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Volumn 13, Issue 1, 2016, Pages 58-69

Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis

Author keywords

Clinical trials; Multiple sclerosis; Primary progressive; Progression; Secondary progressive; Therapeutics

Indexed keywords

AMILORIDE; BIOTIN; CORTICOTROPIN; DOMPERIDONE; EPIGALLOCATECHIN GALLATE; ERYTHROPOIETIN; FLUOXETINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUDILAST; IDEBENONE; IMILECLEUCEL T; LITHIUM; MASITINIB; NATALIZUMAB; OCRELIZUMAB; OXCARBAZEPINE; PEPTIDE VACCINE; PHENYTOIN; RILUZOLE; RITUXIMAB; SIMVASTATIN; SIPONIMOD; THIOCTIC ACID; IMMUNOLOGIC FACTOR;

EID: 84955361508     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-015-0409-z     Document Type: Review
Times cited : (76)

References (146)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • COI: 1:CAS:528:DC%2BD1cXht12gtLvN
    • Compston A, Coles A. Multiple sclerosis. Lancet 2008;372:1502–1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 3
    • 84955361828 scopus 로고    scopus 로고
    • National MS Society. The MS disease modifyinf medicatiobs. Accessed June 7, 2015.
    • National MS Society. The MS disease modifyinf medicatiobs. Available at: http://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Brochure-The-MS-Disease-Modifying-Medications.pdf. Accessed June 7, 2015.
  • 4
    • 84922554905 scopus 로고    scopus 로고
    • Treatment of progressive multiple sclerosis: what works, what does not, and what is needed
    • Feinstein A, Freeman J, Lo AC. Treatment of progressive multiple sclerosis: what works, what does not, and what is needed. Lancet Neurol 2015;14:194–207.
    • (2015) Lancet Neurol , vol.14 , pp. 194-207
    • Feinstein, A.1    Freeman, J.2    Lo, A.C.3
  • 5
    • 84929459738 scopus 로고    scopus 로고
    • Progressive multiple sclerosis
    • COI: 1:CAS:528:DC%2BC2MXns1Ggsbk%3D
    • Ontaneda D, Fox RJ. Progressive multiple sclerosis. Curr Opin Neurol 2015;28:237–243.
    • (2015) Curr Opin Neurol , vol.28 , pp. 237-243
    • Ontaneda, D.1    Fox, R.J.2
  • 6
    • 84908300995 scopus 로고    scopus 로고
    • Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity
    • Browne P, Chandraratna D, Angood C, et al. Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology 2014;83:1022–1024.
    • (2014) Neurology , vol.83 , pp. 1022-1024
    • Browne, P.1    Chandraratna, D.2    Angood, C.3
  • 7
    • 84922565713 scopus 로고    scopus 로고
    • A much-needed focus on progression in multiple sclerosis
    • Thompson AJ. A much-needed focus on progression in multiple sclerosis. Lancet Neurol 2015;14:133–135.
    • (2015) Lancet Neurol , vol.14 , pp. 133-135
    • Thompson, A.J.1
  • 8
    • 84955340669 scopus 로고    scopus 로고
    • International Progressive MS Alliance. Facts and figures. Accessed June 4, 2015.
    • International Progressive MS Alliance. Facts and figures. Available at: http://www.progressivemsalliance.org/progressive-ms/facts-and-figures/. Accessed June 4, 2015.
  • 9
    • 84868023178 scopus 로고    scopus 로고
    • Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS
    • Fox RJ, Thompson A, Baker D, et al. Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS. Mult Scler 2012;18:1534–1540.
    • (2012) Mult Scler , vol.18 , pp. 1534-1540
    • Fox, R.J.1    Thompson, A.2    Baker, D.3
  • 10
    • 84922485376 scopus 로고    scopus 로고
    • Pathological mechanisms in progressive multiple sclerosis
    • COI: 1:CAS:528:DC%2BC2MXovF2ltA%3D%3D
    • Mahad DH, Trapp BD, Lassmann H. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol 2015;14:183–193.
    • (2015) Lancet Neurol , vol.14 , pp. 183-193
    • Mahad, D.H.1    Trapp, B.D.2    Lassmann, H.3
  • 11
    • 84878828439 scopus 로고    scopus 로고
    • Disease-specific molecular events in cortical multiple sclerosis lesions
    • Fischer MT, Wimmer I, Hoftberger R, et al. Disease-specific molecular events in cortical multiple sclerosis lesions. Brain 2013;136:1799–1815.
    • (2013) Brain , vol.136 , pp. 1799-1815
    • Fischer, M.T.1    Wimmer, I.2    Hoftberger, R.3
  • 12
    • 84892914956 scopus 로고    scopus 로고
    • Neurological deficits caused by tissue hypoxia in neuroinflammatory disease
    • COI: 1:CAS:528:DC%2BC2cXht1ehsbc%3D
    • Davies AL, Desai RA, Bloomfield PS, et al. Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Ann Neurol 2013;74:815–825.
    • (2013) Ann Neurol , vol.74 , pp. 815-825
    • Davies, A.L.1    Desai, R.A.2    Bloomfield, P.S.3
  • 14
    • 70449418132 scopus 로고    scopus 로고
    • Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial
    • COI: 1:CAS:528:DC%2BD1MXhsVehtr3N
    • Hawker K, O'Connor P, Freedman MS, et al. Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol 2009;66:460–471.
    • (2009) Ann Neurol , vol.66 , pp. 460-471
    • Hawker, K.1    O'Connor, P.2    Freedman, M.S.3
  • 15
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R, Howell O, Vora A, et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007;130:1089–1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3
  • 16
    • 84867707040 scopus 로고    scopus 로고
    • Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis
    • Choi SR, Howell OW, Carassiti D, et al. Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis. Brain 2012;135:2925–2937.
    • (2012) Brain , vol.135 , pp. 2925-2937
    • Choi, S.R.1    Howell, O.W.2    Carassiti, D.3
  • 17
    • 79954611536 scopus 로고    scopus 로고
    • Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS
    • COI: 1:CAS:528:DC%2BC3MXkt1Kmsbo%3D
    • Kowarik MC, Pellkofer HL, Cepok S, et al. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. Neurology 2011;76:1214–1221.
    • (2011) Neurology , vol.76 , pp. 1214-1221
    • Kowarik, M.C.1    Pellkofer, H.L.2    Cepok, S.3
  • 18
    • 84922522615 scopus 로고    scopus 로고
    • Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives
    • Ontaneda D, Fox RJ, Chataway J. Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives. Lancet Neurol 2015;14:208–223.
    • (2015) Lancet Neurol , vol.14 , pp. 208-223
    • Ontaneda, D.1    Fox, R.J.2    Chataway, J.3
  • 19
    • 84890027447 scopus 로고    scopus 로고
    • Challenges in multiple sclerosis; how to define occurence of progression
    • Brinar VV, Barun B. Challenges in multiple sclerosis; how to define occurence of progression. Clin Neurol Neurosurg 2013;115(Suppl. 1):S30-S34.
    • (2013) Clin Neurol Neurosurg , vol.115 , pp. S30-S34
    • Brinar, V.V.1    Barun, B.2
  • 20
    • 84905819646 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: the 2013 revisions
    • Lublin FD, Reingold SC, Cohen JA, et al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology 2014;83:278–286.
    • (2014) Neurology , vol.83 , pp. 278-286
    • Lublin, F.D.1    Reingold, S.C.2    Cohen, J.A.3
  • 21
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: an overview
    • Lassmann H, Bruck W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathol 2007;17:210–218.
