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Volumn 48, Issue 2, 2016, Pages 117-125

Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations

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EID: 84956615603     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3471     Document Type: Article
Times cited : (61)

References (81)
  • 1
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis E., et al A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 2
    • 84874189784 scopus 로고    scopus 로고
    • Highly recurrent TERT promoter mutations in human melanoma
    • Huang F.W., et al. Highly recurrent TERT promoter mutations in human melanoma. Science 339, 957-959 (2013
    • (2013) Science , vol.339 , pp. 957-959
    • Huang, F.W.1
  • 3
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov L.B., et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 4
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-Associated genes
    • Lawrence M.S., et al. Mutational heterogeneity in cancer and the search for new cancer-Associated genes. Nature 499, 214-218 (2013
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1
  • 5
    • 84892833777 scopus 로고    scopus 로고
    • Discovery and saturation analysis of cancer genes across 21 tumour types
    • Lawrence M.S., et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495-501 (2014
    • (2014) Nature , vol.505 , pp. 495-501
    • Lawrence, M.S.1
  • 6
    • 84907067643 scopus 로고    scopus 로고
    • Expanding the computational toolbox for mining cancer genomes
    • Ding, L., Wendl, M.C., McMichael, J.F., & Raphael, B.J. Expanding the computational toolbox for mining cancer genomes. Nat. Rev. Genet. 15, 556-570 (2014
    • (2014) Nat. Rev. Genet , vol.15 , pp. 556-570
    • Ding, L.1    Wendl, M.C.2    McMichael, J.F.3    Raphael, B.J.4
  • 7
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H., et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 8
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons D.W., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1
  • 9
    • 84897427928 scopus 로고    scopus 로고
    • A common cancer-Associated DNA polymerase e mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading
    • Kane, D.P., & Shcherbakova, P.V A common cancer-Associated DNA polymerase e mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading. Cancer Res. 74, 1895-1901 (2014
    • (2014) Cancer Res , vol.74 , pp. 1895-1901
    • Kane, D.P.1    Shcherbakova, P.V.2
  • 10
    • 84864598664 scopus 로고    scopus 로고
    • MuSiC: Identifying mutational significance in cancer genomes
    • Dees N.D., et al. MuSiC: identifying mutational significance in cancer genomes. Genome Res. 22, 1589-1598 (2012
    • (2012) Genome Res , vol.22 , pp. 1589-1598
    • Dees, N.D.1
  • 11
    • 84883467378 scopus 로고    scopus 로고
    • OncodriveCLUST: Exploiting the positional clustering of somatic mutations to identify cancer genes
    • Tamborero, D., Gonzalez-Perez, A., & Lopez-Bigas, N. OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes. Bioinformatics 29, 2238-2244 (2013
    • (2013) Bioinformatics , vol.29 , pp. 2238-2244
    • Tamborero, D.1    Gonzalez-Perez, A.2    Lopez-Bigas, N.3
  • 12
    • 84911379962 scopus 로고    scopus 로고
    • E-Driver: A novel method to identify protein regions driving cancer
    • Porta-Pardo, E., & Godzik, A. e-Driver: a novel method to identify protein regions driving cancer. Bioinformatics 30, 3109-3114 (2014
    • (2014) Bioinformatics , vol.30 , pp. 3109-3114
    • Porta-Pardo, E.1    Godzik, A.2
  • 13
    • 77957662209 scopus 로고    scopus 로고
    • Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3' UTRs
    • Schnall-Levin, M., Zhao, Y., Perrimon, N., & Berger, B. Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3' UTRs. Proc. Natl. Acad. Sci. USA 107, 15751-15756 (2010
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 15751-15756
    • Schnall-Levin, M.1    Zhao, Y.2    Perrimon, N.3    Berger, B.4
  • 14
    • 79955613250 scopus 로고    scopus 로고
