-
1
-
-
13844271705
-
Edg8/S1P5: An oligodendroglial receptor with dual function on process retraction and cell survival
-
DOI 10.1523/JNEUROSCI.4645-04.2005
-
Jaillard C, Harrison S, Stankoff B, et al. Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci 2005;25:1459-1469. (Pubitemid 40250722)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.6
, pp. 1459-1469
-
-
Jaillard, C.1
Harrison, S.2
Stankoff, B.3
Aigrot, M.S.4
Calver, A.R.5
Duddy, G.6
Walsh, F.S.7
Pangalos, M.N.8
Arimura, N.9
Kaibuchi, K.10
Zalc, B.11
Lubetzki, C.12
-
2
-
-
35348940243
-
Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells
-
DOI 10.1002/glia.20576
-
Jung CG, Kim HJ, Miron VE, et al. Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia 2007;55:1656-1667. (Pubitemid 47612852)
-
(2007)
GLIA
, vol.55
, Issue.16
, pp. 1656-1667
-
-
Jung, C.G.1
Kim, H.J.2
Miron, V.E.3
Cook, S.4
Kennedy, T.E.5
Foster, C.A.6
Antel, J.P.7
Soliven, B.8
-
3
-
-
0345376673
-
Microglial activation state and lysophospholipid acid receptor expression
-
DOI 10.1016/j.ijdevneu.2003.09.003
-
Tham CS, Lin FF, Rao TS, Yu N, Webb M. Microglial activation state and lysophospholipid acid receptor expression. Int J Dev Neurosci 2003;21:431-443. (Pubitemid 37491477)
-
(2003)
International Journal of Developmental Neuroscience
, vol.21
, Issue.8
, pp. 431-443
-
-
Tham, C.-S.1
Lin, F.-F.2
Rao, T.S.3
Yu, N.4
Webb, M.5
-
4
-
-
39049125218
-
FTY720 modulates human oligodendrocyte progenitor process extension and survival
-
DOI 10.1002/ana.21227
-
Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann Neurol 2008;63:61-71. (Pubitemid 351240552)
-
(2008)
Annals of Neurology
, vol.63
, Issue.1
, pp. 61-71
-
-
Miron, V.E.1
Jung, C.G.2
Kim, H.J.3
Kennedy, T.E.4
Soliven, B.5
Antel, J.P.6
-
5
-
-
35548984947
-
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors
-
DOI 10.1124/jpet.107.123927
-
Coelho RP, Payne SG, Bittman R, Spiegel S, Sato-Bigbee C. The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J Pharmacol Exp Ther 2007;323:626-635. (Pubitemid 350005137)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.323
, Issue.2
, pp. 626-635
-
-
Coelho, R.P.1
Payne, S.G.2
Bittman, R.3
Spiegel, S.4
Sato-Bigbee, C.5
-
6
-
-
77951073508
-
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
-
Chun J, Hartung HP. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol 2010;33:91-101.
-
(2010)
Clin Neuropharmacol
, vol.33
, pp. 91-101
-
-
Chun, J.1
Hartung, H.P.2
-
7
-
-
34247554847
-
Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
-
DOI 10.1096/fj.06-7420com
-
Novgorodov AS, El-Alwani M, Bielawski J, Obeid LM, Gudz TI. Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. FASEB J 2007;21:1503-1514. (Pubitemid 46684852)
-
(2007)
FASEB Journal
, vol.21
, Issue.7
, pp. 1503-1514
-
-
Novgorodov, A.S.1
El-Alwani, M.2
Bielawski, J.3
Obeid, L.M.4
Gudz, T.I.5
-
8
-
-
53149089045
-
Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod
-
Miron VE, Hall JA, Kennedy TE, Soliven B, Antel JP. Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am J Pathol 2008;173:1143-1152.
-
(2008)
Am J Pathol
, vol.173
, pp. 1143-1152
-
-
Miron, V.E.1
Hall, J.A.2
Kennedy, T.E.3
Soliven, B.4
Antel, J.P.5
-
9
-
-
53049085954
-
Central nervous system-directed effects of FTY720 (fingolimod)
-
Miron VE, Schubart A, Antel JP. Central nervous system-directed effects of FTY720 (fingolimod). J Neurol Sci 2008;274:13-17.