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.F.3
  • 22
    • 82255160649 scopus 로고    scopus 로고
    • Age and disability accumulation in multiple sclerosis
    • COI: 1:STN:280:DC%2BC3Mfmtlalug%3D%3D
    • Scalfari A, Neuhaus A, Daumer M, Ebers GC, Muraro PA. Age and disability accumulation in multiple sclerosis. Neurology 2011;77:1246–1252.
    • (2011) Neurology , vol.77 , pp. 1246-1252
    • Scalfari, A.1    Neuhaus, A.2    Daumer, M.3    Ebers, G.C.4    Muraro, P.A.5
  • 23
    • 33244466021 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis: a unifying concept
    • Confavreux C, Vukusic S. Natural history of multiple sclerosis: a unifying concept. Brain 2006;129:606–616.
    • (2006) Brain , vol.129 , pp. 606-616
    • Confavreux, C.1    Vukusic, S.2
  • 24
    • 84925936255 scopus 로고    scopus 로고
    • Relapses and disability accumulation in progressive multiple sclerosis
    • Paz Soldan MM, Novotna M, Abou Zeid N, et al. Relapses and disability accumulation in progressive multiple sclerosis. Neurology 2015;84:81–88.
    • (2015) Neurology , vol.84 , pp. 81-88
    • Paz Soldan, M.M.1    Novotna, M.2    Abou Zeid, N.3
  • 25
    • 84958106126 scopus 로고    scopus 로고
    • Primary progressive MS evolving from radiologically isolated syndrome, Ann Neurol
    • Kantarci OH, Lebrun C, Siva A, et al. Primary progressive MS evolving from radiologically isolated syndrome. Ann Neurol 2015. doi:10.1002/ana.24564.
    • (2015) et al
    • Kantarci, O.H.1    Lebrun, C.2    Siva, A.3
  • 26
    • 84893483687 scopus 로고    scopus 로고
    • Immunosuppressive treatments in multiple sclerosis
    • Okuda DT. Immunosuppressive treatments in multiple sclerosis. Handb Clin Neurol 2014;122:503–511.
    • (2014) Handb Clin Neurol , vol.122 , pp. 503-511
    • Okuda, D.T.1
  • 27
    • 68949125991 scopus 로고
    • Double-masked trial of azathioprine in multiple sclerosis. British and Dutch Multiple Sclerosis Azathioprine Trial Group
    • Anon. Double-masked trial of azathioprine in multiple sclerosis. British and Dutch Multiple Sclerosis Azathioprine Trial Group. Lancet 1988;2:179–183.
    • (1988) Lancet , vol.2 , pp. 179-183
    • Anon1
  • 28
    • 0025345601 scopus 로고
    • Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. The Multiple Sclerosis Study Group
    • Anon. Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. The Multiple Sclerosis Study Group. Ann Neurol 1990;27:591–605.
    • (1990) Ann Neurol , vol.27 , pp. 591-605
    • Anon1
  • 29
    • 0025967752 scopus 로고
    • The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. The Canadian Cooperative Multiple Sclerosis Study Group
    • Anon. The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. The Canadian Cooperative Multiple Sclerosis Study Group. Lancet 1991;337:441–446.
    • (1991) Lancet , vol.337 , pp. 441-446
    • Anon1
  • 30
    • 4644250609 scopus 로고    scopus 로고
    • Intravenous immunoglobulin in secondary progressive multiple sclerosis: randomised placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD2cXnvVOiu7g%3D
    • Hommes OR, Sorensen PS, Fazekas F, et al. Intravenous immunoglobulin in secondary progressive multiple sclerosis: randomised placebo-controlled trial. Lancet 2004;364:1149–1156.
    • (2004) Lancet , vol.364 , pp. 1149-1156
    • Hommes, O.R.1    Sorensen, P.S.2    Fazekas, F.3
  • 31
    • 39549098027 scopus 로고    scopus 로고
    • Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre study
    • COI: 1:CAS:528:DC%2BD1cXmtV2rtbk%3D
    • Pohlau D, Przuntek H, Sailer M, et al. Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre study. Mult Scler 2007;13:1107–1117.
    • (2007) Mult Scler , vol.13 , pp. 1107-1117
    • Pohlau, D.1    Przuntek, H.2    Sailer, M.3
  • 32
    • 0031744008 scopus 로고    scopus 로고
    • The Mayo Clinic–Canadian Cooperative trial of sulfasalazine in active multiple sclerosis
    • COI: 1:CAS:528:DyaK1cXns1emtL0%3D
    • Noseworthy JH, O'Brien P, Erickson BJ, et al. The Mayo Clinic–Canadian Cooperative trial of sulfasalazine in active multiple sclerosis. Neurology 1998;51:1342–1352.
    • (1998) Neurology , vol.51 , pp. 1342-1352
    • Noseworthy, J.H.1    O'Brien, P.2    Erickson, B.J.3
  • 33
    • 1942421718 scopus 로고    scopus 로고
    • Multicentre, randomised, double blind, placebo controlled, phase III study of weekly, low dose, subcutaneous interferon beta-1a in secondary progressive multiple sclerosis
    • COI: 1:STN:280:DC%2BD2c3ivVGlsg%3D%3D
    • Andersen O, Elovaara I, Farkkila M, et al. Multicentre, randomised, double blind, placebo controlled, phase III study of weekly, low dose, subcutaneous interferon beta-1a in secondary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2004;75:706–710.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 706-710
    • Andersen, O.1    Elovaara, I.2    Farkkila, M.3
  • 34
    • 8844222623 scopus 로고    scopus 로고
    • North American Study Group on Interferon beta-1b in Secondary Progressive MS. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study
    • Panitch H, Miller A, Paty D, Weinshenker B, North American Study Group on Interferon beta-1b in Secondary Progressive MS. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 2004;63:1788–1795.
    • (2004) Neurology , vol.63 , pp. 1788-1795
    • Panitch, H.1    Miller, A.2    Paty, D.3    Weinshenker, B.4
  • 35
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. European Study Group on interferon beta-1b in secondary progressive MS
    • Anon. Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. European Study Group on interferon beta-1b in secondary progressive MS. Lancet 1998;352:1491–1497.
    • (1998) Lancet , vol.352 , pp. 1491-1497
    • Anon1
  • 36
    • 33846833929 scopus 로고    scopus 로고
    • Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD2sXitlyjt78%3D
    • Wolinsky JS, Narayana PA, O'Connor P, et al. Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann Neurol 2007;61:14–24.
    • (2007) Ann Neurol , vol.61 , pp. 14-24
    • Wolinsky, J.S.1    Narayana, P.A.2    O'Connor, P.3
  • 37
    • 0034624942 scopus 로고    scopus 로고
    • Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators
    • COI: 1:CAS:528:DC%2BD3cXktVCnurk%3D
    • Noseworthy JH, Wolinsky JS, Lublin FD, et al. Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators. Neurology 2000;54:1726–1733.
    • (2000) Neurology , vol.54 , pp. 1726-1733
    • Noseworthy, J.H.1    Wolinsky, J.S.2    Lublin, F.D.3
  • 38
    • 0034646216 scopus 로고    scopus 로고
    • Cladribine and progressive MS: clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group
    • COI: 1:CAS:528:DC%2BD3cXitFalu7Y%3D
    • Rice GP, Filippi M, Comi G. Cladribine and progressive MS: clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group. Neurology 2000;54:1145–1155.
    • (2000) Neurology , vol.54 , pp. 1145-1155
    • Rice, G.P.1    Filippi, M.2    Comi, G.3
  • 39
    • 82955198543 scopus 로고    scopus 로고
    • A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS
    • COI: 1:CAS:528:DC%2BC3MXhtlahs7nM
    • Freedman MS, Bar-Or A, Oger J, et al. A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS. Neurology 2011;77:1551–1560.
