-
1
-
-
0026531017
-
Tumour necrosis factor alpha in stool as a marker of intestinal inflammation
-
Braegger, C.P., Nicholls, S., Murch, S.H., Stephens, S., &, MacDonald, T.T., Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 339, 89-91 (1992).
-
(1992)
Lancet
, vol.339
, pp. 89-91
-
-
Braegger, C.P.1
Nicholls, S.2
Murch, S.H.3
Stephens, S.4
MacDonald, T.T.5
-
2
-
-
0025333699
-
Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
-
MacDonald, T.T., Hutchings, P., Choy, M.Y., Murch, S., &, Cooke, A., Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin. Exp. Immunol. 81, 301-305 (1990).
-
(1990)
Clin. Exp. Immunol.
, vol.81
, pp. 301-305
-
-
MacDonald, T.T.1
Hutchings, P.2
Choy, M.Y.3
Murch, S.4
Cooke, A.5
-
3
-
-
0027451455
-
Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
-
Reinecker, H.C., et al,. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin. Exp. Immunol. 94, 174-181 (1993).
-
(1993)
Clin. Exp. Immunol.
, vol.94
, pp. 174-181
-
-
Reinecker, H.C.1
-
4
-
-
0025912981
-
Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease
-
Murch, S.H., Lamkin, V.A., Savage, M.O., Walker-Smith, J.A., &, MacDonald, T.T., Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease. Gut 32, 913-917 (1991).
-
(1991)
Gut
, vol.32
, pp. 913-917
-
-
Murch, S.H.1
Lamkin, V.A.2
Savage, M.O.3
Walker-Smith, J.A.4
MacDonald, T.T.5
-
5
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
-
Crohn's Disease cA2 Study Group
-
Targan, S.R., et al,. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N. Engl. J. Med. 337, 1029-1035 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
-
6
-
-
0032833517
-
Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease
-
Rutgeerts, P., et al,. Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology 117, 761-769 (1999).
-
(1999)
Gastroenterology
, vol.117
, pp. 761-769
-
-
Rutgeerts, P.1
-
7
-
-
0032913394
-
Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
-
D'haens, G., et al,. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial. Gastroenterology 116, 1029-1034 (1999).
-
(1999)
Gastroenterology
, vol.116
, pp. 1029-1034
-
-
D'Haens, G.1
-
8
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The ACCENT i randomised trial
-
Hanauer, S.B., et al,. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 359, 1541-1549 (2002).
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
-
9
-
-
20444479336
-
Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebo-controlled study
-
Järnerot, G., et al,. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study. Gastroenterology 128, 1805-1811 (2005).
-
(2005)
Gastroenterology
, vol.128
, pp. 1805-1811
-
-
Järnerot, G.1
-
10
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
Rutgeerts, P., et al,. Infliximab for induction and maintenance therapy for ulcerative colitis. N. Engl. J. Med. 353, 2462-2476 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2462-2476
-
-
Rutgeerts, P.1
-
11
-
-
84855674281
-
Long-term infliximab maintenance therapy for ulcerative colitis: The ACT-1 and-2 extension studies
-
Reinisch, W., et al,. Long-term infliximab maintenance therapy for ulcerative colitis: the ACT-1 and-2 extension studies. Inflamm. Bowel Dis. 18, 201-211 (2012).
-
(2012)
Inflamm. Bowel Dis.
, vol.18
, pp. 201-211
-
-
Reinisch, W.1
-
12
-
-
84921325308
-
Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: A network meta-analysis
-
e5; quiz e14-e15
-
Hazlewood, G.S., et al,. Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis. Gastroenterology 148, 344-354.e5; quiz e14-e15 (2015).
-
(2015)
Gastroenterology
, vol.148
, pp. 344-354
-
-
Hazlewood, G.S.1
-
13
-
-
84922323875
-
Efficacy and safety of tumor necrosis factor-α blockers for ulcerative colitis: A systematic review and meta-analysis of published randomized controlled trials
-
Song, Y.-N., &, Zheng, P., Efficacy and safety of tumor necrosis factor-α blockers for ulcerative colitis: a systematic review and meta-analysis of published randomized controlled trials. J. Food Drug Anal. 23, 1-10 (2015).