-
(2008)
J Neurol Sci
, vol.274
, pp. 13-17
-
-
Miron, V.E.1
Schubart, A.2
Antel, J.P.3
-
10
-
-
64049113731
-
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
-
Marsolais D, Rosen H. Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules. Nat Rev Drug Discov 2009;8:297-307.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 297-307
-
-
Marsolais, D.1
Rosen, H.2
-
11
-
-
28844457715
-
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors
-
DOI 10.1111/j.1471-4159.2005.03451.x
-
Saini HS, Coelho RP, Goparaju SK, et al. Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. J Neurochem 2005;95:1298-1310. (Pubitemid 41779255)
-
(2005)
Journal of Neurochemistry
, vol.95
, Issue.5
, pp. 1298-1310
-
-
Saini, H.S.1
Coelho, R.P.2
Goparaju, S.K.3
Jolly, P.S.4
Maceyka, M.5
Spiegel, S.6
Sato-Bigbee, C.7
-
12
-
-
0032494278
-
1 /edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain
-
DOI 10.1002/(SICI)1096-9861(19980907)398:4<587::AID-CNE10>3.0.CO;2- 5
-
Weiner JA, Hecht JH, Chun J. Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol 1998;398:587-598. (Pubitemid 28364536)
-
(1998)
Journal of Comparative Neurology
, vol.398
, Issue.4
, pp. 587-598
-
-
Weiner, J.A.1
Hecht, J.H.2
Chun, J.3
-
13
-
-
51349134916
-
Astrocytes in multiple sclerosis: A product of their environment
-
Nair A, Frederick TJ, Miller SD. Astrocytes in multiple sclerosis: a product of their environment. Cell Mol Life Sci 2008;65:2702-2720.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 2702-2720
-
-
Nair, A.1
Frederick, T.J.2
Miller, S.D.3
-
14
-
-
34548206670
-
Astrocytes: Friends or foes in multiple sclerosis?
-
Williams A, Piaton G, Lubetzki C. Astrocytes: friends or foes in multiple sclerosis? Glia 2007;55:1300-1312.
-
(2007)
Glia
, vol.55
, pp. 1300-1312
-
-
Williams, A.1
Piaton, G.2
Lubetzki, C.3
-
15
-
-
20344398223
-
Astrocyte activation and reactive gliosis
-
DOI 10.1002/glia.20207
-
Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005;50:427-434. (Pubitemid 40780846)
-
(2005)
GLIA
, vol.50
, Issue.4
, pp. 427-434
-
-
Pekny, M.1
Nilsson, M.2
-
16
-
-
0034924474
-
Sphingosine-1-phosphate induces proliferation of astrocytes: Regulation by intracellular signalling cascades
-
Pebay A, Toutant M, Premont J, et al. Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. Eur J Neurosci 2001;13:2067-2076. (Pubitemid 32664301)
-
(2001)
European Journal of Neuroscience
, vol.13
, Issue.12
, pp. 2067-2076
-
-
Pebay, A.1
Toutant, M.2
Premont, J.3
Calvo, C.-F.4
Venance, L.5
Cordier, J.6
Glowinski, J.7
Tence, M.8
-
17
-
-
34047253376
-
Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors
-
DOI 10.1016/j.neuropharm.2006.11.010, PII S0028390806003972
-
Osinde M, Mullershausen F, Dev KK. Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. Neuropharmacology 2007;52:1210-1218. (Pubitemid 46546406)
-
(2007)
Neuropharmacology
, vol.52
, Issue.5
, pp. 1210-1218
-
-
Osinde, M.1
Mullershausen, F.2
Dev, K.K.3
-
18
-
-
0141918792
-
Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes
-
DOI 10.1016/S0006-8993(03)03527-3
-
Rao TS, Lariosa-Willingham KD, Lin FF, et al. Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. Brain Res 2003;990:182-194. (Pubitemid 37244074)
-
(2003)
Brain Research
, vol.990
, Issue.1-2
, pp. 182-194
-
-
Rao, T.S.1
Lariosa-Willingham, K.D.2
Lin, F.-F.3
Palfreyman, E.L.4
Yu, N.5
Chun, J.6
Webb, M.7
-
19
-
-
0142241216
-
Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes
-
Sorensen SD, Nicole O, Peavy RD, et al. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Mol Pharmacol 2003;64:1199-1209.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1199-1209
-
-
Sorensen, S.D.1
Nicole, O.2
Peavy, R.D.3
-
20
-
-
77951050159
-
Evidence for neural S1P receptor signaling in EAE and FTY720 efficacy
-
Gardell S, Choi JW, Anliker B, Lu M, Kennedy G, Chun J. Evidence for neural S1P receptor signaling in EAE and FTY720 efficacy. Mult Scler 2007;13:S70.
