Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins

American Journal of Obstetrics and Gynecology

Volumn 197, Issue 6, 2007, Pages 599.e1-599.e7

  Attardi, Barbara J ^a,c   Zeleznik, Anthony ^b,c   Simhan, Hyagriv ^b,c   Chiao, Jye Ping ^b,c   Mattison, Donald R ^c   Caritis, Steve N ^b,c  

^a BIOQUAL INC   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

17 alpha hydroxyprogesterone caproate; glucocorticoid receptors; preterm birth; progesterone receptors; transactivation

Indexed keywords

17ALPHA ACETOXY 11BETA (4 DIMETHYLAMINOPHENYL) 19 NORPREGNA 4,9 DIENE 3,20 DIONE; 17ALPHA ACETOXY 11BETA (4 DIMETHYLAMINOPHENYL) 21 METHOXY 19 NORPREGNA 4,9 DIENE 3,20 DIONE; ALKALINE PHOSPHATASE; GESTAGEN; GLUCOCORTICOID RECEPTOR; HYDROXYPROGESTERONE; HYDROXYPROGESTERONE ACETATE; HYDROXYPROGESTERONE CAPROATE; MIFEPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CANCER CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSOL; GENE EXPRESSION REGULATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; RECEPTOR AFFINITY; THYMUS; TRANSACTIVATION; UTERUS;

EID: 36448934175     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2007.05.024     Document Type: Article

References (36)