-
(2015)
J. Food Drug Anal.
, vol.23
, pp. 1-10
-
-
Song, Y.-N.1
Zheng, P.2
-
14
-
-
84955307057
-
Characteristics of anti-TNF-associated skin lesions in inflammatory bowel disease patients: A cohort study
-
e-pub ahead of print
-
Cleynen, I., et al,. Characteristics of anti-TNF-associated skin lesions in inflammatory bowel disease patients: a cohort study. Ann. Intern. Med. (2015); e-pub ahead of print.
-
(2015)
Ann. Intern. Med.
-
-
Cleynen, I.1
-
15
-
-
84868336049
-
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
-
Jostins, L., et al,. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119-124 (2012).
-
(2012)
Nature
, vol.491
, pp. 119-124
-
-
Jostins, L.1
-
16
-
-
79955563439
-
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
-
Strober, W., &, Fuss, I.J., Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140, 1756-1767 (2011).
-
(2011)
Gastroenterology
, vol.140
, pp. 1756-1767
-
-
Strober, W.1
Fuss, I.J.2
-
17
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn, W.J., et al,. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 135, 1130-1141 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
-
18
-
-
84871701834
-
Ustekinumab induction and maintenance therapy in refractory Crohn's disease
-
Sandborn, W.J., et al,. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N. Engl. J. Med. 367, 1519-1528 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1519-1528
-
-
Sandborn, W.J.1
-
19
-
-
84901433463
-
Profile of ustekinumab and its potential in patients with moderate-to-severe Crohn's disease
-
Tuskey, A., &, Behm, B.W., Profile of ustekinumab and its potential in patients with moderate-to-severe Crohn's disease. Clin. Exp. Gastroenterol. 7, 173-179 (2014).
-
(2014)
Clin. Exp. Gastroenterol.
, vol.7
, pp. 173-179
-
-
Tuskey, A.1
Behm, B.W.2
-
20
-
-
80053935432
-
Ustekinumab in a patient with Crohn's disease and anti-TNF-α-induced psoriasis [in Spanish]
-
Sansõ Sureda, A., Rocamora Durán, V., Sapinã Camarõ, A., Royo Escosa, V., &, Bosque Lõpez, M.J., Ustekinumab in a patient with Crohn's disease and anti-TNF-α-induced psoriasis [in Spanish]. Gastroenterol. Hepatol. 34, 546-550 (2011).
-
(2011)
Gastroenterol. Hepatol.
, vol.34
, pp. 546-550
-
-
Sansõ Sureda, A.1
Rocamora Durán, V.2
Sapinã Camarõ, A.3
Royo Escosa, V.4
Bosque Lõpez, M.J.5
-
21
-
-
84868680312
-
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
Hueber, W., et al,. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61, 1693-1700 (2012).
-
(2012)
Gut
, vol.61
, pp. 1693-1700
-
-
Hueber, W.1
-
22
-
-
33847351136
-
The JAK-STAT signaling pathway: Input and output integration
-
Murray, P.J., The JAK-STAT signaling pathway: input and output integration. J. Immunol. 178, 2623-2629 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 2623-2629
-
-
Murray, P.J.1
-
23
-
-
84882433613
-
Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease
-
Coskun, M., Salem, M., Pedersen, J., &, Nielsen, O.H., Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease. Pharmacol. Res. 76, 1-8 (2013).
-
(2013)
Pharmacol. Res.
, vol.76
, pp. 1-8
-
-
Coskun, M.1
Salem, M.2
Pedersen, J.3
Nielsen, O.H.4
-
24
-
-
79955027327
-
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
-
Ghoreschi, K., et al,. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J. Immunol. 186, 4234-4243 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 4234-4243
-
-
Ghoreschi, K.1
-
26
-
-
84865013186
-
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
-
Sandborn, W.J., et al,. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N. Engl. J. Med. 367, 616-624 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 616-624
-
-
Sandborn, W.J.1
-
27
-
-
84906792069
-
A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease
-
e2
-
Sandborn, W.J., et al,. A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease. Clin. Gastroenterol. Hepatol. 12, 1485-1493.e2 (2014).