-
(2007)
Mult Scler
, vol.13
-
-
Gardell, S.1
Choi, J.W.2
Anliker, B.3
Lu, M.4
Kennedy, G.5
Chun, J.6
-
21
-
-
48049096529
-
Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease
-
Wu YP, Mizugishi K, Bektas M, Sandhoff R, Proia RL. Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. Hum Mol Genet 2008;17:2257-2264.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2257-2264
-
-
Wu, Y.P.1
Mizugishi, K.2
Bektas, M.3
Sandhoff, R.4
Proia, R.L.5
-
22
-
-
65949105042
-
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
-
Mullershausen F, Zecri F, Cetin C, Billich A, Guerini D, Seuwen K. Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol 2009;5:428-434.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 428-434
-
-
Mullershausen, F.1
Zecri, F.2
Cetin, C.3
Billich, A.4
Guerini, D.5
Seuwen, K.6
-
23
-
-
33645101159
-
S1P inhibits gap junctions in astrocytes: Involvement of G and Rho GTPase/ROCK
-
Rouach N, Pebay A, Meme W, et al. S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. Eur J Neurosci 2006;23:1453-1464.
-
(2006)
Eur J Neurosci
, vol.23
, pp. 1453-1464
-
-
Rouach, N.1
Pebay, A.2
Meme, W.3
-
24
-
-
0037440379
-
Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes
-
DOI 10.1002/glia.10180
-
Yamagata K, Tagami M, Torii Y, et al. Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. Glia 2003;41:199-206. (Pubitemid 36262197)
-
(2003)
GLIA
, vol.41
, Issue.2
, pp. 199-206
-
-
Yamagata, K.1
Tagami, M.2
Torii, Y.3
Takenaga, F.4
Tsumagari, S.5
Itoh, S.6
Yamori, Y.7
Nara, Y.8
-
25
-
-
77956568581
-
Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions
-
Van Doorn R, Van Horssen J, Verzijl D, et al. Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions. Glia 2010;58:1465-1476.
-
(2010)
Glia
, vol.58
, pp. 1465-1476
-
-
Van Doorn, R.1
Van Horssen, J.2
Verzijl, D.3
-
26
-
-
74449093467
-
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
-
Nayak D, Huo Y, Kwang WX, et al. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience 2010;166:132-144.
-
(2010)
Neuroscience
, vol.166
, pp. 132-144
-
-
Nayak, D.1
Huo, Y.2
Kwang, W.X.3
-
27
-
-
79952019190
-
Differential responses of human microglia and blood-derived myeloid cells to FTY720
-
Sep 6 [Epub ahead of print]
-
Durafourt BA, Lambert C, Johnson TA, Blain M, Bar-Or A, Antel JP. Differential responses of human microglia and blood-derived myeloid cells to FTY720. J Neuroimmunol 2010 Sep 6 [Epub ahead of print].
-
(2010)
J Neuroimmunol
-
-
Durafourt, B.A.1
Lambert, C.2
Johnson, T.A.3
Blain, M.4
Bar-Or, A.5
Antel, J.P.6
-
28
-
-
33846021925
-
1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury
-
DOI 10.1634/stemcells.2006-0223
-
Kimura A, Ohmori T, Ohkawa R, et al. Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells 2007;25:115-124. (Pubitemid 46052981)
-
(2007)
Stem Cells
, vol.25
, Issue.1
, pp. 115-124
-
-
Kimura, A.1
Ohmori, T.2
Ohkawa, R.3
Madoiwa, S.4
Mimuro, J.5
Murakami, T.6
Kobayashi, E.7
Hoshino, Y.8
Yatomi, Y.9
Sakata, Y.10
-
29
-
-
33845985634
-
Effects of LPA and S1P on the nervous system and implications for their involvement in disease
-
DOI 10.2174/138945007779315669
-
Herr DR, Chun J. Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Curr Drug Targets 2007;8:155-167. (Pubitemid 46043906)
-
(2007)
Current Drug Targets
, vol.8
, Issue.1
, pp. 155-167
-
-
Herr, D.R.1
Chun, J.2
-
30
-
-
3543132506
-
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension
-
DOI 10.1083/jcb.200402016
-
Toman RE, Payne SG, Watterson KR, et al. Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. J Cell Biol 2004;166:381-392. (Pubitemid 39031241)
-
(2004)
Journal of Cell Biology
, vol.166
, Issue.3
, pp. 381-392
-
-
Toman, R.E.1
Payne, S.G.2
Watterson, K.R.3
Maceyka, M.4
Lee, N.H.5
Milstien, S.6
Bigbee, J.W.7
Spiegel, S.8
-
31
-
-
34247552132
-
Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons
-
DOI 10.1128/MCB.01465-06
-
Kajimoto T, Okada T, Yu H, Goparaju SK, Jahangeer S, Nakamura S. Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. Mol Cell Biol 2007;27:3429-3440. (Pubitemid 46685218)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.9
, pp. 3429-3440
-
-
Kajimoto, T.1
Okada, T.2
Yu, H.3
Goparaju, S.K.4
Jahangeer, S.5
Nakamura, S.-I.6
-
32
-
-
77953865510
-
Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms
-
Norman E, Cutler RG, Flannery R, Wang Y, Mattson MP. Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. J Neurochem 2010;114:430-439.
