메뉴 건너뛰기




Volumn 1238, Issue , 2015, Pages 487-509

Use of epigenetic modulators as a powerful adjuvant for breast cancer therapies

Author keywords

Breast cancer; DNA; DNMT; DNMTi; Epigenetic; HDAC; HDACi; Histone; Methylation; Therapy

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADENOSINE; AZACITIDINE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; ENTINOSTAT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HISTONE DEACETYLASE INHIBITOR; METHIONINE; MICRORNA; PANOBINOSTAT; VALPROIC ACID; VORINOSTAT; DNA (CYTOSINE 5) METHYLTRANSFERASE; PHARMACEUTICAL VEHICLES AND ADDITIVES;

EID: 84955349268     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-1804-1_25     Document Type: Article
Times cited : (12)

References (120)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917. doi: 10.1002/ijc.25516
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.-R.2    Bray, F.3    Forman, D.4    Mathers, C.5    Parkin, D.M.6
  • 3
    • 33749002551 scopus 로고    scopus 로고
    • Models of genetic susceptibility to breast cancer
    • Antoniou AC, Easton DF (2006) Models of genetic susceptibility to breast cancer. Oncogene 25:5898–5905. doi: 10.1038/sj.onc.1209879
    • (2006) Oncogene , vol.25 , pp. 5898-5905
    • Antoniou, A.C.1    Easton, D.F.2
  • 4
    • 84884559633 scopus 로고    scopus 로고
    • Molecular and cellular heterogeneity in breast cancer: Challenges for personalized medicine
    • Rivenbark AG, O’Connor SM, Coleman WB (2013) Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine. Am J Pathol 183:1113–1124. doi: 10.1016/j.ajpath.2013.08.002.
    • (2013) Am J Pathol , vol.183 , pp. 1113-1124
    • Rivenbark, A.G.1    O’connor, S.M.2    Coleman, W.B.3
  • 5
    • 0027498979 scopus 로고
    • Increasing incidence of breast cancer in family with BRCA1 mutation
    • Narod S, Lynch H, Conway T, Watson P, Feunteun J, Lenoir G (1993) Increasing incidence of breast cancer in family with BRCA1 mutation. Lancet 341:1101–1102
    • (1993) Lancet , vol.341 , pp. 1101-1102
    • Narod, S.1    Lynch, H.2    Conway, T.3    Watson, P.4    Feunteun, J.5    Lenoir, G.6
  • 7
    • 0037310198 scopus 로고    scopus 로고
    • Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma
    • Gupta A, Godwin AK, Vanderveer L, Lu A, Liu J (2003) Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res 63:664–673
    • (2003) Cancer Res , vol.63 , pp. 664-673
    • Gupta, A.1    Godwin, A.K.2    Vanderveer, L.3    Lu, A.4    Liu, J.5
  • 12
    • 77149122714 scopus 로고    scopus 로고
    • Epigenetic regulation in estrogen receptor positive breast cancer—role in treatment response
    • Pathiraja TN, Stearns V, Oesterreich S (2010) Epigenetic regulation in estrogen receptor positive breast cancer—role in treatment response. J Mammary Gland Biol Neoplasia 15:35–47. doi: 10.1007/s10911-010-9166-0
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 35-47
    • Pathiraja, T.N.1    Stearns, V.2    Oesterreich, S.3
  • 13
    • 33745685866 scopus 로고    scopus 로고
    • Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: Tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
    • Sharma D, Saxena NK, Davidson NE, Vertino PM (2006) Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res 66:6370–6378. doi: 10.1158/0008-5472.CAN-06-0402
    • (2006) Cancer Res , vol.66 , pp. 6370-6378
    • Sharma, D.1    Saxena, N.K.2    Davidson, N.E.3    Vertino, P.M.4
  • 14
    • 65249157050 scopus 로고    scopus 로고
    • Epigenetics, DNA methylation, and chromatin modifying drugs
    • Szyf M (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 49:243–263. doi: 10.1146/annurev-pharmtox-061008-103102
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 243-263
    • Szyf, M.1
  • 15
    • 33746679765 scopus 로고    scopus 로고
    • Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2’-deoxycytidine (Decitabine) on human breast carcinoma cells
    • Hurtubise A, Momparler RL (2006) Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2’-deoxycytidine (decitabine) on human breast carcinoma cells. Cancer Chemother Pharmacol 58:618–625. doi: 10.1007/s00280-006-0225-6
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 618-625
    • Hurtubise, A.1    Momparler, R.L.2
  • 16
    • 0034917318 scopus 로고    scopus 로고
    • Antineoplastic action of 5-aza-2’-deoxycytidineand histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells
    • Bovenzi V, Momparler RL (2001) Antineoplastic action of 5-aza-2’-deoxycytidineand histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. Cancer Chemother Pharmacol 48:71–76
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 71-76
    • Bovenzi, V.1    Momparler, R.L.2
  • 17
    • 77951236061 scopus 로고    scopus 로고
    • Epigenetic repression of PDZ-LIM domain-containing protein 2 implications for the biology and treatment of breast cancer
    • Qu Z, Fu J, Yan P, Hu J, Cheng S-Y, Xiao G (2010) Epigenetic repression of PDZ-LIM domain-containing protein 2 implications for the biology and treatment of breast cancer. J Biol Chem 285:11786–11792. doi: 10.1074/jbc.M109.086561
    • (2010) J Biol Chem , vol.285 , pp. 11786-11792
    • Qu, Z.1    Fu, J.2    Yan, P.3    Hu, J.4    Cheng, S.-Y.5    Xiao, G.6
  • 18
    • 77956945027 scopus 로고    scopus 로고
    • Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells
    • Das PM, Thor AD, Edgerton SM, Barry SK, Chen DF, Jones FE (2010) Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells. Oncogene 29:5214–5219. doi: 10.1038/onc.2010.271
