Adaptive trial designs: A review of barriers and opportunities

Trials

Volumn 13, Issue , 2012, Pages

  Kairalla, John A ^a   Coffey, Christopher S ^b   Thomann, Mitchell A ^b   Muller, Keith E ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Adaptive designs; Comparative effectiveness research; Flexible designs; Group sequential; Internal pilot; Power; Sample size re estimation; Small clinical trials

Indexed keywords

ADAPTIVE DESIGN; CLINICAL RESEARCH; CLINICAL TRIAL (TOPIC); COMPARATIVE STUDY; DRUG EFFICACY; DRUG RESEARCH; LEARNING; MAXIMUM TOLERATED DOSE; RANDOMIZATION; REVIEW; SAMPLE SIZE; STUDY DESIGN; TOXICITY;

CLINICAL TRIALS AS TOPIC; HUMANS; RANDOM ALLOCATION; RESEARCH DESIGN; SAMPLE SIZE;

EID: 84865271518     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/1745-6215-13-145     Document Type: Review

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