Thyroid nodules and thyroid autoimmunity in the context of environmental pollution

Reviews in Endocrine and Metabolic Disorders

Volumn 16, Issue 4, 2015, Pages 319-340

  Benvenga, Salvatore ^a   Antonelli, Alessandro ^b   Vita, Roberto ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Autoimmune thyroid diseases; Pollution; Thyroid; Thyroid cancer

Indexed keywords

ENDOCRINE DISRUPTOR; POLLUTANT;

AUTOIMMUNE THYROIDITIS; DIFFERENTIATED THYROID CANCER; ECONOMIC ASPECT; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL ANIMAL; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LAW ENFORCEMENT; META ANALYSIS (TOPIC); NONHUMAN; OCCUPATIONAL EXPOSURE; POLLUTION; REVIEW; THYROID NODULE; AUTOIMMUNITY; CHEMICALLY INDUCED; DRUG EFFECTS; POLLUTANT; THYROID GLAND; THYROID TUMOR; TOXICITY;

AUTOIMMUNITY; ENVIRONMENTAL POLLUTANTS; ENVIRONMENTAL POLLUTION; HUMANS; THYROID GLAND; THYROID NEOPLASMS; THYROID NODULE;

EID: 84955580231     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-016-9327-6     Document Type: Review

References (166)

1. Carmi G, Amital H. The geoepidemiology of autoimmunity: capsules from the 7th international congress on autoimmunity, Ljubljana, Slovenia, May 2010. Isr Med Assoc J. 2011;13:121–7.
2. Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid. 1998;8:827–56.
3. Guarneri F, Benvenga S. Environmental factors and genetic background that interact to cause autoimmune thyroid disease. Curr Opin Endocrinol Diabetes Obes. 2007;14:398–409.
4. Duntas LH. Environmental factors and autoimmune thyroiditis. Nat Clin Pract Endocrinol Metab. 2008;4:454–60.
5. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. Endocrine-disrupting chemicals: an endocrine society scientific statement. Endocr Rev. 2009;30:293–342.
6. Boas M, Feldt-Rasmussen U, Main KM. Thyroid effects of endocrine disrupting chemicals. Mol Cell Endocrinol. 2012;355:240–8.
7. Gore AC, Crews D, Doan LL, La Merril M, Patisaul H, Zota. Introduction to Endocrine Disrupting Chemicals (EDCs). A guide for public interest organizations and policy-makers. http://www.endocrine.org/~/media/endosociety/files/advocacy-and-outreach/important-documents/introduction-to-endocrine-disrupting-chemicals.pdf (2014). Accessed 10 Jan 2016.
8. Latina A, Gullo D, Trimarchi F, Benvenga S. Hashimoto’s thyroiditis: similar and dissimilar characteristics in neighboring areas. Possible implications for the epidemiology of thyroid cancer. PLoS One. 2013;8:e55450.
9. Caturegli P, De Remigis A, Chuang K, Dembele M, Iwama A, Iwama S. Hashimoto’s thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology reports. Thyroid. 2013;23:142–50.
10. Haugen BR, Alexander EK, Bible KC, Doherty G, Mandel SJ, Nikiforov YE, et al. American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2015.
11. Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, et al. American thyroid association guidelines task force. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid. 2015;25:716–59.
12. Benvenga S, Trimarchi F. Changed presentation of Hashimoto’s thyroiditis in north-eastern Sicily and Calabria (southern Italy) based on a 31-year experience. Thyroid. 2008;18:429–41.
13. Rizzo M, Rossi RT, Bonaffini O, Scisca C, Altavilla G, Calbo L, et al. Increased annual frequency of Hashimoto’s thyroiditis between years 1988 and 2007 at a cytological unit of Sicily. Ann Endocrinol (Paris). 2010;71:525–34.
14. Laureti S, Vecchi L, Santeusanio F, Falorni A. Is the prevalence of Addison’s disease underestimated? J Clin Endocrinol Metab. 1999;84:1762.
15. Løvås K, Husebye ES. High prevalence and increasing incidence of Addison’s disease in western Norway. Clin Endocrinol. 2002;56:787–91.
16. Meyer G, Neumann K, Badenhoop K, Linder R. Increasing prevalence of Addison’s disease in German females: health insurance data 2008–2012. Eur J Endocrinol. 2014;170:367–73.
17. Arpi ML, Fichera G, Mancuso M, Lucenti C, Italia S, Tomaselli L, et al. A ten-year (1989–1998) perspective study of the incidence of Type 1 diabetes in the district of Catania (Sicily) in a 0–14 year age group. J Endocrinol Invest. 2002;25:414–9.
