메뉴 건너뛰기




Volumn 64, Issue 20, 2004, Pages 7610-7617

Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling

Author keywords

[No Author keywords available]

Indexed keywords

20ALPHA HYDROXYSTEROID DEHYDROGENASE; CELL NUCLEUS RECEPTOR; PROGESTERONE RECEPTOR; PROTEIN AKR1C1; PROTEIN AKR1C2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 5644227416     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1608     Document Type: Article
Times cited : (107)

References (52)
  • 1
    • 0034673201 scopus 로고    scopus 로고
    • Effect of hormone replacement therapy on breast cancer risk: Estrogen versus estrogen plus progestin
    • Bethesda
    • Ross RK, Paganini-Hill A, Wan PC, et al. Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst (Bethesda) 2000;92:328-32.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 328-332
    • Ross, R.K.1    Paganini-Hill, A.2    Wan, P.C.3
  • 2
    • 0027304028 scopus 로고
    • Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk
    • Pike MC, Spicer DV, Dahmoush L, et al. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev 1993;15:17-35.
    • (1993) Epidemiol Rev , vol.15 , pp. 17-35
    • Pike, M.C.1    Spicer, D.V.2    Dahmoush, L.3
  • 3
    • 0035995599 scopus 로고    scopus 로고
    • Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics
    • Soyal S, Ismail PM, Li J, et al. Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics. Breast Cancer Res 2002;4:191-6.
    • (2002) Breast Cancer Res , vol.4 , pp. 191-196
    • Soyal, S.1    Ismail, P.M.2    Li, J.3
  • 4
    • 0033305372 scopus 로고    scopus 로고
    • Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals
    • Lange CA, Richer JK, Horwitz KB. Hypothesis: progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals. Mol Endocrinol 1999;13:829-36.
    • (1999) Mol Endocrinol , vol.13 , pp. 829-836
    • Lange, C.A.1    Richer, J.K.2    Horwitz, K.B.3
  • 6
    • 0025293539 scopus 로고
    • Progestin regulation of cellular proliferation
    • Clarke CL, Sutherland RL. Progestin regulation of cellular proliferation. Endocr Rev 1990;11:266-301.
    • (1990) Endocr Rev , vol.11 , pp. 266-301
    • Clarke, C.L.1    Sutherland, R.L.2
  • 7
    • 0037830132 scopus 로고    scopus 로고
    • Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: The Women's Health Initiative Randomized Trial
    • Chlebowski RT, Hendrix SL, Langer RD, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. JAMA 2003;289:3243-53.
    • (2003) JAMA , vol.289 , pp. 3243-3253
    • Chlebowski, R.T.1    Hendrix, S.L.2    Langer, R.D.3
  • 8
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative Randomized Controlled Trial
    • Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative Randomized Controlled Trial. JAMA 2002;288:321-33.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3
  • 9
    • 0031848636 scopus 로고    scopus 로고
    • Functional role of estrogen metabolism in target cells: Review and perspectives
    • Lond
    • Zhu BT, Conney AH. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis (Lond) 1998;19:1-27.
    • (1998) Carcinogenesis , vol.19 , pp. 1-27
    • Zhu, B.T.1    Conney, A.H.2
  • 10
    • 0032718655 scopus 로고    scopus 로고
    • Aromatase and intracrinology of estrogen in hormone-dependent tumors
    • Basel
    • Harada N. Aromatase and intracrinology of estrogen in hormone-dependent tumors. Oncology (Basel) 1999;57(Suppl 2):7-16.
    • (1999) Oncology , vol.57 , Issue.2 SUPPL. , pp. 7-16
    • Harada, N.1
  • 12
    • 0036293455 scopus 로고    scopus 로고
    • Prevention and treatment of breast cancer by suppressing aromatase activity and expression
    • Chen S, Zhou D, Okubo T, et al. Prevention and treatment of breast cancer by suppressing aromatase activity and expression. Ann N Y Acad Sci 2002;963:229-38.
