메뉴 건너뛰기




Volumn 34, Issue 10, 2013, Pages 2401-2408

Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/snail signaling

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; FIBRONECTIN; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PROTEIN KINASE B; PROTEIN RAB25; RAB PROTEIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 84885142254     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt187     Document Type: Article
Times cited : (64)

References (40)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • Jemal, A. et al. (2010) Cancer statistics, 2010. CA. Cancer J. Clin., 60, 277-300.
    • (2010) CA. Cancer J. Clin. , vol.60 , pp. 277-300
    • Jemal, A.1
  • 2
    • 33745050371 scopus 로고    scopus 로고
    • Mechanisms of disease: The epidemiology of bladder cancer
    • Pelucchi, C. et al. (2006) Mechanisms of disease: The epidemiology of bladder cancer. Nat. Clin. Pract. Urol., 3, 327-340.
    • (2006) Nat. Clin. Pract. Urol. , vol.3 , pp. 327-340
    • Pelucchi, C.1
  • 3
    • 34247346908 scopus 로고    scopus 로고
    • Superficial and muscle-invasive bladder cancer: principles of management for outcomes assessments
    • Parekh, D.J. et al. (2006) Superficial and muscle-invasive bladder cancer: principles of management for outcomes assessments. J. Clin. Oncol., 24, 5519-5527.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5519-5527
    • Parekh, D.J.1
  • 4
    • 41349097718 scopus 로고    scopus 로고
    • Molecular biomarkers in urothelial bladder cancer
    • Kim, W.J. et al. (2008) Molecular biomarkers in urothelial bladder cancer. Cancer Sci., 99, 646-652.
    • (2008) Cancer Sci. , vol.99 , pp. 646-652
    • Kim, W.J.1
  • 5
    • 37249084084 scopus 로고    scopus 로고
    • Rab GTPases at a glance
    • Schwartz, S.L. et al. (2007) Rab GTPases at a glance. J. Cell Sci., 120(Pt 22), 3905-3910.
    • (2007) J. Cell Sci. , vol.120 , Issue.PART 22 , pp. 3905-3910
    • Schwartz, S.L.1
  • 6
    • 0027160730 scopus 로고
    • Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung
    • Goldenring, J.R. et al. (1993) Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J. Biol. Chem., 268, 18419-18422.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18419-18422
    • Goldenring, J.R.1
  • 7
    • 0035158088 scopus 로고    scopus 로고
    • Myosin vb is associated with plasma membrane recycling systems
    • Lapierre, L.A. et al. (2001) Myosin vb is associated with plasma membrane recycling systems. Mol. Biol. Cell, 12, 1843-1857.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1843-1857
    • Lapierre, L.A.1
  • 8
    • 68849107901 scopus 로고    scopus 로고
    • The emerging role of the RAB25 small GTPase in cancer
    • Agarwal, R. et al. (2009) The emerging role of the RAB25 small GTPase in cancer. Traffic, 10, 1561-1568.
    • (2009) Traffic , vol.10 , pp. 1561-1568
    • Agarwal, R.1
  • 9
    • 16844384058 scopus 로고    scopus 로고
    • Emerging role of RAB GTPases in cancer and human disease
    • Cheng, K.W. et al. (2005) Emerging role of RAB GTPases in cancer and human disease. Cancer Res., 65, 2516-2519.
    • (2005) Cancer Res. , vol.65 , pp. 2516-2519
    • Cheng, K.W.1
  • 10
    • 9144271680 scopus 로고    scopus 로고
    • The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
    • Cheng, K.W. et al. (2004) The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat. Med., 10, 1251-1256.
    • (2004) Nat. Med. , vol.10 , pp. 1251-1256
    • Cheng, K.W.1
  • 11
    • 34848816931 scopus 로고    scopus 로고
    • Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
    • Caswell, P.T. et al. (2007) Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev. Cell, 13, 496-510.
    • (2007) Dev. Cell , vol.13 , pp. 496-510
    • Caswell, P.T.1
  • 12
    • 84855966245 scopus 로고    scopus 로고
    • Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression
    • Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev. Cell, 22, 131-145.
    • (2012) Dev. Cell , vol.22 , pp. 131-145
    • Dozynkiewicz, M.A.1
  • 13
    • 84868088466 scopus 로고    scopus 로고
    • Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis
    • Yin, Y.X. et al. (2012) Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis. Tumour Biol., 33, 1581-1587.
    • (2012) Tumour Biol. , vol.33 , pp. 1581-1587
    • Yin, Y.X.1
  • 14
    • 33646405753 scopus 로고    scopus 로고
    • Loss of RAB25 expression in breast cancer
    • Cheng, J.M. et al. (2006) Loss of RAB25 expression in breast cancer. Int. J. Cancer, 118, 2957-2964.
    • (2006) Int. J. Cancer , vol.118 , pp. 2957-2964
    • Cheng, J.M.1
  • 15
    • 77949756773 scopus 로고    scopus 로고
    • Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas
    • Nam, K.T. et al. (2010) Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J. Clin. Invest., 120, 840-849.
    • (2010) J. Clin. Invest. , vol.120 , pp. 840-849
    • Nam, K.T.1
  • 16
    • 78650886573 scopus 로고    scopus 로고
    • Rab25 as a tumour suppressor in colon carcinogenesis
    • Goldenring, J.R. et al. (2011) Rab25 as a tumour suppressor in colon carcinogenesis. Br. J. Cancer, 104, 33-36.
    • (2011) Br. J. Cancer , vol.104 , pp. 33-36
    • Goldenring, J.R.1
  • 17
    • 84869228632 scopus 로고    scopus 로고
    • Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma
    • Tong, M. et al. (2012) Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma. Cancer Res., 72, 6024-6035.
    • (2012) Cancer Res. , vol.72 , pp. 6024-6035
    • Tong, M.1
  • 18
    • 84855191863 scopus 로고    scopus 로고
    • The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2
    • Zheng, F. et al. (2012) The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut, 61, 278-289.
    • (2012) Gut , vol.61 , pp. 278-289
    • Zheng, F.1
  • 19
    • 0023340925 scopus 로고
    • Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue
    • Remmele, W. et al. (1987) Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe, 8, 138-140.
    • (1987) Pathologe , vol.8 , pp. 138-140
    • Remmele, W.1
  • 20
    • 33745228107 scopus 로고    scopus 로고
    • Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer
    • Saussez, S. et al. (2006) Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer. Ann. Surg. Oncol., 13, 999-1009.
    • (2006) Ann. Surg. Oncol. , vol.13 , pp. 999-1009
    • Saussez, S.1
  • 21
    • 8444244786 scopus 로고    scopus 로고
    • X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization
    • Camp, R.L. et al. (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin. Cancer Res., 10, 7252-7259.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7252-7259
    • Camp, R.L.1
  • 22
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    • Larue, L. et al. (2005) Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene, 24, 7443-7454.
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1
  • 23
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • Altomare, D.A. et al. (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene, 24, 7455-7464.
    • (2005) Oncogene , vol.24 , pp. 7455-7464
    • Altomare, D.A.1
  • 24
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
    • Bakin, A.V. et al. (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem., 275, 36803-36810.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36803-36810
    • Bakin, A.V.1
  • 25
    • 0037728809 scopus 로고    scopus 로고
    • The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    • Grille, S.J. et al. (2003) The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res., 63, 2172-2178.
    • (2003) Cancer Res. , vol.63 , pp. 2172-2178
    • Grille, S.J.1
  • 26
    • 84861580616 scopus 로고    scopus 로고
    • Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression
    • Wen, W. et al. (2012) Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. Hepatology, 55, 1787-1798.
    • (2012) Hepatology , vol.55 , pp. 1787-1798
    • Wen, W.1
  • 27
    • 84863230667 scopus 로고    scopus 로고
    • BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway
    • Chen, R. et al. (2012) BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway. Cancer Res., 72, 1579-1587.
    • (2012) Cancer Res. , vol.72 , pp. 1579-1587
    • Chen, R.1
  • 28
    • 84858019563 scopus 로고    scopus 로고
    • Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3-and MTA1/Wnt1 protein-dependent pathways
    • Yan, D. et al. (2012) Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3-and MTA1/Wnt1 protein-dependent pathways. J. Biol. Chem., 287, 8598-8612.
    • (2012) J. Biol. Chem. , vol.287 , pp. 8598-8612
    • Yan, D.1
  • 29
    • 84863230459 scopus 로고    scopus 로고
    • Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer
    • Li, Z. et al. (2012) Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer. Ann. Oncol., 23, 638-646.
    • (2012) Ann. Oncol. , vol.23 , pp. 638-646
    • Li, Z.1
  • 30
    • 77954687468 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP2A induces an epithelial- mesenchymal transition and increases the number of side population stemlike cancer cells in nasopharyngeal carcinoma
    • Kong, Q.L. et al. (2010) Epstein-Barr virus-encoded LMP2A induces an epithelial- mesenchymal transition and increases the number of side population stemlike cancer cells in nasopharyngeal carcinoma. PLoS Pathog., 6, e1000940.
    • (2010) PLoS Pathog. , vol.6
    • Kong, Q.L.1
  • 31
    • 72849130207 scopus 로고    scopus 로고
    • The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    • Song, L.B. et al. (2009) The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J. Clin. Invest., 119, 3626-3636.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3626-3636
    • Song, L.B.1
  • 32
    • 84858276094 scopus 로고    scopus 로고
    • Acquisition of EMT phenotype in the gefitinibresistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway
    • Maseki, S. et al. (2012) Acquisition of EMT phenotype in the gefitinibresistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway. Br. J. Cancer, 106, 1196-1204.
    • (2012) Br. J. Cancer , vol.106 , pp. 1196-1204
    • Maseki, S.1
  • 33
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak, K. et al. (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer, 9, 265-273.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1
  • 34
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J.P. (2002) Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer, 2, 442-454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 35
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: twist in development and metastasis
    • Kang, Y. et al. (2004) Epithelial-mesenchymal transitions: twist in development and metastasis. Cell, 118, 277-279.
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1
  • 36
    • 81055125819 scopus 로고    scopus 로고
    • Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction
    • Xue, Y. et al. (2011) Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction. PLoS One, 6, e27748.
    • (2011) PLoS One , vol.6
    • Xue, Y.1
  • 37
    • 78149397646 scopus 로고    scopus 로고
    • Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers
    • Bruyere, F. et al. (2010) Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers. Urol. Oncol., 28, 591-596.
    • (2010) Urol. Oncol. , vol.28 , pp. 591-596
    • Bruyere, F.1
  • 38
    • 84860578009 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
    • Celià-Terrassa, T. et al. (2012) Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J. Clin. Invest., 122, 1849-1868.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1849-1868
    • Celià-Terrassa, T.1
  • 39
    • 36349011403 scopus 로고    scopus 로고
    • Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
    • Julien, S. et al. (2007) Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene, 26, 7445-7456.
    • (2007) Oncogene , vol.26 , pp. 7445-7456
    • Julien, S.1
  • 40
    • 76649134077 scopus 로고    scopus 로고
    • Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
    • McConkey, D.J. et al. (2009) Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer. Cancer Metastasis Rev., 28, 335-344.
    • (2009) Cancer Metastasis Rev. , vol.28 , pp. 335-344
    • McConkey, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.