αv and β1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways

Osteoarthritis and Cartilage

Volumn 18, Issue 2, 2010, Pages 249-256

  Chai, D H ^a   Arner, E C ^b   Griggs, D W ^b   Grodzinsky, A J ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b PFIZER INC   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Agarose culture; Chondrocyte; Dynamic compression; Integrin; Mechanical stimulation; Mechanotransduction; Proteoglycan synthesis

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; AGAROSE; ALPHA5 INTEGRIN; BETA1 INTEGRIN; BLOCKING ANTIBODY; DISINTEGRIN; GLYCOSAMINOGLYCAN; INTEGRIN RECEPTOR; METHYLENE BLUE; PEPTIDOMIMETIC AGENT; PROLINE; PROTEOGLYCAN; SULFATE; SULFUR 35; TRITIUM; VERY LATE ACTIVATION ANTIGEN 5; INTEGRIN; SEPHAROSE;

ANIMAL CELL; ARTICLE; CARTILAGE; CARTILAGE CELL; COMPRESSION; CONTROLLED STUDY; COW; DNA CONTENT; EXPLANT; EXTRACELLULAR MATRIX; HYPOTHESIS; IMPLANTATION; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEOGLYCAN SYNTHESIS; TISSUE ENGINEERING; ANIMAL; ARTICULAR CARTILAGE; BIOSYNTHESIS; CATTLE; CELL CULTURE; CHEMISTRY; COMPRESSIVE STRENGTH; CULTURE TECHNIQUE; CYTOLOGY; DRUG ANTAGONISM; MECHANICAL STRESS; METHODOLOGY; PHYSIOLOGY;

ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; CHONDROCYTES; COMPRESSIVE STRENGTH; CULTURE TECHNIQUES; GLYCOSAMINOGLYCANS; INTEGRINS; PROTEOGLYCANS; SEPHAROSE; STRESS, MECHANICAL;

EID: 74149085207     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2009.09.002     Document Type: Article

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