Cervical remodeling/ripening at term and preterm delivery: The same mechanism initiated by different mediators and different effector cells

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Gonzalez, Juan M ^a   Dong, Zhong ^a   Romero, Roberto ^a   Girardi, Guillermina ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; PROGESTERONE; PROGESTERONE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIRTH; CELL INFILTRATION; COLLAGEN DEGRADATION; COLUMNAR EPITHELIUM; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; EFFECTOR CELL; ENZYME RELEASE; ENZYME SYNTHESIS; EPITHELIUM CELL; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MACROPHAGE; MOUSE; NONHUMAN; PREMATURE LABOR; PROGESTERONE BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TERM BIRTH; UTERINE CERVIX RIPENING; ANIMAL; BLOOD; C57BL MOUSE; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; PREGNANCY; UTERINE CERVIX;

MUS;

ANIMALS; CERVIX UTERI; COMPLEMENT ACTIVATION; FEMALE; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; OBSTETRIC LABOR, PREMATURE; PREGNANCY; PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 80355123654     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026877     Document Type: Article

References (29)

1. Iams JD, Berghella V, (2010) Care for women with prior preterm birth. Am J Obstet Gynecol 203: 89-100.
2. Iams JD, Romero R, Culhane JF, Goldenberg RL, (2008) Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. Lancet 371: 164-175.
3. Goldenberg RL, Culhane JF, Iams JD, Romero R, (2008) Epidemiology and causes of preterm birth. Lancet 371: 75-84.
4. Word RA, Li XH, (2007) Cervical function during pregnancy and parturition in Preterm Birth: Mechanisms, mediators, prediction, preventions and interventions. pp. 19-34 Edited by Petraglia F, London, Informa Healthcare.
5. Timmons B, Akins M, Mahendroo M, (2010) Cervical remodeling during pregnancy and parturition. Trends Endocrinol Metab 21: 353-361.
6. Ludmir J, Sehdev HM, (2000) Anatomy and physiology of the uterine cervix. Clin Obstet Gynecol 43: 433-439.
7. Gonzalez JM, Franzke CV, Yang F, Romero R, Girardi G, (2011) Complement activation triggers metalloproteinases release inducing cervical remodelling and preterm birth in mice. Am J Pathol 179: 838-849.
8. Russell WMS, Burch RL, (1959) The principles of humane experimental technique London Methuen & Co. LTD.
9. Tveita AA, Rekvig OP, Zykova SN, (2008) Increased glomerular matrixmetalloproteinase activity in murine lupus nephritis. Kidney Int 74: 1150-1158.
10. Fichorova RN, Rheinwald JG, Anderson DJ, (1997) Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod 57: 847-855.
11. Challis JRG, Matthew SG, Gibb W, Lye SJ, (2001) Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 21: 514-550.
12. Stygar D, Wang H, Vladic YS, Ekman G, Eriksson H, et al. (2002) Increased level of matrix metalloproteinases 2 and 9 in the ripening process of the human cervix. Biol Reprod 67: 889-894.
13. Choi SJ, Jung KL, Oh SY, Kim JH, Roh CR, (2009) Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition. Eur J Obstet Gynecol Reprod Biol 142: 43-47.
14. Lynch AM, Gibbs RS, Murphy JR, Byers T, Neville MC, et al. (2008) Complement activation fragment Bb in early pregnancy and spontaneous preterm birth. Am J Obstet Gynecol 199: 354-358.
15. Elimian A, Figueroa R, Canterino J, Aguero-Rosenfeld UM, Tejani N, (1998) Amniotic fluid complement C3 as a marker of intra-amniotic infection. Obstet Gynecol 92: 72-76.
16. Vaisbuch E, Romero R, Erez O, Mazaki-Tovi S, Kusanovic JP, et al. (2009) Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 22: 905-916.
17. Gonzalez JM, Xu H, Chai J, Ofori E, Elovitz MA, (2009) Preterm and term cervical ripening in CD1 Mice (Mus musculus): similar or divergent molecular mechanisms? Biol Reprod 81: 1226-1232.
18. Holt R, Timmons BC, Akgul Y, Akins ML, Mahendroo M, (2011) The molecular mechanisms of cervical ripening differ between term and preterm birth. Endocrinology 152: 1036-1046.
19. Timmons BC, Mahendroo M, (2006) Timing of neutrophil activation and expression of proinflammatory markers do not support a role for neutrophils in cervical ripening in the mouse. Biol Reprod 74: 236-245.
20. Hassan SS, Romero R, Tarca AL, Nhan-Chang CL, Vaisbuch E, et al. (2009) The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process. J Matern Fetal Neonatal Med 22: 1183-1193.
21. Liggins GC, (1978) Ripening of the cervix. Semin Perinatol 2: 261-271.
22. Kelly RW, (2002) Inflammatory mediators and cervical ripening. J Reprod Immunol 57: 217-224.
23. Malmström E, Sennström M, Holmberg A, Frielingsdorf H, Eklund E, et al. (2007) The importance of fibroblasts in remodeling of the human uterine cervix during pregnancy and parturition. Mol Hum Reprod 3: 333-341.
24. Imada K, Ito A, Sato T, Namiki M, Nagase H, et al. (1997) Hormonal regulation of matrix metalloproteinase 9/gelatinase B gene expression in rabbit uterine cervical fibroblasts. Biol Reprod 56: 575-580.
25. Dubicke A, Akerud, Sennstrom M, Hamad RR, Bystrom B, et al. (2008) Different secretion patterns of matrix metalloproteinases and IL-8 and effect of corticotropin-releasing hormone in preterm and term cervical fibroblasts. Mol Hum Reprod 14: 641-647.
26. Thomson AJ, Telfer JF, Young A, Campbell S, Stewart CJ, et al. (1999) Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Hum Reprod 14: 229-236.
27. Gomez-Lopez N, Guilbert LJ, Olson DM, (2010) Invasion of the leukocytes into the fetal-maternal interface during pregnancy. J Leukoc Biol 88: 625-633.
28. Rodríguez HA, Kass L, Varayoud J, Ramos JG, Ortega HH, Durando M, et al. (2003) Collagen remodelling in the guinea-pig uterine cervix at term is associated with a decrease in progesterone receptor expression. Mol Hum Reprod 9: 807-813.
29. Becher NK, Waldorf A, Hein M, Uldbjerg N, (2009) The cervical mucus plug: structured review of the literature. Acta Obstet Gynecol Scand 88: 502-913.