    • (2011) Neurology , vol.77 , pp. 1551-1560
    • Freedman, M.S.1    Bar-Or, A.2    Oger, J.3
  • 40
    • 84881556664 scopus 로고    scopus 로고
    • Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC3sXhtFSmurjE
    • Zajicek J, Ball S, Wright D, et al. Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial. Lancet Neurol 2013;12:857–865.
    • (2013) Lancet Neurol , vol.12 , pp. 857-865
    • Zajicek, J.1    Ball, S.2    Wright, D.3
  • 41
    • 0035451681 scopus 로고    scopus 로고
    • Plasmid vaccination with insulin b chain prevents autoimmune diabetes in nonobese diabetic mice
    • COI: 1:CAS:528:DC%2BD3MXmtlSju78%3D
    • Bot A, Smith D, Bot S, et al. Plasmid vaccination with insulin b chain prevents autoimmune diabetes in nonobese diabetic mice. J Immunol 2001;167:2950–2955.
    • (2001) J Immunol , vol.167 , pp. 2950-2955
    • Bot, A.1    Smith, D.2    Bot, S.3
  • 42
    • 31544467633 scopus 로고    scopus 로고
    • The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy
    • Coles AJ, Cox A, Le Page E, et al. The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol 2006;253:98–108.
    • (2006) J Neurol , vol.253 , pp. 98-108
    • Coles, A.J.1    Cox, A.2    Le Page, E.3
  • 43
    • 84940614089 scopus 로고    scopus 로고
    • Oral fingolimod versus placebo in patients with primary progressive multiple sclerosis (PPMS): results of the INFORMS phase III trial. The 67th Annual Meeting of the American Academy of Neurology, Washington, DC
    • Lublin FD, Miller D, Freedman M, et al. Oral fingolimod versus placebo in patients with primary progressive multiple sclerosis (PPMS): results of the INFORMS phase III trial. The 67th Annual Meeting of the American Academy of Neurology, Washington, DC, April 18–25, 2015.
    • (2015) April , pp. 18-25
    • Lublin, F.D.1    Miller, D.2    Freedman, M.3
  • 44
    • 0036022681 scopus 로고    scopus 로고
    • Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials
    • COI: 1:CAS:528:DC%2BD38Xms1Sju7s%3D
    • Wiendl H, Hohlfeld R. Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials. BioDrugs 2002;16:183–200.
    • (2002) BioDrugs , vol.16 , pp. 183-200
    • Wiendl, H.1    Hohlfeld, R.2
  • 45
    • 84873627152 scopus 로고    scopus 로고
    • Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis
    • Arnason BG, Berkovich R, Catania A, Lisak RP, Zaidi M. Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis. Mult Scler 2013;19:130–136.
    • (2013) Mult Scler , vol.19 , pp. 130-136
    • Arnason, B.G.1    Berkovich, R.2    Catania, A.3    Lisak, R.P.4    Zaidi, M.5
  • 46
    • 80054820904 scopus 로고    scopus 로고
    • Treatment of infantile spasms: emerging insights from clinical and basic science perspectives
    • Stafstrom CE, Arnason BG, Baram TZ, et al. Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. J Child Neurol 2011;26:1411–1421.
    • (2011) J Child Neurol , vol.26 , pp. 1411-1421
    • Stafstrom, C.E.1    Arnason, B.G.2    Baram, T.Z.3
  • 47
    • 45849102029 scopus 로고    scopus 로고
    • Neuroprotective actions of melanocortins: a therapeutic opportunity
    • COI: 1:CAS:528:DC%2BD1cXnvVGlsLw%3D
    • Catania A. Neuroprotective actions of melanocortins: a therapeutic opportunity. Trends Neurosci 2008;31:353–360.
    • (2008) Trends Neurosci , vol.31 , pp. 353-360
    • Catania, A.1
  • 48
    • 0036152061 scopus 로고    scopus 로고
    • Biotin: the forgotten vitamin
    • COI: 1:CAS:528:DC%2BD38XovVCktw%3D%3D
    • Said HM. Biotin: the forgotten vitamin. Am J Clin Nutr 2002;75:179–180.
    • (2002) Am J Clin Nutr , vol.75 , pp. 179-180
    • Said, H.M.1
  • 49
    • 0031817568 scopus 로고    scopus 로고
    • Biotin-responsive basal ganglia disease: a novel entity
    • Ozand PT, Gascon GG, Al Essa M, et al. Biotin-responsive basal ganglia disease: a novel entity. Brain 1998;121:1267–1279.
    • (1998) Brain , vol.121 , pp. 1267-1279
    • Ozand, P.T.1    Gascon, G.G.2    Al Essa, M.3
  • 50
    • 84873679672 scopus 로고    scopus 로고
    • Biotin-responsive basal ganglia disease revisited: clinical, radiologic, and genetic findings
    • Tabarki B, Al-Shafi S, Al-Shahwan S, et al. Biotin-responsive basal ganglia disease revisited: clinical, radiologic, and genetic findings. Neurology 2013;80:261–267.
    • (2013) Neurology , vol.80 , pp. 261-267
    • Tabarki, B.1    Al-Shafi, S.2    Al-Shahwan, S.3
  • 52
    • 84925057313 scopus 로고    scopus 로고
    • High doses of biotin in chronic progressive multiple sclerosis: a pilot study
    • Sedel F, Papeix C, Bellanger A, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Mult Scler Relat Disord 2015;4:159–169.
    • (2015) Mult Scler Relat Disord , vol.4 , pp. 159-169
    • Sedel, F.1    Papeix, C.2    Bellanger, A.3
  • 53
    • 84955403437 scopus 로고    scopus 로고
    • Effect of MD1003 (high doses of biotin) in progressive multiple sclerosis: results of a pivotal phase III randomized double blind placebo controlled study. The 67th Annual Meeting of the American Academy of Neurology, Wasgington, DC
    • Tourbah A, Frenay CL, Edan G, et al. Effect of MD1003 (high doses of biotin) in progressive multiple sclerosis: results of a pivotal phase III randomized double blind placebo controlled study. The 67th Annual Meeting of the American Academy of Neurology, Wasgington, DC, April 18–25, 2015.
    • (2015) April , pp. 18-25
    • Tourbah, A.1    Frenay, C.L.2    Edan, G.3
  • 54
    • 79551700814 scopus 로고    scopus 로고
    • Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model
    • Vergo S, Craner MJ, Etzensperger R, et al. Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model. Brain 2011;134:571–584.
    • (2011) Brain , vol.134 , pp. 571-584
    • Vergo, S.1    Craner, M.J.2    Etzensperger, R.3
  • 55
    • 36849009834 scopus 로고    scopus 로고
    • Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
    • COI: 1:CAS:528:DC%2BD2sXhtl2gs7fP
    • Friese MA, Craner MJ, Etzensperger R, et al. Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med 2007;13:1483–1489.
    • (2007) Nat Med , vol.13 , pp. 1483-1489
    • Friese, M.A.1    Craner, M.J.2    Etzensperger, R.3
  • 56
    • 77953503937 scopus 로고    scopus 로고
    • Riluzole, neuroprotection and amyotrophic lateral sclerosis
    • COI: 1:CAS:528:DC%2BC3cXmvFCnu7c%3D
    • Cheah BC, Vucic S, Krishnan AV, Kiernan MC. Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr Med Chem 2010;17:1942–1199.
    • (2010) Curr Med Chem , vol.17 , pp. 1199-1942
    • Cheah, B.C.1    Vucic, S.2    Krishnan, A.V.3    Kiernan, M.C.4
  • 58
    • 63849303038 scopus 로고    scopus 로고
    • Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect
    • COI: 1:CAS:528:DC%2BD1MXivVamur4%3D
    • Lim CM, Kim SW, Park JY, Kim C, Yoon SH, Lee JK. Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect. J Neurosci Res 2009;87:1037–1045.
