2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells

Free Radical Biology and Medicine

Volumn 92, Issue , 2016, Pages 61-77

  Sun, Wen ^a   Bao, Jiaolin ^a   Lin, Wei ^a   Gao, Hongwei ^a   Zhao, Wenwen ^a   Zhang, Qingwen ^a   Leung, Chung Hang ^a   Ma, Dik Lung ^b   Lu, Jinjian ^a   Chen, Xiuping ^a  

^a UNIVERSITY OF MACAU   (Macao)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Apoptosis; Cancer; MAM; Necroptosis; NO; ROS

Indexed keywords

2 METHOXY 6 ACETYL 7 METHYLJUGLONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 8; GLUTATHIONE; GLUTATHIONE DISULFIDE; HISTONE H2AX; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NAPHTHOQUINONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG; JUGLONE; NOS2 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIPLE CANCER; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; MCF-7 CELL LINE; MELANOMA, EXPERIMENTAL; METABOLISM; MOUSE; NECROSIS; OXIDATIVE STRESS; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MCF-7 CELLS; MELANOMA, EXPERIMENTAL; MICE; NAPHTHOQUINONES; NECROSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84956769908     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.01.014     Document Type: Article

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