Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway

Journal of Applied Toxicology

Volumn 35, Issue 9, 2015, Pages 992-998

  Guo, Hongwei ^a   Yang, Hui ^a   Chen, Huanhuan ^a   Li, Wen ^a   Tang, Jinmei ^a   Cheng, Pei ^a   Xie, Yuchun ^a   Liu, Yun ^a   Ding, Guoxian ^a   Cui, Dai ^a   Zheng, Xuqin ^a   Duan, Yu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

FoxO3a; NIS; PI3K Akt; Polychlorinated biphenyls 118; Thyrocyte dysfunction

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2,3',4,4 ,5 PENTACHLOROBIPHENYL; DIMETHYL SULFOXIDE; MESSENGER RNA; POLYCHLORINATED BIPHENYL; SODIUM IODIDE SYMPORTER; THYROGLOBULIN; THYROXINE; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; 2,3',4,4',5-PENTACHLOROBIPHENYL; COTRANSPORTER; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; POLLUTANT; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THYROCYTE DYSFUNCTION; THYROID DISEASE; THYROID HORMONE BLOOD LEVEL; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOLOGY; POLLUTANT; PRIMARY CELL CULTURE; REAL TIME POLYMERASE CHAIN REACTION; THYROID GLAND; TOXICITY; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; ENVIRONMENTAL POLLUTANTS; EPITHELIAL CELLS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; POLYCHLORINATED BIPHENYLS; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYMPORTERS; THYROID GLAND;

EID: 84937935164     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3032     Document Type: Article

References (33)

