메뉴 건너뛰기




Volumn 4, Issue 3, 2013, Pages

Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells

Author keywords

Breast cancer; Entinostat; ErbB2; ErbB3; HDAC; MiRNA

Indexed keywords

ENTINOSTAT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; MESSENGER RNA; MICRORNA; MICRORNA 125A; MICRORNA 125B; MICRORNA 205; PANOBINOSTAT; UNCLASSIFIED DRUG; VORINOSTAT; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; ERBB2 PROTEIN, HUMAN; ERBB3 PROTEIN, HUMAN; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; INDOLE DERIVATIVE; MIRN125 MICRORNA, HUMAN; MIRN205 MICRORNA, HUMAN; PYRIDINE DERIVATIVE;

EID: 84875886681     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.79     Document Type: Article
Times cited : (115)

References (60)
  • 1
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: Revisiting erbb2 and discovering erbb3
    • Baselga J, Swain SM. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer 2009; 9: 463-475.
    • (2009) Nat Rev Cancer , vol.9 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 2
    • 63749086305 scopus 로고    scopus 로고
    • Erbb receptors and signaling pathways in cancer
    • Hynes NE, MacDonald G. ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 2009; 21: 177-184.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 177-184
    • Hynes, N.E.1    MacDonald, G.2
  • 3
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the her-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 5
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab - Mechanism of action and use in clinical practice
    • Hudis CA. Trastuzumab - mechanism of action and use in clinical practice. N Engl J Med 2007; 357: 39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 6
    • 34249672864 scopus 로고    scopus 로고
    • Trastuzumab: Triumphs and tribulations
    • Nahta R, Esteva FJ. Trastuzumab: triumphs and tribulations. Oncogene 2007; 26: 3637-3643.
    • (2007) Oncogene , vol.26 , pp. 3637-3643
    • Nahta, R.1    Esteva, F.J.2
  • 7
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to her2-targeted therapy in human breast cancer
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006; 3: 269-280.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 8
    • 0042307325 scopus 로고    scopus 로고
    • The erbb2/erbb3 heterodimer functions as an oncogenic unit: Erbb2 requires erbb3 to drive breast tumor cell proliferation
    • Holbro T, Beerli RR, Maurer F, Koziczak M, Barbas 3rd CF, Hynes NE. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci USA 2003; 100: 8933-8938.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3    Koziczak, M.4    Barbas III, C.F.5    Hynes, N.E.6
  • 9
    • 48649092620 scopus 로고    scopus 로고
    • A central role for her3 in her2-amplified breast cancer: Implications for targeted therapy
    • Lee-Hoeflich ST, Crocker L, Yao E, Pham T, Munroe X, Hoeflich KP et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res 2008; 68: 5878-5887.
    • (2008) Cancer Res , vol.68 , pp. 5878-5887
    • Lee-Hoeflich, S.T.1    Crocker, L.2    Yao, E.3    Pham, T.4    Munroe, X.5    Hoeflich, K.P.6
  • 10
    • 0034045040 scopus 로고    scopus 로고
    • Histone deacetylases, transcriptional control, and cancer
    • Cress WD, Seto E. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 2000; 184: 1-16.
    • (2000) J Cell Physiol , vol.184 , pp. 1-16
    • Cress, W.D.1    Seto, E.2
  • 11
    • 0034252183 scopus 로고    scopus 로고
    • Histone acetylation modifiers in the pathogenesis of malignant disease
    • Mahlknecht U, Hoelzer D. Histone acetylation modifiers in the pathogenesis of malignant disease. Mol Med 2000; 6: 623-644.
    • (2000) Mol Med , vol.6 , pp. 623-644
    • Mahlknecht, U.1    Hoelzer, D.2
  • 12
  • 13
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006; 6: 38-51.
    • (2006) Nat Rev Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 14
    • 41149141516 scopus 로고    scopus 로고
    • Histone deacetylases: Target enzymes for cancer therapy
    • Mottet D, Castronovo V. Histone deacetylases: target enzymes for cancer therapy. Clin Exp Metastasis 2008; 25: 183-189.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 183-189
    • Mottet, D.1    Castronovo, V.2
  • 15
    • 34547924046 scopus 로고    scopus 로고
    • Hats and hdacs: From structure, function and regulation to novel strategies for therapy and prevention
    • Yang XJ, Seto E. HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene 2007; 26: 5310-5318.