-
(2010)
J Neurochem
, vol.114
, pp. 430-439
-
-
Norman, E.1
Cutler, R.G.2
Flannery, R.3
Wang, Y.4
Mattson, M.P.5
-
33
-
-
67651171665
-
Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS
-
Sim-Selley LJ, Goforth PB, Mba MU, et al. Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. J Neurochem 2009;110:1191-1202.
-
(2009)
J Neurochem
, vol.110
, pp. 1191-1202
-
-
Sim-Selley, L.J.1
Goforth, P.B.2
Mba, M.U.3
-
34
-
-
0034887535
-
An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability
-
MacLennan AJ, Carney PR, Zhu WJ, et al. An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability. Eur J Neurosci 2001;14:203-209.
-
(2001)
Eur J Neurosci
, vol.14
, pp. 203-209
-
-
MacLennan, A.J.1
Carney, P.R.2
Zhu, W.J.3
-
35
-
-
0037067769
-
Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P/LP(B2)/EDG-5 and S1P/LP(B3)/EDG-3
-
Ishii I, Ye X, Friedman B, et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P/LP(B2)/EDG-5 and S1P/LP(B3)/EDG-3. J Biol Chem 2002;277:25152-25159.
-
(2002)
J Biol Chem
, vol.277
, pp. 25152-25159
-
-
Ishii, I.1
Ye, X.2
Friedman, B.3
-
36
-
-
61649121740
-
FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: Expression of central nervous system genes and reversal of blood-brain-barrier damage
-
Foster CA, Mechtcheriakova D, Storch MK, et al. FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage. Brain Pathol 2009;19:254-266.
-
(2009)
Brain Pathol
, vol.19
, pp. 254-266
-
-
Foster, C.A.1
Mechtcheriakova, D.2
Storch, M.K.3
-
37
-
-
77953225859
-
Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
-
Miron VE, Ludwin SK, Darlington PJ, et al. Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol 2010;176:2682-2694.
-
(2010)
Am J Pathol
, vol.176
, pp. 2682-2694
-
-
Miron, V.E.1
Ludwin, S.K.2
Darlington, P.J.3
-
38
-
-
79955645727
-
Neurobiological effects of sphingosine 1-phosphate receptor in the cuprizone model
-
In Press
-
Kim HJ, Miron VE, Dukala D, et al. Neurobiological effects of sphingosine 1-phosphate receptor in the cuprizone model. FASEB J 2011 (In Press).
-
(2011)
FASEB J
-
-
Kim, H.J.1
Miron, V.E.2
Dukala, D.3
-
39
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
DOI 10.1074/jbc.C200176200
-
Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002;277:21453-21457. (Pubitemid 34952287)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.24
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
Zollinger, M.12
Lynch, K.R.13
-
40
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
DOI 10.1126/science.1070238
-
Mandala S, Hajdu R, Bergstrom J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002;296:346-349. (Pubitemid 34303689)
-
(2002)
Science
, vol.296
, Issue.5566
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
Thornton, R.7
Shei, G.-J.8
Card, D.9
Keohane, C.10
Rosenbach, M.11
Hale, J.12
Lynch, C.L.13
Rupprecht, K.14
Parsons, W.15
Rosen, H.16
-
41
-
-
3242683494
-
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice
-
DOI 10.1016/j.jneuroim.2004.04.015, PII S0165572804001560
-
Webb M, Tham CS, Lin FF, et al. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J Neuroimmunol 2004;153:108-121. (Pubitemid 38950933)
-
(2004)
Journal of Neuroimmunology
, vol.153
, Issue.1-2
, pp. 108-121
-
-
Webb, M.1
Tham, C.-S.2
Lin, F.-F.3
Lariosa-Willingham, K.4
Yu, N.5
Hale, J.6
Mandala, S.7
Chun, J.8
Rao, T.S.9
-
42
-
-
77951439611
-
The S1P1/S1P5 receptor modulator BAF312 reverses neurological deficits in ongoing EAE, reduces specific lymphocyte subsets in healthy volunteers and is a potential new multiple sclerosis therapy
-
Nuesslein-Hildesheim B, Gergely P, Wallstrom E, et al. The S1P1/S1P5 receptor modulator BAF312 reverses neurological deficits in ongoing EAE, reduces specific lymphocyte subsets in healthy volunteers and is a potential new multiple sclerosis therapy. Mult Scler 2009;15:S126.
