Long term exposure to organochlorine pesticides and thyroid function in children from Cidade dos Meninos, Rio de Janeiro, Brazil

Environmental Research

Volumn 117, Issue , 2012, Pages 68-74

  Freire, Carmen ^a,b   Koifman, Rosalina Jorge ^a   Sarcinelli, Paula ^a   Rosa, Ana Cristina ^a   Clapauch, Ruth ^c   Koifman, Sergio ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^c HOSPITAL DA LAGOA   (Brazil)

Author keywords

Childhood; Organochlorine; Pesticides; Thyroid hormones; TSH

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; ALDRIN; ALPHA HEXACHLOROCYCLOHEXANE; BETA HEXACHLOROCYCLOHEXANE; CHLORDANE; CHLORPHENOTANE; DIELDRIN; ENDOSULFAN; ENDOSULFAN 1; ENDOSULFAN 2; ENDRIN; GAMMA CHLORDANE; HEPTACHLOR; HEXACHLOROBENZENE; LINDANE; LIOTHYRONINE; METHOXYCHLOR; MIREX; ORGANOCHLORINE PESTICIDE; THYROTROPIN; THYROXINE; TRANSNONACHLOR; UNCLASSIFIED DRUG;

CHEMICAL INDUSTRY; CHILD HEALTH; ENVIRONMENTAL FATE; HEALTH MONITORING; HORMONE; LONG-TERM CHANGE; ORGANOFLUORINE; POLLUTION EXPOSURE; SERUM; SPATIOTEMPORAL ANALYSIS;

ADOLESCENT; ARTICLE; BRAZIL; CHILD; FEMALE; HEALTH SURVEY; HUMAN; INFANT; LIPID BLOOD LEVEL; LONG TERM EXPOSURE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; THYROID FUNCTION;

ADOLESCENT; AGE FACTORS; BRAZIL; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, GAS; ENVIRONMENTAL EXPOSURE; HUMANS; HYDROCARBONS, CHLORINATED; INFANT; LINEAR MODELS; LIPIDS; PESTICIDES; SEX FACTORS; SOLID PHASE EXTRACTION; THYROID FUNCTION TESTS; THYROID GLAND; THYROID HORMONES; URBAN POPULATION;

BRAZIL; CIDADE DOS MENINOS; RIO DE JANEIRO [BRAZIL];

EID: 84864932995     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2012.06.009     Document Type: Article

References (57)

