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Volumn 11, Issue 2, 2012, Pages 150-156

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: An open-label phase 2a proof-of-concept study

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BACTERIAL INFECTION; CLINICAL ARTICLE; EVOKED VISUAL RESPONSE; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MULTIPLE SCLEROSIS; NEUROPROTECTION; OPTIC NERVE; PRIORITY JOURNAL; RASH; UNITED KINGDOM; VISUAL ACUITY; VISUAL SYSTEM;

EID: 84856023693     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(11)70305-2     Document Type: Article
Times cited : (501)

References (33)
  • 1
    • 33746588738 scopus 로고    scopus 로고
    • The epidemiology of multiple sclerosis in Europe
    • Pugliatti M, Rosati G, Carton H, et al. The epidemiology of multiple sclerosis in Europe. Eur J Neurol 2006, 13:700-722.
    • (2006) Eur J Neurol , vol.13 , pp. 700-722
    • Pugliatti, M.1    Rosati, G.2    Carton, H.3
  • 2
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A Multiple sclerosis. Lancet 2008, 372:1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 3
    • 54949143968 scopus 로고    scopus 로고
    • Alemtuzumab vs interferon beta-1a in early multiple sclerosis
    • Coles AJ, Compston DAS, Selmaj KW, et al. Alemtuzumab vs interferon beta-1a in early multiple sclerosis. N Engl J Med 2008, 359:1786-1801.
    • (2008) N Engl J Med , vol.359 , pp. 1786-1801
    • Coles, A.J.1    Compston, D.A.S.2    Selmaj, K.W.3
  • 4
    • 34547497820 scopus 로고    scopus 로고
    • Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study
    • Kappos L, Freedman MS, Polman CH, et al. Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study. Lancet 2007, 370:389-397.
    • (2007) Lancet , vol.370 , pp. 389-397
    • Kappos, L.1    Freedman, M.S.2    Polman, C.H.3
  • 5
    • 33749672732 scopus 로고    scopus 로고
    • The curious incident of disability in multiple sclerosis trials
    • Coles A The curious incident of disability in multiple sclerosis trials. Lancet Neurol 2006, 5:899-900.
    • (2006) Lancet Neurol , vol.5 , pp. 899-900
    • Coles, A.1
  • 6
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 7
    • 58149265734 scopus 로고    scopus 로고
    • The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair
    • Arthur A, Zannettino A, Gronthos S The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. J Cell Physiol 2009, 218:237-245.
    • (2009) J Cell Physiol , vol.218 , pp. 237-245
    • Arthur, A.1    Zannettino, A.2    Gronthos, S.3
  • 8
    • 79958829029 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases
    • Uccelli A, Laroni A, Freedman MS Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases. Lancet Neurol 2011, 10:649-656.
    • (2011) Lancet Neurol , vol.10 , pp. 649-656
    • Uccelli, A.1    Laroni, A.2    Freedman, M.S.3
  • 9
    • 79551656899 scopus 로고    scopus 로고
    • The prospect of stem cells as multi-faceted purveyors of immune modulation, repair and regeneration in multiple sclerosis
    • Payne N, Siatskas C, Barnard A, Bernard CCA The prospect of stem cells as multi-faceted purveyors of immune modulation, repair and regeneration in multiple sclerosis. Curr Stem Cell Res Ther 2011, 6:50-62.
    • (2011) Curr Stem Cell Res Ther , vol.6 , pp. 50-62
    • Payne, N.1    Siatskas, C.2    Barnard, A.3    Bernard, C.C.A.4
  • 10
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005, 106:1755-1761.
    • (2005) Blood , vol.106 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3
  • 11
    • 33746862992 scopus 로고    scopus 로고
    • Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice
    • Zhang J, Li Y, Lu M, et al. Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice. J Neurosci Res 2006, 84:587-595.
    • (2006) J Neurosci Res , vol.84 , pp. 587-595
    • Zhang, J.1    Li, Y.2    Lu, M.3
  • 12
    • 65649113921 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    • Bai L, Lennon DP, Eaton V, et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 2009, 57:1192-1203.
    • (2009) Glia , vol.57 , pp. 1192-1203
    • Bai, L.1    Lennon, D.P.2    Eaton, V.3
  • 13
    • 34147126415 scopus 로고    scopus 로고
    • Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis
    • Gerdoni E, Gallo B, Casazza S, et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol 2007, 61:219-227.
    • (2007) Ann Neurol , vol.61 , pp. 219-227
    • Gerdoni, E.1    Gallo, B.2    Casazza, S.3
  • 14
    • 45149103232 scopus 로고    scopus 로고
    • Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis
    • Kassis I, Grigoriadis N, Gowda-Kurkalli B, et al. Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis. Arch Neurol 2008, 65:753-761.
    • (2008) Arch Neurol , vol.65 , pp. 753-761
    • Kassis, I.1    Grigoriadis, N.2    Gowda-Kurkalli, B.3
  • 15
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
    • Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008, 371:1579-1586.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3