    • (2010) Oncogene , vol.29 , pp. 5214-5219
    • Das, P.M.1    Thor, A.D.2    Edgerton, S.M.3    Barry, S.K.4    Chen, D.F.5    Jones, F.E.6
  • 21
    • 40149092689 scopus 로고    scopus 로고
    • Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo
    • Ateeq B, Unterberger A, Szyf M, Rabbani SA (2008) Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia 10:266–278
    • (2008) Neoplasia , vol.10 , pp. 266-278
    • Ateeq, B.1    Unterberger, A.2    Szyf, M.3    Rabbani, S.A.4
  • 22
    • 84855354318 scopus 로고    scopus 로고
    • DNA demethylation by 5-aza-2- deoxycytidine treatment abrogates 17 beta-estradiolinduced cell growth and restores expression of DNA repair genes in human breast cancer cells
    • Singh KP, Treas J, Tyagi T, Gao W (2012) DNA demethylation by 5-aza-2- deoxycytidine treatment abrogates 17 beta-estradiolinduced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Lett 316:62–69. doi: 10.1016/j.canlet.2011.10.022
    • (2012) Cancer Lett , vol.316 , pp. 62-69
    • Singh, K.P.1    Treas, J.2    Tyagi, T.3    Gao, W.4
  • 23
    • 84879741034 scopus 로고    scopus 로고
    • Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer
    • Di Cello F, Cope L, Li H, Jeschke J, Wang W, Baylin SB, Zahnow CA (2013) Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer. PLoS ONE 8:e68630. doi: 10.1371/journal.pone.0068630
    • (2013) Plos ONE , vol.8 , pp. e68630
    • Di Cello, F.1    Cope, L.2    Li, H.3    Jeschke, J.4    Wang, W.5    Baylin, S.B.6    Zahnow, C.A.7
  • 24
    • 84880709210 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2′-deoxycytidine (AZA) in breast cancer cells
    • Zeng L, Jarrett C, Brown K, Gillespie KM, Holly JMP, Perks CM (2013) Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2′-deoxycytidine (AZA) in breast cancer cells. Exp Cell Res 319:2282–2295. doi: 10.1016/j.yexcr.2013.06.011
    • (2013) Exp Cell Res , vol.319 , pp. 2282-2295
    • Zeng, L.1    Jarrett, C.2    Brown, K.3    Gillespie, K.M.4    Holly, J.5    Perks, C.M.6
  • 25
    • 0035477320 scopus 로고    scopus 로고
    • Synergistic activation of functional estrogen receptor (ER)-α by DNA methyltransferase and histone deacetylase inhibition in human ER-α-negative breast cancer cells
    • Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG, Davidson NE (2001) Synergistic activation of functional estrogen receptor (ER)-α by DNA methyltransferase and histone deacetylase inhibition in human ER-α-negative breast cancer cells. Cancer Res 61:7025–7029
    • (2001) Cancer Res , vol.61 , pp. 7025-7029
    • Yang, X.1    Phillips, D.L.2    Ferguson, A.T.3    Nelson, W.G.4    Herman, J.G.5    Davidson, N.E.6
  • 26
    • 83055194490 scopus 로고    scopus 로고
    • Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline- based chemotherapy and the demethylating agent decitabine
    • Ari F, Napieralski R, Ulukaya E, Dere E, Colling C, Honert K, Krüger A, Kiechle M, Schmitt M (2011) Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline- based chemotherapy and the demethylating agent decitabine. Cell Biochem Funct 29:651–659. doi: 10.1002/cbf.1801
    • (2011) Cell Biochem Funct , vol.29 , pp. 651-659
    • Ari, F.1    Napieralski, R.2    Ulukaya, E.3    Dere, E.4    Colling, C.5    Honert, K.6    Krüger, A.7    Kiechle, M.8    Schmitt, M.9
  • 27
    • 47549097004 scopus 로고    scopus 로고
    • Trichostatin A and 5 Aza-2′ deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR
    • Pryzbylkowski P, Obajimi O, Keen JC (2008) Trichostatin A and 5 Aza-2′ deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. Breast Cancer Res Treat 111:15–25. doi: 10.1007/s10549-007-9751-0
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 15-25
    • Pryzbylkowski, P.1    Obajimi, O.2    Keen, J.C.3
  • 28
    • 77953608981 scopus 로고    scopus 로고
    • Long-term genistein treatment of MCF-7 cells decreases acetylated histone 3 expression and alters growth responses to mitogens and histone deacetylase inhibitors
    • Jawaid K, Crane SR, Nowers JL, Lacey M, Whitehead SA (2010) Long-term genistein treatment of MCF-7 cells decreases acetylated histone 3 expression and alters growth responses to mitogens and histone deacetylase inhibitors. J Steroid Biochem Mol Biol 120:164–171. doi: 10.1016/j.jsbmb.2010.04.007
    • (2010) J Steroid Biochem Mol Biol , vol.120 , pp. 164-171
    • Jawaid, K.1    Crane, S.R.2    Nowers, J.L.3    Lacey, M.4    Whitehead, S.A.5
  • 29
    • 84856230176 scopus 로고    scopus 로고
    • Enhancement of chemotherapeutic effi cacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b
    • Sandhu R, Rivenbark AG, Coleman WB (2012) Enhancement of chemotherapeutic effi cacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b. Breast Cancer Res Treat 131:3 85–399. doi: 10.1007/s10549-011-1409-2
    • (2012) Breast Cancer Res Treat , vol.131 , Issue.3 , pp. 85-399
    • Sandhu, R.1    Rivenbark, A.G.2    Coleman, W.B.3
  • 30
    • 77955853899 scopus 로고    scopus 로고
    • Demethylating agent 5-aza-2- deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents
    • Mirza S, Sharma G, Pandya P, Ralhan R (2010) Demethylating agent 5-aza-2- deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents. Mol Cell Biochem 342:101–109. doi: 10.1007/s11010-010-0473-y
    • (2010) Mol Cell Biochem , vol.342 , pp. 101-109
    • Mirza, S.1    Sharma, G.2    Pandya, P.3    Ralhan, R.4