    • (2002) Ann N Y Acad Sci , vol.963 , pp. 229-238
    • Chen, S.1    Zhou, D.2    Okubo, T.3
  • 13
    • 0034711188 scopus 로고    scopus 로고
    • Prostaglandin F2 alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77
    • Stocco CO, Zhong L, Sugimoto Y, et al. Prostaglandin F2 alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. J Biol Chem 2000;275:37202-11.
    • (2000) J Biol Chem , vol.275 , pp. 37202-37211
    • Stocco, C.O.1    Zhong, L.2    Sugimoto, Y.3
  • 14
    • 0014272960 scopus 로고
    • Progesterone catabolism in the rat ovary: A regulatory mechanism for progestational potency during pregnancy
    • Wiest WG, Kidwell WR, Balogh K. Progesterone catabolism in the rat ovary: a regulatory mechanism for progestational potency during pregnancy. Endocrinology 1968;82:844-59.
    • (1968) Endocrinology , vol.82 , pp. 844-859
    • Wiest, W.G.1    Kidwell, W.R.2    Balogh, K.3
  • 15
    • 0017806420 scopus 로고
    • Initiation of human parturition. IX. Progesterone metabolism by placentas of early and late human gestation
    • Milewich L, Gant NF, Schwarz BE, et al. Initiation of human parturition. IX. Progesterone metabolism by placentas of early and late human gestation. Obstet Gynecol 1978;51:278-80.
    • (1978) Obstet Gynecol , vol.51 , pp. 278-280
    • Milewich, L.1    Gant, N.F.2    Schwarz, B.E.3
  • 16
    • 0018713598 scopus 로고
    • Metabolism of progesterone by placentas from several mammalian species in vitro
    • Diaz-Zagoya JC, Wiest WG, Arias F. Metabolism of progesterone by placentas from several mammalian species in vitro. Am J Obstet Gynecol 1979;135:809-13.
    • (1979) Am J Obstet Gynecol , vol.135 , pp. 809-813
    • Diaz-Zagoya, J.C.1    Wiest, W.G.2    Arias, F.3
  • 17
    • 0030925341 scopus 로고    scopus 로고
    • Molecular endocrinology of hydroxysteroid dehydrogenases
    • Penning TM. Molecular endocrinology of hydroxysteroid dehydrogenases. Endocr Rev 1997;18:281-305.
    • (1997) Endocr Rev , vol.18 , pp. 281-305
    • Penning, T.M.1
  • 18
    • 0037606195 scopus 로고    scopus 로고
    • A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13
    • Vergnes L, Phan J, Stolz A, et al. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res 2003;44:503-11.
    • (2003) J Lipid Res , vol.44 , pp. 503-511
    • Vergnes, L.1    Phan, J.2    Stolz, A.3
  • 19
    • 0019142208 scopus 로고
    • Steroid binding specificity of the hamster uterine progesterone receptor
    • Wilks JW, Spilman CH, Campbell JA. Steroid binding specificity of the hamster uterine progesterone receptor. Steroids 1980;35:697-706.
    • (1980) Steroids , vol.35 , pp. 697-706
    • Wilks, J.W.1    Spilman, C.H.2    Campbell, J.A.3
  • 20
    • 0030034858 scopus 로고    scopus 로고
    • Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells
    • Hara A, Matsuura K, Tamada Y, et al. Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. Biochem J 1996;313:373-6.
    • (1996) Biochem J , vol.313 , pp. 373-376
    • Hara, A.1    Matsuura, K.2    Tamada, Y.3
  • 21
    • 0037324845 scopus 로고    scopus 로고
    • Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone
    • Higaki Y, Usami N, Shintani S, et al. Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. Chem Biol Interact 2003;143-144:503-13.
    • (2003) Chem Biol Interact , vol.143-144 , pp. 503-513
    • Higaki, Y.1    Usami, N.2    Shintani, S.3
  • 22
    • 0033624660 scopus 로고    scopus 로고
    • Characterization of a human 20alpha-hydroxysteroid dehydrogenase
    • Zhang Y, Dufort I, Rheault P, et al. Characterization of a human 20alpha-hydroxysteroid dehydrogenase. J Mol Endocrinol 2001;25:221-8.
