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Volumn 19, Issue 12, 2015, Pages 2691-2701

Analysis of different HER-2 mutations in breast cancer progression and drug resistance

Author keywords

Breast cancer; Cancer risk; HER 2; HER 2 mutation; Resistance; Variants

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; LAPATINIB; QUINAZOLINE DERIVATIVE; TRASTUZUMAB;

EID: 84955185171     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12662     Document Type: Article
Times cited : (49)

References (110)
  • 1
    • 84925831666 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications
    • Iqbal N, Iqbal N. Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications. Mol Biol Int. 2014; 2014: 852748.
    • (2014) Mol Biol Int , vol.2014 , pp. 852748
    • Iqbal, N.1    Iqbal, N.2
  • 2
    • 0028250050 scopus 로고
    • The c-erbB-2 protein in oncogenesis: molecular structure to molecular epidemiology
    • Brandt-Rauf PW, Pincus MR, Carney WP. The c-erbB-2 protein in oncogenesis: molecular structure to molecular epidemiology. Crit Rev Oncog. 1994; 5: 313-29.
    • (1994) Crit Rev Oncog , vol.5 , pp. 313-329
    • Brandt-Rauf, P.W.1    Pincus, M.R.2    Carney, W.P.3
  • 3
    • 66149084032 scopus 로고    scopus 로고
    • Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study
    • Telesco SE, Radhakrishnan R. Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study. Biophys J. 2009; 96: 2321-34.
    • (2009) Biophys J , vol.96 , pp. 2321-2334
    • Telesco, S.E.1    Radhakrishnan, R.2
  • 4
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2010; 141: 1117-34.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 5
    • 4944232647 scopus 로고    scopus 로고
    • Intragenic ERBB2 kinase mutations in tumours
    • Stephens P, Hunter C, Bignell G, et al. Intragenic ERBB2 kinase mutations in tumours. Nature. 2004; 431: 525-6.
    • (2004) Nature , vol.431 , pp. 525-526
    • Stephens, P.1    Hunter, C.2    Bignell, G.3
  • 6
    • 84899948353 scopus 로고    scopus 로고
    • HER2 aberrations in cancer: implications for therapy
    • Yan M, Parker BA, Schwab R, et al. HER2 aberrations in cancer: implications for therapy. Cancer Treat Rev. 2014; 40: 770-80.
    • (2014) Cancer Treat Rev , vol.40 , pp. 770-780
    • Yan, M.1    Parker, B.A.2    Schwab, R.3
  • 7
    • 31544449750 scopus 로고    scopus 로고
    • Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
    • Lee JW, Soung YH, Seo SH, et al. Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. Clin Cancer Res. 2006; 12: 57-61.
    • (2006) Clin Cancer Res , vol.12 , pp. 57-61
    • Lee, J.W.1    Soung, Y.H.2    Seo, S.H.3
  • 8
    • 27944499351 scopus 로고    scopus 로고
    • EGFR and erbB2 mutation status in Japanese lung cancer patients
    • Sasaki H, Shimizu S, Endo K, et al. EGFR and erbB2 mutation status in Japanese lung cancer patients. Int J Cancer. 2006; 118: 180-4.
    • (2006) Int J Cancer , vol.118 , pp. 180-184
    • Sasaki, H.1    Shimizu, S.2    Endo, K.3
  • 9
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008; 455: 1069-75.
    • (2008) Nature , vol.455 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 10
    • 34547470997 scopus 로고    scopus 로고
    • The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272
    • Minami Y, Shimamura T, Shah K, et al. The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272. Oncogene. 2007; 26: 5023-7.
    • (2007) Oncogene , vol.26 , pp. 5023-5027
    • Minami, Y.1    Shimamura, T.2    Shah, K.3
  • 11
    • 39049153060 scopus 로고    scopus 로고
    • Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib
    • Gilmer TM, Cable L, Alligood K, et al. Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib. Cancer Res. 2008; 68: 571-9.
    • (2008) Cancer Res , vol.68 , pp. 571-579
    • Gilmer, T.M.1    Cable, L.2    Alligood, K.3
  • 12
    • 84922262212 scopus 로고    scopus 로고
    • HER2 gene mutations in non-small cell lung carcinomas: concurrence with her2 gene amplification and her2 protein expression and phosphorylation
    • Suzuki M, Shiraishi K, Yoshida A, et al. HER2 gene mutations in non-small cell lung carcinomas: concurrence with her2 gene amplification and her2 protein expression and phosphorylation. Lung Cancer. 2015; 87: 14-22.
