-
1
-
-
0028267896
-
Frequency of glucocorticoid resistance and dependency in Crohn's disease
-
Munkholm P, Langholz E, Davidsen M, Binder V. Frequency of glucocorticoid resistance and dependency in Crohn's disease. Gut. 1994;35(3):360-362.
-
(1994)
Gut.
, vol.35
, Issue.3
, pp. 360-362
-
-
Munkholm, P.1
Langholz, E.2
Davidsen, M.3
Binder, V.4
-
2
-
-
0025219580
-
Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Thérapeutique des Affections Inflammatoires Digestives
-
Modigliani R, Mary JY, Simon JF, et al. Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Thérapeutique des Affections Inflammatoires Digestives. Gastroenterology. 1990;98(4):811-818.
-
(1990)
Gastroenterology.
, vol.98
, Issue.4
, pp. 811-818
-
-
Modigliani, R.1
Mary, J.Y.2
Simon, J.F.3
-
4
-
-
0029134702
-
Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis
-
Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med. 1995;123(2):132-142.
-
(1995)
Ann Intern Med.
, vol.123
, Issue.2
, pp. 132-142
-
-
Pearson, D.C.1
May, G.R.2
Fick, G.H.3
Sutherland, L.R.4
-
5
-
-
84921430591
-
Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease
-
Sandborn W, Sutherland L, Pearson D, May G, Modigliani R, Prantera C. Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease. Cochrane Database Syst Rev. 2000;(2):CD000545.
-
(2000)
Cochrane Database Syst Rev.
, Issue.2
-
-
Sandborn, W.1
Sutherland, L.2
Pearson, D.3
May, G.4
Modigliani, R.5
Prantera, C.6
-
6
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
-
Targan SR, Hanauer SB, van Deventer SJH, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. N Engl J Med. 1997;337(15):1029-1035.
-
(1997)
N Engl J Med.
, vol.337
, Issue.15
, pp. 1029-1035
-
-
Targan, S.R.1
Hanauer, S.B.2
van Deventer, S.J.H.3
-
7
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
-
Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet. 2002;359(9317):1541-1549.
-
(2002)
Lancet.
, vol.359
, Issue.9317
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
-
8
-
-
32044451548
-
Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
-
Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology. 2006;130(2):323-332.
-
(2006)
Gastroenterology.
, vol.130
, Issue.2
, pp. 323-332
-
-
Hanauer, S.B.1
Sandborn, W.J.2
Rutgeerts, P.3
-
9
-
-
33846242958
-
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
-
Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology. 2007;132(1):52-65.
-
(2007)
Gastroenterology.
, vol.132
, Issue.1
, pp. 52-65
-
-
Colombel, J.F.1
Sandborn, W.J.2
Rutgeerts, P.3
-
10
-
-
34447523749
-
Certolizumab pegol for the treatment of Crohn's disease
-
Sandborn WJ, Feagan BG, Stoinov S, et al. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med. 2007;357(3):228-238.
-
(2007)
N Engl J Med.
, vol.357
, Issue.3
, pp. 228-238
-
-
Sandborn, W.J.1
Feagan, B.G.2
Stoinov, S.3
-
11
-
-
34447515607
-
Maintenance therapy with certolizumab pegol for Crohn's disease
-
Schreiber S, Khaliq-Kareemi M, Lawrance IC, et al. Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med. 2007;357(3):239-250.
-
(2007)
N Engl J Med.
, vol.357
, Issue.3
, pp. 239-250
-
-
Schreiber, S.1
Khaliq-Kareemi, M.2
Lawrance, I.C.3
-
12
-
-
44849131569
-
Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease
-
Behm BW, Bickston SJ. Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2008;(1):CD006893.
-
(2008)
Cochrane Database Syst Rev.
, Issue.1
-
-
Behm, B.W.1
Bickston, S.J.2
-
13
-
-
77950988234
-
Infliximab, azathioprine, or combination therapy for Crohn's disease
-
Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med. 2010;362(15):1383-1395.
-
(2010)
N Engl J Med.
, vol.362
, Issue.15
, pp. 1383-1395
-
-
Colombel, J.F.1
Sandborn, W.J.2
Reinisch, W.3
-
14
-
-
84872094478
-
Novel targets for inflammatory bowel disease therapeutics
-
Lowenberg M, D'Haens G. Novel targets for inflammatory bowel disease therapeutics. Curr Gastroenterol Reports. 2013;15(2):311.
-
(2013)
Curr Gastroenterol Reports.
, vol.15
, Issue.2
, pp. 311
-
-
Lowenberg, M.1
D'Haens, G.2
-
15
-
-
77955277832
-
Certolizumab pegol in patients with moderate to severe Crohn's disease and secondary failure to infliximab
-
Sandborn WJ, Abreu MT, D'Haens G, et al. Certolizumab pegol in patients with moderate to severe Crohn's disease and secondary failure to infliximab. Clin Gastroenterol Hepatol. 2010;8(8):688-695. e2.
-
(2010)
Clin Gastroenterol Hepatol.
