Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women

Environmental Research

Volumn 138, Issue , 2015, Pages 298-305

  Llop, Sabrina ^a,b   Lopez Espinosa, Maria Jose ^a,b   Murcia, Mario ^a,b   Alvarez Pedrerol, Mar ^b,c,d   Vioque, Jesús ^b,e   Aguinagalde, Xabier ^f   Julvez, Jordi ^b,c,d   Aurrekoetxea, Juan J ^g,h,i   Espada, Mercedes ^j   Santa Marina, Loreto ^b,g,h   Rebagliato, Marisa ^a,b,k   Ballester, Ferran ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^d INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^e MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^f Laboratorio de Salud Pública de Alava   (Spain)

^g Subdireccion de Salud Publica de Guipuzcoa   (Spain)

^h BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

ⁱ UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^j Laboratorio de Salud Pública   (Spain)

^k UNIVERSITAT JAUME I   (Spain)

more..

Author keywords

Endocrine disruption; Iodine supplementation; Mercury; Prenatal exposure; Thyroid

Indexed keywords

IODINE; LIOTHYRONINE; MERCURY; THYROID HORMONE; THYROTROPIN; THYROXINE;

BLOOD; HEALTH RISK; HORMONE; IODINE; MERCURY (ELEMENT); PREGNANCY; REGRESSION ANALYSIS; SYNERGISM; WOMENS HEALTH;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CHILD DEVELOPMENT; COHORT ANALYSIS; DEMOGRAPHY; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS DEVELOPMENT; FREE THYROXINE INDEX; GESTATION PERIOD; HUMAN; MAJOR CLINICAL STUDY; MATERNAL AGE; MINERAL SUPPLEMENTATION; MULTICENTER STUDY; PREGNANT WOMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; THYROID FUNCTION; THYROID HORMONE BLOOD LEVEL; UMBILICAL CORD BLOOD; ABSORPTION; ATOMIC ABSORPTION SPECTROMETRY; BLOOD; CHEMISTRY; DIET SUPPLEMENTATION; DRUG EFFECTS; ENVIRONMENTAL MONITORING; FETUS BLOOD; FLUOROIMMUNOASSAY; PREGNANCY; SPAIN;

SPAIN;

ABSORPTION, PHYSICOCHEMICAL; ADULT; COHORT STUDIES; DIETARY SUPPLEMENTS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; FETAL BLOOD; FLUOROIMMUNOASSAY; HUMANS; IODINE; MERCURY; PREGNANCY; SPAIN; SPECTROPHOTOMETRY, ATOMIC; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 84924121504     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2015.02.026     Document Type: Article

References (48)