    • (2015) Lung Cancer , vol.87 , pp. 14-22
    • Suzuki, M.1    Shiraishi, K.2    Yoshida, A.3
  • 13
    • 84858002759 scopus 로고    scopus 로고
    • Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
    • De Greve J, Teugels E, Geers C, et al. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer. 2012; 76: 123-7.
    • (2012) Lung Cancer , vol.76 , pp. 123-127
    • De Greve, J.1    Teugels, E.2    Geers, C.3
  • 14
    • 80052029219 scopus 로고    scopus 로고
    • Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck
    • Del Campo J, Hitt R, Sebastian P, et al. Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck. Br J Cancer. 2011; 105: 618-27.
    • (2011) Br J Cancer , vol.105 , pp. 618-627
    • Del Campo, J.1    Hitt, R.2    Sebastian, P.3
  • 15
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    • Bang Y-J, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010; 376: 687-97.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.-J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 16
    • 80051552392 scopus 로고    scopus 로고
    • Identification of the coexisting HER2 gene amplification and novel mutations in the HER2 protein-overexpressed mucinous epithelial ovarian cancer
    • Lin W-L, Kuo W-H, Chen F-L, et al. Identification of the coexisting HER2 gene amplification and novel mutations in the HER2 protein-overexpressed mucinous epithelial ovarian cancer. Ann Surg Oncol. 2011; 18: 2388-94.
    • (2011) Ann Surg Oncol , vol.18 , pp. 2388-2394
    • Lin, W.-L.1    Kuo, W.-H.2    Chen, F.-L.3
  • 17
    • 33746742412 scopus 로고    scopus 로고
    • Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma
    • Lassus H, Sihto H, Leminen A, et al. Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma. J Mol Med. 2006; 84: 671-81.
    • (2006) J Mol Med , vol.84 , pp. 671-681
    • Lassus, H.1    Sihto, H.2    Leminen, A.3
  • 18
    • 33845874148 scopus 로고    scopus 로고
    • A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma
    • Bekaii-Saab T, Williams N, Plass C, et al. A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma. BMC Cancer. 2006; 6: 278.
    • (2006) BMC Cancer , vol.6 , pp. 278
    • Bekaii-Saab, T.1    Williams, N.2    Plass, C.3
  • 19
    • 84930757741 scopus 로고    scopus 로고
    • Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer
    • Tschui J, Vassella E, Bandi N, et al. Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer. Virchows Arch. 2015; 466: 1-8.
    • (2015) Virchows Arch , vol.466 , pp. 1-8
    • Tschui, J.1    Vassella, E.2    Bandi, N.3
  • 20
    • 70849095560 scopus 로고    scopus 로고
    • Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer
    • bgp206
    • Kubo T, Kuroda Y, Shimizu H, et al. Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer. Carcinogenesis. 2009; 30: bgp206.
    • (2009) Carcinogenesis , vol.30
    • Kubo, T.1    Kuroda, Y.2    Shimizu, H.3
  • 21
    • 28144437798 scopus 로고    scopus 로고
    • Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR
    • Cohen EE, Lingen MW, Martin LE, et al. Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR. Clin Cancer Res. 2005; 11: 8105-8.
    • (2005) Clin Cancer Res , vol.11 , pp. 8105-8108
    • Cohen, E.E.1    Lingen, M.W.2    Martin, L.E.3
  • 22
    • 84866360342 scopus 로고    scopus 로고
    • Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
    • Arcila ME, Chaft JE, Nafa K, et al. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res. 2012; 18: 4910-8.
    • (2012) Clin Cancer Res , vol.18 , pp. 4910-4918
    • Arcila, M.E.1    Chaft, J.E.2    Nafa, K.3
  • 23
    • 84873918443 scopus 로고    scopus 로고
    • Activating HER2 mutations in HER2 gene amplification negative breast cancer
    • Bose R, Kavuri SM, Searleman AC, et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov. 2013; 3: 224-37.
    • (2013) Cancer Discov , vol.3 , pp. 224-237
    • Bose, R.1    Kavuri, S.M.2    Searleman, A.C.3
  • 24
    • 84884712563 scopus 로고    scopus 로고
    • Mutational analysis of breast cancer: Guiding personalized treatments
    • Matthew J. Mutational analysis of breast cancer: Guiding personalized treatments. Breast. 2013; 22: S19-21.
    • (2013) Breast , vol.22 , pp. S19-S21
    • Matthew, J.1
  • 25
    • 33745689525 scopus 로고    scopus 로고
    • ERBB2 kinase domain mutation in the lung squamous cell carcinoma
    • Lee JW, Soung YH, Kim SY, et al. ERBB2 kinase domain mutation in the lung squamous cell carcinoma. Cancer Lett. 2006; 237: 89-94.
