Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface

American Journal of Obstetrics and Gynecology

Volumn 213, Issue 6, 2015, Pages 846.e1-846.e19

  Furcron, Amy Eunice ^a,b   Romero, Roberto ^a,c   Plazyo, Olesya ^a   Unkel, Ronald ^a   Xu, Yi ^a   Hassan, Sonia S ^a,b   Chaemsaithong, Piya ^a,b   Mahajan, Arushi ^b   Gomez Lopez, Nardhy ^a,b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

decidua; endotoxin; interleukin 1 ; macrophages; matrix metalloproteinase 9; myometrium; neutrophils; preterm birth; preterm labor; regulatory T cells

Indexed keywords

ENDOTOXIN; ESTRADIOL; GAMMA INTERFERON; GELATINASE B; HYDROXYPROGESTERONE CAPROATE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; POLYCARBOPHIL; PROGESTERONE; PROTEIN; PROTEIN ARG1; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 17-ALPHA-HYDROXY-PROGESTERONE CAPROATE; ANTIINFLAMMATORY AGENT; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; PROGESTERONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DECIDUA; DELIVERY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETOPLACENTAL UNIT; FETUS; FLOW CYTOMETRY; IMMUNOPHENOTYPING; INNATE IMMUNITY; LEUKOCYTE; MACROPHAGE; MALE; MONITORING; MONOCYTE; MOUSE; MYOMETRIUM; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; POLARIZATION; PREMATURE LABOR; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; ANIMAL; C57BL MOUSE; CYTOLOGY; ESCHERICHIA COLI; INTRAVAGINAL DRUG ADMINISTRATION; METABOLISM; PREGNANCY; PREMATURE BIRTH; UTERINE CERVIX;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CERVIX UTERI; DECIDUA; ENDOTOXINS; ESCHERICHIA COLI; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HYDROXYPROGESTERONES; INTERFERON-GAMMA; INTERLEUKIN-1BETA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MICE, INBRED C57BL; MONOCYTES; MYOMETRIUM; NEUTROPHILS; PREGNANCY; PREMATURE BIRTH; PROGESTERONE; PROGESTERONE CONGENERS;

EID: 84955465112     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2015.08.010     Document Type: Article

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