    • (2009) J Neurosci Res , vol.87 , pp. 1037-1045
    • Lim, C.M.1    Kim, S.W.2    Park, J.Y.3    Kim, C.4    Yoon, S.H.5    Lee, J.K.6
  • 59
    • 36849007594 scopus 로고    scopus 로고
    • Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation
    • Alme MN, Wibrand K, Dagestad G, Bramham CR. Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast 2007;2007:26496.
    • (2007) Neural Plast , vol.2007 , pp. 26496
    • Alme, M.N.1    Wibrand, K.2    Dagestad, G.3    Bramham, C.R.4
  • 60
    • 54349085579 scopus 로고    scopus 로고
    • LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence
    • COI: 1:CAS:528:DC%2BD1cXhtVOrtL%2FM
    • Rudick RA, Mi S, Sandrock AW, Jr. LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence. Expert Opin Biol Ther 2008;8:1561–1570.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 1561-1570
    • Rudick, R.A.1    Mi, S.2    Sandrock, A.W.3
  • 61
    • 22844453047 scopus 로고    scopus 로고
    • LINGO-1 negatively regulates myelination by oligodendrocytes
    • COI: 1:CAS:528:DC%2BD2MXksVeitrg%3D
    • Mi S, Miller RH, Lee X, et al. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 2005;8:745–751.
    • (2005) Nat Neurosci , vol.8 , pp. 745-751
    • Mi, S.1    Miller, R.H.2    Lee, X.3
  • 62
    • 59249084979 scopus 로고    scopus 로고
    • Prospects of repair in multiple sclerosis
    • COI: 1:CAS:528:DC%2BD1MXhsFKmsbk%3D
    • Yong VW. Prospects of repair in multiple sclerosis. J Neurol Sci 2009;277(Suppl. 1):S16-S18.
    • (2009) J Neurol Sci , vol.277 , pp. S16-S18
    • Yong, V.W.1
  • 63
    • 84955414898 scopus 로고    scopus 로고
    • Evidence of remyelination with the anti-LINGO-1 monoclonal antibody BIIB033 after acute optic neuritis. The 67th Annual Meeting of the American Academy of Neurology, Wasgington, DC
    • Cadavid D, Balcer L, Galetta S, et al. Evidence of remyelination with the anti-LINGO-1 monoclonal antibody BIIB033 after acute optic neuritis. The 67th Annual Meeting of the American Academy of Neurology, Wasgington, DC, April 18–25, 2015.
    • (2015) April , pp. 18-25
    • Cadavid, D.1    Balcer, L.2    Galetta, S.3
  • 64
    • 51149108773 scopus 로고    scopus 로고
    • Prolactin and dopamine: what is the connection? A review article
    • Fitzgerald P, Dinan TG. Prolactin and dopamine: what is the connection? A review article. J Psychopharmacol 2008;22:12–19.
    • (2008) J Psychopharmacol , vol.22 , pp. 12-19
    • Fitzgerald, P.1    Dinan, T.G.2
  • 65
    • 84908028349 scopus 로고    scopus 로고
    • The dual role of domperidone in gastroparesis and lactation
    • COI: 1:CAS:528:DC%2BC2cXhtVOjtLnL
    • Phan H, DeReese A, Day AJ, Carvalho M. The dual role of domperidone in gastroparesis and lactation. Int J Pharm Compd 2014;18:203–207.
    • (2014) Int J Pharm Compd , vol.18 , pp. 203-207
    • Phan, H.1    DeReese, A.2    Day, A.J.3    Carvalho, M.4
  • 66
  • 67
    • 84925280673 scopus 로고    scopus 로고
    • Prolactin in combination with interferon-beta reduces disease severity in an animal model of multiple sclerosis
    • Zhornitsky S, Johnson TA, Metz LM, Weiss S, Yong VW. Prolactin in combination with interferon-beta reduces disease severity in an animal model of multiple sclerosis. J Neuroinflamm 2015;12:55.
    • (2015) J Neuroinflamm , vol.12 , pp. 55
    • Zhornitsky, S.1    Johnson, T.A.2    Metz, L.M.3    Weiss, S.4    Yong, V.W.5
  • 68
    • 84894212725 scopus 로고    scopus 로고
    • Multiple sclerosis in pregnancy
    • Coyle PK. Multiple sclerosis in pregnancy. Continuum (Minneap Minn) 2014;20:42–59.
    • (2014) Continuum (Minneap Minn) , vol.20 , pp. 42-59
    • Coyle, P.K.1
  • 69
    • 20044373442 scopus 로고    scopus 로고
    • Emerging biological roles for erythropoietin in the nervous system
    • COI: 1:CAS:528:DC%2BD2MXks1Oitb8%3D
    • Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 2005;6:484–494.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 484-494
    • Brines, M.1    Cerami, A.2
  • 70
    • 84993790552 scopus 로고    scopus 로고
    • Recombinant human erythropoietin: novel strategies for neuroprotective/neuro-regenerative treatment of multiple sclerosis
    • Bartels C, Spate K, Krampe H, Ehrenreich H. Recombinant human erythropoietin: novel strategies for neuroprotective/neuro-regenerative treatment of multiple sclerosis. Ther Adv Neurol Disord 2008;1:193–206.
    • (2008) Ther Adv Neurol Disord , vol.1 , pp. 193-206
    • Bartels, C.1    Spate, K.2    Krampe, H.3    Ehrenreich, H.4
  • 71
    • 9644278256 scopus 로고    scopus 로고
    • Beneficial effect of erythropoietin on experimental allergic encephalomyelitis
    • COI: 1:CAS:528:DC%2BD2MXit1ChtA%3D%3D
    • Li W, Maeda Y, Yuan RR, Elkabes S, Cook S, Dowling P. Beneficial effect of erythropoietin on experimental allergic encephalomyelitis. Ann Neurol 2004;56:767–777.
    • (2004) Ann Neurol , vol.56 , pp. 767-777
    • Li, W.1    Maeda, Y.2    Yuan, R.R.3    Elkabes, S.4    Cook, S.5    Dowling, P.6
  • 72
    • 34848841517 scopus 로고    scopus 로고
    • Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis
    • Ehrenreich H, Fischer B, Norra C, et al. Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis. Brain 2007;130:2577–2588.
    • (2007) Brain , vol.130 , pp. 2577-2588
    • Ehrenreich, H.1    Fischer, B.2    Norra, C.3
  • 73
    • 84904271569 scopus 로고    scopus 로고
    • Autologous bone marrow transplantation for the treatment of multiple sclerosis
    • Radaelli M, Merlini A, Greco R, et al. Autologous bone marrow transplantation for the treatment of multiple sclerosis. Curr Neurol Neurosci Rep 2014;14:478.
    • (2014) Curr Neurol Neurosci Rep , vol.14 , pp. 478
    • Radaelli, M.1    Merlini, A.2    Greco, R.3
  • 74
    • 85050579080 scopus 로고    scopus 로고
    • Stem cell therapy in multiple sclerosis: a future perspective
    • Harris VK, Sadiq SA. Stem cell therapy in multiple sclerosis: a future perspective. Neurodegener Dis Manag 2015;5:167–170.
    • (2015) Neurodegener Dis Manag , vol.5 , pp. 167-170
    • Harris, V.K.1    Sadiq, S.A.2
  • 75
    • 0030714110 scopus 로고    scopus 로고
    • Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study
    • COI: 1:STN:280:DyaK1c%2FktlGksQ%3D%3D
    • Fassas A, Anagnostopoulos A, Kazis A, et al. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study. Bone Marrow Transplant 1997;20:631–638.