    • (2006) Cancer Lett , vol.237 , pp. 89-94
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 26
    • 80052558779 scopus 로고    scopus 로고
    • Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers
    • Tomizawa K, Suda K, Onozato R, et al. Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers. Lung Cancer. 2011; 74: 139-44.
    • (2011) Lung Cancer , vol.74 , pp. 139-144
    • Tomizawa, K.1    Suda, K.2    Onozato, R.3
  • 27
    • 84866609400 scopus 로고    scopus 로고
    • HER2 mutations in non-small-cell lung cancer can be continually targeted
    • Kelly RJ, Carter CA, Giaccone G. HER2 mutations in non-small-cell lung cancer can be continually targeted. J Clin Oncol. 2012; 30: 3318-9.
    • (2012) J Clin Oncol , vol.30 , pp. 3318-3319
    • Kelly, R.J.1    Carter, C.A.2    Giaccone, G.3
  • 28
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • Shah SP, Morin RD, Khattra J, et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature. 2009; 461: 809-13.
    • (2009) Nature , vol.461 , pp. 809-813
    • Shah, S.P.1    Morin, R.D.2    Khattra, J.3
  • 29
    • 84862526929 scopus 로고    scopus 로고
    • The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    • Shah SP, Roth A, Goya R, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 2012; 486: 395-9.
    • (2012) Nature , vol.486 , pp. 395-399
    • Shah, S.P.1    Roth, A.2    Goya, R.3
  • 30
    • 33750627353 scopus 로고    scopus 로고
    • Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features
    • Buttitta F, Barassi F, Fresu G, et al. Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features. Int J Cancer. 2006; 119: 2586-91.
    • (2006) Int J Cancer , vol.119 , pp. 2586-2591
    • Buttitta, F.1    Barassi, F.2    Fresu, G.3
  • 31
    • 20144386787 scopus 로고    scopus 로고
    • Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
    • Shigematsu H, Takahashi T, Nomura M, et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res. 2005; 65: 1642-6.
    • (2005) Cancer Res , vol.65 , pp. 1642-1646
    • Shigematsu, H.1    Takahashi, T.2    Nomura, M.3
  • 32
    • 33746154236 scopus 로고    scopus 로고
    • Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272
    • Shimamura T, Ji H, Minami Y, et al. Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272. Cancer Res. 2006; 66: 6487-91.
    • (2006) Cancer Res , vol.66 , pp. 6487-6491
    • Shimamura, T.1    Ji, H.2    Minami, Y.3
  • 33
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004; 350: 2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 34
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010; 11: 121-8.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 35
    • 0029884715 scopus 로고    scopus 로고
    • Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization
    • Pauletti G, Godolphin W, Press MF, et al. Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization. Oncogene. 1996; 13: 63-72.
    • (1996) Oncogene , vol.13 , pp. 63-72
    • Pauletti, G.1    Godolphin, W.2    Press, M.F.3
  • 36
    • 84927798358 scopus 로고    scopus 로고
    • Challenges of immunohistochemistry for individualized cancer chemotherapy
    • Kamoshida S. Challenges of immunohistochemistry for individualized cancer chemotherapy. Rinsho Byori. 2014; 62: 710-8.
    • (2014) Rinsho Byori , vol.62 , pp. 710-718
    • Kamoshida, S.1
  • 37
    • 84911908120 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831
    • Perez EA, Romond EH, Suman VJ, et al. Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831. J Clin Oncol. 2014; 32: 3744-52.
    • (2014) J Clin Oncol , vol.32 , pp. 3744-3752
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3
  • 38
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001; 344: 783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 39
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005; 353: 1673-84.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 40
    • 84911926434 scopus 로고    scopus 로고
    • Biomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer
    • Baselga J, Cortés J, Im S-A, et al. Biomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer. J Clin Oncol. 2014; 32: 3753-61.
    • (2014) J Clin Oncol , vol.32 , pp. 3753-3761
    • Baselga, J.1    Cortés, J.2    Im, S.-A.3
  • 41
    • 84873905911 scopus 로고    scopus 로고
    • Activating mutations in HER2: neu opportunities and neu challenges
    • Weigelt B, Reis-Filho JS. Activating mutations in HER2: neu opportunities and neu challenges. Cancer Discov. 2013; 3: 145-7.
    • (2013) Cancer Discov , vol.3 , pp. 145-147
    • Weigelt, B.1    Reis-Filho, J.S.2
  • 42
    • 84923373832 scopus 로고    scopus 로고
    • HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer
    • Boulbes DR, Arold ST, Chauhan GB, et al. HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Mol Oncol. 2014; 9: 586-600.