18. Viskari H, Koskela P, Lönnrot M, Luonuansuu S, Reunanen A, Baer M, et al. Can enterovirus infections explain the increasing incidence of type 1 diabetes? Diabetes Care. 2000;23:414–6.
19. Gyürüs E, Patterson C, Soltész G. “Constantly rising or peaks and plateaus?” Incidence of childhood type 1 diabetes in Hungary (1989–2009). Orv Hetil. 2011;152:1692–7.
20. Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G, EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet. 2009;373:2027–33.
21. Grandbastien B, Peeters M, Franchimont D, Gower-Rousseau C, Speckel D, Rutgeerts P, et al. Anticipation in familial Crohn’s disease. Gut. 1998;42:170–4.
22. Radstake TR, Barrera P, Albers MJ, Swinkels HL, van de Putte LB, van Riel PL, et al. Genetic anticipation in rheumathoid arthritis in Europe. J Rheumatol. 2001;28:962–7.
23. Bodin J, Bølling AK, Becher R, Kuper F, Løvik M, Nygaard UC. Transmaternal bisphenol a exposure accelerates diabetes type 1 development in NOD mice. Toxicol Sci. 2014;137:311–23.
24. Hathout EH, Beeson WL, Ischander M, Rao R, Mace JW. Air pollution and type 1 diabetes in children. Pediatr Diabetes. 2006;7:81–7.
25. Sumelathi ML, Tienari PJ, Wikström J, Palo J, Hakama M. Regional and temporal variation in the incidence of multiple sclerosis in Finland 1979–1993. Neuroepidemiology. 2000;19:67–75.
26. Holmberg M, Murtonen A, Elovaara I, Sumelahti ML. Increased female MS incidence and differences in gender-specific risk in medium- and high-risk regions in Finland from 1981–2010. Mult Scler Int. 2013;2013:182516.
27. Legler J, Fletcher T, Govarts E, Porta M, Blumberg B, Heindel JJ, et al. Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the european union. J Clin Endocrinol Metab. 2015;100:1278–88.
28. Hauser R, Skakkebaek NE, Hass U, Toppari J, Juul A, Andersson AM, et al. Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the european union. J Clin Endocrinol Metab. 2015;100:1267–77.
29. Trasande L, Zoeller RT, Hass U, Kortenkamp A, Grandjean P, Myers JP, et al. Estimating burden and disease costs of exposure to endocrine-disrupting chemicals in the european union. J Clin Endocrinol Metab. 2015;100:1245–55.
30. Newman BD, Maher JF, Subauste JS, Uwaifo GI, Bigler SA, Koch CA. Clustering of sebaceous gland carcinoma, papillary thyroid carcinoma and breast cancer in a woman as a new cancer susceptibility disorder: a case report. J Med Case Rep. 2009;3:6905.
31. OSHA Hazard Information Bulletins. Potential health hazards associated with handling pipe used in oil and gas production. https://www.osha.gov/dts/hib/hib_data/hib19890126.html. Accessed 10 Jan 2016.
32. AFSCME Health & Safety Fact Sheet. Welding hazards. http://www.afscme.org/news/publications/workplace-health-and-safety/fact-sheets/pdf/Welding-Hazards-AFSCME-fact-sheet.pdf. Accessed 10 Jan 2016.
33. Sherman SI. Thyroid carcinoma. Lancet. 2003;361:501–11.
34. Marcello MA, Malandrino P, Almeida JF, Martins MB, Cunha LL, Bufalo NE, et al. The influence of the environment on the development of thyroid tumors: a new appraisal. Endocrinol Relat Cancer. 2014;21:T235–54.
35. Al-Ahmadi K, Al-Zahrani A. Spatial autocorrelation of cancer incidence in Saudi Arabia. Int J Environ Res Public Health. 2013;10:7207–28.
36. Leux C, Guénel P. Risk factors of thyroid tumors: role of environmental and occupational exposures to chemical pollutants. Rev Epidemiol Sante Publique. 2010;58:359–67.
37. Fernández-Navarro P, García-Pérez J, Ramis R, Boldo E, López-Abente G. Proximity to mining industry and cancer mortality. Sci Total Environ. 2012;435–436:66–73.
38. Comba P, Ricci P, Iavarone I, Pirastu R, Buzzoni C, Fusco M, et al. Cancer incidence in Italian contaminated sites. Ann Ist Super Sanita. 2014;50:186–91.