  • 31
    • 84865988286 scopus 로고    scopus 로고
    • Epigenetic modulation of the biophysical properties of drug-resistant cell lipids to restore drug transport and endocytic functions
    • Vijayaraghavalu S, Peetla C, Lu S, Labhasetwar V (2012) Epigenetic modulation of the biophysical properties of drug-resistant cell lipids to restore drug transport and endocytic functions. Mol Pharm 9:2730–2742. doi: 10.1021/mp300281t
    • (2012) Mol Pharm , vol.9 , pp. 2730-2742
    • Vijayaraghavalu, S.1    Peetla, C.2    Lu, S.3    Labhasetwar, V.4
  • 32
    • 84872146371 scopus 로고    scopus 로고
    • Highly synergistic effect of sequential treatment with epigenetic and anticancer drugs to overcome drug resistance in breast cancer cells is mediated via activation of p21 gene expression leading to G2/M cycle arrest
    • Vijayaraghavalu S, Dermawan JK, Cheriyath V, Labhasetwar V (2013) Highly synergistic effect of sequential treatment with epigenetic and anticancer drugs to overcome drug resistance in breast cancer cells is mediated via activation of p21 gene expression leading to G2/M cycle arrest. Mol Pharm 10:337–352. doi: 10.1021/mp3004622
    • (2013) Mol Pharm , vol.10 , pp. 337-352
    • Vijayaraghavalu, S.1    Dermawan, J.K.2    Cheriyath, V.3    Labhasetwar, V.4
  • 36
    • 70449713327 scopus 로고    scopus 로고
    • 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats
    • Tikoo K, Ali IY, Gupta J, Gupta C (2009) 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats. Toxicol Lett 191:158–166. doi: 10.1016/j.toxlet.2009.08.018
    • (2009) Toxicol Lett , vol.191 , pp. 158-166
    • Tikoo, K.1    Ali, I.Y.2    Gupta, J.3    Gupta, C.4
  • 37
    • 84921766276 scopus 로고    scopus 로고
    • NCT 00030615. Decitabine in treating patients with advanced solid tumors
    • Weber J (2002) NCT 00030615. Decitabine in treating patients with advanced solid tumors. https://clinicaltrials.gov
    • (2002)
    • Weber, J.1
  • 40
    • 84921744752 scopus 로고    scopus 로고
    • NCT 00748553. A phase I/II clinical trial of vidaza with abraxane in the treatment of patients with advanced or metastatic solid tumors and breast cancer (VA)
    • Khong HT (2008) NCT 00748553. A phase I/II clinical trial of vidaza with abraxane in the treatment of patients with advanced or metastatic solid tumors and breast cancer (VA). https://clinicaltrials.gov
    • (2008)
    • Khong, H.T.1
  • 41
    • 33947153008 scopus 로고    scopus 로고
    • Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer
    • Feng W, Lu Z, Luo RZ, Zhang X, Seto E, Liao WS-L, Yu Y (2007) Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. Int J Cancer 120:1664–1668. doi: 10.1002/ijc.22474
    • (2007) Int J Cancer , vol.120 , pp. 1664-1668
    • Feng, W.1    Lu, Z.2    Luo, R.Z.3    Zhang, X.4    Seto, E.5    Liao, W.-L.6    Yu, Y.7
  • 42
  • 43
    • 78751475720 scopus 로고    scopus 로고
    • Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment
    • Chakravarty G, Rider B, Mondal D (2011) Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. Cancer Biol Ther 11:71–83. doi: 10.4161/cbt.11.1.13952
    • (2011) Cancer Biol Ther , vol.11 , pp. 71-83
    • Chakravarty, G.1    Rider, B.2    Mondal, D.3
  • 44
    • 77956627130 scopus 로고    scopus 로고
    • Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein
    • Kim S-H, Kang H-J, Na H, Lee M-O (2010) Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein. Breast Cancer Res 12:R22. doi: 10.1186/bcr2562
    • (2010) Breast Cancer Res , vol.12 , pp. R22
    • Kim, S.-H.1    Kang, H.-J.2    Na, H.3    Lee, M.-O.4
  • 45
    • 23744495968 scopus 로고    scopus 로고
    • Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A
    • Reid G, Métivier R, Lin C-Y, Denger S, Ibberson D, Ivacevic T, Brand H, Benes V, Liu ET, Gannon F (2005) Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. Oncogene 24:4894–4907. doi: 10.1038/sj.onc.1208662
    • (2005) Oncogene , vol.24 , pp. 4894-4907
    • Reid, G.1    Métivier, R.2    Lin, C.-Y.3    Denger, S.4    Ibberson, D.5    Ivacevic, T.6    Brand, H.7    Benes, V.8    Liu, E.T.9    Gannon, F.10
  • 46
    • 1642339046 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor α-negative breast cancer cells to tamoxifen
    • Jang ER, Lim S-J, Lee ES, Jeong G, Kim T-Y, Bang Y-J, Lee J-S (2003) The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor α-negative breast cancer cells to tamoxifen. Oncogene 23:1724–1736. doi: 10.1038/sj.onc.1207315
    • (2003) Oncogene , vol.23 , pp. 1724-1736
    • Jang, E.R.1    Lim, S.-J.2    Lee, E.S.3    Jeong, G.4    Kim, T.-Y.5    Bang, Y.-J.6    Lee, J.-S.7
  • 47
    • 84855283939 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor trichostatin A alters microRNA expression profi les in apoptosis-resistant breast cancer cells
    • Collins-Burow B (2011) The histone deacetylase inhibitor trichostatin A alters microRNA expression profi les in apoptosis-resistant breast cancer cells. Oncol Rep. doi: 10.3892/or.2011.1488
    • (2011) Oncol Rep
    • Collins-Burow, B.1
  • 48
    • 84862006182 scopus 로고    scopus 로고
    • The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression
    • Tu Z, Li H, Ma Y, Tang B, Tian J, Akers W, Achilefu S, Gu Y (2012) The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression. Mol Cell Biochem 366: 111–122. doi: 10.1007/s11010-012-1288-9
    • (2012) Mol Cell Biochem , vol.366 , pp. 111-122