    • (2001) J Mol Endocrinol , vol.25 , pp. 221-228
    • Zhang, Y.1    Dufort, I.2    Rheault, P.3
  • 23
    • 0028366074 scopus 로고
    • Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding
    • Lou H, Hammond L, Sharma V, et al. Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding. J Biol Chem 1994;269:8416-22.
    • (1994) J Biol Chem , vol.269 , pp. 8416-8422
    • Lou, H.1    Hammond, L.2    Sharma, V.3
  • 24
    • 0037372349 scopus 로고    scopus 로고
    • Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism
    • Ji Q, Chang L, VanDenBerg D, et al. Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism. Prostate 2003;54:275-89.
    • (2003) Prostate , vol.54 , pp. 275-289
    • Ji, Q.1    Chang, L.2    VanDenBerg, D.3
  • 25
    • 0033057937 scopus 로고    scopus 로고
    • Immunocytochemical localization of type 5 17beta-hydroxysteroid dehydrogenase in human reproductive tissues
    • Pelletier G, Luu-The V, Tetu B, et al. Immunocytochemical localization of type 5 17beta-hydroxysteroid dehydrogenase in human reproductive tissues. J Histochem Cytochem 1999;47:731-8.
    • (1999) J Histochem Cytochem , vol.47 , pp. 731-738
    • Pelletier, G.1    Luu-The, V.2    Tetu, B.3
  • 26
    • 0036314874 scopus 로고    scopus 로고
    • Recombinant human platelet-derived growth factor and transforming growth factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require phosphatidylinositol- 3′ kinase
    • Han YP, Nien YD, Garner WL. Recombinant human platelet-derived growth factor and transforming growth factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require phosphatidylinositol-3′ kinase. Wound Repair Regen 2002;10:169-76.
    • (2002) Wound Repair Regen , vol.10 , pp. 169-176
    • Han, Y.P.1    Nien, Y.D.2    Garner, W.L.3
  • 27
    • 0035884589 scopus 로고    scopus 로고
    • M. Expression of gonadotropin receptor and growth responses to key reproductive hormones in normal and malignant human ovarian surface epithelial cells
    • Syed V, Ulinski G, Mok SC, et al. M. Expression of gonadotropin receptor and growth responses to key reproductive hormones in normal and malignant human ovarian surface epithelial cells. Cancer Res 2001;61:6768-76.
    • (2001) Cancer Res , vol.61 , pp. 6768-6776
    • Syed, V.1    Ulinski, G.2    Mok, S.C.3
  • 28
    • 0034651239 scopus 로고    scopus 로고
    • The 4-pregnene and 5alpha-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion
    • Wiebe JP, Muzia D, Hu J, et al. The 4-pregnene and 5alpha-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion. Cancer Res 2000;60:936-43.
    • (2000) Cancer Res , vol.60 , pp. 936-943
    • Wiebe, J.P.1    Muzia, D.2    Hu, J.3
  • 29
    • 0035995602 scopus 로고    scopus 로고
    • The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis
    • Anderson E. The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Breast Cancer Res 2002;4:197-201.
    • (2002) Breast Cancer Res , vol.4 , pp. 197-201
    • Anderson, E.1
  • 30
    • 0025129726 scopus 로고
    • Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
    • Soule HD, Maloney TM, Wolman SR, et al. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 1990;50:6075-86.
    • (1990) Cancer Res , vol.50 , pp. 6075-6086
    • Soule, H.D.1    Maloney, T.M.2    Wolman, S.R.3
  • 31
    • 0034969823 scopus 로고    scopus 로고
    • Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase
    • Tomlinson JW, Stewart PM. Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase. Best Pract Res Clin Endocrinol Metab 2001;15:61-78.