, vol.8
, Issue.8
-
-
Sandborn, W.J.1
Abreu, M.T.2
D'Haens, G.3
-
16
-
-
84871701834
-
Ustekinumab induction and maintenance therapy in refractory Crohn's disease
-
Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med. 2012;367(16):1519-1528.
-
(2012)
N Engl J Med.
, vol.367
, Issue.16
, pp. 1519-1528
-
-
Sandborn, W.J.1
Gasink, C.2
Gao, L.L.3
-
17
-
-
0345358584
-
The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
-
Trinchieri G, Pflanz S, Kastelein RA. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity. 2003;19(5):641-644.
-
(2003)
Immunity.
, vol.19
, Issue.5
, pp. 641-644
-
-
Trinchieri, G.1
Pflanz, S.2
Kastelein, R.A.3
-
18
-
-
69749101475
-
The IL-12 family of cytokines in infection, inflammation and autoimmune disorders
-
Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets. 2009;8(1):40-52.
-
(2009)
Inflamm Allergy Drug Targets.
, vol.8
, Issue.1
, pp. 40-52
-
-
Gee, K.1
Guzzo, C.2
Che Mat, N.F.3
Ma, W.4
Kumar, A.5
-
19
-
-
84877083150
-
Ustekinumab in chronic immune-mediated diseases: A review of long term safety and patient improvement
-
Toussirot E, Michel F, Béreau M, Binda D. Ustekinumab in chronic immune-mediated diseases: a review of long term safety and patient improvement. Patient Prefer Adherence. 2013;7:369-377.
-
(2013)
Patient Prefer Adherence.
, vol.7
, pp. 369-377
-
-
Toussirot, E.1
Michel, F.2
Béreau, M.3
Binda, D.4
-
20
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
Mannon PJ, Fuss IJ, Mayer L, et al. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med. 2004;351(20):2069-2079.
-
(2004)
N Engl J Med.
, vol.351
, Issue.20
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
-
21
-
-
33750133513
-
Interleukin-12 and Th1 immune response in Crohn's disease: Pathogenetic relevance and therapeutic implication
-
Peluso I, Pallone F, Monteleone G. Interleukin-12 and Th1 immune response in Crohn's disease: pathogenetic relevance and therapeutic implication. World J Gastroenterol. 2006;12(35):5606-5610.
-
(2006)
World J Gastroenterol.
, vol.12
, Issue.35
, pp. 5606-5610
-
-
Peluso, I.1
Pallone, F.2
Monteleone, G.3
-
22
-
-
33846036986
-
IL-23: A master regulator in Crohn disease
-
Neurath MF. IL-23: a master regulator in Crohn disease. Nat Med. 2007;13(1):26-28.
-
(2007)
Nat Med.
, vol.13
, Issue.1
, pp. 26-28
-
-
Neurath, M.F.1
-
23
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006;314(5804):1461-1463.
-
(2006)
Science.
, vol.314
, Issue.5804
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
-
24
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13(5):715-725.
-
(2000)
Immunity.
, vol.13
, Issue.5
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
-
25
-
-
33646417072
-
The IL-23/IL-17 axis in inflammation
-
Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. J Clin Invest. 2006;116(5):1218-1222.
-
(2006)
J Clin Invest.
, vol.116
, Issue.5
, pp. 1218-1222
-
-
Iwakura, Y.1
Ishigame, H.2
-
26
-
-
53049091561
-
A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology. 2008;135(4):1130-1141.
-
(2008)
Gastroenterology.
, vol.135
, Issue.4
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
-
27
-
-
84857774124
-
The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases
-
Toussirot E. The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases. Inflamm Allergy Drug Targets. 2012;11(2): 159-168.
-
(2012)
Inflamm Allergy Drug Targets.
, vol.11
, Issue.2
, pp. 159-168
-
-
Toussirot, E.1
-
28
-
-
80052623228
-
Ustekinumab: A review of its use in the management of moderate to severe plaque psoriasis
-
Croxtall JD. Ustekinumab: a review of its use in the management of moderate to severe plaque psoriasis. Drugs. 2011;71(13):1733-1753.
-
(2011)
Drugs.
, vol.71
, Issue.13
, pp. 1733-1753
-
-
Croxtall, J.D.1
-
29
-
-
33846889522
-
A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis
-
Krueger GG, Langley RG, Leonardi C, et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med. 2007;356(6):580-592.
-
(2007)
N Engl J Med.
, vol.356
, Issue.6
, pp. 580-592
-
-
Krueger, G.G.1
Langley, R.G.2
Leonardi, C.3
-
30
-
-
43449111187
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
-
Leonardi CL, Kimball AB, Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet. 2008;371(9625): 1665-1674.
-
(2008)
Lancet.
, vol.371
, Issue.9625
, pp. 1665-1674
-
-
Leonardi, C.L.1
Kimball, A.B.2
Papp, K.A.3
-
31
-
-
43449139402
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
-
Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet. 2008;371(9625): 1675-1684.
-
(2008)
Lancet.