    • Tu, Z.1    Li, H.2    Ma, Y.3    Tang, B.4    Tian, J.5    Akers, W.6    Achilefu, S.7    Gu, Y.8
  • 49
    • 84880509091 scopus 로고    scopus 로고
    • Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance
    • Pitta CA, Papageorgis P, Charalambous C, Constantinou AI (2013) Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. Cancer Lett 337:167–176. doi: 10.1016/j.canlet.2013.05.031
    • (2013) Cancer Lett , vol.337 , pp. 167-176
    • Pitta, C.A.1    Papageorgis, P.2    Charalambous, C.3    Constantinou, A.I.4
  • 50
    • 59349106138 scopus 로고    scopus 로고
    • Timing is everything: Order of administration of 5-aza 2′ deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity
    • Hostetter CL, Licata LA, Keen JC (2009) Timing is everything: Order of administration of 5-aza 2′ deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. Cancer Lett 275:178–184. doi: 10.1016/j.canlet.2008.10.005
    • (2009) Cancer Lett , vol.275 , pp. 178-184
    • Hostetter, C.L.1    Licata, L.A.2    Keen, J.C.3
  • 51
    • 44749085668 scopus 로고    scopus 로고
    • ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor
    • Fan J, Yin W-J, Lu J-S, Wang L, Wu J, Wu F-Y, Di G-H, Shen Z-Z, Shao Z-M (2008) ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. J Cancer Res ClinOncol 134:883–890. doi: 10.1007/s00432-008-0354-x
    • (2008) J Cancer Res Clinoncol , vol.134 , pp. 883-890
    • Fan, J.1    Yin, W.-J.2    Lu, J.-S.3    Wang, L.4    Wu, J.5    Wu, F.-Y.6    Di, G.-H.7    Shen, Z.-Z.8    Shao, Z.-M.9
  • 52
    • 84872779585 scopus 로고    scopus 로고
    • Inhibition of lymphangiogenic factor VEGF-C expression and production by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in breast cancer cells
    • Hung W-C (2012) Inhibition of lymphangiogenic factor VEGF-C expression and production by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in breast cancer cells. Oncol Rep. doi: 10.3892/or.2012.2188
    • (2012) Oncol Rep
    • Hung, W.-C.1
  • 53
    • 84885414197 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo
    • Chiu H-W, Yeh Y-L, Wang Y-C, Huang W-J, Chen Y-A, Chiou Y-S, Ho S-Y, Lin P, Wang Y-J (2013) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo. PLoS ONE 8:e76340. doi: 10.1371/journal.pone.0076340
    • (2013) Plos ONE , vol.8 , pp. e76340
    • Chiu, H.-W.1    Yeh, Y.-L.2    Wang, Y.-C.3    Huang, W.-J.4    Chen, Y.-A.5    Chiou, Y.-S.6    Ho, S.-Y.7    Lin, P.8    Wang, Y.-J.9
  • 54
    • 81755171451 scopus 로고    scopus 로고
    • MiR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
    • Eades G, Yang M, Yao Y, Zhang Y, Zhou Q (2011) miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. J Biol Chem 286:40725–40733. doi: 10.1074/jbc.M111.275495
    • (2011) J Biol Chem , vol.286 , pp. 40725-40733
    • Eades, G.1    Yang, M.2    Yao, Y.3    Zhang, Y.4    Zhou, Q.5
  • 55
    • 84866523199 scopus 로고    scopus 로고
    • SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line
    • Bellarosa D, Bressan A, Bigioni M, Parlani M, Maggi CA, Binaschi M (2012) SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line. Int J Oncol 41:1486–1494. doi: 10.3892/ijo.2012.1551
    • (2012) Int J Oncol , vol.41 , pp. 1486-1494
    • Bellarosa, D.1    Bressan, A.2    Bigioni, M.3    Parlani, M.4    Maggi, C.A.5    Binaschi, M.6
  • 56
    • 84874812625 scopus 로고    scopus 로고
    • Drug resistant breast cancer cell line displays cancer stem cell phenotype and responds sensitively to epigenetic drug SAHA
    • Lu S, Labhasetwar V (2013) Drug resistant breast cancer cell line displays cancer stem cell phenotype and responds sensitively to epigenetic drug SAHA. Drug Deliv Transl Res 3: 183–194. doi: 10.1007/s13346-012-0113-z
    • (2013) Drug Deliv Transl Res , vol.3 , pp. 183-194
    • Lu, S.1    Labhasetwar, V.2
  • 57
  • 58
    • 84856230241 scopus 로고    scopus 로고
    • Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells
    • Huang Y, Vasilatos SN, Boric L, Shaw PG, Davidson NE (2012) Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells. Breast Cancer Res Treat 131:777–789. doi: 10.1007/s10549-011-1480-8
    • (2012) Breast Cancer Res Treat , vol.131 , pp. 777-789
    • Huang, Y.1    Vasilatos, S.N.2    Boric, L.3    Shaw, P.G.4    Davidson, N.E.5
  • 59
    • 84878964098 scopus 로고    scopus 로고
    • Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
    • Vasilatos SN, Katz TA, Oesterreich S, Wan Y, Davidson NE, Huang Y (2013) Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Carcinogenesis 34:1196–1207. doi: 10.1093/carcin/bgt033
    • (2013) Carcinogenesis , vol.34 , pp. 1196-1207
    • Vasilatos, S.N.1    Katz, T.A.2    Oesterreich, S.3    Wan, Y.4    Davidson, N.E.5    Huang, Y.6
  • 60
    • 78649330519 scopus 로고    scopus 로고
    • The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: Cytotoxic drug and inducer of sodium-iodide symporter (NIS)
    • Fortunati N, Catalano MG, Marano F, Mugoni V, Pugliese M, Bosco O, Mainini F, Boccuzzi G (2010) The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: cytotoxic drug and inducer of sodium-iodide symporter (NIS). Breast Cancer Res Treat 124:667–675. doi: 10.1007/s10549-010-0789-z
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 667-675
    • Fortunati, N.1    Catalano, M.G.2    Marano, F.3    Mugoni, V.4    Pugliese, M.5    Bosco, O.6    Mainini, F.7    Boccuzzi, G.8
  • 62
    • 77954627516 scopus 로고    scopus 로고