1. Abdelouahab N., Mergler D., Takser L., Vanier C., St-Jean M., Baldwin M., Spear P.A., Chan H.M. Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada). Environ Res. 2008, 107:380-392.
2. Andersson M., de B.B., Delange F., Zupan J. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the technical consultation. Public Health Nutr. 2007, 10:1606-1611.
3. Barregard L., Lindstedt G., Schutz A., Sallsten G. Endocrine function in mercury exposed chloralkali workers. Occup. Environ Med 1994, 51:536-540.
4. Becker D.V., Braverman L.E., Delange F., Dunn J.T., Franklyn J.A., Hollowell J.G., Lamm S.H., Mitchell M.L., Pearce E., Robbins J., Rovet J.F. Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid 2006, 16:949-951.
5. Bjerregaard P., Hansen J.C. Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland. Sci. Total Environ. 2000, 245:195-202.
6. Bjornberg K.A., Vahter M., Petersson-Grawe K., Glynn A., Cnattingius S., Darnerud P.O., Atuma S., Aune M., Becker W., Berglund M. Methyl mercury and inorganic mercury in Swedish pregnant women and in cord blood: influence of fish consumption. Environ. Health Perspect. 2003, 111:637-641.
7. Chen A., Kim S.S., Chung E., Dietrich K.N. Thyroid hormones in relation to lead, mercury, and cadmium exposure in the National Health and Nutrition Examination Survey, 2007-2008. Environ. Health Perspect. 2013, 121:181-186.
8. Ellingsen D.G., Efskind J., Haug E., Thomassen Y., Martinsen I., Gaarder P.I. Effects of low mercury vapour exposure on the thyroid function in chloralkali workers. J Appl. Toxicol. 2000, 20:483-489.
9. Glinoer D. The importance of iodine nutrition during pregnancy. Public Health Nutr. 2007, 10:1542-1546.
10. Grandjean P., Weihe P., White R.F., Debes F., Araki S., Yokoyama K., Murata K., Sorensen N., Dahl R., Jorgensen P.J. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol. Teratol. 1997, 19:417-428.
11. Guxens M., Ballester F., Espada M., Fernandez M.F., Grimalt J.O., Ibarluzea J., Olea N., Rebagliato M., Tardon A., Torrent M., Vioque J., Vrijheid M., Sunyer J. Cohort profile: the INMA-INfancia y Medio Ambiente-(Environment and Childhood) Project. Int. J. Epidemiol. 2012, 41:930-940.
12. Haddow J.E., Palomaki G.E., Allan W.C., Williams J.R., Knight G.J., Gagnon J., O'Heir C.E., Mitchell M.L., Hermos R.J., Waisbren S.E., Faix J.D., Klein R.Z. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N. Engl. J. Med. 1999, 341:549-555.
13. Jedrychowski W., Perera F., Jankowski J., Rauh V., Flak E., Caldwell K.L., Jones R.L., Pac A., Lisowska-Miszczyk I. Fish consumption in pregnancy, cord blood mercury level and cognitive and psychomotor development of infants followed over the first three years of life: Krakow epidemiologic study. Environ. Int. 2007, 33:1057-1062.
14. Julvez J., varez-Pedrerol M., Rebagliato M., Murcia M., Forns J., Garcia-Esteban R., Lertxundi N., Espada M., Tardon A., Riano G.I., Sunyer J. Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. Epidemiology 2013, 24:150-157.
15. Kohrle J. Local activation and inactivation of thyroid hormones: the deiodinase family. Mol. Cell Endocrinol. 1999, 151:103-119.
16. Langer P. Persistent organochlorinated pollutants (PCB, DDE, HCB, dioxins, furans) and the thyroid-review 2008. Endocr. Regul. 2008, 42:79-104.
17. Laurberg P., Cerqueira C., Ovesen L., Rasmussen L.B., Perrild H., Andersen S., Pedersen I.B., Carle A. Iodine intake as a determinant of thyroid disorders in populations. Best Pract. Res. Clin. Endocrinol. Metab. 2010, 24:13-27.
18. Lederman S.A., Jones R.L., Caldwell K.L., Rauh V., Sheets S.E., Tang D., Viswanathan S., Becker M., Stein J.L., Wang R.Y., Perera F.P. Relation between cord blood mercury levels and early child development in a World Trade Center cohort. Environ. Health Perspect. 2008, 116:1085-1091.
19. Lee B.E., Hong Y.C., Park H., Ha M., Koo B.S., Chang N., Roh Y.M., Kim B.N., Kim Y.J., Kim B.M., Jo S.J., Ha E.H. Interaction between GSTM1/GSTT1 polymorphism and blood mercury on birth weight. Environ. Health Perspect. 2010, 118:437-442.
20. Li Y., Shan Z., Teng W., Yu X., Li Y., Fan C., Teng X., Guo R., Wang H., Li J., Chen Y., Wang W., Chawinga M., Zhang L., Yang L., Zhao Y., Hua T. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months. Clin. Endocrinol. 2010, 72:825-829.
21. Llop S., Ballester F., Vizcaino E., Murcia M., Lopez-Espinosa M.J., Rebagliato M., Vioque J., Marco A., Grimalt J.O. Concentrations and determinants of organochlorine levels among pregnant women in Eastern Spain. Sci. Total Environ. 2010, 408:5758-5767.
22. Moleti M., Di B.B., Giorgianni G., Mancuso A., De V.A., Alibrandi A., Trimarchi F., Vermiglio F. Maternal thyroid function in different conditions of iodine nutrition in pregnant women exposed to mild-moderate iodine deficiency: an observational study. Clin. Endocrinol. 2011, 74:762-768.
23. Mori K., Yoshida K., Hoshikawa S., Ito S., Yoshida M., Satoh M., Watanabe C. Effects of perinatal exposure to low doses of cadmium or methylmercury on thyroid hormone metabolism in metallothionein-deficient mouse neonates. Toxicology 2006, 228:77-84.
