Matrix metalloproteinases: Effectors of development and normal physiology

Genes and Development

Volumn 14, Issue 17, 2000, Pages 2123-2133

  Vu, Thiennu H ^a   Werb, Zena ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANGIOGENESIS; ANIMAL CELL; BONE DEVELOPMENT; BREAST DEVELOPMENT; CELL MIGRATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; MORPHOGENESIS; MOUSE; NIDATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; WOUND HEALING;

ANIMALS; BONE AND BONES; CELL MOVEMENT; EMBRYO IMPLANTATION; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MAMMARY GLANDS, ANIMAL; MATRIX METALLOPROTEINASES; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; TRANSGENES; WOUND HEALING;

EID: 0033848986     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.815400     Document Type: Review

References (75)

1. Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation
2. Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene
3. The 84-kDa form of human matrix metalloproteinase-9 degrades substance P and gelatin
4. Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos
5. Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones
6. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle
7. Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components
8. Impaired wound contraction in stromelysin-1-deficient mice
9. Stromelysin-1-deficient fibroblasts display impaired contraction in vitro
10. Bone development
11. Induction of matrix metalloproteinase MMP-9 (92-kDa gelatinase) by retinoic acid in human neuroblastoma SKNBE cells: Relevance to neuronal differentiation
12. Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch
13. Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease
14. Degradation of kinins, angiotensins and substance P by polymorphonuclear matrix metalloproteinases MMP 8 and MMP 9
15. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma
16. Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology
17. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development
18. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor
19. Interstitial collagenase is required for angiogenesis in vitro
20. Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures
21. Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: A role for matrix metalloproteinases
22. Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases
23. The role of interstitial collagens in cleft formation of mouse embryonic submandibular gland during initial branching
24. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
25. Collagenolytic activity in amphibian tissues: A tissue culture assay
26. Think globally, act locally: The making of a mouse mammary gland
27. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
28. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
29. Degradation of decorin by matrix metalloproteinases: Identification of the cleavage sites, kinetic analyses and transforming growth factor-betal release
30. Degradation of interleukin 1β by matrix metalloproteinases
31. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation
32. Role of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis
33. The genetic transformation of bone biology
34. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
35. The role of matrix metalloproteinase activity in the maturation of human capillary endothelial cells in vitro
36. Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice
37. Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro
38. Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3)
39. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
40. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells
41. Functional overlap between two classes of matrix-degrading proteases in wound healing
42. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1
43. Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichy-motrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
44. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure
45. TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2
46. Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9
47. Modulation of the biological functions of galectin-3 by matrix metalloproteinases
48. Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes
49. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
50. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
51. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
52. The cleavage of prourokinase type plasminogen activator by stromelysin-1
53. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)
54. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
55. Elevated matrix metalloproteases and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vasularization
56. Insulin-like growth factor binding protein (IGFBP) proteases: Functional regulators of cell growth
57. Molecular genetics of implantation in the mouse
58. Impaired wound healing in mice with a disrupted plasminogen gene
59. The migration of purified osteoclasts through collagen is inhibited by matrix metalloproteinase inhibitors
60. Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: Evidence for a role in mammary tissue remodeling
61. Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro
62. Generation of biologically active IL-1 beta by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1 beta processing
63. Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin
64. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
65. Biology and regulation of the matrix metalloproteinases
66. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression
67. Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation
68. Proteolytic cleavage of urokinase-type plasminogen activator by stromelysin-1 (MMP-3)
69. The role of protein-tyrosine phosphorylation and gelatinase production in the migration and proliferation of smooth muscle cells
70. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
71. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
72. Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development
73. Proteolysis of insulin-like growth factor binding protein-3 in serum from pregnant, non-pregnant and fetal rats by matrix metalloproteinases and serine proteases
74. Defective trophoblast function in mice with a targeted mutation of Ets2
75. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis