,. 2007. Mechanical regulation of matrix metalloproteinases. Front Biosci 12: 507-527.
37. Natoli RM, Athanasiou KA,. 2008. P188 reduces cell death and IGF-I reduces GAG release following single-impact loading of articular cartilage. J Biomech Eng 130: 041012.
38. Natoli RM, Scott CC, Athanasiou KA,. 2008. Temporal effects of impact on articular cartilage cell death, gene expression, matrix biochemistry, and biomechanics. Ann Biomed Eng 36: 780-792.
39. Chou CH, Cheng WT, Kuo TF, et al. 2007. Fibrin glue mixed with gelatin/hyaluronic acid/chondroitin-6-sulfate tri-copolymer for articular cartilage tissue engineering: the results of real-time polymerase chain reaction. J Biomed Mater Res A 82: 757-767.
40. Bevill S,. 2009. Regional variations in knee joint articular cartilage mechanobiology: a consideration in the initiation of osteoarthritis. Stanford University, Ph.D. dissertation.
41. Steibel JP, Poletto R, Coussens PM, et al. 2009. A powerful and flexible linear mixed model framework for the analysis of relative quantification RT-PCR data. Genomics 94: 146-152.
42. McCulloch R, Ashwell MS, O'Nan AT, et al. 2010. Differential gene expression of chondrocytes from a porcine impact injury model using suitable reference genes. 56th Annual Meeting of the Orthopedic Research Society, New Orleans, LA, 2010, p 951.
43. Benjamini Y, Hochberg Y,. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 57: 289-300.
44. Sandell LJ, Aigner T,. 2001. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 3: 107-113.
45. Jones SE, Jomary C,. 2002. Clusterin. Int J Biochem Cell Biol 34: 427-431.
46. Koorts AM, Levay PF, Hall AN, et al. 2012. Expression of the H- and L-subunits of ferritin in bone marrow macrophages of patients with osteoarthritis. Exp Biol Med (Maywood) 237: 688-693.
47. Ota T, Katsuki I,. 1998. Ferritin subunits in sera and synovial fluids from patients with rheumatoid arthritis. J Rheumatol 25: 2315-2318.
48. Heller RA, Schena M, Chai A, et al. 1997. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA 94: 2150-2155.
49. Rogers JT, Bridges KR, Durmowicz GP, et al. 1990. Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem 265: 14572-14578.
50. Matsumoto T, Tsurumoto T,. 2001. Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters. Clin Exp Rheumatol 19: 655-660.
51. Haglund L, Bernier SM, Onnerfjord P, et al. 2008. Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage. Matrix Biol 27: 107-118.
52. Sheikine Y, Sirsjo A,. 2008. CXCL16/SR-PSOX-a friend or a foe in atherosclerosis? Atherosclerosis 197: 487-495.
53. Kamei M, Yoneda K, Kume N, et al. 2007. Scavenger receptors for oxidized lipoprotein in age-related macular degeneration. Invest Ophthalmol Vis Sci 48: 1801-1807.
54. Cecil DL, Terkeltaub R,. 2008. Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes. J Immunol 180: 8378-8385.
55. Leong DJ, Li YH, Gu XI, et al. 2011. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J 25: 182-191.
56. Wei T, Kulkarni NH, Zeng QQ, et al. 2010. Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. Osteoarthritis Cartilage 18: 992-1000.
57. Stevens AL, Wishnok JS, White FM, et al. 2009. Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol Cell Proteomics 8: 1475-1489.
58. Zhang YW, Su Y, Lanning N, et al. 2005. Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc Natl Acad Sci USA 102: 11740-11745.
59. Leong DJ, Gu XI, Li Y, et al. 2010. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Matrix Biol 29: 420-426.