-
(2009)
Mult Scler
, vol.15
-
-
Nuesslein-Hildesheim, B.1
Gergely, P.2
Wallstrom, E.3
-
43
-
-
77951485851
-
Preclinical evaluation of a selective sphingosine 1-phosphate receptor-1 modulator: In vitro binding selectivity and effects on experimental autoimmune encephalomyelitis in rats
-
Shimozato T, Tomisato W, Doi H, et al. Preclinical evaluation of a selective sphingosine 1-phosphate receptor-1 modulator: in vitro binding selectivity and effects on experimental autoimmune encephalomyelitis in rats. Mult Scler 2009;15:S78.
-
(2009)
Mult Scler
, vol.15
-
-
Shimozato, T.1
Tomisato, W.2
Doi, H.3
-
44
-
-
76449093957
-
S1P1 receptor signaling on cells of astrocytic lineages in experimental autoimmune encephalomyelitis: A role in disease progression and efficacy of fingolimod (FTY720)
-
Choi JW, Herr D, Lee C-W, Teo S, Kennedy G, Chun J. S1P1 receptor signaling on cells of astrocytic lineages in experimental autoimmune encephalomyelitis: a role in disease progression and efficacy of fingolimod (FTY720). Mult Scler 2008;14:S37.
-
(2008)
Mult Scler
, vol.14
-
-
Choi, J.W.1
Herr, D.2
Lee, C.-W.3
Teo, S.4
Kennedy, G.5
Chun, J.6
-
45
-
-
55749104704
-
A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
-
Wheeler D, Bandaru VV, Calabresi PA, Nath A, Haughey NJ. A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis. Brain 2008;131:3092-3102.
-
(2008)
Brain
, vol.131
, pp. 3092-3102
-
-
Wheeler, D.1
Bandaru, V.V.2
Calabresi, P.A.3
Nath, A.4
Haughey, N.J.5
-
46
-
-
77951991002
-
Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: Significance for apoptosis and multiple sclerosis
-
Qin J, Berdyshev E, Goya J, Natarajan V, Dawson G. Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis. J Biol Chem 2010;285:14134-14143.
-
(2010)
J Biol Chem
, vol.285
, pp. 14134-14143
-
-
Qin, J.1
Berdyshev, E.2
Goya, J.3
Natarajan, V.4
Dawson, G.5
-
47
-
-
77953361436
-
Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis
-
Kulakowska A, Zendzian-Piotrowska M, Baranowski M, et al. Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis. Neurosci Lett 2010;477:149-152.
-
(2010)
Neurosci Lett
, vol.477
, pp. 149-152
-
-
Kulakowska, A.1
Zendzian-Piotrowska, M.2
Baranowski, M.3
-
48
-
-
0033198306
-
Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes
-
Hida H, Nagano S, Takeda M, Soliven B. Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes. J Neurosci 1999;19:7458-7467. (Pubitemid 29404602)
-
(1999)
Journal of Neuroscience
, vol.19
, Issue.17
, pp. 7458-7467
-
-
Hida, H.1
Nagano, S.2
Takeda, M.3
Soliven, B.4
-
49
-
-
34548443292
-
FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis
-
DOI 10.1016/j.brainresbull.2007.06.023, PII S0361923007002055
-
Balatoni B, Storch MK, Swoboda EM, et al. FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. Brain Res Bull 2007;74:307-316. (Pubitemid 47368881)
-
(2007)
Brain Research Bulletin
, vol.74
, Issue.5
, pp. 307-316
-
-
Balatoni, B.1
Storch, M.K.2
Swoboda, E.-M.3
Schonborn, V.4
Koziel, A.5
Lambrou, G.N.6
Hiestand, P.C.7
Weissert, R.8
Foster, C.A.9
-
50
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-415.
-
(2010)
N Engl J Med
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
51
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401.
-
(2010)
N Engl J Med
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
|