    • Genome analysis reveals interplay between 5' UTR introns and nuclear mRNA export for secretory and mitochondrial genes
    • Cenik C., et al. Genome analysis reveals interplay between 5' UTR introns and nuclear mRNA export for secretory and mitochondrial genes. PLoS Genet. 7, e1001366 (2011
    • (2011) PLoS Genet , vol.7 , pp. e1001366
    • Cenik, C.1
  • 15
    • 84890072854 scopus 로고    scopus 로고
    • Exonic transcription factor binding directs codon choice and affects protein evolution
    • Stergachis A.B., et al. Exonic transcription factor binding directs codon choice and affects protein evolution. Science 342, 1367-1372 (2013
    • (2013) Science , vol.342 , pp. 1367-1372
    • Stergachis, A.B.1
  • 16
    • 84907221438 scopus 로고    scopus 로고
    • RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
    • Wolfe A.L., et al. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature 513, 65-70 (2014
    • (2014) Nature , vol.513 , pp. 65-70
    • Wolfe, A.L.1
  • 19
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489 57-74 (2012
    • (2012) Nature , vol.489 , pp. 57-74
  • 20
    • 84908894973 scopus 로고    scopus 로고
    • Genome-wide analysis of noncoding regulatory mutations in cancer
    • Weinhold, N., Jacobsen, A., Schultz, N., Sander, C., & Lee, W. Genome-wide analysis of noncoding regulatory mutations in cancer. Nat. Genet. 46, 1160-1165 (2014
    • (2014) Nat. Genet , vol.46 , pp. 1160-1165
    • Weinhold, N.1    Jacobsen, A.2    Schultz, N.3    Sander, C.4    Lee, W.5
  • 21
    • 84922527340 scopus 로고    scopus 로고
    • Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types
    • Fredriksson, N.J., Ny, L., Nilsson, J.A., & Larsson, E. Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types. Nat. Genet. 46, 1258-1263 (2014
    • (2014) Nat. Genet , vol.46 , pp. 1258-1263
    • Fredriksson, N.J.1    Ny, L.2    Nilsson, J.A.3    Larsson, E.4
  • 22
    • 84896366070 scopus 로고    scopus 로고
    • Synonymous mutations frequently act as driver mutations in human cancers
    • Supek, F., Miñana, B., Valcárcel, J., Gabaldón, T., & Lehner, B. Synonymous mutations frequently act as driver mutations in human cancers. Cell 156, 1324-1335 (2014
    • (2014) Cell , vol.156 , pp. 1324-1335
    • Supek, F.1    Miñana, B.2    Valcárcel, J.3    Gabaldón, T.4    Lehner, B.5
  • 23
    • 84933278181 scopus 로고    scopus 로고
    • Recurrent somatic mutations in regulatory regions of human cancer genomes
    • Melton, C., Reuter, J.A., Spacek, D.V., & Snyder, M. Recurrent somatic mutations in regulatory regions of human cancer genomes. Nat. Genet. 47, 710-716 (2015
    • (2015) Nat. Genet , vol.47 , pp. 710-716
    • Melton, C.1    Reuter, J.A.2    Spacek, D.V.3    Snyder, M.4
  • 25
    • 84926157747 scopus 로고    scopus 로고
    • Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
    • Leiserson M.D.M., et al. Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat. Genet. 47, 106-114 (2015
    • (2015) Nat. Genet , vol.47 , pp. 106-114
    • Leiserson, M.D.M.1
  • 26
    • 84907420733 scopus 로고    scopus 로고
    • Regulatory analysis of the C elegans genome with spatiotemporal resolution
    • Araya C.L., et al. Regulatory analysis of the C. elegans genome with spatiotemporal resolution. Nature 512, 400-405 (2014
    • (2014) Nature , vol.512 , pp. 400-405
    • Araya, C.L.1
  • 27
    • 84911470871 scopus 로고    scopus 로고
    • Conservation of trans-Acting circuitry during mammalian regulatory evolution
    • Stergachis A.B., et al. Conservation of trans-Acting circuitry during mammalian regulatory evolution. Nature 515, 365-370 (2014
    • (2014) Nature , vol.515 , pp. 365-370
    • Stergachis, A.B.1
  • 28
    • 84923362619 scopus 로고    scopus 로고
    • Integrative analysis of 111 reference human epigenomes
    • Roadmap Epigenomics Consortium
    • Roadmap Epigenomics Consortium. Integrative analysis of 111 reference human epigenomes. Nature 518 317-330 (2015
    • (2015) Nature , vol.518 , pp. 317-330
  • 29
    • 84862506964 scopus 로고    scopus 로고