    • (2001) Best Pract Res Clin Endocrinol Metab , vol.15 , pp. 61-78
    • Tomlinson, J.W.1    Stewart, P.M.2
  • 32
    • 18744415956 scopus 로고    scopus 로고
    • Expression of the progesterone receptor and progesterone-metabolising enzymes in the female and male human kidney
    • Bumke-Vogt C, Bahr V, Diederich S, et al. Expression of the progesterone receptor and progesterone-metabolising enzymes in the female and male human kidney. J Endocrinol 2002;175:349-64.
    • (2002) J Endocrinol , vol.175 , pp. 349-364
    • Bumke-Vogt, C.1    Bahr, V.2    Diederich, S.3
  • 33
    • 0035931332 scopus 로고    scopus 로고
    • Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney
    • Quinkler M, Johanssen S, Bumke-Vogt C, et al. Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney. Mol Cell Endocrinol 2001;171:21-4.
    • (2001) Mol Cell Endocrinol , vol.171 , pp. 21-24
    • Quinkler, M.1    Johanssen, S.2    Bumke-Vogt, C.3
  • 34
    • 0015183415 scopus 로고
    • Progesterone levels in amniotic fluid and plasma from women. I. Levels during normal pregnancy
    • Johansson ED, Jonasson LE. Progesterone levels in amniotic fluid and plasma from women. I. Levels during normal pregnancy. Acta Obstet Gynecol Scand 1971;50: 339-43.
    • (1971) Acta Obstet Gynecol Scand , vol.50 , pp. 339-343
    • Johansson, E.D.1    Jonasson, L.E.2
  • 35
    • 3042716504 scopus 로고    scopus 로고
    • Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells
    • Wiebe JP, Lewis MJ. Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)- hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells. BMC Cancer 2003;3:9.
    • (2003) BMC Cancer , vol.3 , pp. 9
    • Wiebe, J.P.1    Lewis, M.J.2
  • 36
    • 0033083205 scopus 로고    scopus 로고
    • Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: Implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase
    • Burczynski ME, Lin HK, Penning TM. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res 1999;59:607-14.
    • (1999) Cancer Res , vol.59 , pp. 607-614
    • Burczynski, M.E.1    Lin, H.K.2    Penning, T.M.3
  • 37
    • 13044304179 scopus 로고    scopus 로고
    • Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
    • Perou CM, Jeffrey SS, Van de Rijn M, et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci USA 1999;96:9212-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9212-9217
    • Perou, C.M.1    Jeffrey, S.S.2    Van De Rijn, M.3
  • 38
    • 0018144601 scopus 로고
    • Steroid metabolism in normal mammary gland and in the dimethylbenzanthracene-induced mammary tumor of rats
    • Mori M, Tominaga T, Tamaoki BI. Steroid metabolism in normal mammary gland and in the dimethylbenzanthracene-induced mammary tumor of rats. Endocrinology 1978;102:1387-97.
    • (1978) Endocrinology , vol.102 , pp. 1387-1397
    • Mori, M.1    Tominaga, T.2    Tamaoki, B.I.3
  • 39
    • 5644274754 scopus 로고    scopus 로고
    • Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma
    • Lewis MJ, Wiebe JP, Heathcote JG. Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. BMC Cancer 2004;4:27.
    • (2004) BMC Cancer , vol.4 , pp. 27
    • Lewis, M.J.1    Wiebe, J.P.2    Heathcote, J.G.3
  • 40
    • 0026636999 scopus 로고
    • The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer?
    • Horwitz KB. The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev 1992;13:146-63.
    • (1992) Endocr Rev , vol.13 , pp. 146-163
    • Horwitz, K.B.1
  • 41
    • 0029586264 scopus 로고
    • Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells. II. T47D cell lines
    • Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells. II. T47D cell lines. Steroid Biochem Mol Biol 1995;55:439-44.
    • (1995) Steroid Biochem Mol Biol , vol.55 , pp. 439-444
    • Schoonen, W.G.1    Joosten, J.W.2    Kloosterboer, H.J.3
  • 42
    • 0029417037 scopus 로고
    • Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells. I. MCF-7 cell lines
    • Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells. I. MCF-7 cell lines. Steroid Biochem Mol Biol 1995;55:423-37.