    • (1997) Bone Marrow Transplant , vol.20 , pp. 631-638
    • Fassas, A.1    Anagnostopoulos, A.2    Kazis, A.3
  • 76
    • 0141816715 scopus 로고    scopus 로고
    • High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis
    • COI: 1:CAS:528:DC%2BD3sXnslykt7g%3D
    • Nash RA, Bowen JD, McSweeney PA, et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Blood 2003;102:2364–2372.
    • (2003) Blood , vol.102 , pp. 2364-2372
    • Nash, R.A.1    Bowen, J.D.2    McSweeney, P.A.3
  • 77
    • 79953208669 scopus 로고    scopus 로고
    • Long-term results of stem cell transplantation for MS: a single-center experience
    • COI: 1:STN:280:DC%2BC3M3osFKiuw%3D%3D
    • Fassas A, Kimiskidis VK, Sakellari I, et al. Long-term results of stem cell transplantation for MS: a single-center experience. Neurology 2011;76:1066–1070.
    • (2011) Neurology , vol.76 , pp. 1066-1070
    • Fassas, A.1    Kimiskidis, V.K.2    Sakellari, I.3
  • 78
    • 84923015120 scopus 로고    scopus 로고
    • High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim report
    • Nash RA, Hutton GJ, Racke MK, et al. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim report. JAMA Neurol 2015;72:159–169.
    • (2015) JAMA Neurol , vol.72 , pp. 159-169
    • Nash, R.A.1    Hutton, G.J.2    Racke, M.K.3
  • 79
    • 84856023693 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
    • Connick P, Kolappan M, Crawley C, et al. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012;11:150–156.
    • (2012) Lancet Neurol , vol.11 , pp. 150-156
    • Connick, P.1    Kolappan, M.2    Crawley, C.3
  • 80
    • 33747093820 scopus 로고    scopus 로고
    • The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family
    • COI: 1:CAS:528:DC%2BD28XkvVynsr8%3D
    • Gibson LC, Hastings SF, McPhee I, et al. The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family. Eur J Pharmacol 2006;538:39–42.
    • (2006) Eur J Pharmacol , vol.538 , pp. 39-42
    • Gibson, L.C.1    Hastings, S.F.2    McPhee, I.3
  • 81
    • 4444245524 scopus 로고    scopus 로고
    • Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis
    • COI: 1:CAS:528:DC%2BD2cXosF2rtrg%3D
    • Feng J, Misu T, Fujihara K, et al. Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis. Mult Scler 2004;10:494–498.
    • (2004) Mult Scler , vol.10 , pp. 494-498
    • Feng, J.1    Misu, T.2    Fujihara, K.3
  • 82
    • 1242284201 scopus 로고    scopus 로고
    • Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
    • COI: 1:CAS:528:DC%2BD2cXht1Kjtbc%3D
    • Mizuno T, Kurotani T, Komatsu Y, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology 2004;46:404–411.
    • (2004) Neuropharmacology , vol.46 , pp. 404-411
    • Mizuno, T.1    Kurotani, T.2    Komatsu, Y.3
  • 83
    • 77950258250 scopus 로고    scopus 로고
    • Ibudilast in relapsing-remitting multiple sclerosis: a neuroprotectant?
    • COI: 1:STN:280:DC%2BC3c3is1Crsw%3D%3D
    • Barkhof F, Hulst HE, Drulovic J, et al. Ibudilast in relapsing-remitting multiple sclerosis: a neuroprotectant? Neurology 2010;74:1033–1040.
    • (2010) Neurology , vol.74 , pp. 1033-1040
    • Barkhof, F.1    Hulst, H.E.2    Drulovic, J.3
  • 84
    • 84925491335 scopus 로고    scopus 로고
    • Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?
    • COI: 1:CAS:528:DC%2BC2cXhs1GmsbrN
    • Jaber S, Polster BM. Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier? J Bioenerg Biomembr 2015;47:111–118.
    • (2015) J Bioenerg Biomembr , vol.47 , pp. 111-118
    • Jaber, S.1    Polster, B.M.2
  • 85
    • 0033007106 scopus 로고    scopus 로고
    • Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes
    • COI: 1:CAS:528:DyaK1MXis1akuro%3D
    • Civenni G, Bezzi P, Trotti D, Volterra A, Racagni G. Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur J Pharmacol 1999;370:161–167.
    • (1999) Eur J Pharmacol , vol.370 , pp. 161-167
    • Civenni, G.1    Bezzi, P.2    Trotti, D.3    Volterra, A.4    Racagni, G.5
  • 86
    • 84884132096 scopus 로고    scopus 로고
    • The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse
    • COI: 1:CAS:528:DC%2BC3sXhtFCht7vM
    • Fiebiger SM, Bros H, Grobosch T, et al. The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse. J Neuroimmunol 2013;262:66–71.
    • (2013) J Neuroimmunol , vol.262 , pp. 66-71
    • Fiebiger, S.M.1    Bros, H.2    Grobosch, T.3
  • 87
    • 47249106357 scopus 로고    scopus 로고
    • Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS
    • COI: 1:CAS:528:DC%2BD1cXht1SnsLzP
    • Salinthone S, Yadav V, Bourdette DN, Carr DW. Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS. Endocr Metab Immune Disord Drug Targets 2008;8:132–142.
    • (2008) Endocr Metab Immune Disord Drug Targets , vol.8 , pp. 132-142
    • Salinthone, S.1    Yadav, V.2    Bourdette, D.N.3    Carr, D.W.4
  • 88
    • 0036790853 scopus 로고    scopus 로고
    • Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD38Xns1ajtLc%3D
    • Marracci GH, Jones RE, McKeon GP, Bourdette DN. Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis. J Neuroimmunol 2002;131:104–114.
    • (2002) J Neuroimmunol , vol.131 , pp. 104-114
    • Marracci, G.H.1    Jones, R.E.2    McKeon, G.P.3    Bourdette, D.N.4
  • 89
    • 15544390831 scopus 로고    scopus 로고
    • Lipoic acid in multiple sclerosis: a pilot study
    • COI: 1:CAS:528:DC%2BD2MXjtVymt7g%3D
    • Yadav V, Marracci G, Lovera J, et al. Lipoic acid in multiple sclerosis: a pilot study. Mult Scler 2005;11:159–165.
    • (2005) Mult Scler , vol.11 , pp. 159-165
    • Yadav, V.1    Marracci, G.2    Lovera, J.3
  • 90
    • 33947597084 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
    • COI: 1:CAS:528:DC%2BD2sXjtlynu7w%3D
    • Jope RS, Yuskaitis CJ, Beurel E. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 2007;32:577–595.
    • (2007) Neurochem Res , vol.32 , pp. 577-595
    • Jope, R.S.1    Yuskaitis, C.J.2    Beurel, E.3
  • 92
    • 70349658639 scopus 로고    scopus 로고
    • Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
    • Dubreuil P, Letard S, Ciufolini M, et al. Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS One 2009;4:e7258.
    • (2009) PLoS One , vol.4
    • Dubreuil, P.1    Letard, S.2    Ciufolini, M.3
  • 93
    • 56649100738 scopus 로고    scopus 로고
    • Human mast cells stimulate activated T cells: implications for multiple sclerosis
    • COI: 1:CAS:528:DC%2BD1MXhtVajtr0%3D
    • Theoharides TC, Kempuraj D, Kourelis T, Manola A. Human mast cells stimulate activated T cells: implications for multiple sclerosis. Ann N Y Acad Sci 2008;1144:74–82.
    • (2008) Ann N Y Acad Sci , vol.1144 , pp. 74-82
    • Theoharides, T.C.1    Kempuraj, D.2    Kourelis, T.3    Manola, A.4
  • 94
    • 84942198757 scopus 로고    scopus 로고
    • The crucial role of mast cells in blood–brain barrier alterations
    • COI: 1:CAS:528:DC%2BC2MXptFOhtr0%3D
    • Ribatti D. The crucial role of mast cells in blood–brain barrier alterations. Exp Cell Res 2015;338:119–125.