    • A program for annotating and predicting the effects of single nucleotide polymorphisms SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; Iso-2; iso-3
    • Cingolani, P., et al A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) 6, 80-92 (2012
    • (2012) Fly (Austin) , vol.6 , pp. 80-92
    • Cingolani, P.1
  • 30
    • 45749146270 scopus 로고    scopus 로고
    • A density-based algorithm for discovering clusters in large spatial databases with noise
    • Martin, E., Kriegel, H.P., Jörg, S., & Xiaowei, X A density-based algorithm for discovering clusters in large spatial databases with noise. KDD 96, 226-231 (1996
    • (1996) KDD , vol.96 , pp. 226-231
    • Martin, E.1    Kriegel, H.P.2    Jörg, S.3    Xiaowei, X.4
  • 31
    • 1542515338 scopus 로고    scopus 로고
    • A census of human cancer genes
    • Futreal P.A., et al A census of human cancer genes. Nat. Rev. Cancer 4, 177-183 (2004
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 177-183
    • Futreal, P.A.1
  • 33
    • 84877113990 scopus 로고    scopus 로고
    • Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms
    • Malhotra A., et al. Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms. Genome Res. 23, 762-776 (2013
    • (2013) Genome Res , vol.23 , pp. 762-776
    • Malhotra, A.1
  • 34
    • 0035266292 scopus 로고    scopus 로고
    • Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library
    • Jåger D., et al. Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library. Cancer Res. 61, 2055-2061 (2001
    • (2001) Cancer Res , vol.61 , pp. 2055-2061
    • Jåger, D.1
  • 35
    • 84861697187 scopus 로고    scopus 로고
    • Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis
    • Mei Y.-P., et al. Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis. Oncogene 31, 2794-2804 (2012
    • (2012) Oncogene , vol.31 , pp. 2794-2804
    • Mei, Y.-P.1
  • 36
    • 85017015396 scopus 로고    scopus 로고
    • Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer
    • 15 October 2015
    • Okugawa Y. et al. Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. Gut http://dx.doi.org/10.1136/gutjnl-2015-309359 (15 October 2015
    • Gut
    • Okugawa, Y.1
  • 37
    • 84885184379 scopus 로고    scopus 로고
    • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
    • Budinska, E., et al. Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. J. Pathol. 231, 63-76 (2013
    • (2013) J. Pathol , vol.231 , pp. 63-76
    • Budinska, E.1
  • 38
    • 84920269464 scopus 로고    scopus 로고
    • Proteomics Tissue-based map of the human proteome
    • Uhlén M., et al. Proteomics. Tissue-based map of the human proteome. Science 347, 1260419 (2015
    • (2015) Science , vol.347 , pp. 1260419
    • Uhlén, M.1
  • 39
    • 84871214022 scopus 로고    scopus 로고
    • MiRmap: Comprehensive prediction of microRNA target repression strength
    • Vejnar, C.E., & Zdobnov, E.M. MiRmap: comprehensive prediction of microRNA target repression strength. Nucleic Acids Res. 40, 11673-11683 (2012
    • (2012) Nucleic Acids Res , vol.40 , pp. 11673-11683
    • Vejnar, C.E.1    Zdobnov, E.M.2
  • 40
    • 84883473859 scopus 로고    scopus 로고
    • The p90 RSK family members: Common functions and isoform specificity
    • Lara, R., Seckl, M.J., & Pardo, O.E. The p90 RSK family members: common functions and isoform specificity. Cancer Res. 73, 5301-5308 (2013
    • (2013) Cancer Res , vol.73 , pp. 5301-5308
    • Lara, R.1    Seckl, M.J.2    Pardo, O.E.3
  • 41
    • 84887083535 scopus 로고    scopus 로고
    • TCPA: A resource for cancer functional proteomics data
    • Li J., et al. TCPA: a resource for cancer functional proteomics data. Nat. Methods 10, 1046-1047 (2013
    • (2013) Nat. Methods , vol.10 , pp. 1046-1047
    • Li, J.1
  • 42
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1
  • 43
    • 84925545317 scopus 로고    scopus 로고
    • PI3K in cancer: Divergent roles of isoforms, modes of activation and therapeutic targeting
    • Thorpe, L.M., Yuzugullu, H., & Zhao, J.J. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat. Rev. Cancer 15, 7-24 (2015
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 7-24
    • Thorpe, L.M.1    Yuzugullu, H.2    Zhao, J.J.3
  • 44
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Integrated genomic characterization of endometrial carcinoma. Nature 497 67-73 (2013
    • (2013) Nature , vol.497 , pp. 67-73
  • 45
    • 34447503808 scopus 로고    scopus 로고
    • Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
    • Miled N., et al. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317, 239-242 (2007
    • (2007) Science , vol.317 , pp. 239-242
    • Miled, N.1
  • 46
    • 37249056471 scopus 로고    scopus 로고
    • The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations
    • Huang C.-H., et al. The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations. Science 318, 1744-1748 (2007
    • (2007) Science , vol.318 , pp. 1744-1748
    • Huang, C.-H.1
  • 47
    • 84908347335 scopus 로고    scopus 로고
    • Investigating the structure and dynamics of the PIK3CA wild-Type and H1047R oncogenic mutant
    • Gkeka P., et al. Investigating the structure and dynamics of the PIK3CA wild-Type and H1047R oncogenic mutant. PLoS Comput. Biol. 10, e1003895 (2014
    • (2014) PLoS Comput. Biol , vol.10 , pp. e1003895
    • Gkeka, P.1
  • 48
    • 84866544615 scopus 로고    scopus 로고
    • Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)
    • Burke, J.E., Perisic, O., Masson, G.R., Vadas, O., & Williams, R.L. Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA). Proc. Natl. Acad. Sci. USA 109, 15259-15264 (2012
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 15259-15264
    • Burke, J.E.1    Perisic, O.2    Masson, G.R.3    Vadas, O.4    Williams, R.L.5
  • 49
    • 84908664886 scopus 로고    scopus 로고
    • Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling
    • Haling J.R., et al. Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling. Cancer Cell 26, 402-413 (2014
    • (2014) Cancer Cell , vol.26 , pp. 402-413
    • Haling, J.R.1
  • 50
    • 74549134502 scopus 로고    scopus 로고
    • Human cancer protein-protein interaction network: A structural perspective
    • Kar, G., Gursoy, A., & Keskin, O. Human cancer protein-protein interaction network: a structural perspective. PLoS Comput. Biol. 5, e1000601 (2009
    • (2009) PLoS Comput. Biol , vol.5 , pp. e1000601
    • Kar, G.1    Gursoy, A.2    Keskin, O.3
  • 51
    • 84896739938 scopus 로고    scopus 로고
    • Interaction-based discovery of functionally important genes in cancers
    • Ghersi, D., & Singh, M. Interaction-based discovery of functionally important genes in cancers. Nucleic Acids Res. 42, e18 (2014
    • (2014) Nucleic Acids Res , vol.42 , pp. e18
    • Ghersi, D.1    Singh, M.2
  • 52
    • 84905039882 scopus 로고    scopus 로고
    • Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome
    • Cheng F., et al. Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome. Mol. Biol. Evol. 31, 2156-2169 (2014
    • (2014) Mol. Biol. Evol , vol.31 , pp. 2156-2169
    • Cheng, F.1
  • 53
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent SPOP FOXA1 and MED12 mutations in prostate cancer
    • Barbieri, C.E., et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat. Genet. 44, 685-689 (2012
    • (2012) Nat. Genet , vol.44 , pp. 685-689
    • Barbieri, C.E.1
  • 54
    • 84872510974 scopus 로고    scopus 로고
    • SMAD2 SMAD3 and SMAD4 mutations in colorectal cancer
    • Fleming, N.I., et al. SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. Cancer Res. 73, 725-735 (2013
    • (2013) Cancer Res , vol.73 , pp. 725-735
    • Fleming, N.I.1
  • 55
    • 84887512911 scopus 로고    scopus 로고
    • Histone H3.3 mutations: A variant path to cancer
    • Yuen, B.T.K., & Knoepfler, P.S. Histone H3.3 mutations: a variant path to cancer. Cancer Cell 24, 567-574 (2013
    • (2013) Cancer Cell , vol.24 , pp. 567-574
    • Yuen, B.T.K.1    Knoepfler, P.S.2
  • 56
    • 84857047339 scopus 로고    scopus 로고
    • PhosphoSitePlus: A comprehensive resource for investigating the structure and function of experimentally determined post-Translational modifications in man and mouse
