Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: Thyroid autonomy may play a protective role

Endocrine-Related Cancer

Volumn 16, Issue 4, 2009, Pages 1251-1260

  Fiore, E ^a   Rago, T ^a   Provenzale, M A ^a   Scutari, M ^a   Ugolini, C ^a   Basolo, F ^a   Di Coscio, G ^a   Berti, P ^a   Grasso, L ^a   Elisei, R ^a   Pinchera, A ^a   Vitti, P ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

THYROID ANTIBODY; THYROTROPIN;

AGE DISTRIBUTION; ARTICLE; ASPIRATION BIOPSY; ASPIRATION CYTOLOGY; AUTOIMMUNITY; BENIGN TUMOR; CONTROLLED STUDY; FREE THYROXINE INDEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NODULAR GOITER; PAPILLARY CARCINOMA; PREVALENCE; SENSITIVITY AND SPECIFICITY; THYROID CANCER; THYROID FUNCTION TEST; THYROID NODULE; THYROTROPIN BLOOD LEVEL;

AUTOANTIBODIES; BIOPSY, FINE-NEEDLE; CARCINOMA, PAPILLARY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RISK FACTORS; THYROID FUNCTION TESTS; THYROID NEOPLASMS; THYROID NODULE; THYROTROPIN;

EID: 72549095371     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-09-0036     Document Type: Article

References (32)

1. Aghini-Lombardi F, Antonangeli L, Martino E, Vitti P, Maccherini D, Leoli F, Rago T, Grasso L, Valeriano R, Balestrieri A et al. 1999 The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. Journal of Clinical Endocrinology and Metabolism 84 561-566.
2. 4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002). Thyroid 17 1211-1223.
3. Baker JR Jr 1995 The immune response to papillary thyroid cancer. Journal of Clinical Endocrinology and Metabolism 80 3419-3420.
4. Biondi B, Filetti S & Schlumberger M 2005 Thyroid-hormone therapy and thyroid cancer: a reassessment. Nature Clinical Practice. Endocrinology & Metabolism 1 32-40.
5. Boelaert K, Horacek J, Holder RL, Watkinson JC, Sheppard MC & Franklyn JA 2006 Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. Journal of Clinical Endocrinology and Metabolism 91 4295-4301. (Pubitemid 44833401)
6. British Thyroid Association, Royal College of Physicians 2007 Fine-needle aspiration cytology. In Report of the Thyroid Cancer Guidelines Update Group, edn 2, pp 9-10. Ed P Perros. London: Royal College of Physicians.
7. Ciampi R & Nikiforov YE 2007 RET/PTC rearrangements RAF mutations in thyroid tumorigenesis. Endocrinology 148 936-941.
8. Dailey ME, Lindsay S & Skahen R 1955 Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. A.M.A. Archives of Surgery 70 291-297.
9. Davies L & Welch HG 2006 Increasing incidence of thyroid cancer in the United States, 1973-2002. Journal of the American Medical Association 295 2164-2167.
10. Fenzi GF, Ceccarelli C, Macchia E, Monzani F, Bartalena L, Giani C, Ceccarelli P, Lippi F, Baschieri L & Pinchera A 1985 Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area. Clinical Endocrinology 23 115-122. (Pubitemid 15015332)
11. Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Sigurdsson A, Bergthorsson JT, He H, Blondal T, Geller F, Jakobsdottir M et al. 2009 Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Nature Genetics 41 460-464.
12. Haymart MR, Glinberg SL, Liu J, Sippel RS, Jaume JC & Chen H 2008a Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clinical Endocrinology [in press].
13. Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC & Chen H 2008b Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage. Journal of Clinical Endocrinology and Metabolism 93 809-814.
14. Hirabayashi RN & Lindsay S 1965 The relation of thyroid carcinoma and chronic thyroiditis. Surgery, Gynecology and Obstetrics 121 243-252.
15. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA & Braverman LE 2002 Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Endocrinology and Metabolism 87 489-499.
16. Holm LE, Blomgren H & Lowhagen T 1985 Cancer risks in patients with chronic lymphocytic thyroiditis. New England Journal of Medicine 312 601-604. (Pubitemid 15133674)
17. Hundahl SA, Fleming ID, Fremgen AM & Menck HR 1998 A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 (see comments). Cancer 83 2638-2648.
18. Jonklaas J, Nsouli-Maktabi H & Soldin SJ 2008 Endogenous thyrotropin and triiodothyronine concentrations in individuals with thyroid cancer. Thyroid 18 943-952.
19. Mazzaferri EL 1991 Treating differentiated thyroid carcinoma: where do we draw the line? Mayo Clinic Proceedings 66 105-111.
20. Mazzaferri EL 1999 An overview of the management of papillary and follicular thyroid carcinoma. Thyroid 9 421-427. (Pubitemid 29244917)
21. Mazzaferri EL & Jhiang SM 1994 Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. American Journal of Medicine 97 418-428. (Pubitemid 24345593)
22. Mazzaferri EL & Young RL 1981 Papillary thyroid carcinoma: a 10 year follow-up report of the impact of therapy in 576 patients. American Journal of Medicine 70 511-518.
23. Ngan ES, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY et al. 2009 A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma. Journal of the National Cancer Institute 101 162-175.
24. Nikiforova MN & Nikiforov YE 2008 Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis. Expert Review of Molecular Diagnostics 8 83-95.
25. Okayasu I, Fujiwara M, Hara Y, Tanaka Y & Rose NR 1995 Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer 76 2312-2318.
26. Polyzos SA, Kappaita M, Efstathiadou Z, Poulakos P, Slavakis A, Sofianou D, Flaris N, Leontsini M, Kourtis A & Avramidis A 2008 Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules. Journal of Cancer Research and Clinical Oncology 134 953-960.
27. Sipos JA & Mazzaferri EL 2008 The therapeutic management of differentiated thyroid cancer. Expert Opinion on Pharmacotherapy 9 2627-2637.
28. Sobin L 2002 UICC TNM Classification of Malignant Tumours. New York: Wiley Liss.
29. Surks MI & Hollowell JG 2007 Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 92 4575-4582.
30. The Papanicolaou Society of Cytopathology Task Force on Standards of Practice 1996 Guidelines of the Papanicolaou Society of Cytopathology for the examination of fine-needle aspiration specimens from thyroid nodules. Diagnostic Cytopathology 15 84-89. (Pubitemid 26230085)
31. Vitti P, Mariotti S, Marcocci C, Chiovato L, Giachetti M, Fenzi G & Pinchera A 1990 Thyroid autoimmunity and thyroid autonomy. Acta Medica Austriaca 17 90-92.
32. Walker RP & Paloyan E 1990 The relationship between Hashimoto's thyroiditis, thyroid neoplasia, and primary hyperparathyroidism. Otolaryngologic Clinics of North America 23 291-302. (Pubitemid 20139194)