  • 16
    • 67649604299 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans
    • Sun L, Akiyama K, Zhang H, et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009, 27:1421-1432.
    • (2009) Stem Cells , vol.27 , pp. 1421-1432
    • Sun, L.1    Akiyama, K.2    Zhang, H.3
  • 17
    • 77749279645 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients
    • Carrion F, Nova E, Ruiz C, et al. Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Lupus 2010, 19:317-322.
    • (2010) Lupus , vol.19 , pp. 317-322
    • Carrion, F.1    Nova, E.2    Ruiz, C.3
  • 18
    • 34249056207 scopus 로고    scopus 로고
    • Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study
    • Mohyeddin Bonab M, Yazdanbakhsh S, Lotfi J, et al. Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study. Iran J Immunol 2007, 4:50-57.
    • (2007) Iran J Immunol , vol.4 , pp. 50-57
    • Mohyeddin Bonab, M.1    Yazdanbakhsh, S.2    Lotfi, J.3
  • 19
    • 77956651196 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study
    • Yamout B, Hourani R, Salti H, et al. Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. J Neuroimmunol 2010, 227:185-189.
    • (2010) J Neuroimmunol , vol.227 , pp. 185-189
    • Yamout, B.1    Hourani, R.2    Salti, H.3
  • 20
    • 77957964299 scopus 로고    scopus 로고
    • Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    • Karussis D, Karageorgiou C, Vaknin-Dembinsky A, et al. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol 2010, 67:1187-1194.
    • (2010) Arch Neurol , vol.67 , pp. 1187-1194
    • Karussis, D.1    Karageorgiou, C.2    Vaknin-Dembinsky, A.3
  • 21
    • 65349186498 scopus 로고    scopus 로고
    • Proof of concept studies for tissue-protective agents in multiple sclerosis
    • Mehta LR, Schwid SR, Arnold DL, et al. Proof of concept studies for tissue-protective agents in multiple sclerosis. Mult Scler 2009, 15:542-546.
    • (2009) Mult Scler , vol.15 , pp. 542-546
    • Mehta, L.R.1    Schwid, S.R.2    Arnold, D.L.3
  • 22
    • 67349237447 scopus 로고    scopus 로고
    • Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis
    • Kolappan M, Henderson APD, Jenkins TM, et al. Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis. J Neurol 2009, 256:305-319.
    • (2009) J Neurol , vol.256 , pp. 305-319
    • Kolappan, M.1    Henderson, A.P.D.2    Jenkins, T.M.3
  • 23
    • 79952084861 scopus 로고    scopus 로고
    • The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
    • Connick P, Kolappan M, Patani R, et al. The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. Trials 2011, 12:62.
    • (2011) Trials , vol.12 , pp. 62
    • Connick, P.1    Kolappan, M.2    Patani, R.3
  • 24
    • 0020686503 scopus 로고
    • New diagnostic criteria for multiple sclerosis: guidelines for research protocols
    • Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983, 13:227-231.
    • (1983) Ann Neurol , vol.13 , pp. 227-231
    • Poser, C.M.1    Paty, D.W.2    Scheinberg, L.3
  • 25
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8:315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 26
    • 33747622065 scopus 로고    scopus 로고
    • Application of array CGH on archival formalin-fixed paraffin-embedded tissues including small numbers of microdissected cells
    • Johnson NA, Hamoudi RA, Ichimura K, et al. Application of array CGH on archival formalin-fixed paraffin-embedded tissues including small numbers of microdissected cells. Lab Invest 2006, 86:968-978.
    • (2006) Lab Invest , vol.86 , pp. 968-978
    • Johnson, N.A.1    Hamoudi, R.A.2    Ichimura, K.3
  • 28
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD, Reingold SC Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996, 46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 29
    • 0041522756 scopus 로고    scopus 로고
    • Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance
    • Barkhof F, Bruck W, De Groot CJA, et al. Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance. Arch Neurol 2003, 60:1073-1081.
    • (2003) Arch Neurol , vol.60 , pp. 1073-1081
    • Barkhof, F.1    Bruck, W.2    De Groot, C.J.A.3
  • 31
  • 32
    • 33749530905 scopus 로고    scopus 로고
    • Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells
    • Rivera FJ, Couillard-Despres S, Pedre X, et al. Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Stem Cells 2006, 24:2209-2219.
    • (2006) Stem Cells , vol.24 , pp. 2209-2219
    • Rivera, F.J.1    Couillard-Despres, S.2    Pedre, X.3
  • 33
    • 33846935754 scopus 로고    scopus 로고
    • Human mesenchymal stem cells signals regulate neural stem cell fate
    • Bai L, Caplan A, Lennon D, Miller RH Human mesenchymal stem cells signals regulate neural stem cell fate. Neurochem Res 2007, 32:353-362.
    • (2007) Neurochem Res , vol.32 , pp. 353-362
    • Bai, L.1    Caplan, A.2    Lennon, D.3    Miller, R.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.