, vol.371
, Issue.9625
, pp. 1675-1684
-
-
Papp, K.A.1
Langley, R.G.2
Lebwohl, M.3
-
32
-
-
60249084148
-
Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: Randomised, double-blind, placebo-controlled, crossover trial
-
Gottlieb A, Menter A, Mendelsohn A, et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet. 2009;373(9664):633-640.
-
(2009)
Lancet.
, vol.373
, Issue.9664
, pp. 633-640
-
-
Gottlieb, A.1
Menter, A.2
Mendelsohn, A.3
-
33
-
-
84883134297
-
Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial
-
McInnes IB, Kavanaugh A, Gottlieb AB, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet. 2013;382(9894):780-789.
-
(2013)
Lancet.
, vol.382
, Issue.9894
, pp. 780-789
-
-
McInnes, I.B.1
Kavanaugh, A.2
Gottlieb, A.B.3
-
37
-
-
84859826969
-
Long-term safety experience of ustekinumab in patients with moderate-to-severe psoriasis (part I of II): Results from analyses of general safety parameters from pooled Phase 2 and 3 clinical trials
-
Lebwohl M, Leonardi C, Griffiths CE, et al. Long-term safety experience of ustekinumab in patients with moderate-to-severe psoriasis (part I of II): results from analyses of general safety parameters from pooled Phase 2 and 3 clinical trials. J Am Acad Dermatol. 2012;66(5): 731-741.
-
(2012)
J Am Acad Dermatol.
, vol.66
, Issue.5
, pp. 731-741
-
-
Lebwohl, M.1
Leonardi, C.2
Griffiths, C.E.3
-
38
-
-
84859869815
-
Long-term safety experience of ustekinumab in patients with moderate to severe psoriasis (part II of II): Results from analyses of infections and malignancy from pooled phase II and III clinical trials
-
Gordon KB, Papp KA, Langley RG, et al. Long-term safety experience of ustekinumab in patients with moderate to severe psoriasis (part II of II): results from analyses of infections and malignancy from pooled phase II and III clinical trials. J Am Acad Dermatol. 2012;66(5): 742-751.
-
(2012)
J Am Acad Dermatol.
, vol.66
, Issue.5
, pp. 742-751
-
-
Gordon, K.B.1
Papp, K.A.2
Langley, R.G.3
-
39
-
-
84875433817
-
Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: Final results from 5 years of follow-up
-
Papp KA, Griffiths CE, Gordon K, et al. Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up. Br J Dermatol. 2013;168(4):844-854.
-
(2013)
Br J Dermatol.
, vol.168
, Issue.4
, pp. 844-854
-
-
Papp, K.A.1
Griffiths, C.E.2
Gordon, K.3
-
40
-
-
80855163580
-
Ustekinumab decreases work limitations, improves work productivity, and reduces work days missed in patients with moderate-to-severe psoriasis: Results from PHOENIX 2
-
Reich K, Schenkel B, Zhao N, et al. Ustekinumab decreases work limitations, improves work productivity, and reduces work days missed in patients with moderate-to-severe psoriasis: results from PHOENIX 2. J Dermatol Treat. 2011;22(6):337-347.
-
(2011)
J Dermatol Treat.
, vol.22
, Issue.6
, pp. 337-347
-
-
Reich, K.1
Schenkel, B.2
Zhao, N.3
-
41
-
-
77955921585
-
Ustekinumab significantly improves symptoms of anxiety, depression, and skin-related quality of life in patients with moderate-to-severe psoriasis: Results from a randomized, double-blind, placebo-controlled phase III trial
-
Langley RG, Feldman SR, Han C, et al. Ustekinumab significantly improves symptoms of anxiety, depression, and skin-related quality of life in patients with moderate-to-severe psoriasis: results from a randomized, double-blind, placebo-controlled phase III trial. J Am Acad Dermatol. 2010;63(3):457-465.
-
(2010)
J Am Acad Dermatol.
, vol.63
, Issue.3
, pp. 457-465
-
-
Langley, R.G.1
Feldman, S.R.2
Han, C.3
-
42
-
-
79959816954
-
Impact of ustekinumab on health-related quality of life and sexual difficulties associated with psoriasis: Results from two phase III clinical trials
-
Guenther L, Han C, Szapary P, et al. Impact of ustekinumab on health-related quality of life and sexual difficulties associated with psoriasis: results from two phase III clinical trials. J Am Acad Dermatol. 2011;25(7):851-857.
-
(2011)
J Am Acad Dermatol.
, vol.25
, Issue.7
, pp. 851-857
-
-
Guenther, L.1
Han, C.2
Szapary, P.3
-
43
-
-
84860566158
-
Briakinumab (ABT874) for treatment of Crohn's disease
-
Late breaking abstract presented at:, October 23-27, Barcelona, Spain. Abstract OP051D
-
Panniccione R, Sandborne W, Gordon G, et al. Briakinumab (ABT874) for treatment of Crohn's disease. Late breaking abstract presented at: 18th United European Gastroenterology Week (UEWG); October 23-27; 2010; Barcelona, Spain. Abstract OP051D.
-
(2010)
18th United European Gastroenterology Week (UEWG)
-
-
Panniccione, R.1
Sandborne, W.2
Gordon, G.3
|