39. Wingren G, Hatschek T, Axelson O. Determinants of papillary cancer of the thyroid. Am J Epidemiol. 1993;138:482–91.
40. Kleinman EJ, Christos PJ, Gerber LM, Reilly JP, Moran WF, Einstein AJ, et al. NYPD cancer incidence rates 1995–2014 encompassing the entire world trade center cohort. J Occup Environ Med. 2015;57:e101–13.
41. Yamamoto M, Endoh K, Nakadaira H, Nakamura K. Ecological correlation studies on standardized incidence ratios of malignant neoplasms contracted from different sources of drinking water supply. Nihon Eiseigaku Zasshi. 1999;54:526–33.
42. Yang L, Sun TT, Yuan YN, Wang N. Time trends and pathological characteristics of thyroid cancer in urban Beijing, 1995–2010. Zhonghua Yu Fang Yi Xue Za Zhi. 2013;47:109–12.
43. Li K, Lin G, Zhou Q, Wu X. Time trends of the incidence of thyroid cancer in urban Guangzhou, 2000–2011. Zhonghua Yu Fang Yi Xue Za Zhi. 2015;49:142–6.
44. http://www.dailyfinance.com/2010/11/29/10-cities-with-worlds-worst-air. Accessed 10 Jan 2016.
45. http://www.theguardian.com/world/2014/feb/25/china-toxic-air-pollution-nuclear-winter-scientists. Accessed 10 Jan 2016.
46. Bahadoran Z, Mirmiran P, Ghasemi A, Kabir A, Azizi F, Hadaegh F. Is dietary nitrate/nitrite exposure a risk factor for development of thyroid abnormality? A systematic review and meta-analysis. Nitric Oxide. 2015;47:65–76.
47. Garmendia Madariaga A, Santos Palacios S, Guillén-Grima F, Galofré JC. The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis. J Clin Endocrinol Metab. 2014;99:923–31.
48. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): national health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489–99.
49. Benvenga S. Update on thyroid cancer. Horm Metab Res. 2008;40:323–8.
50. Feldt-Rasmussen U, Rasmussen AK. Autoimmunity in differentiated thyroid cancer: significance and related clinical problems. Hormones. 2010;9:109–17.
51. Benvenga S. On the association between Hashimoto’s thyroiditis and papillary thyroid carcinoma: looking 100 years back, and hopefully, fewer years ahead to sort out this association. Thyroid. 2013;23:1180–1.
52. Rizzo M, Sindoni A, Talamo Rossi R, Bonaffini O, Panetta S, Scisca C, et al. Annual increase in the frequency of papillary thyroid carcinoma as diagnosed by fine-needle aspiration at a cytology unit in Sicily. Hormones (Athens). 2013;12:46–57.
53. Zhang Y, Dai J, Wu T, Yang N, Yin Z. The study of the coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol. 2014;140:1021–6.
54. Lun Y, Wu X, Xia Q, Han Y, Zhang X, Liu Z, et al. Hashimoto’s thyroiditis as a risk factor of papillary thyroid cancer may improve cancer prognosis. Otolaryngol Head Neck Surg. 2013;148:396–402.
55. Zhang L, Li H, Ji QH, Zhu YX, Wang ZY, Wang Y, et al. The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s disease. BMC Cancer. 2012;12:610.
56. Boelaert K, Horacek J, Holder RL, Watkinson JC, Sheppard MC, Franklyn JA. Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. J Clin Endocrinol Metab. 2006;91:4295–301.
57. Fiore E, Rago T, Provenzale MA, Scutari M, Ugolini C, Basolo F, et al. Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role. Endocr Relat Cancer. 2009;16:1251–60.
58. Fiore E, Vitti P. Serum TSH and risk of papillary thyroid cancer in nodular thyroid disease. J Clin Endocrinol Metab. 2012;97:1134–45.
59. Pinchera A, Fenzi GF, Bartalena L, Chiovato L, Marcocci C. Thyroiditis. In: de Visscher M, editor. The Thyroid Gland. New York: Raven; 1980. p. 413–41.
60. How J, Thomson AW, Milton JI, Scott RM, Bewsher PD, Horne CHW. Thyroid antigen-induced leukocyte procoagulant activity: a novel approach to the study of cell-mediated immunity in Graves’ disease and Hashimoto’s thyroiditis. In: Walfish PG, Wall JR, Volpe R, editors. Autoimmunity and the Thyroid. Orlando: Academic; 1985. p. 349–50.
61. Matsubayashi S, Tamai H, Nagaj K, Takaichi Y, Suzuki T, Matsuzuka F, et al. Monoclonal gammopathy in Hashimoto’s thyroiditis and malignant lymphoma of the thyroid gland. In: Medeiros-Neto G, Gaitan E, editors. Frontiers in Thyroidology. New York: Plenum Press; 1986. p. 1299–302.