    • (2007) Oncogene , vol.26 , pp. 5310-5318
    • Yang, X.J.1    Seto, E.2
  • 16
    • 80052703387 scopus 로고    scopus 로고
    • Entinostat for treatment of solid tumors and hematologic malignancies
    • Knipstein J, Gore L. Entinostat for treatment of solid tumors and hematologic malignancies. Expert Opin Investig Drugs 2011; 20: 1455-1467.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 1455-1467
    • Knipstein, J.1    Gore, L.2
  • 17
    • 0035113602 scopus 로고    scopus 로고
    • Ms-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type ii receptor expression in human breast cancer cells
    • Lee BI, Park SH, Kim JW, Sausville EA, Kim HT, Nakanishi O et al. MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells. Cancer Res 2001; 61: 931-934.
    • (2001) Cancer Res , vol.61 , pp. 931-934
    • Lee, B.I.1    Park, S.H.2    Kim, J.W.3    Sausville, E.A.4    Kim, H.T.5    Nakanishi, O.6
  • 18
    • 0037085474 scopus 로고    scopus 로고
    • Transcriptional regulation of the transforming growth factor beta type ii receptor gene by histone acetyltransferase and deacetylase is mediated by nf-y in human breast cancer cells
    • Park SH, Lee SR, Kim BC, Cho EA, Patel SP, Kang HB et al. Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. J Biol Chem 2002; 277: 5168-5174.
    • (2002) J Biol Chem , vol.277 , pp. 5168-5174
    • Park, S.H.1    Lee, S.R.2    Kim, B.C.3    Cho, E.A.4    Patel, S.P.5    Kang, H.B.6
  • 19
    • 22744437647 scopus 로고    scopus 로고
    • Hdac inhibitors enhance the apoptosis-inducing potential of trail in breast carcinoma
    • Singh TR, Shankar S, Srivastava RK. HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma. Oncogene 2005; 24: 4609-4623.
    • (2005) Oncogene , vol.24 , pp. 4609-4623
    • Singh, T.R.1    Shankar, S.2    Srivastava, R.K.3
  • 20
    • 53049107304 scopus 로고    scopus 로고
    • Sp1-mediated trail induction in chemosensitization
    • Xu J, Zhou JY, Wei WZ, Philipsen S, Wu GS. Sp1-mediated TRAIL induction in chemosensitization. Cancer Res 2008; 68: 6718-6726.
    • (2008) Cancer Res , vol.68 , pp. 6718-6726
    • Xu, J.1    Zhou, J.Y.2    Wei, W.Z.3    Philipsen, S.4    Wu, G.S.5
  • 21
    • 51049117752 scopus 로고    scopus 로고
    • Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of dna methyltransferase 1 in human breast cancer cells
    • Zhou Q, Agoston AT, Atadja P, Nelson WG, Davidson NE. Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells. Mol Cancer Res 2008; 6: 873-883.
    • (2008) Mol Cancer Res , vol.6 , pp. 873-883
    • Zhou, Q.1    Agoston, A.T.2    Atadja, P.3    Nelson, W.G.4    Davidson, N.E.5
  • 23
    • 79952237710 scopus 로고    scopus 로고
    • Functional activation of the estrogen receptor-alpha and aromatase by the hdac inhibitor entinostat sensitizes er-negative tumors to letrozole
    • Sabnis GJ, Goloubeva O, Chumsri S, Nguyen N, Sukumar S, Brodie AM. Functional activation of the estrogen receptor-alpha and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole. Cancer Res 2011; 71: 1893-1903.
    • (2011) Cancer Res , vol.71 , pp. 1893-1903
    • Sabnis, G.J.1    Goloubeva, O.2    Chumsri, S.3    Nguyen, N.4    Sukumar, S.5    Brodie, A.M.6
  • 24
    • 70350540711 scopus 로고    scopus 로고
    • Hdac inhibitor sndx-275 induces apoptosis in erbb2-overexpressing breast cancer cells via down-regulation of erbb3 expression
    • Huang X, Gao L, Wang S, Lee CK, Ordentlich P, Liu B. HDAC inhibitor SNDX-275 induces apoptosis in erbB2-overexpressing breast cancer cells via down-regulation of erbB3 expression. Cancer Res 2009; 69: 8403-8411.