    • (2015) Exp Cell Res , vol.338 , pp. 119-125
    • Ribatti, D.1
  • 95
    • 84861980282 scopus 로고    scopus 로고
    • Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study
    • COI: 1:CAS:528:DC%2BC38XhslCisLzL
    • Vermersch P, Benrabah R, Schmidt N, et al. Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study. BMC Neurol 2012;12:36.
    • (2012) BMC Neurol , vol.12 , pp. 36
    • Vermersch, P.1    Benrabah, R.2    Schmidt, N.3
  • 96
    • 78650520026 scopus 로고    scopus 로고
    • MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity
    • COI: 1:CAS:528:DC%2BC3cXhs1WgtLnK
    • Girvan RC, Knight DA, O'Loughlin CJ, Hayman CM, Hermans IF, Webster GA. MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity. Vaccine 2011;29:545–557.
    • (2011) Vaccine , vol.29 , pp. 545-557
    • Girvan, R.C.1    Knight, D.A.2    O'Loughlin, C.J.3    Hayman, C.M.4    Hermans, I.F.5    Webster, G.A.6
  • 97
    • 84900309635 scopus 로고    scopus 로고
    • Targeting innate receptors with MIS416 reshapes Th responses and suppresses CNS disease in a mouse model of multiple sclerosis
    • White M, Webster G, O'Sullivan D, Stone S, La Flamme AC. Targeting innate receptors with MIS416 reshapes Th responses and suppresses CNS disease in a mouse model of multiple sclerosis. PLoS One 2014;9:e87712.
    • (2014) PLoS One , vol.9
    • White, M.1    Webster, G.2    O'Sullivan, D.3    Stone, S.4    La Flamme, A.C.5
  • 98
    • 84955347158 scopus 로고    scopus 로고
    • Innate Immunotherapeutics. MIS416. Accessed June 14, 2015.
    • Innate Immunotherapeutics. MIS416. Available at: http://www.innateimmunotherapeutics.com/irm/content/clinical-trials.aspx?RID=307. Accessed June 14, 2015.
  • 99
    • 43249103954 scopus 로고    scopus 로고
    • Getting specific: monoclonal antibodies in multiple sclerosis
    • COI: 1:CAS:528:DC%2BD1cXntlSjtLg%3D
    • Lutterotti A, Martin R. Getting specific: monoclonal antibodies in multiple sclerosis. Lancet Neurol 2008;7:538–547.
    • (2008) Lancet Neurol , vol.7 , pp. 538-547
    • Lutterotti, A.1    Martin, R.2
  • 100
    • 84893352807 scopus 로고    scopus 로고
    • Monoclonal antibodies in treatment of multiple sclerosis
    • COI: 1:CAS:528:DC%2BC2cXitFWktrc%3D
    • Rommer PS, Dudesek A, Stuve O, Zettl UK. Monoclonal antibodies in treatment of multiple sclerosis. Clin Exp Immunol 2014;175:373–384.
    • (2014) Clin Exp Immunol , vol.175 , pp. 373-384
    • Rommer, P.S.1    Dudesek, A.2    Stuve, O.3    Zettl, U.K.4
  • 101
    • 84902186393 scopus 로고    scopus 로고
    • Natalizumab in progressive MS: results of an open-label, phase 2A, proof-of-concept trial
    • COI: 1:CAS:528:DC%2BC2cXntlGiu70%3D
    • Romme Christensen J, Ratzer R, Bornsen L, et al. Natalizumab in progressive MS: results of an open-label, phase 2A, proof-of-concept trial. Neurology 2014;82:1499–1507.
    • (2014) Neurology , vol.82 , pp. 1499-1507
    • Romme Christensen, J.1    Ratzer, R.2    Bornsen, L.3
  • 102
    • 84955398276 scopus 로고    scopus 로고
    • Biogen reports top-line results from phase 3 study evaluating natalizumab in secondary progressive MS. Accessed 13 Dec 2015.
    • Biogen reports top-line results from phase 3 study evaluating natalizumab in secondary progressive MS. Available at: http://media.biogen.com. Accessed 13 Dec 2015.
  • 103
    • 41649088476 scopus 로고    scopus 로고
    • DNA-based vaccines: the future of multiple sclerosis therapy?
    • Stuve O, Cravens PD, Eagar TN. DNA-based vaccines: the future of multiple sclerosis therapy? Expert Rev Neurother 2008;8:351–360.
    • (2008) Expert Rev Neurother , vol.8 , pp. 351-360
    • Stuve, O.1    Cravens, P.D.2    Eagar, T.N.3
  • 104
    • 21044452341 scopus 로고    scopus 로고
    • TCR peptide vaccination in multiple sclerosis: boosting a deficient natural regulatory network that may involve TCR-specific CD4 + CD25+ Treg cells
    • COI: 1:CAS:528:DC%2BD2MXlsFelsbs%3D
    • Vandenbark AA. TCR peptide vaccination in multiple sclerosis: boosting a deficient natural regulatory network that may involve TCR-specific CD4 + CD25+ Treg cells. Curr Drug Targets Inflamm Allergy 2005;4:217–229.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 217-229
    • Vandenbark, A.A.1
  • 105
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • COI: 1:CAS:528:DC%2BD28Xot1OntLs%3D
    • Wu Y, Borde M, Heissmeyer V, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006;126:375–387.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3
  • 106
    • 37149039794 scopus 로고    scopus 로고
    • Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis
    • COI: 1:CAS:528:DC%2BD1cXnsFWjsw%3D%3D
    • Vandenbark AA, Culbertson NE, Bartholomew RM, et al. Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis. Immunology 2008;123:66–78.
    • (2008) Immunology , vol.123 , pp. 66-78
    • Vandenbark, A.A.1    Culbertson, N.E.2    Bartholomew, R.M.3
  • 107
    • 84880133254 scopus 로고    scopus 로고
    • Neuroprotection for acute optic neuritis – can it work?
    • COI: 1:STN:280:DC%2BC2MjkvFyitQ%3D%3D
    • Raftopoulos RE, Kapoor R. Neuroprotection for acute optic neuritis – can it work? Mult Scler Relat Disord 2013;2:307–311.
    • (2013) Mult Scler Relat Disord , vol.2 , pp. 307-311
    • Raftopoulos, R.E.1    Kapoor, R.2
  • 108
    • 34547773583 scopus 로고    scopus 로고
    • Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine
    • COI: 1:CAS:528:DC%2BD2sXhtVajsr3E
    • Black JA, Liu S, Carrithers M, Carrithers LM, Waxman SG. Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine. Ann Neurol 2007;62:21–33.
    • (2007) Ann Neurol , vol.62 , pp. 21-33
    • Black, J.A.1    Liu, S.2    Carrithers, M.3    Carrithers, L.M.4    Waxman, S.G.5
  • 109
    • 84876035929 scopus 로고    scopus 로고
    • Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis
    • Morsali D, Bechtold D, Lee W, et al. Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis. Brain 2013;136:1067–1082.
    • (2013) Brain , vol.136 , pp. 1067-1082
    • Morsali, D.1    Bechtold, D.2    Lee, W.3
  • 110
    • 77953476309 scopus 로고    scopus 로고
    • Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial
    • COI: 1:CAS:528:DC%2BC3cXpsFajur4%3D
    • Kapoor R, Furby J, Hayton T, et al. Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial. Lancet Neurol 2010;9:681–688.