62. Pedersen BK, Feldt-Rasmussen U, Perrild H, Mohlom Hansen J, Christensen T. Natural killer activity in Hashimoto, Graves’ disease and euthyroid exophthalmos. In: Pichera A, Ingbar SH, McKenzie JM, Fenzi GF, editors. Thyroid Autoimmunity. New York: Plenum Press; 1987. p. 339–41.
63. Nordmeyer JP, Shafeh TA, Heckmann C. Thyroid sonography in autoimmune thyroiditis. A prospective study on 123 patients. Acta Endocrinol (Copenh). 1990;122:391–6.
64. Feldt-Rasmussen U, Hoier-Madsen M, Rasmussen NG, Hegedus L, Hornnes PJ, Perrild H. In: Scherbaum WA, Bogner U, Weinheimer B, Bottazzo GF, editors. Autoimmune Thyroiditis: Approaches Towards Its Etiological Differentiation. Berlin: Springer; 1991. p. 77–82.
65. Sostre S, Reyes MM. Sonographic diagnosis and grading of Hashimoto’s thyroiditis. J Endocrinol Invest. 1991;14:115–21.
66. Rieu M, Richard A, Rosillo M, Laplanche S, Ropion V, Fombeur J-P, et al. Effects of thyroid status on thyroid autoimmunity expression in euthyroid and hypothyroid patients with Hashimoto’s thyroiditis. Clin Endocrinol. 1994;40:529–35.
67. Ruf J, Feldt-Rasmussen U, Hegedus L, Ferrand M, Carayon P. Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. Clin Endocrinol Metab. 1994;79:1404–9.
68. Doufas AG, Mastorakos G, Chatzioannu S, Tseleni-Balafonta S, Piperingos G, Boukis M, et al. The predominant form of non-toxic goiter is now autoimmune thyroiditis. Eur J Endocrinol. 1999;140:505–11.
69. Corapçioğlu D, Tonyukuk V, Kiyan M, Yilmaz AE, Emral R, Kamel N, et al. Relationship between thyroid autoimmunity and Yersinia enterocolitica antibodies. Thyroid. 2002;12:613–7.
70. Liakata E, Philippou G, Souvatzoglou A, Lymberi P, Carayanniotis G. Assessment of the frequency of mutant (hrpt-)T lymphocytes from peripheral blood of patients with Hashimoto’s thyroiditis. Thyroid. 2003;13:631–6.
71. Azizi F, Raiszadeh F, Solati M, Etemadi A, Rahmani M, Arabi M. Serum paraoxonase 1 activity is decreased in thyroid dysfunction. J Endocrinol Invest. 2003;26:703–9.
72. Hidaka Y, Kimura M, Izumi Y, Takano T, Tatsumi KI, Amino N. Increased serum concentration of eosinophil-derived neurotoxin in patients with Grave’s disease. Thyroid. 2003;13:129–32.
73. Sahin I, Turan N, Kosar F, Taskapan C, Gunen H. Evaluation of autonomic activity in patients with subclinical hypothyroidism. J Endocrinol Invest. 2005;28:209–13.
74. Altinova AE, Toruner F, Karakoc A, Yeltkin I, Ayvaz G, Cakir N. Arslan M Serum ghrelin levels in patients with Hashimoto’s thyroiditis. Thyroid. 2006;16:1259–64.
75. Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L, et al. Lowgrade systemic inflammation causes endothelial dysfunction in patients with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2006;91:5076–82.
76. Wang J, Li P, Sun L, Sun Y, Fang S, Liu X. Diagnostic value of strain ratio measurement in differential diagnosis of thyroid nodules coexisted with Hashimoto thyroiditis. Int J Clin Exp Med. 2015;8:6420–6.
77. Yetkin DO, Dogantekin B. The lipid parameters and lipoprotein(a) excess in Hashimoto thyroiditis. Int J Endocrinol. 2015;2015:952729.
78. Xue H, Yang Y, Zhang Y, Song S, Zhang L, Ma L, et al. Macrophage migration inhibitory factor interacting with Th17 cells may be involved in the pathogenesis of autoimmune damage in Hashimoto’s thyroiditis. Mediators Inflamm. 2015;621072.
79. Djurovic J, Stojkovic O, Ozdemir O, Silan F, Akurut C, Todorovic J, et al. Association between FokI, ApaI and TaqI RFLP polymorphisms in VDR gene and Hashimoto’s thyroiditis: preliminary data from female patients in Serbia. Int J Immunogenet. 2015;42:190–4.