    • Hornbeck P.V., et al. PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-Translational modifications in man and mouse. Nucleic Acids Res. 40, D261-D270 (2012
    • (2012) Nucleic Acids Res , vol.40 , pp. D261-D270
    • Hornbeck, P.V.1
  • 57
    • 9144271680 scopus 로고    scopus 로고
    • The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
    • Cheng K.W., et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat. Med. 10, 1251-1256 (2004
    • (2004) Nat. Med , vol.10 , pp. 1251-1256
    • Cheng, K.W.1
  • 58
    • 84885142254 scopus 로고    scopus 로고
    • Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling
    • Zhang J., et al. Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling. Carcinogenesis 34, 2401-2408 (2013
    • (2013) Carcinogenesis , vol.34 , pp. 2401-2408
    • Zhang, J.1
  • 59
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola G.M., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475, 106-109 (2011
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1
  • 60
    • 5644227416 scopus 로고    scopus 로고
    • Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling
    • Ji Q., et al. Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling. Cancer Res. 64, 7610-7617 (2004
    • (2004) Cancer Res , vol.64 , pp. 7610-7617
    • Ji, Q.1
  • 61
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough M., et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res. 66, 2815-2825 (2006
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1
  • 62
    • 33644909044 scopus 로고    scopus 로고
    • AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
    • Rižner, T.L., Š;muc, T., Rupreht, R., Šinkovec, J., & Penning, T.M. AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer. Mol. Cell. Endocrinol. 248, 126-135 (2006
    • (2006) Mol. Cell. Endocrinol , vol.248 , pp. 126-135
    • Rižner, T.L.1    Šmuc, T.2    Rupreht, R.3    Šinkovec, J.4    Penning, T.M.5
  • 63
    • 40649096375 scopus 로고    scopus 로고
    • Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
    • Zhao, L., & Vogt, P.K. Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc. Natl. Acad. Sci. USA 105, 2652-2657 (2008
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 2652-2657
    • Zhao, L.1    Vogt, P.K.2
  • 64
    • 84921569189 scopus 로고    scopus 로고
    • Activation of diverse signalling pathways by oncogenic PIK3CA mutations
    • Wu X., et al. Activation of diverse signalling pathways by oncogenic PIK3CA mutations. Nat. Commun. 5, 4961 (2014
    • (2014) Nat. Commun , vol.5 , pp. 4961
    • Wu, X.1
  • 65
    • 84945248976 scopus 로고    scopus 로고
    • Non-coding recurrent mutations in chronic lymphocytic leukaemia
    • Puente X.S., et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature 526, 519-524 (2015
    • (2015) Nature , vol.526 , pp. 519-524
    • Puente, X.S.1
  • 66
    • 84925615834 scopus 로고    scopus 로고
    • Differential DNA mismatch repair underlies mutation rate variation across the human genome
    • Supek, F., & Lehner, B. Differential DNA mismatch repair underlies mutation rate variation across the human genome. Nature 521, 81-84 (2015
    • (2015) Nature , vol.521 , pp. 81-84
    • Supek, F.1    Lehner, B.2
  • 67
    • 84924072858 scopus 로고    scopus 로고
    • Lagging-strand replication shapes the mutational landscape of the genome
    • Reijns M.A.M., et al. Lagging-strand replication shapes the mutational landscape of the genome. Nature 518, 502-506 (2015
    • (2015) Nature , vol.518 , pp. 502-506
    • Reijns, M.A.M.1
  • 68
    • 84856019858 scopus 로고    scopus 로고
    • The DNA damage response and cancer therapy
    • Lord, C.J., & Ashworth, A. The DNA damage response and cancer therapy. Nature 481, 287-294 (2012
    • (2012) Nature , vol.481 , pp. 287-294
    • Lord, C.J.1    Ashworth, A.2
  • 69
    • 84883432724 scopus 로고    scopus 로고
    • An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
    • Roberts S.A., et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45, 970-976 (2013
