Thyroid and growth hormone concentrations in 8-year-old children exposed in utero to dioxins and polychlorinated biphenyls

Journal of Toxicological Sciences

Volumn 40, Issue 3, 2015, Pages 309-319

  Su, Pen Hua ^a,b   Chen, Hsiao Yen ^c   Chen, Suh Jen ^a   Chen, Jia Yuh ^a,b   Liou, Saou Hsing ^c,d   Wang, Shu Li ^c,d  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Children; Dioxins; Growth hormone; Polychlorinated biphenyls; Thyroid hormones

Indexed keywords

DIMETHOXANE; GROWTH HORMONE; POLYCHLORINATED BIPHENYL; THYROID HORMONE; THYROXINE BINDING GLOBULIN; DIOXIN; LIOTHYRONINE; POLLUTANT; SOMATOMEDIN BINDING PROTEIN 3; THYROXINE;

ARTICLE; BLOOD PRESSURE MONITORING; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHILD; ENVIRONMENTAL PROTECTION; EVALUATION AND FOLLOW UP; FEMALE; GAS CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PREGNANCY; PRESCHOOL CHILD; RADIOIMMUNOASSAY; SCHOOL CHILD; SCORING SYSTEM; TOXICITY TESTING; ADVERSE EFFECTS; BLOOD; DOSE RESPONSE; FETOMATERNAL TRANSFUSION; MATERNAL EXPOSURE; METABOLISM; POLLUTANT; PRENATAL EXPOSURE;

CHILD; DIOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; MALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; THYROXINE; THYROXINE-BINDING GLOBULIN; TRIIODOTHYRONINE;

EID: 84929170740     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.40.309     Document Type: Article

References (31)

