Epigenetic modulation of the biophysical properties of drug-resistant cell lipids to restore drug transport and endocytic functions

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2730-2742

  Vijayaraghavalu, Sivakumar ^a   Peetla, Chiranjeevi ^a   Lu, Shan ^a   Labhasetwar, Vinod ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

cancer cell membrane; cancer therapy; drug resistance; epigenetic; membrane rigidity; P glycoprotein; sphingomyelin

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DOXORUBICIN; GLYCOPROTEIN P; LIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

ARTICLE; BIOPHYSICS; BREAST CANCER; CELL MEMBRANE; CELL MEMBRANE FLUIDITY; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG TRANSPORT; ENDOCYTOSIS; ENZYME ACTIVITY; EPIGENETICS; HUMAN; HUMAN CELL; LIPOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; AZACITIDINE; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL MEMBRANE; DNA METHYLATION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, NEOPLASM; ENDOCYTOSIS; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; HUMANS; LIPID METABOLISM; MCF-7 CELLS; P-GLYCOPROTEIN;

EID: 84865988286     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300281t     Document Type: Article

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