1. Meis P., Klebanoff M., Thom E., et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesteron caproate. N Engl J Med 348 (2003) 2379-2385
2. Keirse M. Progesterone administration in pregnancy may prevent preterm delivery. BJOG 97 (1990) 149-154
3. Csapo A. The "see-saw" theory of parturition: the fetus and birth. Ciba Found Dymp 47 (1977) 159-210
4. Liggins G.C., Fairclough R.J., Grieves S.A., Forster C.S., and Knox B.S. Parturition in the sheep. Ciba Found Symp 47 (1977) 5-30
5. Liggins G.C., Fairclough R.J., Grieves S.A., Kendall J.Z., and Knox B.S. The mechanism of initiation of parturition in the ewe. Recent Prog Horm Res 29 (1973) 111-159
6. Challis J.R., and Manning F.A. Control of parturition in subhuman primates. Semin Perinatal 2 (1978) 247-260
7. MacDonald P.C., Porter J.C., Schwartz B.E., and Johnston J.M. Initiation of parturition in the human female. Semin Perinatal 2 (1978) 273-286
8. Challis J., Matthews S., Gibb W., and Lye S. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 200 (2000) 514-550
9. In: Adashi E.Y., Rock A., and Rosenwakr Z. (Eds). Reproductive endocrinology, surgery and technology (1996), Lippincott-Raven Publishers, Philadelphia 458
10. Junkmann K. Estrogens with prolonged action. Exp Pathol Pharmakol 220 (1953) 358-364
11. Kessler W., and Borman A. Some biological activities of certain progestogens. Ann NY Acad Sci 220 (1953) 358-364
12. Reifenstein E. Introduction of marked as well as prolonged biologic activity by esterification;17-alpha-hydroxyprogesterone caproate, a unique progestational compound. Fertil Steril 8 (1957) 50-79
13. Karalis K., Goodwin G., and Majzoub J.A. Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med 2 (1996) 556-560
14. Jeschke U., Mylonas T., Richter D.U., et al. Regulation of progesterone production in human term trophoblasts in vitro by CRH, ACTH and cortisol (prednisone). Arch Gynecol Obstet 272 (2005) 7-12
15. Attardi B.J., Burgenson J., Hild S.A., Reel J.R., and Blye R.P. CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914. Mol Cell Endocrinol 188 (2002) 111-123
16. Christensen K., Estes P.A., Onate S.A., et al. Characterization and functional properties of the A and B forms of human progesterone receptors synthesized in a baculovirus system. Mol Endocrinol 5 (1991) 1755-1770
17. Archer T.K., Zaniewski V., Moyer M.L., and Nordeen S.K. The differential capacity of glucocorticoids and progestins to alter chromatin structure and induce gene expression in human breast cancer cells. Mol Endocrinol 8 (1994) 1154-1162
18. Mymryk J.S., Berard D., Hager G.L., and Archer T.K. Mouse mammary tumor virus chromatin in human breast cancer cells is constitutively hypersensitive and exhibits steroid hormone-independent loading of transcription factors in vivo. Mol Cell Biol 15 (1995) 26-34
19. Horwitz K.B. The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells. Endocrinology 116 (1985) 2236-2245
20. Attardi B.J., Burgenson J., Hild S.A., and Reel J.R. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol 88 (2004) 277-288
21. Markiewicz L., and Gurpide E. Estrogenic and progestagenic activities coexisting in steroidal drugs: quantitative evaluation by in vitro bioassays with human cells. J Steroid Biochem 48 (1993) 89-94
22. Leonhardt S.A., Boonyarantanakaornkit V., and Edwards D.P. Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids 68 (2003) 761-770
23. Haluska G., Wells B., Hirst J., Brenner R., Sadowsky R., and Novy M. Progesterone receptor localization and isoforms in myometrium, decidua and fetal membranes from rhesus macaques: evidence of functional progesterone withdrawal at parturition. J Soc Gynecol Invest 9 (2002) 125-136
24. Vegeto E., Shahbaz M.M., Wen D.X., Goldman M.E., O'Malley B.W., and McDonnell D.P. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 7 (1993) 1244-1255
25. Wei L.L., and Miner R. Evidence for the existence of a third progesterone receptor protein in human breast cancer cell line T47D. Cancer Res 54 (1994) 340-343
26. Wei L.L., Hawkins P., Baker C., Norris B., Sheridan P.L., and Quinn P.G. An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity. Mol Endocrinol 10 (1996) 1379-1387
27. Condon J.C., Hardy D.B., Kovaric K., and Mendelson C.R. Upregulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of NF-κB may contribute to the onset of labor through inhibition of PR function. Mol Endocrinol 20 (2006) 764-775
28. Johnson J.W.C., Lee P.A., Zachary A.S., Calhoun S., and Migeon C.J. High-risk prematurity-progestin treatment and steroid studies. Obstet Gynecol 54 (1979) 412-418
29. Hartikainen-Sorri A., Kauppila A., and Tuimala R. Inefficacy of 17α-hydroxyprogesterone caproate in the prevention of prematurity in twin pregnancy. Obstet Gynecol 6 (1980) 692-695
30. Benjamin D., and Jost J.P. Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation. Nucleic Acids Res 29 (2001) 3603-3610
31. Elovitz M.A., and Mrinalini C. The use of progestational agents for preterm birth: lessons from a mouse model. Am J Obstet Gynecol 195 (2006) 1004-1010
32. Kistner R.W., and Baginsky W. Observations on the use of 17-alpha-hydroxy-progesterone caproate on primary metastatic endometrial carcinoma. Surg Forum 12 (1961) 424-426
33. Varga A., and Henrisken E. Clinical and histopathologic evaluation of the effect of 17-alpha-hydroxyprogesterone-17-n-caproate on endometrial carcinoma. Obstet Gynecol 18 (1961) 658-672
34. Petrocelli T., and Lye S.J. Regulation of transcripts encoding the myometrial gap junction protein, connexin-43, by estrogen and progesterone. Endocrinology 133 (1993) 284-290
35. Grazzini E., Guillon G., Mouillac B., and Zingg H. Inhibition of oxytocin receptor function by direct binding of progesterone. Nature 392 (1988) 509-512
36. Sargent I.L., Borzychowski A.M., and Redman C.W. NK cells and human pregnancy-an inflammatory view. Trends Immunol 27 (2006) 399-404