    • (2010) Lancet Neurol , vol.9 , pp. 681-688
    • Kapoor, R.1    Furby, J.2    Hayton, T.3
  • 111
    • 0026586019 scopus 로고
    • A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group
    • COI: 1:STN:280:DyaK387jtFSktg%3D%3D
    • Beck RW, Cleary PA, Anderson MM, Jr., et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. N Engl J Med 1992;326:581–588.
    • (1992) N Engl J Med , vol.326 , pp. 581-588
    • Beck, R.W.1    Cleary, P.A.2    Anderson, M.M.3
  • 112
    • 67349237447 scopus 로고    scopus 로고
    • Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis
    • Kolappan M, Henderson AP, Jenkins TM, et al. Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis. J Neurol 2009;256:305–319.
    • (2009) J Neurol , vol.256 , pp. 305-319
    • Kolappan, M.1    Henderson, A.P.2    Jenkins, T.M.3
  • 113
    • 84955346729 scopus 로고    scopus 로고
    • Phenytoin is neuroprotective in acute optic neuritis: results of a phase 2 randomized controlled trial. The 67th Annual Meeting of the American Academy of Neurology, Wasgington, DC
    • Kapoor R, Raftopoulos R, Hickman S, et al. Phenytoin is neuroprotective in acute optic neuritis: results of a phase 2 randomized controlled trial. The 67th Annual Meeting of the American Academy of Neurology, Wasgington, DC, April 18–25, 2015.
    • (2015) April , pp. 18-25
    • Kapoor, R.1    Raftopoulos, R.2    Hickman, S.3
  • 114
    • 84922252365 scopus 로고    scopus 로고
    • Intrathecal rituximab therapy in multiple sclerosis: review of evidence supporting the need for future trials
    • COI: 1:CAS:528:DC%2BC2MXit1ehtQ%3D%3D
    • Bonnan M, Ferrari S, Bertandeau E, et al. Intrathecal rituximab therapy in multiple sclerosis: review of evidence supporting the need for future trials. Curr Drug Targets 2014;15:1205–1214.
    • (2014) Curr Drug Targets , vol.15 , pp. 1205-1214
    • Bonnan, M.1    Ferrari, S.2    Bertandeau, E.3
  • 115
    • 84955372766 scopus 로고    scopus 로고
    • Montalban X, Hemmer B, Rammohan K, et al. Efficacy and safety of ocrelizumab in primary progressive multiple sclerosis - results of the placebo-controlled, double-blind, Phase III ORATORIO study. Mult Scler 2015 Supplement, p780-808. 29p.
    • Montalban X, Hemmer B, Rammohan K, et al. Efficacy and safety of ocrelizumab in primary progressive multiple sclerosis - results of the placebo-controlled, double-blind, Phase III ORATORIO study. Mult Scler 2015 Supplement, p780-808. 29p.
  • 117
    • 33748175510 scopus 로고    scopus 로고
    • Statins in the treatment of central nervous system autoimmune disease
    • COI: 1:CAS:528:DC%2BD28XptFCitbw%3D
    • Weber MS, Youssef S, Dunn SE, et al. Statins in the treatment of central nervous system autoimmune disease. J Neuroimmunol 2006;178:140–148.
    • (2006) J Neuroimmunol , vol.178 , pp. 140-148
    • Weber, M.S.1    Youssef, S.2    Dunn, S.E.3
  • 118
    • 2442589337 scopus 로고    scopus 로고
    • Are statins a treatment option for multiple sclerosis?
    • COI: 1:CAS:528:DC%2BD2cXltlCqt7s%3D
    • Neuhaus O, Stuve O, Zamvil SS, Hartung HP. Are statins a treatment option for multiple sclerosis? Lancet Neurol 2004;3:369–371.
    • (2004) Lancet Neurol , vol.3 , pp. 369-371
    • Neuhaus, O.1    Stuve, O.2    Zamvil, S.S.3    Hartung, H.P.4
  • 119
    • 84939933682 scopus 로고    scopus 로고
    • Statin treatment in multiple sclerosis: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC2MXlsV2itro%3D
    • Pihl-Jensen G, Tsakiri A, Frederiksen JL. Statin treatment in multiple sclerosis: a systematic review and meta-analysis. CNS Drugs 2015;29:277–291.
    • (2015) CNS Drugs , vol.29 , pp. 277-291
    • Pihl-Jensen, G.1    Tsakiri, A.2    Frederiksen, J.L.3
  • 120
    • 0038458980 scopus 로고    scopus 로고
    • Statins as potential therapeutic agents in neuroinflammatory disorders
    • Stuve O, Youssef S, Steinman L, Zamvil SS. Statins as potential therapeutic agents in neuroinflammatory disorders. Curr Opin Neurol 2003;16:393–401.
    • (2003) Curr Opin Neurol , vol.16 , pp. 393-401
    • Stuve, O.1    Youssef, S.2    Steinman, L.3    Zamvil, S.S.4
  • 121
    • 84903318797 scopus 로고    scopus 로고
    • Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial
    • COI: 1:CAS:528:DC%2BC2cXksF2ntb4%3D
    • Chataway J, Schuerer N, Alsanousi A, et al. Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Lancet 2014;383:2213–2221.
    • (2014) Lancet , vol.383 , pp. 2213-2221
    • Chataway, J.1    Schuerer, N.2    Alsanousi, A.3
  • 123
    • 34247554847 scopus 로고    scopus 로고
    • Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
    • COI: 1:CAS:528:DC%2BD2sXltlamt7g%3D
    • Novgorodov AS, El-Alwani M, Bielawski J, Obeid LM, Gudz TI. Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. FASEB J 2007;21:1503–1514.
    • (2007) FASEB J , vol.21 , pp. 1503-1514
    • Novgorodov, A.S.1    El-Alwani, M.2    Bielawski, J.3    Obeid, L.M.4    Gudz, T.I.5
  • 124
    • 84897954386 scopus 로고    scopus 로고
    • Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions
    • COI: 1:CAS:528:DC%2BC2cXhtFSmsLbL
    • Brana C, Frossard MJ, Pescini Gobert R, Martinier N, Boschert U, Seabrook TJ. Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions. Neuropathol Appl Neurobiol 2014;40:564–578.
    • (2014) Neuropathol Appl Neurobiol , vol.40 , pp. 564-578
    • Brana, C.1    Frossard, M.J.2    Pescini Gobert, R.3    Martinier, N.4    Boschert, U.5    Seabrook, T.J.6
  • 125
    • 79952012176 scopus 로고    scopus 로고
    • The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators
    • COI: 1:CAS:528:DC%2BC3MXit1artbw%3D
    • Soliven B, Miron V, Chun J. The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. Neurology 2011;76:S9-S14.
    • (2011) Neurology , vol.76 , pp. S9-S14
    • Soliven, B.1    Miron, V.2    Chun, J.3
  • 126
    • 84880327078 scopus 로고    scopus 로고
    • Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study
    • COI: 1:CAS:528:DC%2BC3sXpt12huro%3D
    • Selmaj K, Li DK, Hartung HP, et al. Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study. Lancet Neurol 2013;12:756–767.
    • (2013) Lancet Neurol , vol.12 , pp. 756-767
    • Selmaj, K.1    Li, D.K.2    Hartung, H.P.3
  • 127
    • 84955349966 scopus 로고    scopus 로고
    • Siponimod (BAF312) for the Treatment of Secondary Progressive Multiple Sclerosis: Design of the Phase 3 EXPAND Trial. The 65th Annual Meeting of the American Academy of Neurology, San Diego, CA
    • Kappos L, Bar-Or A, Cree B, et al. Siponimod (BAF312) for the Treatment of Secondary Progressive Multiple Sclerosis: Design of the Phase 3 EXPAND Trial. The 65th Annual Meeting of the American Academy of Neurology, San Diego, CA, March 16–23, 2013.
