Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents

Molecular and Cellular Biochemistry

Volumn 342, Issue 1-2, 2010, Pages 101-109

  Mirza, Sameer ^a   Sharma, Gayatri ^a,b   Pandya, Pranav ^b   Ralhan, Ranju ^a,c,d  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b Dev Sanskriti Vishwa Vidhyalaya ^*  (India)

^c UNIVERSITY OF TORONTO   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

5 Aza 2 deoxycytidine; Anticancer agents; Breast carcinoma; Chemosensitivity; Demethylating agent

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE; DOXORUBICIN; FLUOROURACIL; PACLITAXEL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL STRAIN MCF 7; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; DNA METHYLATION; DRUG EFFICACY; DRUG POTENTIATION; FLOW MEASUREMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AZACITIDINE; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; DNA METHYLATION; DNA MODIFICATION METHYLASES; DOXORUBICIN; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PACLITAXEL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 77955853899     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0473-y     Document Type: Article

References (21)

1. M Esteller 2008 Epigenetics in cancer N Engl J Med 358 11 1148 1159 10.1056/NEJMra072067 1:CAS:528:DC%2BD1cXjt1ahs7Y%3D 18337604 (Pubitemid 351398489)
2. RL Momparler 2005 Pharmacology of 5-aza-2′-deoxycytidine (decitabine) Semin Hematol 42 3 Suppl 2 S9 S16 10.1053/j.seminhematol.2005.05. 002 1:CAS:528:DC%2BD2MXpsFekt7c%3D 16015507 (Pubitemid 40961867)
3. M Lubbert M Daskalakis R Kunzmann M Engelhardt Y Guo P Wijermans 2004 Nonclonal neutrophil responses after successful treatment of myelodysplasia with low-dose 5-aza-2′-deoxycytidine (decitabine) Leuk Res 28 12 1267 1271 10.1016/j.leukres.2004.04.002 1:CAS:528:DC%2BD2cXotlSmtLY%3D 15475067 (Pubitemid 39314406)
4. X Zhang M Yashiro M Ohira J Ren K Hirakawa 2006 Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma Cancer Sci 97 9 938 944 10.1111/j.1349-7006.2006.00253.x 1:CAS:528:DC%2BD28XpsFelsbo%3D 16805821 (Pubitemid 44151277)
5. A Hurtubise RL Momparler 2004 Evaluation of antineoplastic action of 5-aza-2′-deoxycytidine (Dacogen) and docetaxel (Taxotere) on human breast, lung and prostate carcinoma cell lines Anticancer Drugs 15 2 161 167 10.1097/00001813-200402000-00010 1:CAS:528:DC%2BD2cXivFakt70%3D 15075673
6. A Jemal R Siegel E Ward Y Hao J Xu T Murray MJ Thun 2008 Cancer statistics CA Cancer J Clin 58 2 71 96 10.3322/CA.2007.0010 18287387 (Pubitemid 351521864)
7. V Guarneri PF Conte 2004 The curability of breast cancer and the treatment of advanced disease Eur J Nucl Med Mol Imaging 31 S149 S161 10.1007/s00259-004-1538-5 15107948
8. C Balch JS Montgomery HI Paik S Kim S Kim TH Huang KP Nephew 2005 New anti-cancer strategies: epigenetic therapies and biomarkers Front Biosci 10 1897 1931 10.2741/1668 1:CAS:528:DC%2BD2MXivVygsb0%3D 15769674
9. B Drewinko TL Loo B Brown JA Gottlieb EJ Freireich 1976 Combination chemotherapy in vitro with adriamycin. Observations of additive, antagonistic, and synergistic effects when used in two-drug combinations on cultured human lymphoma cells Cancer Biochem Biophys 1 4 187 195 1:CAS:528:DyaE28XkvVOitLs%3D 975020
10. AK Virmani A Rathi S Zochbauer-Muller N Sacchi Y Fukuyama D Bryant A Maitra, et al. 2000 Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas J Natl Cancer Inst 92 16 1303 1307 10.1093/jnci/92.16.1303 1:CAS:528:DC%2BD3cXmtlektrw%3D 10944551
11. A Dallol NF Da Silva P Viacava JD Minna I Bieche ER Mahe F Latif 2002 SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers Cancer Res 62 20 5874 5880 1:CAS:528:DC%2BD38XotFykt7Y%3D 12384551
12. ML Gonzalgo CP Pavlovich SM Lee WG Nelson 2003 Prostate cancer detection by GSTP1 methylation analysis of post biopsy urine specimens Clin Cancer Res 9 7 2673 2677 1:CAS:528:DC%2BD3sXlt1yrs7o%3D 12855646
13. E Evron CB Umbricht D Korz V Raman DM Loeb B Niranjan L Buluwela, et al. 2001 Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation Cancer Res 61 6 2782 2787 1:CAS:528:DC%2BD3MXisVSktr4%3D 11289162
14. J Qi YQ Zhu MF Huang D Yang 2005 Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor World J Gastroenterol 11 13 2022 2025 1:CAS:528:DC%2BD2MXktFyqsro%3D 15800999
15. Y Gomyo J Sasaki C Branch JA Roth T Mukhopadhyay 2004 5-Aza-2′-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells Oncogene 23 40 6779 6787 10.1038/sj.onc.1207381 1:CAS:528:DC%2BD2cXntFGnurw%3D 15273730 (Pubitemid 39280009)
16. R Kaminski K Kozar J Niderla T Grzela G Wilczynski JS Skierski M Koronkiewicz, et al. 2004 Demethylating agent 5-aza-2′-deoxycytidine enhances expression of TNFRI and promotes TNF-mediated apoptosis in vitro and in vivo Oncol Rep 12 3 509 516 1:CAS:528:DC%2BD2cXnt1entrs%3D 15289829
17. A Hurtubise RL Momparler 2004 Evaluation of antineoplastic action of 5-aza-2′-deoxycytidine (Dacogen) and docetaxel (Taxotere) on human breast, lung and prostate carcinoma cell lines Anticancer Drugs 15 161 167 10.1097/00001813-200402000-00010 1:CAS:528:DC%2BD2cXivFakt70%3D 15075673
18. T Kanda M Tada F Imazeki O Yokosuka K Nagao H Saisho 2005 5-Aza-2′-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines Oncol Rep 14 4 975 979 16142360
19. JS Kim S Lee T Lee YW Lee JB Trepel 2001 Transcriptional activation of p21WAF1/CIP1 by apicidin, a novel histone deacetylase inhibitor Biochem Biophy Res Comm 281 866 871 10.1006/bbrc.2001.4434 1:CAS:528:DC%2BD3MXhs1Chur0%3D (Pubitemid 32917810)
20. HE Broome CM Dargan S Krajewski JC Reed 1995 Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal J Immunol 155 5 2311 2317 1:CAS:528:DyaK2MXnsFygtbw%3D 7650367
21. ML Agarwal A Agarwal WR Taylor GR Stark 1995 p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts Proc Natl Acad Sci USA 92 18 8493 8497 10.1073/pnas.92.18.8493 1:CAS:528:DyaK2MXnvVylsrs%3D 7667317