    • (2009) Cancer Res , vol.69 , pp. 8403-8411
    • Huang, X.1    Gao, L.2    Wang, S.3    Lee, C.K.4    Ordentlich, P.5    Liu, B.6
  • 25
    • 79957514394 scopus 로고    scopus 로고
    • Hdac inhibitor sndx-275 enhances efficacy of trastuzumab in erbb2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance
    • Huang X, Wang S, Lee CK, Yang X, Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Lett 2011; 307: 72-79.
    • (2011) Cancer Lett , vol.307 , pp. 72-79
    • Huang, X.1    Wang, S.2    Lee, C.K.3    Yang, X.4    Liu, B.5
  • 26
    • 58249088751 scopus 로고    scopus 로고
    • Micrornas: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 27
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: Microrna biogenesis pathways and their regulation
    • Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 2009; 11: 228-234.
    • (2009) Nat Cell Biol , vol.11 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 28
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - Micrornas with a role in cancer
    • Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6: 259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 29
    • 57749086300 scopus 로고    scopus 로고
    • Micrornas and cancer: Past, present, and potential future
    • Nelson KM, Weiss GJ. MicroRNAs and cancer: past, present, and potential future. Mol Cancer Ther 2008; 7: 3655-3660.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3655-3660
    • Nelson, K.M.1    Weiss, G.J.2
  • 30
    • 33846188098 scopus 로고    scopus 로고
    • Micrornas as oncogenes and tumor suppressors
    • Zhang B, Pan X, Cobb GP, Anderson TA. microRNAs as oncogenes and tumor suppressors. Dev Biol 2007; 302: 1-12.
    • (2007) Dev Biol , vol.302 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3    Anderson, T.A.4
  • 33
    • 38749137007 scopus 로고    scopus 로고
    • Microrna epigenetic alterations in human cancer: One step forward in diagnosis and treatment
    • Yang N, Coukos G, Zhang L. MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment. Int J Cancer 2008; 122: 963-968.
    • (2008) Int J Cancer , vol.122 , pp. 963-968
    • Yang, N.1    Coukos, G.2    Zhang, L.3
  • 34
    • 44349124725 scopus 로고    scopus 로고
    • Genomic and epigenetic alterations deregulate microrna expression in human epithelial ovarian cancer
    • Zhang L, Volinia S, Bonome T, Calin GA, Greshock J, Yang N et al. Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci USA 2008; 105: 7004-7009.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7004-7009
    • Zhang, L.1    Volinia, S.2    Bonome, T.3    Calin, G.A.4    Greshock, J.5    Yang, N.6
  • 35
    • 32944462300 scopus 로고    scopus 로고
    • Rapid alteration of microrna levels by histone deacetylase inhibition
    • Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res 2006; 66: 1277-1281.
    • (2006) Cancer Res , vol.66 , pp. 1277-1281
    • Scott, G.K.1    Mattie, M.D.2    Berger, C.E.3    Benz, S.C.4    Benz, C.C.5
  • 36
    • 0029830451 scopus 로고    scopus 로고
    • Overexpression of c-erbb-2/neu in breast cancer cells confers increased resistance to taxol via mdr-1-independent mechanisms
    • Yu D, Liu B, Tan M, Li J, Wang SS, Hung MC. Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms. Oncogene 1996; 13: 1359-1365.
    • (1996) Oncogene , vol.13 , pp. 1359-1365
    • Yu, D.1    Liu, B.2    Tan, M.3    Li, J.4    Wang, S.S.5    Hung, M.C.6
  • 37
    • 84874601302 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors restore cell surface expression of the coxsackie adenovirus receptor and enhance cmv promoter activity in castration-resistant prostate cancer cells
    • Kasman L, Onicescu G, Voelkel-Johnson C. Histone deacetylase inhibitors restore cell surface expression of the coxsackie adenovirus receptor and enhance CMV promoter activity in castration-resistant prostate cancer cells. Prostate Cancer 2012; 2012: 137163.
    • (2012) Prostate Cancer , vol.2012 , pp. 137163
    • Kasman, L.1    Onicescu, G.2    Voelkel-Johnson, C.3
  • 38
    • 76749161754 scopus 로고    scopus 로고
    • An hdac inhibitor enhances the antitumor activity of a cmv promoter-driven dna vaccine
    • Lai MD, Chen CS, Yang CR, Yuan SY, Tsai JJ, Tu CF et al. An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine. Cancer Gene Ther 2010; 17: 203-211.