80. Thomas T, Sreedharan S, Khadilkar UN, Deviprasad D, Kamath MP, Bhojwani KM, et al. Clinical, biochemical & cytomorphologic study on Hashimoto’s thyroiditis. Indian J Med Res. 2014;140:729–35.
81. Ayaz T, Sahin SB, Sahin OZ, Cure MC, Sumer F, Ilkkilic K. Serum macrophage migration inhibitory factor levels in Hashimoto’s thyroiditis; a case control study. Thyroid Res. 2014;7:11.
82. Bai X, Sun J, Wang W, Shan Z, Zheng H, Li Y, et al. Increased differentiation of Th22 cells in Hashimoto’s thyroiditis. Endocr J. 2014;61:1181–90.
83. Cai T, Wang X, Muhali FS, Song R, Shi X, Jiang W, et al. Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study. Arq Bras Endocrinol Metabol. 2014;58:640–5.
84. Ceylan I, Yener S, Bayraktar F, Secil M. Roles of ultrasound and power Doppler ultrasound for diagnosis of Hashimoto thyroiditis in anti-thyroid marker-positive euthyroid subjects. Quant Imaging Med Surg. 2014;4:232–8.
85. Kapila K, Sathar SA, Al-Rabah NA, Prahash A, Seshadri MS. Chronic lymphocytic (Hashimoto’s) thyroiditis in Kuwait diagnosed by fine needle aspirates. Ann Saudi Med. 1995;15:363–6.
86. Cardia MS, Lima N, Knobel M, Medeiros-Neto G. Evaluation of a coated-tube assay for antithyrotropin receptor antibodies in patients with Graves’ disease and other thyroid disorders. Thyroid. 2004;14:295–300.
87. Liu Y, Tang X, Tian J, Zhu C, Peng H, Rui K, et al. Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto’s thyroiditis. Int J Mol Sci. 2014;15:21674–86.
88. Takeshima K, Ariyasu H, Inaba H, Inagaki Y, Yamaoka H, Furukawa Y, et al. Distribution of serum immunoglobulin G4 levels in Hashimoto’s thyroiditis and clinical features of Hashimoto’s thyroiditis with elevated serum immunoglobulin G4 levels. Endocr J. 2015;62:711–7.
89. Benvenga S, Trimarchi F. Increasing frequency and clinical significance of thyroid hormone autoantibodies. Curr Opin Endocrinol Diabetes. 2004;11:209–13.
90. Benvenga S, Trimarchi F. Thyroid hormone autoantibodies in Hashimoto’s thyroiditis: often transient but also increasingly frequent. Thyroid. 2003;13:995–6.
91. Ruggeri RM, Galletti M, Mandolfino MG, Aragona P, Bartolone S, Giorgianni G, et al. Thyroid hormone autoantibodies in primary Sjögren syndrome and rheumatoid arthritis are more prevalent than in autoimmune thyroid disease, becoming progressively more frequent in these diseases. J Endocrinol Invest. 2002;25:447–54. Erratum in: J Endocrinol Invest. 2002;25:V.
92. Colucci R, Lotti F, Arunachalam M, Lotti T, Dragoni F, Benvenga S, et al. Correlation of serum thyroid hormones autoantibodies with self-reported exposure to thyroid disruptors in a group of nonsegmental vitiligo patients. Arch Environ Contam Toxicol. 2015;69:181–90.
93. Colucci R, Lotti F, Dragoni F, Arunachalam M, Lotti T, Benvenga S, et al. High prevalence of circulating autoantibodies against thyroid hormones in vitiligo and correlation with clinical and historical parameters of patients. Br J Dermatol. 2014;171:786–98.
94. Benvenga S, Pintaudi B, Vita R, Di Vieste G, Di Benedetto A. Serum thyroid hormone autoantibodies in type 1 diabetes mellitus. J Clin Endocrinol Metab. 2015;100:1870–8.
95. El Hag IA, Kollur SM, Chiedozi LC. The role of FNA in the initial management of thyroid lesions: 7-year experience in a district general hospital. Cytopathology. 2003;14:126–30.
96. Mengistu M. Solitary thyroid nodule in adult Ethiopian patients. Analysis and experience in management in a teaching hospital. Trop Geogr Med. 1993;45:126–8.
97. Bashier AH, Abdin, Elhassan M, Sanhouri M, Ahmed ME. Solitary thyroid nodule in Khartoum. East Afr Med J. 1996;73:694–6.
98. Sang CK, Sekadde-Kigondu C, Muchiri L. Fine needle aspiration cytology of thyroid nodules at Kenyatta National Hospital, Nairobi. East Afr Med J. 2007;84:117–20.