-
(2014)
Clin. Gastroenterol. Hepatol.
, vol.12
, pp. 1485-1493
-
-
Sandborn, W.J.1
-
28
-
-
84874267946
-
[OP0263] Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; Results of a phase IIA trial
-
Vanhoutte, F.P., Mazur, M., Namour, F., van der Aa, A., Wigerinck, P., &, van't Klooster, G.A.E., [OP0263] Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIA trial. Ann. Rheum. Dis. 71 (suppl. 3), 145 (2012).
-
(2012)
Ann. Rheum. Dis.
, vol.71
, pp. 145
-
-
Vanhoutte, F.P.1
Mazur, M.2
Namour, F.3
Van Der Aa, A.4
Wigerinck, P.5
Van'T Klooster, G.A.E.6
-
29
-
-
3242698640
-
Iron, anaemia, and inflammatory bowel diseases
-
Gasche, C., Lomer, M.C., Cavill, I., &, Weiss, G., Iron, anaemia, and inflammatory bowel diseases. Gut 53, 1190-1197 (2004).
-
(2004)
Gut
, vol.53
, pp. 1190-1197
-
-
Gasche, C.1
Lomer, M.C.2
Cavill, I.3
Weiss, G.4
-
30
-
-
0026660635
-
Expression of vascular adhesion molecules in inflammatory bowel disease
-
Koizumi, M., King, N., Lobb, R., Benjamin, C., &, Podolsky, D.K., Expression of vascular adhesion molecules in inflammatory bowel disease. Gastroenterology 103, 840-847 (1992).
-
(1992)
Gastroenterology
, vol.103
, pp. 840-847
-
-
Koizumi, M.1
King, N.2
Lobb, R.3
Benjamin, C.4
Podolsky, D.K.5
-
31
-
-
0032733508
-
Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
-
Souza, H.S., Elia, C.C., Spencer, J., &, MacDonald, T.T., Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut 45, 856-863 (1999).
-
(1999)
Gut
, vol.45
, pp. 856-863
-
-
Souza, H.S.1
Elia, C.C.2
Spencer, J.3
MacDonald, T.T.4
-
32
-
-
0027248939
-
Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody
-
Podolsky, D.K., et al,. Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody. J. Clin. Invest. 92, 372-380 (1993).
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 372-380
-
-
Podolsky, D.K.1
-
33
-
-
0029826678
-
Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7
-
Hesterberg, P.E., et al,. Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7. Gastroenterology 111, 1373-1380 (1996).
-
(1996)
Gastroenterology
, vol.111
, pp. 1373-1380
-
-
Hesterberg, P.E.1
-
34
-
-
27644441529
-
Natalizumab induction and maintenance therapy for Crohn's disease
-
Sandborn, W.J., et al,. Natalizumab induction and maintenance therapy for Crohn's disease. N. Engl. J. Med. 353, 1912-1925 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 1912-1925
-
-
Sandborn, W.J.1
-
35
-
-
34247884424
-
Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE trial
-
Targan, S.R., et al,. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE trial. Gastroenterology 132, 1672-1683 (2007).
-
(2007)
Gastroenterology
, vol.132
, pp. 1672-1683
-
-
Targan, S.R.1
-
36
-
-
22844445587
-
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
-
Van Assche, G., et al,. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N. Engl. J. Med. 353, 362-368 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 362-368
-
-
Van Assche, G.1
-
37
-
-
84861022041
-
Risk of natalizumab-associated progressive multifocal leukoencephalopathy
-
Bloomgren, G., et al,. Risk of natalizumab-associated progressive multifocal leukoencephalopathy. N. Engl. J. Med. 366, 1870-1880 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1870-1880
-
-
Bloomgren, G.1
-
38
-
-
84882769357
-
Vedolizumab as induction and maintenance therapy for ulcerative colitis
-
Feagan, B.G., et al,. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N. Engl. J. Med. 369, 699-710 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 699-710
-
-
Feagan, B.G.1
-
39
-
-
84882749768
-
Vedolizumab as induction and maintenance therapy for Crohn's disease
-
Sandborn, W.J., et al,. Vedolizumab as induction and maintenance therapy for Crohn's disease. N. Engl. J. Med. 369, 711-721 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 711-721
-
-
Sandborn, W.J.1
-
40
-
-
84906569062
-
Effects of vedolizumab induction therapy for patients with Crohn's disease in whom tumor necrosis factor antagonist treatment failed
-
e3.