1. Agency for Toxic Substances and Disease Registry-Hexachlorocyclohexane. ATSDR Public Health Statement, September 1995.
2. Alvarez L., Hernandez S., Martinez-de-Mena R., Kolliker-Frers R., Obregon M.J., Kleiman de Pisarev D.L. The role of type I and type II 50 deiodinases on hexachlorobenzene-induced alteration of the hormonal thyroid status. Toxicology 2005, 207:349-362.
3. Alvarez-Pedrerol M., Ribas-Fitó N., Torrent M., Julvez J., Ferrer C., Sunyer J. TSH concentration within the normal range is associated with cognitive function and ADHD symptoms in healthy preschoolers. Clin. Endocrinol. 2007, 66:890-898.
4. Alvarez-Pedrerol M., Ribas-Fitó N., Torrent M., Carrizo D., Garcia-Esteban R., Grimalt J.O., Sunyer J. Thyroid disruption at birth due to prenatal exposure to beta-hexachlorocyclohexane. Environ. Int. 2008, 34:737-740.
5. Arrebola J.P., Cuellar M., Claure E., Quevedo M., Antelo S.R., Mutch E., Ramirez E., Fernandez M.F., Olea N., Mercado L.A. Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and adipose tissue from Bolivia. Environ. Res. 2012, 112:40-47.
6. Asmus C.I., Alonzo H.G., Palácios M., da Silva A., Filhote M.I., Buosi D., Câmara V. Assessment of human health risk from organochlorine pesticide residues in Cidade dos Meninos, Duque de Caxias, Rio de Janeiro, Brazil. Cad. Saúde Pública. 2008, 24:755-766.
7. Bloom M.S., Weiner J.M., Vena J.E., Beehler G.P. Exploring associations between serum levels of select organochlorines and thyroxine in a sample of New York state sportsmen: the New York State Angler Cohort Study. Environ. Res. 2003, 93:52-66.
8. Boas M., Feldt-Rasmussen U., Skakkebaek N.E., Main K.M. Environmental chemicals and thyroid function. Eur. J. Endocrinol. 2006, 154:599-611.
9. Bondy G., Curran I., Doucet J., Armstrong C., Coady L., Hierlihy L., Fernie S., Robertson P., Barker M. Toxicity of trans-nonachlor to Sprague-Dawley rats in a 90-day feeding study. Food Chem. Toxicol. 2004, 42:1015-1027.
10. Carvalho W.A. Fatores de risco relacionados com exposição ocupacional e ambiental a inseticidas organoclorados no Estado da Bahia, Brasil, 1985. Bol. Oficina. Sanit. Panam. 1991, 111:512-524.
11. Coimbra A.M., Reis-Henriques M.A., Darras V.M. Circulating thyroid hormone levels and iodothyronine deiodinase activities in Nile tilapia (Oreochromis niloticus) following dietary exposure to Endosulfan and Aroclor 1254. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 2005, 141:8-14.
12. Crofton K.M. Thyroid disrupting chemicals: mechanisms and mixtures. Int. J. Androl. 2008, 31:209-223.
13. Delgado I.F., Barretto H.H., Kussumi T.A., Alleluia I.B., Baggio Cde A., Paumgartten F.J. Serum levels of organochlorine pesticides and polychlorinated biphenyls among inhabitants of Greater Metropolitan Rio de Janeiro, Brazil. Cad. Saude Publica 2002, 18:519-524.
14. Dowling J.T., Frienkel N., Ingbar S.H. The effect of estrogens upon the peripheral metabolism of thyroxine. J. Clin. Invest. 1974, 39:1119-1130.
15. Fernicola N.A., Azevedo F.A. Serum levels of organochlorine insecticides in humans in São Paulo, Brasil. Vet. Hum. Toxicol. 1982, 24:91-93.
16. Fisher D.A., Nelson J.C., Carlton E., Wilcox R.B. Maturation of human hypothalamic pituitary-thyroid function and control. Thyroid 2000, 10:229-234.
17. Fort D.J., Guiney P.D., Weeks J.A., Thomas J.H., Rogers R.L., Noll A.M., Spaulding C.D. Effect of methoxychlor on various life stages of Xenopus laevis. Toxicol. Sci. 2004, 81:454-466.
18. Giacomini S.M., Hou L., Bertazzi P.A., Baccarelli A. Dioxin effects on neonatal and infant thyroid function: routes of perinatal exposure, mechanisms of action and evidence from epidemiology studies. Int. Arch. Occup. Environ. Health 2006, 79:396-404.
19. Gould J.C., Cooper K.R., Scanes C.G. Effects of polychlorinated biphenyls on thyroid hormones and liver type I monodeiodinase in the chick embryo. Ecotoxicol. Environ. Saf. 1999, 43:195-203.