99. Dong S, Lu GZ, Gao YM, Zhang H, Guo XH, Gao Y. A clinical pathological study of thyroid nodules detected by physical examinations. Zhonghua Nei Ke Za Zhi. 2008;47:189–92.
100. Carrillo AE, Metsios GS, Flouris AD. Effects of secondhand smoke on thyroid function. Inflamm Allergy Drug Targets. 2009;8:359–63.
101. Irmiakova AR, Kochetova OV, Gaĭnullina MK, Sivochalova OV. Viktorova TV Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry. Med Tr Prom Ekol. 2012;5:41–8.
102. Kochetova OV, Gaynullina MK, Viktorova TV. DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease. Gig Sanit. 2014;3:52–6.
103. Langer P, Tajtáková M, Fodor G, Kocan A, Bohov P, Michálek J, et al. Increased thyroid volume and prevalence of thyroid disorders in an area heavily polluted by polychlorinated biphenyls. Eur J Endocrinol. 1998;139:402–9.
104. Caciari T, Casale T, Capozzella A, De Sio S, Rosati MV, Suppi A, et al. Thyroid hormones in male workers exposed to urban stressors. Ann Ig. 2014;26:167–75.
105. Ciarrocca M, Tomei F, Caciari T, Cetica C, Andrè JC, Fiaschetti M, et al. Exposure to arsenic in urban and rural areas and effects on thyroid hormones. Inhal Toxicol. 2012;24:589–98.
106. Pistelli A, Foddis R, Guglielmi G, Bonotti A, Cristaudo A. Prevalence of thyroid disease in healthcare workers occupationally exposed to ionizing radiation at the University Hospital of Pisa. G Ital Med Lav Ergon. 2012;34:280–2.
107. Santini F, Mantovani A, Cristaudo A, Rago T, Marsili A, Buselli R, et al. Thyroid function and exposure to styrene. Thyroid. 2008;18:1065–9.
108. Toft G, Flyvbjerg A, Bonde JP. Thyroid function in Danish greenhouse workers. Environ Health. 2006;5:32.
109. Ellingsen DG, Efskind J, Haug E, Thomassen Y, Martinsen I, Gaarder PI. Effects of low mercury vapour exposure on the thyroid function in chloralkali workers. J Appl Toxicol. 2000;20:483–9.
110. Barregård L, Lindstedt G, Schütz A, Sällsten G. Endocrine function in mercury exposed chloralkali workers. Occup Environ Med. 1994;51:536–40.
111. Barregård L, Eneström S, Ljunghusen O, Wieslander J, Hultman P. A study of autoantibodies and circulating immune complexes in mercury-exposed chloralkali workers. Int Arch Occup Environ Health. 1997;70:101–6.
112. Goldner WS, Sandler DP, Yu F, Hoppin JA, Kamel F, Levan TD. Pesticide use and thyroid disease. among women in the Agricultural Health Study. Am J Epidemiol. 2010;171:455–64.
113. Garry VF. Biomarkers of thyroid function, genotoxicity and agricultural fungicide use. J Biochem Mol Toxicol. 2005;19:175.
114. Bahn AK, Mills JL, Snyder PJ, et al. Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med. 1980;302:31–3.
115. Lamm SH, Braverman LE, Li FX, Richman K, Pino S, Howearth G. Thyroid health status of ammonium perchlorate workers: a cross-sectional occupational health study. J Occup Environ Med. 1999;41:248–60.
116. Gibbs JP, Ahmad R, Crump KS, Houck DP, Leveille TS, Findley JE, et al. Evaluation of a population with occupational exposure to airborne ammonium perchlorate for possible acute or chronic effects on thyroid function. J Occup Environ Med. 1998;40:1072–82.
117. Zhao X, Wang H, Li J, Shan Z, Teng W, Teng X. The correlation between polybrominated diphenyl ethers (PBDEs) and thyroid hormones in the general population: a meta-analysis. PLoS One. 2015;10:e0126989.
118. Zoeller RT. Environmental chemicals impacting the thyroid: targets and consequences. Thyroid. 2007;17:811–7.
119. Leung AM, Pearce EN, Braverman LE. Perchlorate, iodine and the thyroid. Best Pract Res Clin Endocrinol Metab. 2010;24:133–41.
120. Hocking B. Thyroiditis and inflammatory bowel disease associated with 50 Hz magnetic field exposure. Occup Med (Lond). 2004;54:435.
121. Tajtáková M, Semanová Z, Tomková Z, Szökeová E, Majoros J, Rádiková Z, et al. Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area. Chemosphere. 2006;62:559–64.