-
Sands, B.E., et al,. Effects of vedolizumab induction therapy for patients with Crohn's disease in whom tumor necrosis factor antagonist treatment failed. Gastroenterology 147, 618-627.e3 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 618-627
-
-
Sands, B.E.1
-
41
-
-
84937040433
-
Introducing vedolizumab to clinical practice: Who, when, and how
-
Bryant, R.V., Sandborn, W.J., &, Travis, S.P., Introducing vedolizumab to clinical practice: who, when, and how? J. Crohns Colitis 9, 356-366 (2015).
-
(2015)
J. Crohns Colitis
, vol.9
, pp. 356-366
-
-
Bryant, R.V.1
Sandborn, W.J.2
Travis, S.P.3
-
42
-
-
84904857048
-
Etrolizumab as induction therapy for ulcerative colitis: A randomised, controlled, phase 2 trial
-
Vermeire, S., et al,. Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet 384, 309-318 (2014).
-
(2014)
Lancet
, vol.384
, pp. 309-318
-
-
Vermeire, S.1
-
43
-
-
19344374130
-
Smad7 in TGF-beta-mediated negative regulation of gut inflammation
-
Monteleone, G., Pallone, F., &, MacDonald, T.T., Smad7 in TGF-beta-mediated negative regulation of gut inflammation. Trends Immunol. 25, 513-517 (2004).
-
(2004)
Trends Immunol
, vol.25
, pp. 513-517
-
-
Monteleone, G.1
Pallone, F.2
MacDonald, T.T.3
-
44
-
-
54349127897
-
TGF-beta1 and Smad7 in the regulation of IBD
-
Monteleone, G., Boirivant, M., Pallone, F., &, MacDonald, T.T., TGF-beta1 and Smad7 in the regulation of IBD. Mucosal Immunol. 1 (suppl. 1), S50-S53 (2008).
-
(2008)
Mucosal Immunol
, vol.1
, pp. S50-S53
-
-
Monteleone, G.1
Boirivant, M.2
Pallone, F.3
MacDonald, T.T.4
-
45
-
-
0034894059
-
Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
-
Monteleone, G., Kumberova, A., Croft, N.M., McKenzie, C., Steer, H.W., &, MacDonald, T.T., Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J. Clin. Invest. 108, 601-609 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 601-609
-
-
Monteleone, G.1
Kumberova, A.2
Croft, N.M.3
McKenzie, C.4
Steer, H.W.5
MacDonald, T.T.6
-
46
-
-
33845647693
-
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis
-
Boirivant, M., et al,. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 131, 1786-1798 (2006).
-
(2006)
Gastroenterology
, vol.131
, pp. 1786-1798
-
-
Boirivant, M.1
-
47
-
-
84925064199
-
Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease
-
Monteleone, G., et al,. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N. Engl. J. Med. 372, 1104-1113 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1104-1113
-
-
Monteleone, G.1
-
48
-
-
84925068548
-
Oral SMAD7 antisense drug for Crohn's disease
-
Vermeire, S., Oral SMAD7 antisense drug for Crohn's disease. N. Engl. J. Med. 372, 1166-1167 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1166-1167
-
-
Vermeire, S.1
-
49
-
-
84878568056
-
A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease
-
Zorzi, F., et al,. A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Aliment Pharmacol. Ther. 36, 850-857 (2012).
-
(2012)
Aliment Pharmacol. Ther.
, vol.36
, pp. 850-857
-
-
Zorzi, F.1
-
50
-
-
33646271377
-
A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
-
van Deventer, S.J., Wedel, M.K., Baker, B.F., Xia, S., Chuang, E., &, Miner, P.B. Jr., A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis. Aliment Pharmacol. Ther. 23, 1415-1425 (2006).
-
(2006)
Aliment Pharmacol. Ther.