    • (1995) Steroid Biochem Mol Biol , vol.55 , pp. 423-437
    • Schoonen, W.G.1    Joosten, J.W.2    Kloosterboer, H.J.3
  • 43
    • 0345313655 scopus 로고    scopus 로고
    • Progestins inhibit the growth of MDA-MB-231 cells transfected with progesterone receptor complementary DNA
    • Lin VC, Ng EH, Aw SE, Tan MG, et al. Progestins inhibit the growth of MDA-MB-231 cells transfected with progesterone receptor complementary DNA. Clin Cancer Res 1999;5:395-403.
    • (1999) Clin Cancer Res , vol.5 , pp. 395-403
    • Lin, V.C.1    Ng, E.H.2    Aw, S.E.3    Tan, M.G.4
  • 44
    • 0026051580 scopus 로고
    • Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes
    • Musgrove EA, Lee CS, Sutherland RL. Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes. Mol Cell Biol 1991;11:5032-43.
    • (1991) Mol Cell Biol , vol.11 , pp. 5032-5043
    • Musgrove, E.A.1    Lee, C.S.2    Sutherland, R.L.3
  • 45
    • 0023212905 scopus 로고
    • Progestin effects on growth in the human breast cancer cell line T-47D: Possible therapeutic implications
    • Hissom JR, Moore MR. Progestin effects on growth in the human breast cancer cell line T-47D: possible therapeutic implications. Biochem Biophys Res Commun 1987; 145:706-11.
    • (1987) Biochem Biophys Res Commun , vol.145 , pp. 706-711
    • Hissom, J.R.1    Moore, M.R.2
  • 46
    • 0038396147 scopus 로고    scopus 로고
    • Progestins and breast cancer
    • Eden J. Progestins and breast cancer. Am J Obstet Gynecol 2003;188:1123-31.
    • (2003) Am J Obstet Gynecol , vol.188 , pp. 1123-1131
    • Eden, J.1
  • 47
    • 0022508303 scopus 로고
    • A correlative morphologic study of human breast and endometrium in the menstrual cycle
    • Longacre TA, Bartow SA. A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am J Surg Pathol 1986;10:382-93.
    • (1986) Am J Surg Pathol , vol.10 , pp. 382-393
    • Longacre, T.A.1    Bartow, S.A.2
  • 48
    • 8544252436 scopus 로고    scopus 로고
    • Physiological action of progesterone in target tissues
    • Graham JD, Clarke CL. Physiological action of progesterone in target tissues. Endocr Rev 1997;18:502-19.
    • (1997) Endocr Rev , vol.18 , pp. 502-519
    • Graham, J.D.1    Clarke, C.L.2
  • 49
    • 0038167811 scopus 로고    scopus 로고
    • Relationship between long durations and different regimens of hormone therapy and risk of breast cancer
    • Li CI, Malone KE, Porter PL, et al. Relationship between long durations and different regimens of hormone therapy and risk of breast cancer. JAMA 2003;289:3254-63.
    • (2003) JAMA , vol.289 , pp. 3254-3263
    • Li, C.I.1    Malone, K.E.2    Porter, P.L.3
  • 51
    • 0037085303 scopus 로고    scopus 로고
    • Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells
    • Richer JK, Jacobsen BM, Manning NG, et al. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J Biol Chem 2002;277: 5209-18.
    • (2002) J Biol Chem , vol.277 , pp. 5209-5218
    • Richer, J.K.1    Jacobsen, B.M.2    Manning, N.G.3
  • 52
    • 0034674243 scopus 로고    scopus 로고
    • Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF- 7 breast cancer cells
    • Weiler PJ, Wiebe JP. Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4- pregnen-20-one in MCF- 7 breast cancer cells. Biochem Biophys Res Commun 2000;272:731-7.
    • (2000) Biochem Biophys Res Commun , vol.272 , pp. 731-737
    • Weiler, P.J.1    Wiebe, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.