122. Rádiková Z, Tajtáková M, Kocan A, Trnovec T, Seböková E, Klimes I, et al. Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia. Thyroid. 2008;18:353–62.
123. Langer P, Tajtáková M, Kocan A, Petrík J, Koska J, Ksinantová L, et al. Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin. Chemosphere. 2007;69:118–27.
124. Arena S, Latina A, Baratta R, Burgio G, Gullo D, Benvenga S. Chronic lymphocytic thyroiditis: could it be influenced by a petrochemical complex? Data from a cytological study in South-Eastern Sicily. Eur J Endocrinol. 2015;172:383–9.
125. Benvenga S, Vigo MT, Metro D, Granese R, Vita R, Le Donne M. Type of fish consumed and thyroid autoimmunity in pregnancy and postpartum. Endocrine. 2015. doi:10.1007/s12020-015-0698-3.
126. Chevrier J, Warner M, Gunier RB, Brambilla P, Eskenazi B, Mocarelli P. Serum dioxin concentrations and thyroid hormone levels in the Seveso Women’s Health Study. Am J Epidemiol. 2014;180:490–8.
127. Flouris AD, Metsios GS, Jamurtas AZ, Koutedakis Y. Sexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function. Am J Physiol Endocrinol Metab. 2008;294:E456–62.
128. Croes K, Den Hond E, Bruckers L, Govarts E, Schoeters G, Covaci A, et al. Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II). Environ Sci Pollut Res Int. 2015;22:14589–99.
129. Rachmawati D, Muris J, Scheper RJ, Rustemeyer T, Kleverlaan CJ, Feilzer AJ, et al. Continuing the quest for autoimmunity due to oral metal exposure. Autoimmunity. 2015;27:1–8.
130. Llop S, Lopez-Espinosa MJ, Murcia M, Alvarez-Pedrerol M, Vioque J, Aguinagalde X, et al. Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women. Environ Res. 2015;138:298–305.
131. Spaulding SW. The possible roles of environmental factors and the aryl hydrocarbon receptor in the prevalence of thyroid diseases in Vietnam era veterans. Curr Opin Endocrinol Diabetes Obes. 2011;18:315–20.
132. Sarkar A, Knight JC, Babichuk NA, Mulay S. Skewed distribution of hypothyroidism in the coastal communities of Newfoundland, Canada. Environ Int. 2015;83:171–5.
133. Schell LM et al. Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults. Environ Res. 2009;109:86–92.
134. Jain RB. Association between thyroid function and selected organochlorine pesticides: data from NHANES 2001–2002. Sci Total Environ. 2014;466–467:706–15.
135. Chen A, Kim SS, Chung E, Dietrich KN. Thyroid hormones in relation to lead, mercury, and cadmium exposure in the National Health and Nutrition Examination Survey, 2007–2008. Environ Health Perspect. 2013;121:181–6.
136. Jain RB. Association between thyroid profile and perfluoroalkyl acids: data from NHNAES 2007–2008. Environ Res. 2013;126:51–9.
137. Lewis RC, Johns LE, Meeker JD. Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011–2012. Int J Environ Res Public Health. 2015;12:6098–114.
138. Turyk ME, Anderson HA, Persky VW. Relationships of thyroid hormones with polychlorinated biphenyls, dioxins, furans, and DDE in adults. Environ Health Perspect. 2007;115:1197–203.
139. Winquist A, Steenland K. Perfluorooctanoic acid exposure and thyroid disease in community and worker cohorts. Epidemiology. 2014;25:255–64.
140. Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS. Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. national health and nutrition examination survey. Environ Health Perspect. 2010;118:686–92.
141. Li FX, Squartsoff L, Lamm SH. Prevalence of thyroid diseases in Nevada counties with respect to perchlorate in drinking water. J Occup Environ Med. 2001;43:630–4.
142. Camargo RY, Tomimori EK, Neves SC, Knobel M, Medeiros-Neto G. Prevalence of chronic autoimmune thyroiditis in the urban area neighboring a petrochemical complex and a control area in Sao Paulo, Brazil. Clinics. 2006;61:307–12.
143. de Freitas CU, Grimaldi Campos RA, Rodrigues Silva MA, Panachao MR, de Moraes JC, Waissmann W, et al. Can living in the surroundings of a petrochemical complex be a risk factor for autoimmune thyroid disease? Environ Res. 2010;110:112–7.
144. Freire C, Koifman RJ, Sarcinelli PN, Simões Rosa AC, Clapauch R, Koifman S. Long-term exposure to organochlorine pesticides and thyroid status in adults in a heavily contaminated area in Brazil. Environ Res. 2013;127:7–15.