    • (2010) Cancer Gene Ther , vol.17 , pp. 203-211
    • Lai, M.D.1    Chen, C.S.2    Yang, C.R.3    Yuan, S.Y.4    Tsai, J.J.5    Tu, C.F.6
  • 39
    • 67651048598 scopus 로고    scopus 로고
    • Histone acetylation characterizes chromatin presetting by nf1 and oct1 and enhances glucocorticoid receptor binding to the mmtv promoter
    • Astrand C, Belikov S, Wrange O. Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter. Exp Cell Res 2009; 315: 2604-2615.
    • (2009) Exp Cell Res , vol.315 , pp. 2604-2615
    • Astrand, C.1    Belikov, S.2    Wrange, O.3
  • 40
    • 0042567276 scopus 로고    scopus 로고
    • Inhibition of mmtv transcription by hdac inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation
    • Mulholland NM, Soeth E, Smith CL. Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation. Oncogene 2003; 22: 4807-4818.
    • (2003) Oncogene , vol.22 , pp. 4807-4818
    • Mulholland, N.M.1    Soeth, E.2    Smith, C.L.3
  • 41
    • 0029785841 scopus 로고    scopus 로고
    • Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure
    • Bartsch J, Truss M, Bode J, Beato M. Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure. Proc Natl Acad Sci USA 1996; 93: 10741-10746.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10741-10746
    • Bartsch, J.1    Truss, M.2    Bode, J.3    Beato, M.4
  • 42
    • 33847738628 scopus 로고    scopus 로고
    • Coordinate suppression of erbb2 and erbb3 by enforced expression of micro-rna mir-125a or mir-125b
    • Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem 2007; 282: 1479-1486.
    • (2007) J Biol Chem , vol.282 , pp. 1479-1486
    • Scott, G.K.1    Goga, A.2    Bhaumik, D.3    Berger, C.E.4    Sullivan, C.S.5    Benz, C.C.6
  • 43
    • 65549115615 scopus 로고    scopus 로고
    • Mir-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase cepsilon
    • Gandellini P, Folini M, Longoni N, Pennati M, Binda M, Colecchia M et al. miR-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res 2009; 69: 2287-2295.
    • (2009) Cancer Res , vol.69 , pp. 2287-2295
    • Gandellini, P.1    Folini, M.2    Longoni, N.3    Pennati, M.4    Binda, M.5    Colecchia, M.6
  • 45
    • 64149089915 scopus 로고    scopus 로고
    • Suppression of cell growth and invasion by mir-205 in breast cancer
    • Wu H, Zhu S, Mo YY. Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res 2009; 19: 439-448.
    • (2009) Cell Res , vol.19 , pp. 439-448
    • Wu, H.1    Zhu, S.2    Mo, Y.Y.3
  • 46
    • 72449132936 scopus 로고    scopus 로고
    • A short hairpin dna analogous to mir- 125b inhibits c-raf expression, proliferation, and survival of breast cancer cells
    • Hofmann MH, Heinrich J, Radziwill G, Moelling K. A short hairpin DNA analogous to miR- 125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. Mol Cancer Res 2009; 7: 1635-1644.
    • (2009) Mol Cancer Res , vol.7 , pp. 1635-1644
    • Hofmann, M.H.1    Heinrich, J.2    Radziwill, G.3    Moelling, K.4
  • 47
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Overview and perspectives
    • Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res 2007; 5: 981-989.
    • (2007) Mol Cancer Res , vol.5 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 48
    • 0026472124 scopus 로고
    • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    • Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD, Muller WJ. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA 1992; 89: 10578-10582.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10578-10582
    • Guy, C.T.1    Webster, M.A.2    Schaller, M.3    Parsons, T.J.4    Cardiff, R.D.5    Muller, W.J.6
  • 49
    • 78649941638 scopus 로고    scopus 로고
    • The mir-17-92 microrna cluster regulates multiple components of the tgf-beta pathway in neuroblastoma
    • Mestdagh P, Bostrom AK, Impens F, Fredlund E, Van Peer G, De Antonellis P et al. The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma. Mol Cell 2010; 40: 762-773.