    • The HDAC inhibitor LBH589 (Panobinostat) is an inhibitory modulator of aromatase gene expression
    • Chen S, Ye J, Kijima I, Evans D (2010) The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression. Proc Natl Acad Sci 107:11032– 11037. doi: 10.1073/pnas.1000917107
    • (2010) Proc Natl Acad Sci 107:11032– , pp. 11037
    • Chen, S.1    Ye, J.2    Kijima, I.3    Evans, D.4
  • 63
    • 84875886681 scopus 로고    scopus 로고
    • Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells
    • Wang S, Huang J, Lyu H, Lee C-K, Tan J, Wang J, Liu B (2013) Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells. Cell Death Dis 4:e556. doi: 10.1038/cddis.2013.79
    • (2013) Cell Death Dis , vol.4 , pp. e556
    • Wang, S.1    Huang, J.2    Lyu, H.3    Lee, C.-K.4    Tan, J.5    Wang, J.6    Liu, B.7
  • 64
    • 79957514394 scopus 로고    scopus 로고
    • HDAC inhibitor SNDX-275 enhances effi cacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance
    • Huang X, Wang S, Lee C-K, Yang X, Liu B (2011) HDAC inhibitor SNDX-275 enhances effi cacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Lett 307:72–79. doi: 10.1016/j.canlet.2011.03.019
    • (2011) Cancer Lett , vol.307 , pp. 72-79
    • Huang, X.1    Wang, S.2    Lee, C.-K.3    Yang, X.4    Liu, B.5
  • 65
    • 79952237710 scopus 로고    scopus 로고
    • Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole
    • Sabnis GJ, Goloubeva O, Chumsri S, Nguyen N, Sukumar S, Brodie AMH (2011) Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole. Cancer Res 71:1893–1903. doi: 10.1158/0008-5472.CAN-10-2458
    • (2011) Cancer Res , vol.71 , pp. 1893-1903
    • Sabnis, G.J.1    Goloubeva, O.2    Chumsri, S.3    Nguyen, N.4    Sukumar, S.5    Brodie, A.6
  • 66
    • 79958766981 scopus 로고    scopus 로고
    • Aromatase inhibitors and xenograft studies
    • Chumsri S, Sabnis GJ, Howes T, Brodie AMH (2011) Aromatase inhibitors and xenograft studies. Steroids 76:730–735. doi: 10.1016/j.steroids.2011.02.033
    • (2011) Steroids , vol.76 , pp. 730-735
    • Chumsri, S.1    Sabnis, G.J.2    Howes, T.3    Brodie, A.4
  • 67
    • 78650443648 scopus 로고    scopus 로고
    • MS-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivo
    • Srivastava RK, Kurzrock R, Shankar S (2010) MS-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivo. Mol Cancer Ther 9: 3254–3266. doi: 10.1158/1535-7163.MCT-10-0582
    • (2010) Mol Cancer Ther , vol.9 , pp. 3254-3266
    • Srivastava, R.K.1    Kurzrock, R.2    Shankar, S.3
  • 68
    • 1142267455 scopus 로고    scopus 로고
    • Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF 7
    • Olsen CM, Meussen-Elholm ETM, Røste LS, Taubøll E (2004) Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF 7. Mol Cell Endocrinol 213: 173–179. doi: 10.1016/j.mce.2003.10.032
    • (2004) Mol Cell Endocrinol , vol.213 , pp. 173-179
    • Olsen, C.M.1    Meussen-Elholm, E.2    Røste, L.S.3    Taubøll, E.4
  • 69
    • 35348961982 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase enhances the anti-proliferative action of antiestrogens on breast cancer cellsand blocks tamoxifen-induced proliferation of uterine cells
    • Hodges-Gallagher L, Valentine CD, Bader SE, Kushner PJ (2007) Inhibition of histone deacetylase enhances the anti-proliferative action of antiestrogens on breast cancer cellsand blocks tamoxifen-induced proliferation of uterine cells. Breast Cancer Res Treat 105: 297–309. doi: 10.1007/s10549-006-9459-6
    • (2007) Breast Cancer Res Treat , vol.105 , pp. 297-309
    • Hodges-Gallagher, L.1    Valentine, C.D.2    Bader, S.E.3    Kushner, P.J.4
  • 70
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodríguez-Paredes M, Esteller M (2011) Cancer epigenetics reaches mainstream oncology. Nat Med 17:330–339. doi: 10.1038/nm.2305
    • (2011) Nat Med , vol.17 , pp. 330-339
    • Rodríguez-Paredes, M.1    Esteller, M.2
  • 71
    • 50249095068 scopus 로고    scopus 로고
    • Early phase II trial of oral Vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
    • Vansteenkiste J, Van Cutsem E, Dumez H, Chen C, Ricker JL, Randolph SS, Schöffski P (2008) Early phase II trial of oral Vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest New Drugs 26:483–488. doi: 10.1007/s10637-008-9131-6
    • (2008) Invest New Drugs , vol.26 , pp. 483-488
    • Vansteenkiste, J.1    Van Cutsem, E.2    Dumez, H.3    Chen, C.4    Ricker, J.L.5    Randolph, S.S.6    Schöffski, P.7
  • 75
    • 79958084461 scopus 로고    scopus 로고
    • A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
    • Munster PN, Thurn KT, Thomas S, Raha P, Lacevic M, Miller A, Melisko M, Ismail-Khan R, Rugo H, Moasser M, Minton SE (2011) A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br J Cancer 104:1828–1835. doi: 10.1038/bjc.2011.156
    • (2011) Br J Cancer , vol.104 , pp. 1828-1835
    • Munster, P.N.1    Thurn, K.T.2    Thomas, S.3    Raha, P.4    Lacevic, M.5    Miller, A.6    Melisko, M.7    Ismail-Khan, R.8    Rugo, H.9    Moasser, M.10    Minton, S.E.11
  • 77
    • 84879834815 scopus 로고    scopus 로고
    • Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor
    • Yardley DA, Ismail-Khan RR, Melichar B, Lichinitser M, Munster PN, Klein PM, Cruickshank S, Miller KD, Lee MJ, Trepel JB (2013) Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. J Clin Oncol Off J Am Soc Clin Oncol 31:2128–2135. doi: 10.1200/JCO.2012.43.7251
    • (2013) J Clin Oncol off J am Soc Clin Oncol , vol.31 , pp. 2128-2135