145. Freire C, Koifman RJ, Sarcinelli P, Rosa AC, Clapauch R, Koifman S. Long term exposure to organochlorine pesticides and thyroid function in children from Cidade dos Meninos, Rio de Janeiro. Brazil Environ Res. 2012;117:68–74.
146. Téllez Téllez R, Michaud Chacón P, Reyes Abarca C, Blount BC, Van Landingham CB, Crump KS, et al. Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period. Thyroid. 2005;15:963–75.
147. Su PH, Chen HY, Chen SJ, Chen JY, Liou SH, Wang SL. Thyroid and growth hormone concentrations in 8-year-old children exposed in utero to dioxins and polychlorinated biphenyls. J Toxicol Sci. 2015;40:309–19.
148. Tarone RE, Lipworth L, McLaughlin JK. The epidemiology of environmental perchlorate exposure and thyroid function: a comprehensive review. J Occup Environ Med. 2010;52:653–60.
149. Li Y, Ren H, Ren M, Cui F, Yang F, Chen Z, et al. Morvan syndrome plus thyroid dysfunction: a case with chronic mercury exposure. Neurol India. 2014;62:218–9.
150. Baccarelli A, Mocarelli P, Patterson Jr DG, Bonzini M, Pesatori AC, Caporaso N, et al. Immunologic effects of dioxin: new results from Seveso and comparison with other studies. Environ Health Perspect. 2002;110:1169–73.
151. Iaglova NV, Iaglov VV. Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT. Biomed Khim. 2014;60:655–60.
152. Coperchini F, Pignatti P, Lacerenza S, Negri S, Sideri R, Testoni C, et al. Exposure to perfluorinated compounds: in vitro study on thyroid cells. Environ Sci Pollut Res Int. 2015;22:2287–94.
153. Fernie KJ, Palace V, Peters LE, Basu N, Letcher RJ, Karouna-Renier NK, et al. Investigating endocrine and physiological parameters of captive American kestrels exposed by diet to selected organophosphate flame retardants. Environ Sci Technol. 2015;49:7448–55.
154. Kim S, Jung J, Lee I, Jung D, Youn H, Choi K. Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines. Aquat Toxicol. 2015;160:188–96.
155. Wang Q, Liang K, Liu J, Yang L, Guo Y, Liu C, et al. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquat Toxicol. 2013;126:207–13.
156. Zhai W, Huang Z, Chen L, Feng C, Li B, Li T. Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl) phthalate (MEHP). PLoS One. 2014;9:e92465.
157. Guo H, Yang H, Chen H, Li W, Tang J, Cheng P, et al. Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway. J Appl Toxicol. 2015;35:922–8.
158. Liu C, Ha M, Li L, Yang K. PCB153 and p, p’-DDE disorder thyroid hormones via thyroglobulin, deiodinase 2, transthyretin, hepatic enzymes and receptors. Environ Sci Pollut Res Int. 2014;21:11361–9.
159. Liu C, Ha M, Cui Y, Wang C, Yan M, Fu W, et al. JNK pathway decreases thyroid hormones via TRH receptor: a novel mechanism for disturbance of thyroid hormone homeostasis by PCB153. Toxicology. 2012;302:68–76.
160. Sharan S, Nikhil K, Roy P. Disruption of thyroid hormone functions by low dose exposure of tributyltin: an in vitro and in vivo approach. Gen Comp Endocrinol. 2014;206:155–65.
161. Orihuela D. Aluminium effects on thyroid gland function: iodide uptake, hormone biosynthesis and secretion. J Inorg Biochem. 2011;105:1464–8.
162. Daniel AT, Adekilekun TA, Adewale MA, Adekemi AT. Cyanide-induced hyperthyroidism in male Wistar rats. Niger Med J. 2014;55:246–9.
163. Yu L, Han Z, Liu C. A review on the effects of PBDEs on thyroid and reproduction systems in fish. Gen Comp Endocrinol. 2015;219:64–73.
164. Tang JM, Li W, Xie YC, Guo HW, Cheng P, Chen HH, et al. Morphological and functional deterioration of the rat thyroid following chronic exposure to low-dose PCB118. Exp Toxicol Pathol. 2013;65:989–94.
165. Silbergeld EK, Silva IA, Nyland JF. Mercury and autoimmunity: implications for occupational and environmental health. Toxicol Appl Pharmacol. 2005;207:282–92.
166. Nielsen JB, Hultman P. Mercury-induced autoimmunity in mice. Environ Health Perspect. 2002;110:877–81.