Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor α, in response to deacetylase inhibition by valproic acid and trichostatin A

Oncogene

Volumn 24, Issue 31, 2005, Pages 4894-4907

  Reid, George ^a   Métivier, Raphaël ^a,c   Lin, Chin Yo ^b   Denger, Stefanie ^a   Ibberson, David ^a   Ivacevic, Tomi ^a   Brand, Heike ^a   Benes, Vladimir ^a   Liu, Edison T ^b   Gannon, Frank ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Oestrogen signalling; Sirtuin; Transcriptional repression; Trichostatin A; Valproic acid

Indexed keywords

CYCLIN D1; CYCLOHEXIMIDE; ESTROGEN RECEPTOR ALPHA; HISTONE; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; PROTEIN PS2; SIRTUIN; TRANSCRIPTOME; TRICHOSTATIN A; VALPROIC ACID;

ARTICLE; BIPOLAR DISORDER; BREAST CELL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEACETYLATION; DEMETHYLATION; DNA METHYLATION; DOWN REGULATION; ENDOCRINE DISEASE; EPILEPSY; FEMALE; GENE EXPRESSION; GENE NUMBER; HUMAN; MENSTRUATION DISORDER; META ANALYSIS; OBESITY; OSTEOPOROSIS; OVARY CELL; PRIORITY JOURNAL; SILENCER ELEMENT; UPREGULATION; WEIGHT GAIN;

BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA PRIMERS; ENZYME INHIBITORS; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENETIC MARKERS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; KINETICS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; RNA, NEOPLASM; TAMOXIFEN; TRANSCRIPTION, GENETIC; VALPROIC ACID;

EID: 23744495968     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208662     Document Type: Article

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