    • Yardley, D.A.1    Ismail-Khan, R.R.2    Melichar, B.3    Lichinitser, M.4    Munster, P.N.5    Klein, P.M.6    Cruickshank, S.7    Miller, K.D.8    Lee, M.J.9    Trepel, J.B.10
  • 78
    • 84921806786 scopus 로고    scopus 로고
    • NCT 01349959. Azacitidine and entinostat in treating patients with advanced breast cancer
    • Stearns V (2011) NCT 01349959. Azacitidine and entinostat in treating patients with advanced breast cancer. https://clinicaltrials.gov
    • (2011)
    • Stearns, V.1
  • 79
    • 84921730745 scopus 로고    scopus 로고
    • NCT 00777335. Study of panobinostat monotherapy in women with v-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) positive locally recurrent or metastatic breast cancer
    • Finn R (2008) NCT 00777335. Study of panobinostat monotherapy in women with v-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) positive locally recurrent or metastatic breast cancer. https://clinicaltrials.gov
    • (2008)
    • Finn, R.1
  • 80
    • 84866358085 scopus 로고    scopus 로고
    • A phase I trial of oral administration of panobinostat in combination with paclitaxel and carboplatin in patients with solid tumors
    • Jones SF, Infante JR, Thompson DS, Mohyuddin A, Bendell JC, Yardley DA, Burris HA 3rd (2012) A phase I trial of oral administration of panobinostat in combination with paclitaxel and carboplatin in patients with solid tumors. Cancer Chemother Pharmacol 70:471–475. doi: 10.1007/s00280-012-1931-x
    • (2012) Cancer Chemother Pharmacol , vol.70 , pp. 471-475
    • Jones, S.F.1    Infante, J.R.2    Thompson, D.S.3    Mohyuddin, A.4    Bendell, J.C.5    Yardley, D.A.6    Burris, H.A.7
  • 81
    • 84921763309 scopus 로고    scopus 로고
    • NCT 01194908. Re-expression of ER in triple negative breast cancers
    • O’Regan R (2010) NCT 01194908. Re-expression of ER in triple negative breast cancers. https://clinicaltrials.gov
    • (2010)
    • O’regan, R.1
  • 82
    • 84921822876 scopus 로고    scopus 로고
    • NCT 01010854. Valproic acid in combination with FEC100 for primary therapy in patients with breast cancer (VPA- FEC100
    • Munster P (2009) NCT 01010854. Valproic acid in combination with FEC100 for primary therapy in patients with breast cancer (VPA- FEC100). https://clinicaltrials.gov
    • (2009)
    • Munster, P.1
  • 84
    • 84921795164 scopus 로고    scopus 로고
    • NCT 01171924. A phase Ib expansion study investigating the safety, efficacy, and pharmacokinetics of intravenous CUDC- 101 in subjects with advanced head and neck, gastric, breast, liver and non-small cell lung cancer tumors
    • 2010, NCT 01171924. A phase Ib expansion study investigating the safety, efficacy, and pharmacokinetics of intravenous CUDC- 101 in subjects with advanced head and neck, gastric, breast, liver and non-small cell lung cancer tumors. https://clinicaltrials.gov
    • (2010)
  • 86
    • 73449113904 scopus 로고    scopus 로고
    • Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation
    • Hervouet E, Vallette FM, Cartron P-F (2009) Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4:487–499
    • (2009) Epigenetics , vol.4 , pp. 487-499
    • Hervouet, E.1    Vallette, F.M.2    Cartron, P.-F.3
  • 87
    • 84855862393 scopus 로고    scopus 로고
    • Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome
    • Khan SI, Aumsuwan P, Khan IA, Walker LA, Dasmahapatra AK (2012) Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome. Chem Res Toxicol 25:61–73. doi: 10.1021/tx200378c
    • (2012) Chem Res Toxicol , vol.25 , pp. 61-73
    • Khan, S.I.1    Aumsuwan, P.2    Khan, I.A.3    Walker, L.A.4    Dasmahapatra, A.K.5
  • 88
    • 84876084653 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on dna methyltransferases and associated proteins
    • Mirza S, Sharma G, Parshad R, Gupta SD, Pandya P, Ralhan R (2013) Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on dna methyltransferases and associated proteins. J Breast Cancer 16:23–31. doi: 10.4048/jbc.2013.16.1.23
    • (2013) J Breast Cancer , vol.16 , pp. 23-31
    • Mirza, S.1    Sharma, G.2    Parshad, R.3    Gupta, S.D.4    Pandya, P.5    Ralhan, R.6
  • 89
    • 84872843245 scopus 로고    scopus 로고
    • Curcumin induces cell death and restores tamoxifen sensitivity in the antiestrogen-resistant breast cancer cell lines MCF-7/LCC2 and MCF-7/LCC 9
    • Jiang M, Huang O, Zhang X, Xie Z, Shen A, Liu H, Geng M, Shen K (2013) Curcumin induces cell death and restores tamoxifen sensitivity in the antiestrogen-resistant breast cancer cell lines MCF-7/LCC2 and MCF-7/LCC 9. Molecules 18:701–720. doi: 10.3390/molecules18010701
    • (2013) Molecules , vol.18 , pp. 701-720
    • Jiang, M.1    Huang, O.2    Zhang, X.3    Xie, Z.4    Shen, A.5    Liu, H.6    Geng, M.7    Shen, K.8
  • 90
    • 84872335358 scopus 로고    scopus 로고
    • Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein
    • Li Y, Chen H, Hardy TM, Tollefsbol TO (2013) Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. PLoS One 8:e54369. doi: 10.1371/journal.pone.0054369
    • (2013) Plos One , vol.8 , pp. e54369
    • Li, Y.1    Chen, H.2    Hardy, T.M.3    Tollefsbol, T.O.4
  • 91
    • 84871294130 scopus 로고    scopus 로고
    • Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation
    • Montenegro MF, Sáez-Ayala M, Piñero- Madrona A, Cabezas-Herrera J, Rodríguez- López JN (2012) Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation. PLoS One 7:e52231. doi: 10.1371/journal.pone.0052231