, vol.23
, pp. 1415-1425
-
-
Van Deventer, S.J.1
Wedel, M.K.2
Baker, B.F.3
Xia, S.4
Chuang, E.5
Miner, P.B.6
-
51
-
-
33646232502
-
Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left-sided ulcerative colitis: A randomized, double-blind, active-controlled trial
-
Miner, P.B. Jr, Wedel, M.K., Xia, S., &, Baker, B.F., Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left-sided ulcerative colitis: a randomized, double-blind, active-controlled trial. Aliment Pharmacol. Ther. 23, 1403-1413 (2006).
-
(2006)
Aliment Pharmacol. Ther.
, vol.23
, pp. 1403-1413
-
-
Miner, P.B.1
Wedel, M.K.2
Xia, S.3
Baker, B.F.4
-
52
-
-
1342331543
-
An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis
-
Miner, P., Wedel, M., Bane, B., &, Bradley, J., An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis. Aliment Pharmacol. Ther. 19, 281-286 (2004).
-
(2004)
Aliment Pharmacol. Ther.
, vol.19
, pp. 281-286
-
-
Miner, P.1
Wedel, M.2
Bane, B.3
Bradley, J.4
-
53
-
-
33846804162
-
A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease
-
Yacyshyn, B., Chey, W.Y., Wedel, M.K., Yu, R.Z., Paul, D., &, Chuang, E., A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease. Clin. Gastroenterol. Hepatol. 5, 215-220 (2007).
-
(2007)
Clin. Gastroenterol. Hepatol.
, vol.5
, pp. 215-220
-
-
Yacyshyn, B.1
Chey, W.Y.2
Wedel, M.K.3
Yu, R.Z.4
Paul, D.5
Chuang, E.6
-
54
-
-
0033060190
-
Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys
-
Monteith, D.K., et al,. Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys. Toxicol. Pathol. 27, 307-317 (1999).
-
(1999)
Toxicol. Pathol.
, vol.27
, pp. 307-317
-
-
Monteith, D.K.1
-
55
-
-
84884534231
-
Acute kidney injury during therapy with an antisense oligonucleotide directed against PCSK9
-
van Poelgeest, E.P., et al,. Acute kidney injury during therapy with an antisense oligonucleotide directed against PCSK9. Am. J. Kidney Dis. 62, 796-800 (2013).
-
(2013)
Am. J. Kidney Dis.
, vol.62
, pp. 796-800
-
-
Van Poelgeest, E.P.1
-
56
-
-
43449107657
-
Stem cells as potential novel therapeutic strategy for inflammatory bowel disease
-
Duijvestein, M., van den Brink, G.R., &, Hommes, D.W., Stem cells as potential novel therapeutic strategy for inflammatory bowel disease. J. Crohns Colitis 2, 99-106 (2008).
-
(2008)
J. Crohns Colitis
, vol.2
, pp. 99-106
-
-
Duijvestein, M.1
Van Den Brink, G.R.2
Hommes, D.W.3
-
57
-
-
82255163006
-
Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease
-
Hommes, D.W., et al,. Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease. J. Crohns Colitis 5, 543-549 (2011).
-
(2011)
J. Crohns Colitis
, vol.5
, pp. 543-549
-
-
Hommes, D.W.1
-
58
-
-
84887121623
-
Immunomodulatory effects of mesenchymal stromal cells in Crohn's disease
-
Molendijk, I., et al,. Immunomodulatory effects of mesenchymal stromal cells in Crohn's disease. J. Allergy (Cairo) 2012, 187408 (2012).
-
(2012)
J. Allergy (Cairo)
, vol.2012
, pp. 187408
-
-
Molendijk, I.1
-
59
-
-
78649895490
-
Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: Results of a phase i study
-
Duijvestein, M., et al,. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 59, 1662-1669 (2010).
-
(2010)
Gut
, vol.59
, pp. 1662-1669
-
-
Duijvestein, M.1
-
60
-
-
84890190232
-
A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy
-
Forbes, G.M., et al,. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy. Clin. Gastroenterol. Hepatol. 12, 64-71 (2014).
-
(2014)
Clin. Gastroenterol. Hepatol.