    • (2013) Nat. Genet , vol.45 , pp. 970-976
    • Roberts, S.A.1
  • 70
    • 84923358817 scopus 로고    scopus 로고
    • Cell-of-origin chromatin organization shapes the mutational landscape of cancer
    • Polak P., et al. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature 518, 360-364 (2015
    • (2015) Nature , vol.518 , pp. 360-364
    • Polak, P.1
  • 71
    • 84867644046 scopus 로고    scopus 로고
    • A fundamental protein property thermodynamic stability, revealed solely from large-scale measurements of protein function
    • Araya, C.L., et al A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proc. Natl. Acad. Sci. USA 109, 16858-16863 (2012
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 16858-16863
    • Araya, C.L.1
  • 72
    • 84901804745 scopus 로고    scopus 로고
    • Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes
    • Buenrostro J.D., et al. Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes. Nat. Biotechnol. 32, 562-568 (2014
    • (2014) Nat. Biotechnol , vol.32 , pp. 562-568
    • Buenrostro, J.D.1
  • 73
    • 84885842840 scopus 로고    scopus 로고
    • Hidden specificity in an apparently nonspecific RNA-binding protein
    • Guenther U.-P., et al. Hidden specificity in an apparently nonspecific RNA-binding protein. Nature 502, 385-388 (2013
    • (2013) Nature , vol.502 , pp. 385-388
    • Guenther, U.-P.1
  • 74
    • 34247500374 scopus 로고    scopus 로고
    • Python for scientific computing
    • Oliphant, T.E. Python for scientific computing. Comput. Sci. Eng. 9, 10-20 (2007
    • (2007) Comput. Sci. Eng , vol.9 , pp. 10-20
    • Oliphant, T.E.1
  • 75
    • 79952591087 scopus 로고    scopus 로고
    • Python for scientists and engineers
    • Millman, K.J., & Aivazis, M. Python for scientists and engineers. Comput. Sci. Eng. 13, 9-12 (2011
    • (2011) Comput. Sci. Eng , vol.13 , pp. 9-12
    • Millman, K.J.1    Aivazis, M.2
  • 76
    • 84892833416 scopus 로고    scopus 로고
    • eds. van der Walt, S., & Millman, J.)
    • McKinney W. in Proc. 9th Python Sci. Conf. (eds. van der Walt, S., & Millman, J.) 51-56 2010). ISBN-13: 978-1-4583-4619-3
    • (2010) Proc 9th Python Sci. Conf , pp. 51-56
    • McKinney, W.1
  • 77
    • 83355177243 scopus 로고    scopus 로고
    • Pybedtools: A flexible Python library for manipulating genomic datasets and annotations
    • Dale, R.K., Pedersen, B.S., & Quinlan, A.R. Pybedtools: a flexible Python library for manipulating genomic datasets and annotations. Bioinformatics 27, 3423-3424 (2011
    • (2011) Bioinformatics , vol.27 , pp. 3423-3424
    • Dale, R.K.1    Pedersen, B.S.2    Quinlan, A.R.3
  • 78
    • 79952595565 scopus 로고    scopus 로고
    • The NumPy Array: A structure for efficient numerical computation
    • Van der Walt, S., Colbert, S.C., & Varoquaux, G. The NumPy Array: a structure for efficient numerical computation. Comput. Sci. Eng. 13, 22-30 (2011
    • (2011) Comput. Sci. Eng , vol.13 , pp. 22-30
    • Van Der Walt, S.1    Colbert, S.C.2    Varoquaux, G.3
  • 79
    • 80555140075 scopus 로고    scopus 로고
    • Scikit-learn: Machine learning in Python
    • Pedregosa F., et al. Scikit-learn: machine learning in Python. J. Mach. Learn. Res. 12, 2825-2830 (2011
    • (2011) J. Mach. Learn. Res , vol.12 , pp. 2825-2830
    • Pedregosa, F.1
  • 80
    • 65649092976 scopus 로고    scopus 로고
    • Biopython: Freely available Python tools for computational molecular biology and bioinformatics
    • Cock P.J.A., et al. Biopython: freely available Python tools for computational molecular biology and bioinformatics. Bioinformatics 25, 1422-1423 (2009
    • (2009) Bioinformatics , vol.25 , pp. 1422-1423
    • Cock, P.J.A.1
  • 81
    • 84907263788 scopus 로고    scopus 로고
    • Comparative analysis of regulatory information and circuits across distant species
    • Boyle A.P., et al. Comparative analysis of regulatory information and circuits across distant species. Nature 512, 453-456 (2014
    • (2014) Nature , vol.512 , pp. 453-456
    • Boyle, A.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.