    • (2012) Plos One , vol.7 , pp. e52231
    • Montenegro, M.F.1    Sáez-Ayala, M.2    Piñero- Madrona, A.3    Cabezas-Herrera, J.4    Rodríguez- López, J.N.5
  • 92
    • 84867841981 scopus 로고    scopus 로고
    • MicroRNAs in breast cancer initiation and progression
    • Liu H (2012) MicroRNAs in breast cancer initiation and progression. Cell Mol Life Sci 69:3587–3599. doi: 10.1007/s00018-012-1128-9
    • (2012) Cell Mol Life Sci , vol.69 , pp. 3587-3599
    • Liu, H.1
  • 94
    • 80052768726 scopus 로고    scopus 로고
    • Suppression of breast tumor growth and metastasis by an engineered transcription factor
    • Beltran AS, Russo A, Lara H, Fan C, Lizardi PM, Blancafort P (2011) Suppression of breast tumor growth and metastasis by an engineered transcription factor. PLoS ONE 6:e24595. doi: 10.1371/journal.pone.0024595
    • (2011) Plos ONE , vol.6 , pp. e24595
    • Beltran, A.S.1    Russo, A.2    Lara, H.3    Fan, C.4    Lizardi, P.M.5    Blancafort, P.6
  • 95
    • 84860992007 scopus 로고    scopus 로고
    • Choosing the right cell line for breast cancer research
    • Holliday DL, Speirs V (2011) Choosing the right cell line for breast cancer research. Breast Cancer Res 13:215. doi: 10.1186/bcr2889
    • (2011) Breast Cancer Res , vol.13 , pp. 215
    • Holliday, D.L.1    Speirs, V.2
  • 97
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (And more) treatments for cancer
    • Minucci S, Pelicci PG (2006) Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6:38–51. doi: 10.1038/nrc1779
    • (2006) Nat Rev Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 98
    • 84921807604 scopus 로고    scopus 로고
    • NCT 00788931. A trial l of panobinostat given in combination with trastuzumab and paclitaxel in adult female patients with HER2 positive metastatic breast cancer
    • Novartis Pharmaceuticals (2008) NCT 00788931. A trial l of panobinostat given in combination with trastuzumab and paclitaxel in adult female patients with HER2 positive metastatic breast cancer. https://clinicaltrials.gov
    • (2008)
    • Pharmaceuticals, N.1
  • 99
    • 84921811825 scopus 로고    scopus 로고
    • NCT 00632489. LBH589 in combination with capecitabine plus/minus (±) lapatinib in breast cancer patients
    • Burris HA (2008) NCT 00632489. LBH589 in combination with capecitabine plus/minus (±) lapatinib in breast cancer patients. https://clinicaltrials.gov
    • (2008)
    • Burris, H.A.1
  • 100
    • 84921768163 scopus 로고    scopus 로고
    • NCT 01105312. Panobinostat and letrozole in treating patients with metastatic breast cancer. In: clinicaltrials.org
    • Tan W (2010) NCT 01105312. Panobinostat and letrozole in treating patients with metastatic breast cancer. In: clinicaltrials.org
    • (2010)
    • Tan, W.1
  • 101
    • 84921821277 scopus 로고    scopus 로고
    • NCT 00567879. A trial of panobinostat and trastuzumab for adult female patients with HER2 positive metastatic breast cancer whose disease has progressed on or after trastuzumab
    • Pharmaceuticals N (2007) NCT 00567879. A trial of panobinostat and trastuzumab for adult female patients with HER2 positive metastatic breast cancer whose disease has progressed on or after trastuzumab. https://clinicaltrials.gov
    • (2007)
    • Pharmaceuticals, N.1
  • 102
    • 84921797237 scopus 로고    scopus 로고
    • NCT 00777049. Study of panobinostat monotherapy in women with HER2 negative locally recurrent or metastatic breast cancer
    • Hurvitz S (2008) NCT 00777049. Study of panobinostat monotherapy in women with HER2 negative locally recurrent or metastatic breast cancer. https://clinicaltrials.gov
    • (2008)
    • Hurvitz, S.1
  • 103
    • 84921726352 scopus 로고    scopus 로고
    • NCT 00993642. ERB-B4 after treatment with HDAC inhibitor in ER + tamoxifen refractory breast cancer
    • Collins-Burow B (2009) NCT 00993642. ERB-B4 after treatment with HDAC inhibitor in ER + tamoxifen refractory breast cancer. https://clinicaltrials.gov
    • (2009)
    • Collins-Burow, B.1
  • 104
    • 84921755780 scopus 로고    scopus 로고
    • NCT 00020579. MS-275 in treating patients with advanced solid tumors or lymphoma
    • Kummar S (2001) NCT 00020579. MS-275 in treating patients with advanced solid tumors or lymphoma. https://clinicaltrials.gov
    • (2001)
    • Kummar, S.1
  • 105
    • 84921774784 scopus 로고    scopus 로고
    • NCT 01434303. Entinostat, lapatinib ditosylate and trastuzumab in patients with locally recurrent or distant relapsed metastatic breast cancer previously treated with trastuzumab only
    • Ueno N (2011) NCT 01434303. Entinostat, lapatinib ditosylate and trastuzumab in patients with locally recurrent or distant relapsed metastatic breast cancer previously treated with trastuzumab only. https://clinicaltrials.gov
    • (2011)
    • Ueno, N.1
  • 106
    • 84921756704 scopus 로고    scopus 로고
    • NCT 01594398. Study to assess food effect on pharmacokinetics of entinostat in subjects with breast cancer or non-small cell lung cancer (ENCORE110)
    • McCulloch W (2012) NCT 01594398. Study to assess food effect on pharmacokinetics of entinostat in subjects with breast cancer or non-small cell lung cancer (ENCORE110). https://clinicaltrials.gov
    • (2012)
    • McCulloch, W.1
  • 107
    • 84921768087 scopus 로고    scopus 로고
    • NCT 00676663. Study to evaluate exemestane with and without SNDX- 275 in treatment of postmenopausal women with advanced breast cancer (ENCORE301)