, vol.12
, pp. 64-71
-
-
Forbes, G.M.1
-
61
-
-
84945249500
-
Mesenchymal stem cell therapy for inflammatory bowel disease: A systematic review and meta-analysis
-
Dave, M., Mehta, K., Luther, J., Baruah, A., Dietz, A.B., &, Faubion, W.A. Jr., Mesenchymal stem cell therapy for inflammatory bowel disease: a systematic review and meta-analysis. Inflamm. Bowel Dis. 21, 2696-2707 (2015).
-
(2015)
Inflamm. Bowel Dis.
, vol.21
, pp. 2696-2707
-
-
Dave, M.1
Mehta, K.2
Luther, J.3
Baruah, A.4
Dietz, A.B.5
Faubion, W.A.6
-
62
-
-
64049104052
-
Expanded adipose-derived stem cells for the treatment of complex perianal fistula: A phase II clinical trial
-
Garcia-Olmo, D., et al,. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis. Colon Rectum. 52, 79-86 (2009).
-
(2009)
Dis. Colon Rectum.
, vol.52
, pp. 79-86
-
-
Garcia-Olmo, D.1
-
63
-
-
84879459518
-
Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: Results from a multicenter phase I/IIa clinical trial
-
de la Portilla, F., Alba, F., Garciá-Olmo, D., Herreriás, J.M., González, F.X., &, Galindo, A., Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial. Int. J. Colorectal Dis. 28, 313-323 (2013).
-
(2013)
Int. J. Colorectal Dis.
, vol.28
, pp. 313-323
-
-
De La Portilla, F.1
Alba, F.2
Garciá-Olmo, D.3
Herreriás, J.M.4
González, F.X.5
Galindo, A.6
-
64
-
-
84868109200
-
Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease
-
e1-2
-
Desreumaux, P., et al,. Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology 143, 1207-1217.e1-2 (2012).
-
(2012)
Gastroenterology
, vol.143
, pp. 1207-1217
-
-
Desreumaux, P.1
-
65
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier, R.J., &, Podolsky, D.K., Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434 (2007).
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
66
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J.P., et al,. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
67
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura, Y., et al,. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
-
68
-
-
67649183644
-
Colony stimulating factor-1 dependence of paneth cell development in the mouse small intestine
-
Huynh, D., et al,. Colony stimulating factor-1 dependence of paneth cell development in the mouse small intestine. Gastroenterology 137, 136-144 (2009).
-
(2009)
Gastroenterology
, vol.137
, pp. 136-144
-
-
Huynh, D.1
-
69
-
-
29144483937
-
Reduced Paneth cell alpha-defensins in ileal Crohn's disease
-
Wehkamp, J., et al,. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. USA 102, 18129-18134 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
-
70
-
-
84886014303
-
Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics
-
Pastorelli, L., De Salvo, C., Mercado, J.R., Vecchi, M., &, Pizarro, T.T., Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front. Immunol. 4, 280 (2013).
-
(2013)
Front. Immunol.
, vol.4
, pp. 280
-
-
Pastorelli, L.1
De Salvo, C.2
Mercado, J.R.3
Vecchi, M.4
Pizarro, T.T.5
-
71
-
-
67649216750
-
Intestinal barrier function: Molecular regulation and disease pathogenesis
-
quiz 21-22.
-
Groschwitz, K.R., &, Hogan, S.P., Intestinal barrier function: molecular regulation and disease pathogenesis. J. Allergy Clin. Immunol. 124, 3-20; quiz 21-22 (2009).
-
(2009)
J. Allergy Clin. Immunol.
, vol.124
, pp. 3-20
-
-
Groschwitz, K.R.1
Hogan, S.P.2
-
72
-
-
0022970442
-
Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor
-
Hollander, D., Vadheim, C.M., Brettholz, E., Petersen, G.M., Delahunty, T., &, Rotter, J.I., Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann. Intern. Med. 105, 883-885 (1986).
-
(1986)
Ann. Intern. Med.
, vol.105
, pp. 883-885
-
-
Hollander, D.1
Vadheim, C.M.2
Brettholz, E.3
Petersen, G.M.4
Delahunty, T.5
Rotter, J.I.6
-
73
-
-
0034465898
-
Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
-
Irvine, E.J., &, Marshall, J.K., Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology 119, 1740-1744 (2000).