    • (2010) Mol Cell , vol.40 , pp. 762-773
    • Mestdagh, P.1    Bostrom, A.K.2    Impens, F.3    Fredlund, E.4    Van Peer, G.5    De Antonellis, P.6
  • 50
    • 77951092028 scopus 로고    scopus 로고
    • Multiple micrornas modulate p21cip1/waf1 expression by directly targeting its 30 untranslated region
    • Wu S, Huang S, Ding J, Zhao Y, Liang L, Liu T et al. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 30 untranslated region. Oncogene 2010; 29: 2302-2308.
    • (2010) Oncogene , vol.29 , pp. 2302-2308
    • Wu, S.1    Huang, S.2    Ding, J.3    Zhao, Y.4    Liang, L.5    Liu, T.6
  • 51
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of erbb-2 and erbb-3
    • Citri A, Skaria KB, Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 2003; 284: 54-65.
    • (2003) Exp Cell Res , vol.284 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 52
    • 77952338791 scopus 로고    scopus 로고
    • Erbb3/her3 intracellular domain is competent to bind atp and catalyze autophosphorylation
    • Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc Natl Acad Sci USA 2010; 107: 7692-7697.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7692-7697
    • Shi, F.1    Telesco, S.E.2    Liu, Y.3    Radhakrishnan, R.4    Lemmon, M.A.5
  • 53
    • 77950216941 scopus 로고    scopus 로고
    • An erbb3 antibody, mm-121, is active in cancers with ligand-dependent activation
    • Schoeberl B, Faber AC, Li D, Liang MC, Crosby K, Onsum M et al. An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation. Cancer Res 2010; 70: 2485-2494.
    • (2010) Cancer Res , vol.70 , pp. 2485-2494
    • Schoeberl, B.1    Faber, A.C.2    Li, D.3    Liang, M.C.4    Crosby, K.5    Onsum, M.6
  • 54
    • 69849115198 scopus 로고    scopus 로고
    • Therapeutically targeting erbb3: A key node in ligand-induced activation of the erbb receptor-pi3k axis
    • Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L et al. Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis. Sci Signal 2009; 2: ra31.
    • (2009) Sci Signal , vol.2
    • Schoeberl, B.1    Pace, E.A.2    Fitzgerald, J.B.3    Harms, B.D.4    Xu, L.5    Nie, L.6
  • 56
    • 33947202858 scopus 로고    scopus 로고
    • Downregulation of erbb3 abrogates erbb2-mediated tamoxifen resistance in breast cancer cells
    • Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X, Thor AD. Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells. Int J Cancer 2007; 120: 1874-1882.
    • (2007) Int J Cancer , vol.120 , pp. 1874-1882
    • Liu, B.1    Ordonez-Ercan, D.2    Fan, Z.3    Edgerton, S.M.4    Yang, X.5    Thor, A.D.6
  • 57
    • 77954958218 scopus 로고    scopus 로고
    • Elevated expression of erbb3 confers paclitaxel resistance in erbb2-overexpressing breast cancer cells via upregulation of survivin
    • Wang S, Huang X, Lee CK, Liu B. Elevated expression of erbB3 confers paclitaxel resistance in erbB2-overexpressing breast cancer cells via upregulation of Survivin. Oncogene 2010; 29: 4225-4236.
    • (2010) Oncogene , vol.29 , pp. 4225-4236
    • Wang, S.1    Huang, X.2    Lee, C.K.3    Liu, B.4
  • 59
    • 77149135270 scopus 로고    scopus 로고
    • Breast cancer epigenetics: From dna methylation to micrornas
    • Veeck J, Esteller M. Breast cancer epigenetics: from DNA methylation to microRNAs. J Mammary Gland Biol Neoplasia 2010; 15: 5-17.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 5-17
    • Veeck, J.1    Esteller, M.2
  • 60
    • 72449149796 scopus 로고    scopus 로고
    • Estrogenic promotion of erbb2 tyrosine kinase activity in mammary tumor cells requires activation of erbb3 signaling
    • Liu B, Ordonez-Ercan D, Fan Z, Huang X, Edgerton SM, Yang X et al. Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling. Mol Cancer Res 2009; 7: 1882-1892.
    • (2009) Mol Cancer Res , vol.7 , pp. 1882-1892
    • Liu, B.1    Ordonez-Ercan, D.2    Fan, Z.3    Huang, X.4    Edgerton, S.M.5    Yang, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.