24. Morreale de E.G., Obregon M.J., Escobar del R.F. Role of thyroid hormone during early brain development. Eur. J. Endocrinol. 2004, 151(Suppl. 3):U25-U37.
25. Morrissette J., Takser L., St-Amour G., Smargiassi A., Lafond J., Mergler D. Temporal variation of blood and hair mercury levels in pregnancy in relation to fish consumption history in a population living along the St. Lawrence River. Environ. Res. 2004, 95:363-374.
26. Muckle G., Ayotte P., Dewailly E.E., Jacobson S.W., Jacobson J.L. Prenatal exposure of the northern Quebec Inuit infants to environmental contaminants. Environ. Health Perspect. 2001, 109:1291-1299.
27. Nohr S.B., Laurberg P. Opposite variations in maternal and neonatal thyroid function induced by iodine supplementation during pregnancy. J. Clin. Endocrinol. Metab. 2000, 85:623-627.
28. Orito Y., Oku H., Kubota S., Amino N., Shimogaki K., Hata M., Manki K., Tanaka Y., Sugino S., Ueta M., Kawakita K., Nunotani T., Tatsumi N., Ichihara K., Miyauchi A., Miyake M. Thyroid function in early pregnancy in Japanese healthy women: relation to urinary iodine excretion, emesis, and fetal and child development. J. Clin. Endocrinol. Metab. 2009, 94:1683-1688.
29. Pearce E.N., Braverman L.E. Environmental pollutants and the thyroid. Best Pract. Res. Clin. Endocrinol. Metab. 2009, 23:801-813.
30. Pop V.J., Brouwers E.P., Vader H.L., Vulsma T., van Baar A.L., de Vijlder J.J. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin. Endocrinol. 2003, 59:282-288.
31. Pop V.J., Kuijpens J.L., van Baar A.L., Verkerk G., van Son M.M., de Vijlder J.J., Vulsma T., Wiersinga W.M., Drexhage H.A., Vader H.L. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin. Endocrinol. 1999, 50:149-155.
32. Porterfield S.P., Hendrich C.E. The role of thyroid hormones in prenatal and neonatal neurological development-current perspectives. Endocr. Rev. 1993, 14:94-106.
33. Ramon R., Murcia M., Aguinagalde X., Amurrio A., Llop S., Ibarluzea J., Lertxundi A., varez-Pedrerol M., Casas M., Vioque J., Sunyer J., Tardon A., Martinez-Arguelles B., Ballester F. Prenatal mercury exposure in a multicenter cohort study in Spain. Environ. Int. 2011, 37:597-604.
34. Rebagliato M., Murcia M., Espada M., Alvarez-Pedrerol M., Bolumar F., Vioque J., Basterrechea M., Blarduni E., Ramon R., Guxens M., Foradada C.M., Ballester F., Ibarluzea J., Sunyer J. Iodine intake and maternal thyroid function during pregnancy. Epidemiology 2010, 21:62-69.
35. Rebagliato M., Murcia M., varez-Pedrerol M., Espada M., Fernandez-Somoano A., Lertxundi N., Navarrete-Munoz E.M., Forns J., Aranbarri A., Llop S., Julvez J., Tardon A., Ballester F. Iodine supplementation during pregnancy and infant neuropsychological development: INMA Mother and Child Cohort Study. Am. J. Epidemiol. 2013, 177:944-953.
36. Soldin O.P., O'Mara D.M., Aschner M. Thyroid hormones and methylmercury toxicity. Biol. Trace Elem. Res. 2008, 126:1-12.
37. Steuerwald U., Weihe P., Jorgensen P.J., Bjerve K., Brock J., Heinzow B., Budtz-Jorgensen E., Grandjean P. Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J. Pediatr. 2000, 136:599-605.
38. Takser L., Mergler D., Baldwin M., de G.S., Smargiassi A., Lafond J. Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environ. Health Perspect. 2005, 113:1039-1045.
39. United Nations Environment Programme, 2007. Mercury Programme. Available: (accessed 13.04.13). http://www.chem.unep.ch/mercury/Report/JECFA-PTWI.htm.
40. Ursinyova M., Uhnakova I., Serbin R., Masanova V., Husekova Z., Wsolova L. The relation between human exposure to mercury and thyroid hormone status. Biol. Trace Elem. Res. 2012, 148:281-291.
41. US Environmental Protection Agency, 2007. Mercury. Human Exposure. Available: (accessed 13.04.07). http://www.epa.gov/mercury/exposure.htm.
42. Vahter M., Akesson A., Lind B., Bjors U., Schutz A., Berglund M. Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ. Res. 2000, 84:186-194.
43. Vioque J., Navarrete-Munoz E.M., Gimenez-Monzo D., Garcia-de-la-Hera M., Granado F., Young I.S., Ramon R., Ballester F., Murcia M., Rebagliato M., Iniguez C. Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area. Nutr. J. 2013, 12:26.
44. Willett W.C., Sampson L., Stampfer M.J., Rosner B., Bain C., Witschi J., Hennekens C.H., Speizer F.E. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am. J. Epidemiol. 1985, 122:51-65.
45. Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination. A Guide for Programme Managers 2007, World Health Organization (WHO), International Council for the Control of Iodine Deficiency Disorders, Geneva, Switzerland. 3rd edn.
46. Xu J., Yang X.F., Guo H.L., Hou X.H., Liu L.G., Sun X.F. Selenium supplement alleviated the toxic effects of excessive iodine in mice. Biol. Trace Elem. Res. 2006, 111:229-238.
47. Yang X.F., Hou X.H., Xu J., Guo H.L., Yinq C.J., Chen X.Y., Sun X.F. Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake. Biomed. Environ. Sci. 2006, 19:302-308.
48. Yorita Christensen K.L. Metals in blood and urine, and thyroid function among adults in the United States 2007-2008. Int. J. Hyg. Environ. Health 2013, 216:624-632.