-
(2000)
Gastroenterology
, vol.119
, pp. 1740-1744
-
-
Irvine, E.J.1
Marshall, J.K.2
-
74
-
-
57049117856
-
Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities
-
Kim, I., Xu, W., &, Reed, J.C., Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat. Rev. Drug Discov. 7, 1013-1030 (2008).
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 1013-1030
-
-
Kim, I.1
Xu, W.2
Reed, J.C.3
-
75
-
-
80455173818
-
The unfolded protein response and its role in intestinal homeostasis and inflammation
-
Kaser, A., Flak, M.B., Tomczak, M.F., &, Blumberg, R.S., The unfolded protein response and its role in intestinal homeostasis and inflammation. Exp. Cell Res. 317, 2772-2779 (2011).
-
(2011)
Exp. Cell Res.
, vol.317
, pp. 2772-2779
-
-
Kaser, A.1
Flak, M.B.2
Tomczak, M.F.3
Blumberg, R.S.4
-
76
-
-
81055144784
-
Autophagy: Renovation of cells and tissues
-
Mizushima, N., &, Komatsu, M., Autophagy: renovation of cells and tissues. Cell 147, 728-741 (2011).
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
77
-
-
79955790354
-
Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease
-
Henckaerts, L., et al,. Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease. Inflamm. Bowel Dis. 17, 1392-1397 (2011).
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 1392-1397
-
-
Henckaerts, L.1
-
78
-
-
84890842812
-
Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress
-
Hoefkens, E., et al,. Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress. Autophagy 9, 2046-2055 (2013).
-
(2013)
Autophagy
, vol.9
, pp. 2046-2055
-
-
Hoefkens, E.1
-
79
-
-
84876486995
-
The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice
-
e6.
-
Cao, S.S., et al,. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology 144, 989-1000 e6 (2013).
-
(2013)
Gastroenterology
, vol.144
, pp. 989-1000
-
-
Cao, S.S.1
-
80
-
-
84922481563
-
Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death
-
Laukens, D., et al,. Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death. Lab. Invest. 94, 1419-1430 (2014).
-
(2014)
Lab. Invest.
, vol.94
, pp. 1419-1430
-
-
Laukens, D.1
-
81
-
-
84879993550
-
Autophagy: A new target or an old strategy for the treatment of Crohn's disease?
-
Nys, K., Agostinis, P., &, Vermeire, S., Autophagy: a new target or an old strategy for the treatment of Crohn's disease? Nat. Rev. Gastroenterol. Hepatol. 10, 395-401 (2013).
-
(2013)
Nat. Rev. Gastroenterol. Hepatol.
, vol.10
, pp. 395-401
-
-
Nys, K.1
Agostinis, P.2
Vermeire, S.3
-
82
-
-
50249111131
-
Use of sirolimus (rapamycin) to treat refractory Crohn's disease
-
Massey, D.C., Bredin, F., &, Parkes, M., Use of sirolimus (rapamycin) to treat refractory Crohn's disease. Gut 57, 1294-1296 (2008).
-
(2008)
Gut
, vol.57
, pp. 1294-1296
-
-
Massey, D.C.1
Bredin, F.2
Parkes, M.3
-
83
-
-
84918565670
-
The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children
-
Mutalib, M., et al,. The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children. J. Crohns Colitis 8, 1730-1734 (2014).
-
(2014)
J. Crohns Colitis
, vol.8
, pp. 1730-1734
-
-
Mutalib, M.1
-
84
-
-
0035192380
-
Inflammatory bowel disease: Lessons from the IL-10 gene-deficient mouse
-
Madsen, K.L., Inflammatory bowel disease: lessons from the IL-10 gene-deficient mouse. Clin. Invest. Med. 24, 250-257 (2001).
-
(2001)
Clin. Invest. Med.
, vol.24
, pp. 250-257
-
-
Madsen, K.L.1
-
85
-
-
0025887076
-
Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
-
Rutgeerts, P., et al,. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet 338, 771-774 (1991).