    • Yardley D (2008) NCT 00676663. Study to evaluate exemestane with and without SNDX- 275 in treatment of postmenopausal women with advanced breast cancer (ENCORE301). https://clinicaltrials.gov
    • (2008)
    • Yardley, D.1
  • 108
    • 84921746795 scopus 로고    scopus 로고
    • NCT 00828854. A phase 2, multicenter study of the effect of the addition of SNDX-275 to continued aromatase inhibitor (AI) therapy in postmenopausal women With ER + breast cancer whose disease is progressing
    • Pharmaceuticals S (2009) NCT 00828854. A phase 2, multicenter study of the effect of the addition of SNDX-275 to continued aromatase inhibitor (AI) therapy in postmenopausal women With ER + breast cancer whose disease is progressing. https://clinicaltrials.gov
    • (2009)
    • Pharmaceuticals, S.1
  • 109
    • 84921767900 scopus 로고    scopus 로고
    • NCT 01234532. Entinostat and anastrozole in treating postmenopausal women with triple-negative breast cancer that can be removed by surgery
    • Chumsri S (2010) NCT 01234532. Entinostat and anastrozole in treating postmenopausal women with triple-negative breast cancer that can be removed by surgery. https://clinicaltrials.gov
    • (2010)
    • Chumsri, S.1
  • 110
    • 84921756895 scopus 로고    scopus 로고
    • NCT 01720602. Vorinostat in treating patients with stage IV breast cancer receiving hormone therapy
    • Linden H (2012) NCT 01720602. Vorinostat in treating patients with stage IV breast cancer receiving hormone therapy. https://clinicaltrials. gov
    • (2012)
    • Linden, H.1
  • 111
    • 84921735615 scopus 로고    scopus 로고
    • NCT 01153672. Vorinostat in treating patients with stage IV breast cancer receiving aromatase inhibitor therapy
    • Linden H (2010) NCT 01153672. Vorinostat in treating patients with stage IV breast cancer receiving aromatase inhibitor therapy. https://clinicaltrials.gov
    • (2010)
    • Linden, H.1
  • 112
    • 84921746892 scopus 로고    scopus 로고
    • NCT 01084057. Ixabepilone and vorinostat in treating patients with metastatic breast cancer
    • Luu T (2010) NCT 01084057. Ixabepilone and vorinostat in treating patients with metastatic breast cancer. https://clinicaltrials.gov
    • (2010)
    • Luu, T.1
  • 113
    • 84921809065 scopus 로고    scopus 로고
    • NCT00788112. orinostat in treating women with ductal carcinoma in situ of the breast
    • Esserman L (2008) NCT00788112. orinostat in treating women with ductal carcinoma in situ of the breast. https://clinicaltrials.gov
    • (2008)
    • Esserman, L.1
  • 114
    • 84921786373 scopus 로고    scopus 로고
    • NCT 00368875. Vorinostat, paclitaxel, and bevacizumab in treating patients with metastatic breast cancer and/or breast cancer that has recurred in the chest wall and cannot be removed by surgery
    • Sparano J (2006) NCT 00368875. Vorinostat, paclitaxel, and bevacizumab in treating patients with metastatic breast cancer and/or breast cancer that has recurred in the chest wall and cannot be removed by surgery. https://clinicaltrials.gov
    • (2006)
    • Sparano, J.1
  • 115
    • 84921734935 scopus 로고    scopus 로고
    • NCT 00258349. Vorinostat and trastuzumab in treating patients with metastatic or locally recurrent breast cancer
    • Swaby R (2005) NCT 00258349. Vorinostat and trastuzumab in treating patients with metastatic or locally recurrent breast cancer. https://clinicaltrials.gov
    • (2005)
    • Swaby, R.1
  • 116
    • 84921747826 scopus 로고    scopus 로고
    • NCT 00262834. Vorinostat in treating women who are undergoing surgery for newly diagnosed stage I, stage II, or stage III breast cancer
    • Stearns V (2005) NCT 00262834. Vorinostat in treating women who are undergoing surgery for newly diagnosed stage I, stage II, or stage III breast cancer. https://clinicaltrials.gov
    • (2005)
    • Stearns, V.1
  • 117
    • 84921814753 scopus 로고    scopus 로고
    • NCT 00616967. Carboplatin and paclitaxel albumin-stabilized nanoparticle formulation with or without vorinostat in treating women with breast cancer that can be removed by surgery
    • Stearns V (2008) NCT 00616967. Carboplatin and paclitaxel albumin-stabilized nanoparticle formulation with or without vorinostat in treating women with breast cancer that can be removed by surgery. https://clinicaltrials.gov
    • (2008)
    • Stearns, V.1
  • 118
    • 84921712943 scopus 로고    scopus 로고
    • NCT 00132002. Suberoylanilide hydroxamic acid in treating patients with progressive stage IV breast cancer
    • Luu T (2005) NCT 00132002. Suberoylanilide hydroxamic acid in treating patients with progressive stage IV breast cancer. https://clinicaltrials.gov
    • (2005)
    • Luu, T.1
  • 119
    • 84921767715 scopus 로고    scopus 로고
    • NCT 00365599. Phase II trial of SAHA & tamoxifen for patients with breast cancer
    • Minton S (2006) NCT 00365599. Phase II trial of SAHA & tamoxifen for patients with breast cancer. https://clinicaltrials.gov
    • (2006)
    • Minton, S.1
  • 120
    • 84921769899 scopus 로고    scopus 로고
    • NCT 01118975. Vorinostat and lapatinib in advanced solid tumors and advanced breast cancer to evaluate response and biomarkers
    • Chumsri S (2010) NCT 01118975. Vorinostat and lapatinib in advanced solid tumors and advanced breast cancer to evaluate response and biomarkers. https://clinicaltrials.gov
    • (2010)
    • Chumsri, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.