1. Alvarez-Pedrerol, M., Ribas-Fitó, N., Torrent, M., Carrizo, D., Grimalt, J.O. and Sunyer, J. (2008): Effects of PCBs, p,p'-DDT, p,p'-DDE, HCB and beta-HCH on thyroid function in preschool children. Occup. Environ. Med., 65, 452-457.
2. Baccarelli, A., Giacomini, S.M., Corbetta, C., Landi, M.T., Bonzini, M., Consonni, D., Grillo, P., Patterson, D.G., Pesatori, A.C. and Bertazzi, P.A. (2008): Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxin. PLoS Med., 5, e161.
3. Bettendorf, M. (2002): Thyroid disorders in children from birth to adolescence. Eur. J. Nucl. Med. Mol. Imaging, 29 Suppl. 2, S439-446.
4. Blanck, H.M., Marcus, M., Rubin, C., Tolbert, P.E., Hertzberg, V.S., Henderson, A.K. and Zhang, R.H. (2002): Growth in girls exposed in utero and postnatally to polybrominated biphenyls and polychlorinated biphenyls. Epidemiology, 13, 205-210.
5. Boersma, E.R. and Lanting, C.I. (2000): Environmental exposure to polychlorinated biphenyls (PCBs) and dioxins. Consequences for longterm neurological and cognitive development of the child lactation. Adv. Exp. Med. Biol., 478, 271-287.
6. Bucher, H., Prader, A. and Illig, R. (1985): Head circumference, height, bone age and weight in 103 children with congenital hypothyroidism before and during thyroid hormone replacement. Helv. Paediatr. Acta., 40, 305-316.
7. Cheek, A.O., Kow, K., Chen, J. and McLachlan, J.A. (1999): Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid- binding globulin. Environ. Health Perspect., 107, 273-278.
8. Cole, T.J. and Green, P.J. (1992): Smoothing reference centile curves: the LMS method and penalized likelihood. Stat. Med., 11, 1305-1319.
9. Crinnion, W.J. (2011): Polychlorinated biphenyls: persistent pollutants with immunological, neurological, and endocrinological consequences. Altern. Med. Rev., 16, 5-13.
10. Elango, A., Shepherd, B. and Chen, T.T. (2006): Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary. Gen. Comp. Endocrinol., 145, 116-127.
11. Elmlinger, M.W., Kühnel, W., Lambrecht, H.G. and Ranke, M.B. (2001): Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH). Clin. Chem. Lab. Med., 39, 973-979.
12. Gauger, K.J., Giera, S., Sharlin, D.S., Bansal, R., Iannacone, E. and Zoeller, R.T. (2007): Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells. Environ. Health Perspect., 115, 1623-1630.
13. Goodman, J.E., Kerper, L.E., Boyce, C.P., Prueitt, R.L. and Rhomberg, L.R. (2010): Weight-of-evidence analysis of human exposures to dioxins and dioxin-like compounds and associations with thyroid hormone levels during early development. Regul. Toxicol. Pharmacol., 58, 79-99.
14. Ilsen, A., Briët, J.M., Koppe, J.G., Pluim, H.J. and Oosting, J. (1996): Signs of enhanced neuromotor maturation in children due to perinatal load with background levels of dioxins. Follow-up until age 2 years and 7 months. Chemosphere, 33, 1317-1326.
15. Lamb, M.R., Taylor, S., Liu, X., Wolff, M.S., Borrell, L., Matte, T.D., Susser, E.S. and Factor-Litvak, P. (2006): Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysis. Environ. Health Perspect., 114, 779-785.
16. Langer, P. (2008): Persistent organochlorinated pollutants (PCB, DDE, HCB, dioxins, furans) and the thyroid--review 2008. Endocr. Regul., 42, 79-104.
17. Mocarelli, P., Gerthoux, P.M., Needham, L.L., Patterson, D.G.Jr., Limonta, G., Falbo, R., Signorini, S., Bertona, M., Crespi, C., Sarto, C., Scott, P.K., Turner, W.E. and Brambilla, P. (2011): Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environ. Health Perspect., 119, 713-718.
18. Nishimura, N., Yonemoto, J., Miyabara, Y., Fujii-Kuriyama, Y. and Tohyama, C. (2005): Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice. Arch. Toxicol., 79, 260-267.
19. Otake, T., Yoshinaga, J., Enomoto, T., Matsuda, M., Wakimoto, T., Ikegami, M., Suzuki, E., Naruse, H., Yamanaka, T., Shibuya, N., Yasumizu, T. and Kato, N. (2007): Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Environ. Res., 105, 240-246.
20. Park, H.Y., Hertz-Picciotto, I., Sovcikova, E., Kocan, A., Drobna, B. and Trnovec, T. (2010): Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity: a birth cohort study. Environ. Health, 9, 51.
21. Patandin, S., Koopman-Esseboom, C., de Ridder, M.A., Weisglas- Kuperus, N. and Sauer, P.J. (1998): Effects of environmental exposure to polychlorinated biphenyls and dioxins on birth size and growth in Dutch children. Pediatr. Res., 44, 538-545.
22. Pluim, H.J., de Vijlder, J.J., Olie, K., Kok, J.H., Vulsma, T., van Tijn, D.A., van der Slikke, J.W. and Koppe, J.G. (1993): Effects of pre- and postnatal exposure to chlorinated dioxins and furans on human neonatal thyroid hormone concentrations. Environ. Health Perspect., 101, 504-508.
23. Sandau, C.D., Ayotte, P., Dewailly, E., Duffe, J. and Norstrom, R.J. (2002): Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Quebec. Environ. Health Perspect., 110, 411-417.
24. Su, P.H., Chen, J.Y., Chen, J.W. and Wang, S.L. (2010): Growth and thyroid function in children with in utero exposure to dioxin: a 5-year follow-up study. Pediatr. Res., 67, 205-210.
25. Su, P.H., Huang, P.C., Lin, C.Y., Ying, T.H., Chen, J.Y. and Wang, S.L. (2012): The effect of in utero exposure to dioxins and polychlorinated biphenyls on reproductive development in eight year-old children. Environ. Int., 39, 181-187.
26. Tanner, J.M., Whitehouse, R.H., Cameron, N., Marshall, W.A., Healy, M.J.R. and Goldstein, H. (2001): Assessment of skeletal maturity and prediction of adult height (TW3 method). W.B. Sauders, London.
27. Tarim, O. (2011): Thyroid hormones and growth in health and disease. J. Clin. Res. Pediatr. Endocrinol., 3, 51-55.
28. Wang, S.L., Su, P.H., Jong, S.B., Guo, Y.L., Chou, W.L. and Papke, O. (2005): In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns. Environ. Health Perspect., 113, 1645-1650.
29. White, S.S. and Birnbaum, L.S. (2009): An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 27, 197-211.
30. Wilson, C.L. and Safe, S. (1998): Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses. Toxicol. Pathol., 26, 657-671.
31. Yen, P.M. (2001): Physiological and molecular basis of thyroid hormone action. Physiol. Rev., 81, 1097-1142.