20. Hagmar L. Polychlorinated biphenyls and thyroid status in humans: a review. Thyroid 2003, 13:1021-1028.
21. Hunter D.J., Hankinson S., Laden F., Colditz G.A., Manson J.E., Willet W.C., Speizer F.E., Wolff M.S. Plasma organochlorine levels and risk of breast cancer in a prospective study. N. Engl. J. Med. 1997, 337:1253-1258.
22. Instituto Brasileiro de Geografía e Estatística (IBGE), 1991. Censo demográfico. Bairro 17 - Cidade dos Meninos. Município 170 - Duque de Caxias, Rio de Janeiro.
23. Langer P., Tajtaková M., Kocan A., Vlcek M., Petrik J., Chovancova J., Drobna B., Jursa S., Pavuk M., Trnovec T., Sebokova E., Klimes I. Multiple organochlorine pollution and the thyroid. Endocr. Regul. 2006, 40:46-52.
24. Langer P., Kocan A., Tajtakova M., Susienkova K., Radikova Z., Koska J., Ksinantova L., Imrich R., Huckova M., Drobna B., Gasperikova D., Trnovec T., Klimes I. Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin). Thyroid Res. 2009, 2:3.
25. Langer P. The impacts of organochlorines and other persistent pollutants on thyroid and metabolic health. Front. Neuroendocrinol. 2010, 31:497-518.
26. Lazar L., Frumkin R.B., Battat E., Lebenthal Y., Phillip M., Meyerovitch J. Natural history of thyroid function tests over 5 years in a large pediatric cohort. J. Clin. Endocrinol. Metab. 2009, 94:1678-1682.
27. Lopez-Espinosa M.J., Vizcaino E., Murcia M., Llop S., Espada M., Seco V., Marco A., Rebagliato M., Grimalt J.O., Ballester F. Association between thyroid hormone levels and 4,4'-DDE concentrations in pregnant women (Valencia, Spain). Environ. Res. 2009, 109:479-485.
28. Maervoet J., Vermeir G., Covaci A., Van Larebeke N., Koppen G., Schoeters G., Nelen V., Baeyens W., Schepens P., Viaene M.K. Association of thyroid hormone concentrations with levels of organochlorine compounds in cord blood of neonates. Environ. Health Perspect. 2007, 115:1780-1786.
29. Meeker J.D., Altshul L., Hauser R. Serum PCBs, p,p'-DDE and HCB predict thyroid hormone levels in men. Environ. Res. 2007, 104:296-304.
30. Minelli E.V., Ribeiro M.L. DDT and HCH residues in the blood serum of malaria control sprayers. Bull. Environ. Contam. Toxicol. 1996, 57:691-696.
31. Ministério da Saúde, Secretaria de Políticas de Saúde, Departamento de Ciĉncia e Tecnologia em Saúde, 2003. Exposição Humana a Resíduos Organoclorados na Cidade dos Meninos, Município de Duque de Caxias, Rio de Janeiro. Relatório de Trabalho da Comissão Técnica Assessora ao Ministério da Saúde, Brasília, DF.
32. Oppenheimer J.H. Role of plasma proteins in the binding, distribution, and metabolism of the thyroid hormones. N. Engl. J. Med. 1968, 278:1153-1162.
33. Oppenheimer J.H., Schwartz H.L. Molecular basis of thyroid hormone-dependent brain development. Endocrinol. Rev. 1997, 18:462-475.
34. Osius N., Karmaus W., Kruse H., Witten J. Exposure to polychlorinated biphenyls and levels of thyroid hormones in children. Environ. Health Perspect. 1999, 107:843-849.
35. Paumgartten F.J.R., Delgado I.F., Oliveira E.S., Alleluia I.B., Barretto H.H.C., Kussumi T.A. Levels of organochlorine pesticides in the blood of agricultural workers from Rio de Janeiro State, Brazil. Cad. Saúde Pública 1998, 14:33-39.
36. Pelletier C., Doucet E., Imbeault P., Tremblay A. Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T(3) concentration, and resting metabolic rate. Toxicol. Sci. 2002, 67:46-51.
37. Purkey H.E., Palaninathan S.K., Kent K.C., Smith C., Safe S.H., Sacchettini J.C., Kelly J.W. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chem. Biol. 2004, 11:1719-1728.
38. Refetoff S., Robin N.I., Fang V.S. Parameters of thyroid function in serum of 16 selected vertebrate species: a study of PBI, serum T4, free T4, and the pattern of T4 and T3 binding to serum proteins. Endocrinology 1970, 86:793-805.
39. Sala M., Sunyer J., Herrero C., To-Figueras J., Grimalt J. Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population. Occup. Environ. Med. 2001, 58:172-177.
40. Santos Filho E., de Souza e Silva R., Barretto H.H., Inomata O.N., Lemes V.R., Sakuma A.M., Scorsafava M.A. Heavy metal and organochlorine pesticide blood levels in children of 1 to 10 years of age. Rev. Saúde Pública 1993, 27:59-67.
41. Sarcinelli P.N., Pereira A.C., Mesquita S.A., Oliveira-Silva J.J., Meyer A., Menezes M.A., Alves S.R., Mattos R.C., Moreira J.C., Wolff M. Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro. Environ. Res. 2003, 91:143-150.
42. Schell L.M., Gallo M.V., Decaprio A.P., Hubicki L., Denham M., Ravenscroft J., The Akwesasne Task Force on the Environment Thyroid function in relation to burden of PCBs, p,p'-DDE, HCB, mirex and lead among Akwesasne Mohawk youth: a preliminary study. Environ. Toxicol. Pharmacol. 2004, 18:91-99.
43. Schell L.M., Gallo M.V., Denham M., Ravenscroft J., DeCaprio A.P., Carpenter D.O. Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youth. Environ. Health Perspect. 2008, 116:806-813.
44. Schisterman E.F., Whitcomb B.W., Buck Louis G.M., Louis T.A. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ. Health Perspect. 2005, 113:853-857.
45. Scollon E.J., Carr J.A., Cobb G.P. The effect of flight, fasting and p,p'-DDT on thyroid hormones and corticosterone in Gambel's white-crowned sparrow Zonotrichia leucophrys gambelli. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2004, 137:179-189.
46. Sormo E.G., Jussi I., Jussi M., Braathen M., Skaare J.U., Jenssen B.M. Thyroid hormone status in gray seal (Halichoerus grypus) pups from the Baltic Sea and the Atlantic Ocean in relation to organochlorine pollutants. Environ. Toxicol. Chem. 2005, 24:610-616.
47. Surks M.I., Ortiz E., Daniels G.H., Sawin C.T., Col N.F., Cobin R.H., Franklyn J.A., Hershman J.M., Burman K.D., Denke M.A., Gorman C., Cooper R.S., Weissman N.J. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 2004, 291:228-238.
48. Takser L., Mergler D., Baldwin M., Smargiassi A., Lafond J. Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environ. Health Perspect. 2005, 113:1039-1045.
49. The National Academy of Clinical Biochemistry Guía de consenso para el diagnóstico y seguimiento de la enfermedad tiroidea. Acta Bioquím. Clín. Latinoam. 2007, 41:87-119.
50. van Raaij J.A., Frijters C.M., van den Berg J.K. Hexachlorobenzene-induced hypothyroidism. Involvement of different mechanisms by parent compound and metabolite. Biochem. Pharmacol. 1993, 46:1385-1391.
51. van Raaij J.A., Kaptein E., Visser T.J., van den Berg K.J. Increased glucuronidation of thyroid hormone in hexachlorobenzene-treated rats. Biochem. Pharmacol. 1993, 45:627-631.
52. Varona M.E., Díaz-Criollo S.M., Lancheros-Bernal A.R., Murcia-Orjuela A.M., Henao-Londoño G.L., Idrovo A.J. Organochlorine pesticide exposure among agricultural workers in Colombian regions with illegal crops: an exploration in a hidden and dangerous world. Int. J. Environ. Health Res. 2010, 20:407-414.
53. Williams G.R. Neurodevelopmental and neuropsychological actions of thyroid hormone. J. Neuroendocrinol. 2008, 20:784-794.
54. Wolff M.S., Toniolo P.G., Lee E.W., Rivera M., Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J. Natl. Cancer Inst. 1993, 85:648-652.
55. World Health Organization, 1991a. Alpha- and Beta-Hexachlorocyclohexanes (Alpha- and Beta-HCHs) Health and Safety Guide. IPCS/WHO, Geneva [Health and Safety Guide 53].
56. World Health Organization. 1991b. Lindane (Gamma-HCH) Health and Safety Guide. IPCS/WHO, Geneva [Health and Safety Guide 54].
57. Zoeller T. Environmental chemicals impacting the thyroid: targets and consequences. Thyroid 2007, 17:811-817.