-
(1991)
Lancet
, vol.338
, pp. 771-774
-
-
Rutgeerts, P.1
-
86
-
-
85027927719
-
Enterotypes of the human gut microbiome
-
Arumugam, M., et al,. Enterotypes of the human gut microbiome. Nature 473, 174-180 (2011).
-
(2011)
Nature
, vol.473
, pp. 174-180
-
-
Arumugam, M.1
-
87
-
-
55949124035
-
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
-
Sokol, H., et al,. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl. Acad. Sci. USA 105, 16731-16736 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 16731-16736
-
-
Sokol, H.1
-
88
-
-
79953748870
-
Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
-
Joossens, M., et al,. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 60, 631-637 (2011).
-
(2011)
Gut
, vol.60
, pp. 631-637
-
-
Joossens, M.1
-
89
-
-
34249886868
-
CEACAM6 acts as a receptor for adherent-invasive E. Coli, supporting ileal mucosa colonization in Crohn disease
-
Barnich, N., et al,. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J. Clin. Invest. 117, 1566-1574 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1566-1574
-
-
Barnich, N.1
-
90
-
-
84904048875
-
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
-
Machiels, K., et al,. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut 63, 1275-1283 (2014).
-
(2014)
Gut
, vol.63
, pp. 1275-1283
-
-
MacHiels, K.1
-
91
-
-
84896092821
-
The treatment-naive microbiome in new-onset Crohn's disease
-
Gevers, D., et al,. The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe. 15, 382-392 (2014).
-
(2014)
Cell Host Microbe
, vol.15
, pp. 382-392
-
-
Gevers, D.1
-
92
-
-
84930015437
-
Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease
-
e3
-
Vande Casteele, N., et al,. Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease. Gastroenterology 148, 1320-1329.e3 (2015).
-
(2015)
Gastroenterology
, vol.148
, pp. 1320-1329
-
-
Vande Casteele, N.1
-
93
-
-
83555174812
-
Review article: The benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease
-
Chouchana, L., Narjoz, C., Beaune, P., Loriot, M.A., &, Roblin, X., Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease. Aliment Pharmacol. Ther. 35, 15-36 (2012).
-
(2012)
Aliment Pharmacol. Ther.
, vol.35
, pp. 15-36
-
-
Chouchana, L.1
Narjoz, C.2
Beaune, P.3
Loriot, M.A.4
Roblin, X.5
-
94
-
-
0042125511
-
Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer
-
Chang, J.C., et al,. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. Lancet 362, 362-369 (2003).
-
(2003)
Lancet
, vol.362
, pp. 362-369
-
-
Chang, J.C.1
-
95
-
-
59449083459
-
Gene expression signature for recurrence in stage III colorectal cancers
-
Watanabe, T., et al,. Gene expression signature for recurrence in stage III colorectal cancers. Cancer 115, 283-292 (2009).
-
(2009)
Cancer
, vol.115
, pp. 283-292
-
-
Watanabe, T.1
-
96
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock, W., et al,. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 11, 753-762 (2010).
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
-
97
-
-
80053414769
-
Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis
-
Lee, J.C., et al,. Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis. J. Clin. Invest. 121, 4170-4179 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4170-4179
-
-
Lee, J.C.1
-
98
-
-
71049134874
-
Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment
-
Arijs, I., et al,. Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS One 4, e7984 (2009).
-
(2009)
PLoS One
, vol.4
, pp. e7984
-
-
Arijs, I.1
-
99
-
-
78649582943
-
Predictive value of epithelial gene expression profiles for response to infliximab in Crohn's disease
-
Arijs, I., et al,. Predictive value of epithelial gene expression profiles for response to infliximab in Crohn's disease. Inflamm. Bowel Dis. 16, 2090-2098 (2010).
-
(2010)
Inflamm. Bowel Dis.
, vol.16
, pp. 2090-2098
-
-
Arijs, I.1
-
100
-
-
55249091834
-
Current directions in IBD therapy: What goals are feasible with biological modifiers?
-
Sandborn, W.J., Current directions in IBD therapy: what goals are feasible with biological modifiers? Gastroenterology 135, 1442-1447 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 1442-1447
-
-
Sandborn, W.J.1
|