    • (2013) March , pp. 16-23
    • Kappos, L.1    Bar-Or, A.2    Cree, B.3
  • 129
    • 84934944644 scopus 로고    scopus 로고
    • Tea polyphenols in Parkinson's disease
    • Caruana M, Vassallo N. Tea polyphenols in Parkinson's disease. Adv Exp Med Biol 2015;863:117–137.
    • (2015) Adv Exp Med Biol , vol.863 , pp. 117-137
    • Caruana, M.1    Vassallo, N.2
  • 130
    • 6344274849 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD2cXos1GhsLc%3D
    • Aktas O, Prozorovski T, Smorodchenko A, et al. Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol 2004;173:5794–5800.
    • (2004) J Immunol , vol.173 , pp. 5794-5800
    • Aktas, O.1    Prozorovski, T.2    Smorodchenko, A.3
  • 131
    • 84878797867 scopus 로고    scopus 로고
    • Novel immunoregulatory properties of EGCG on reducing inflammation in EAE
    • COI: 1:CAS:528:DC%2BC3sXhtVyqsrbO
    • Sun Q, Zheng Y, Zhang X, et al. Novel immunoregulatory properties of EGCG on reducing inflammation in EAE. Front Biosci 2013;18:332–342.
    • (2013) Front Biosci , vol.18 , pp. 332-342
    • Sun, Q.1    Zheng, Y.2    Zhang, X.3
  • 132
    • 47049091644 scopus 로고    scopus 로고
    • T-cell-based immunotherapy in multiple sclerosis: induction of regulatory immune networks by T-cell vaccination
    • COI: 1:CAS:528:DC%2BD28XhtFKit7rO
    • Hellings N, Raus J, Stinissen P. T-cell-based immunotherapy in multiple sclerosis: induction of regulatory immune networks by T-cell vaccination. Expert Rev Clin Immunol 2006;2:705–716.
    • (2006) Expert Rev Clin Immunol , vol.2 , pp. 705-716
    • Hellings, N.1    Raus, J.2    Stinissen, P.3
  • 133
    • 47049096574 scopus 로고    scopus 로고
    • Autologous T-cell vaccination for multiple sclerosis: a perspective on progress
    • Vandenbark AA, Abulafia-Lapid R. Autologous T-cell vaccination for multiple sclerosis: a perspective on progress. BioDrugs 2008;22:265–273.
    • (2008) BioDrugs , vol.22 , pp. 265-273
    • Vandenbark, A.A.1    Abulafia-Lapid, R.2
  • 134
    • 84861808820 scopus 로고    scopus 로고
    • A randomized clinical trial of autologous T-cell therapy in multiple sclerosis: subset analysis and implications for trial design
    • COI: 1:CAS:528:DC%2BC38XhtFWhu77O
    • Fox E, Wynn D, Cohan S, Rill D, McGuire D, Markowitz C. A randomized clinical trial of autologous T-cell therapy in multiple sclerosis: subset analysis and implications for trial design. Mult Scler 2012;18:843–852.
    • (2012) Mult Scler , vol.18 , pp. 843-852
    • Fox, E.1    Wynn, D.2    Cohan, S.3    Rill, D.4    McGuire, D.5    Markowitz, C.6
  • 135
    • 84893454390 scopus 로고    scopus 로고
    • The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment
    • Robinson AP, Harp CT, Noronha A, Miller SD. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handb Clin Neurol 2014;122:173–189.
    • (2014) Handb Clin Neurol , vol.122 , pp. 173-189
    • Robinson, A.P.1    Harp, C.T.2    Noronha, A.3    Miller, S.D.4
  • 136
    • 77957759539 scopus 로고    scopus 로고
    • Characterization of brain lesions in a mouse model of progressive multiple sclerosis
    • COI: 1:STN:280:DC%2BC3cfpsVGqsQ%3D%3D
    • Levy H, Assaf Y, Frenkel D. Characterization of brain lesions in a mouse model of progressive multiple sclerosis. Exp Neurol 2010;226:148–158.
    • (2010) Exp Neurol , vol.226 , pp. 148-158
    • Levy, H.1    Assaf, Y.2    Frenkel, D.3
  • 137
    • 78650993786 scopus 로고    scopus 로고
    • A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
    • Chataway J, Nicholas R, Todd S, et al. A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Mult Scler 2011;17:81–88.
    • (2011) Mult Scler , vol.17 , pp. 81-88
    • Chataway, J.1    Nicholas, R.2    Todd, S.3
  • 138
    • 84865271518 scopus 로고    scopus 로고
    • Adaptive trial designs: a review of barriers and opportunities
    • Kairalla JA, Coffey CS, Thomann MA, Muller KE. Adaptive trial designs: a review of barriers and opportunities. Trials 2012;13:145.
    • (2012) Trials , vol.13 , pp. 145
    • Kairalla, J.A.1    Coffey, C.S.2    Thomann, M.A.3    Muller, K.E.4
  • 139
    • 51649086407 scopus 로고    scopus 로고
    • Multi-arm clinical trials of new agents: some design considerations
    • COI: 1:CAS:528:DC%2BD1cXosFGitrk%3D
    • Freidlin B, Korn EL, Gray R, Martin A. Multi-arm clinical trials of new agents: some design considerations. Clin Cancer Res 2008;14:4368–4371.
    • (2008) Clin Cancer Res , vol.14 , pp. 4368-4371
    • Freidlin, B.1    Korn, E.L.2    Gray, R.3    Martin, A.4
  • 140
    • 84928812195 scopus 로고    scopus 로고
    • Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis
    • Vesterinen HM, Connick P, Irvine CM, et al. Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis. PLoS One 2015;10:e0117705.
    • (2015) PLoS One , vol.10
    • Vesterinen, H.M.1    Connick, P.2    Irvine, C.M.3
  • 141
    • 6944249912 scopus 로고    scopus 로고
    • Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosis
    • Miller DH. Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosis. NeuroRx 2004;1:284–294.
    • (2004) NeuroRx , vol.1 , pp. 284-294
    • Miller, D.H.1
  • 142
    • 0346103689 scopus 로고    scopus 로고
    • Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS
    • COI: 1:STN:280:DC%2BD3snhtV2ktQ%3D%3D
    • Malmestrom C, Haghighi S, Rosengren L, Andersen O, Lycke J. Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS. Neurology 2003;61:1720–1725.
    • (2003) Neurology , vol.61 , pp. 1720-1725
    • Malmestrom, C.1    Haghighi, S.2    Rosengren, L.3    Andersen, O.4    Lycke, J.5
  • 143
    • 84884471946 scopus 로고    scopus 로고
    • A comparative study of CSF neurofilament light and heavy chain protein in MS
    • Kuhle J, Plattner K, Bestwick JP, et al. A comparative study of CSF neurofilament light and heavy chain protein in MS. Mult Scler 2013;19:1597–1603.
    • (2013) Mult Scler , vol.19 , pp. 1597-1603
    • Kuhle, J.1    Plattner, K.2    Bestwick, J.P.3
  • 144
    • 0036314155 scopus 로고    scopus 로고
    • Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations
    • COI: 1:STN:280:DC%2BD38zjtlKktg%3D%3D
    • Petzold A, Eikelenboom MJ, Gveric D, et al. Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. Brain 2002;125:1462–1473.
    • (2002) Brain , vol.125 , pp. 1462-1473
    • Petzold, A.1    Eikelenboom, M.J.2    Gveric, D.3
  • 146
    • 78650334788 scopus 로고    scopus 로고
    • Biomarker-adaptive clinical trial designs
    • Freidlin B, Korn EL. Biomarker-adaptive clinical trial designs. Pharmacogenomics 2010;11:1679–1682.
    • (2010) Pharmacogenomics , vol.11 , pp. 1679-1682
    • Freidlin, B.1    Korn, E.L.2


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