1. Arnold DL, Bryce F, McGuire PF, Stapley R, Tanner JR, Wrenshall E, Mes J, Fernie S, Tryphonas H, Hayward S, Malcolm S. 1995. Toxicological consequences of aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. Part 2. Reproduction and infant findings. Food Chem. Toxicol.. 33: 457-474. DOI: 10.1016/0278-6915(95)00018-W.
2. Boas M, Feldt-Rasmussen U, Skakkebaek NE, Main KM. 2006. Environmental chemicals and thyroid function. Eur. J. Endocrinol. 154: 599-611. DOI: 10.1530/eje.1.02128.
3. Brown SB, Adams BA, Cyr DG, Eales JG. 2004. Contaminant effects on the teleost fish thyroid. Environ. Toxicol. Chem. 23: 1680-1701. DOI: 10.1897/03-242.
4. Burgering BM, Kops GJ. 2002. Cell cycle and death control: long live Forkheads. Trends Biochem. Sci. 27: 352-360. DOI: 10.1016/S0968-0004(02)02113-8.
5. Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H. 2001. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J. Biol. Chem. 276: 9817-9824. DOI: 10.1074/jbc.M010840200.
6. Collins WT, Jr., Capen CC. 1980. Fine structural lesions and hormonal alterations in thyroid glands of perinatal rats exposed in utero and by the milk to polychlorinated biphenyls. Am. J. Pathol. 99: 125-142.
7. Dickerson SM, Guevara E, Woller MJ, Gore AC. 2009. Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153. Toxicol. Appl. Pharmacol. 237: 237-245. DOI: 10.1016/j.taap.2009.04.001.
8. Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M. 2004. PI3K/Akt signalling pathway and cancer. Cancer Treat. Rev. 30: 193-204. DOI: 10.1016/j.ctrv.2003.07.007.
9. Golden R, Kimbrough R. 2009. Weight of evidence evaluation of potential human cancer risks from exposure to polychlorinated biphenyls: an update based on studies published since 2003. Crit. Rev. Toxicol. 39: 299-331. DOI: 10.1080/10408440802291521.
10. Ishihara A, Sawatsubashi S, Yamauchi K. 2003. Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors. Mol. Cell. Endocrinol. 199: 105-117. DOI: 10.1016/S0303-7207(02)00302-7.
11. Kato Y, Ikushiro S, Haraguchi K, Yamazaki T, Ito Y, Suzuki H, Kimura R, Yamada S, Inoue T, Degawa M. 2004. A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Toxicol. Sci. 81: 309-315. DOI: 10.1093/toxsci/kfh225.
12. Kimbrough RD, Krouskas CA. 2003. Human exposure to polychlorinated biphenyls and health effects: a critical synopsis. Toxicol. Rev. 22: 217-233. DOI: 10.2165/00139709-200322040-00004.
13. Kogai T, Sajid-Crockett S, Newmarch LS, Liu YY, Brent GA. 2008. Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells. J. Endocrinol. 199: 243-252. DOI: 10.1677/JOE-08-0333.
14. Kogai T, Taki K, Brent GA. 2006. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr. Relat. Cancer 13: 797-826. DOI: 10.1677/erc.1.01143.
15. Lee BR, Kamitani T. 2011. Improved immunodetection of endogenous alpha-synuclein. PLoS One 6: e23939. DOI: 10.1371/journal.pone.0023939.
16. Merritt RL, Foran CM. 2007. Influence of persistent contaminants and steroid hormones on glioblastoma cell growth. J. Toxicol. Environ. Health A 70: 19-27. DOI: 10.1080/15287390600748807.
17. Paroder V, Nicola JP, Ginter CS, Carrasco N. 2013. The iodide transport defect-causing mutation R124H: a delta-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter (NIS). J. Cell Sci. 126: 3305-3313. DOI: 10.1242/jcs.120246.
18. Pocar P, Klonisch T, Brandsch C, Eder K, Frohlich C, Hoang-Vu C, Hombach-Klonisch S. 2006. AhR-agonist-induced transcriptional changes of genes involved in thyroid function in primary porcine thyrocytes. Toxicol. Sci. 89: 408-414. DOI: 10.1093/toxsci/kfj042.
19. Portigal CL, Cowell SP, Fedoruk MN, Butler CM, Rennie PS, Nelson CC. 2002. Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. Toxicol. Appl. Pharmacol. 179: 185-194. DOI: 10.1006/taap.2002.9371.
20. Que J, Cao Q, Sui T, Du S, Kong D, Cao X. 2013. Effect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats. Cell Death Dis. 4: e526. DOI: 10.1038/cddis.2013.56.
21. Raju I, Kannan K, Abraham EC. 2013. FoxO3a Serves as a Biomarker of Oxidative Stress in Human Lens Epithelial Cells under Conditions of Hyperglycemia. PLoS One 8: e67126. DOI: 10.1371/journal.pone.0067126.
22. Rankouhi TR, Sanderson JT, van Holsteijn I, van Leeuwen C, Vethaak AD, van den Berg M. 2004. Effects of natural and synthetic estrogens and various environmental contaminants on vitellogenesis in fish primary hepatocytes: comparison of bream (Abramis brama) and carp (Cyprinus carpio). Toxicol. Sci. 81: 90-102. DOI: 10.1093/toxsci/kfh176.
23. Riedel C, Levy O, Carrasco N. 2001. Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. J. Biol. Chem. 276: 21458-21463. DOI: 10.1074/jbc.M100561200.
24. Sanchez-Alonso JA, Lopez-Aparicio P, Recio MN, Perez-Albarsanz MA. 2003. Apoptosis-mediated neurotoxic potential of a planar (PCB 77) and a nonplanar (PCB 153) polychlorinated biphenyl congeners in neuronal cell cultures. Toxicol. Lett. 144: 337-349. DOI: 10.1016/S0378-4274(03)00238-8.
25. Schnitzler JG, Celis N, Klaren PH, Blust R, Dirtu AC, Covaci A, Das K. 2011. Thyroid dysfunction in sea bass (Dicentrarchus labrax): underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism. Aquat. Toxicol. 105: 438-447. DOI: 10.1016/j.aquatox.2011.07.019.
26. Tang JM, Li W, Xie YC, Guo HW, Cheng P, Chen HH, Zheng XQ, Jiang L, Cui D, Liu Y, Ding GX, Duan Y. 2013. Morphological and functional deterioration of the rat thyroid following chronic exposure to low-dose PCB118. Exp. Toxicol. Pathol. 65: 989-994. DOI: 10.1016/j.etp.2013.02.001.
27. Tarkowski S. 1996. A WHO perspective. Int. J. Occup. Med. Environ. Health 9: 1-6.
28. Tran H, Brunet A, Griffith EC, Greenberg ME. 2003. The many forks in FOXO's road. Sci. STKE. 172: RE5. DOI: 10.1126/stke.2003.172.re5.
29. Wade MG, Parent S, Finnson KW, Foster W, Younglai E, McMahon A, Cyr DG, Hughes C. 2002. Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol. Sci. 67: 207-218. DOI: 10.1093/toxsci/67.2.207.
30. Williams DW, Williams ED, Wynford-Thomas D. 1988. Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells. Br. J. Cancer 57: 535-539. DOI: 10.1038/bjc.1988.124.
31. Yang JY, Xia W, Hu MC. 2006. Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int. J. Oncol. 29: 643-648. DOI: 10.3892/ijo.29.3.643.
32. Zaballos MA, Garcia B, Santisteban P. 2008. Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells. Mol. Endocrinol. 22: 1183-1199. DOI: 10.1210/me.2007-0093.
33. Zhao G, Wang Z, Zhou H, Zhao Q. 2009. Burdens of PBBs, PBDEs, and PCBs in tissues of the cancer patients in the e-waste disassembly sites in Zhejiang, China. Sci. Total Environ. 407: 4831-4837. DOI: 10.1016/j.scitotenv.2009.05.031.