    • (2014) Mol Oncol , vol.9 , pp. 586-600
    • Boulbes, D.R.1    Arold, S.T.2    Chauhan, G.B.3
  • 43
    • 84892170782 scopus 로고    scopus 로고
    • A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma
    • Ross JS, Wang K, Gay LM, et al. A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma. Clin Cancer Res. 2014; 20: 68-75.
    • (2014) Clin Cancer Res , vol.20 , pp. 68-75
    • Ross, J.S.1    Wang, K.2    Gay, L.M.3
  • 44
    • 33745727112 scopus 로고    scopus 로고
    • HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
    • Wang SZE, Narasanna A, Perez-Torres M, et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell. 2006; 10: 25-38.
    • (2006) Cancer Cell , vol.10 , pp. 25-38
    • Wang, S.Z.E.1    Narasanna, A.2    Perez-Torres, M.3
  • 45
    • 84925285811 scopus 로고    scopus 로고
    • Somatic mutations of the HER2 in metastatic breast cancer
    • Fang Y, Jiang Y, Wang X, et al. Somatic mutations of the HER2 in metastatic breast cancer. Tumour Biol. 2014; 35: 11851-4.
    • (2014) Tumour Biol , vol.35 , pp. 11851-11854
    • Fang, Y.1    Jiang, Y.2    Wang, X.3
  • 46
    • 84890767985 scopus 로고    scopus 로고
    • Activating mutations in ERBB2 and their impact on diagnostics and treatment
    • Herter-Sprie GS, Greulich H, Wong K-K. Activating mutations in ERBB2 and their impact on diagnostics and treatment. Front Oncol. 2013; 3: 86.
    • (2013) Front Oncol , vol.3 , pp. 86
    • Herter-Sprie, G.S.1    Greulich, H.2    Wong, K.-K.3
  • 47
    • 84865994665 scopus 로고    scopus 로고
    • Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
    • Greulich H, Kaplan B, Mertins P, et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci USA. 2012; 109: 14476-81.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 14476-14481
    • Greulich, H.1    Kaplan, B.2    Mertins, P.3
  • 48
    • 77955660663 scopus 로고    scopus 로고
    • Diverse somatic mutation patterns and pathway alterations in human cancers
    • 869-U103
    • Kan ZY, Jaiswal BS, Stinson J, et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature. 2010; 466: 869-U103.
    • (2010) Nature , vol.466
    • Kan, Z.Y.1    Jaiswal, B.S.2    Stinson, J.3
  • 49
    • 84906971961 scopus 로고    scopus 로고
    • Treatment of metastatic extramammary Paget's disease associated with adnexal adenocarcinoma, with anti-HER2 drugs based on genomic alteration ERBB2 S310F
    • Vornicova O, Hershkovitz D, Yablonski-Peretz T, et al. Treatment of metastatic extramammary Paget's disease associated with adnexal adenocarcinoma, with anti-HER2 drugs based on genomic alteration ERBB2 S310F. Oncologist. 2014; 19: 1006-7.
    • (2014) Oncologist , vol.19 , pp. 1006-1007
    • Vornicova, O.1    Hershkovitz, D.2    Yablonski-Peretz, T.3
  • 50
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474: 609-15.
    • (2011) Nature , vol.474 , pp. 609-615
  • 51
    • 84887423150 scopus 로고    scopus 로고
    • Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation
    • Serra V, Vivancos A, Puente XS, et al. Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation. Cancer Discov. 2013; 3: 1238-44.
    • (2013) Cancer Discov , vol.3 , pp. 1238-1244
    • Serra, V.1    Vivancos, A.2    Puente, X.S.3
  • 52
    • 84892666476 scopus 로고    scopus 로고
    • Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas
    • djt338
    • Yamamoto H, Higasa K, Sakaguchi M, et al. Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst. 2014; 106: djt338.
    • (2014) J Natl Cancer Inst , vol.106
    • Yamamoto, H.1    Higasa, K.2    Sakaguchi, M.3
  • 53
    • 84984985644 scopus 로고    scopus 로고
    • Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy
    • dju291
    • Parra-Palau JL, Morancho B, Peg V, et al. Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy. J Natl Cancer Inst. 2014; 106: dju291.
    • (2014) J Natl Cancer Inst , vol.106
    • Parra-Palau, J.L.1    Morancho, B.2    Peg, V.3
  • 54
    • 68849092790 scopus 로고    scopus 로고
    • An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance
    • Mitra D, Brumlik MJ, Okamgba SU, et al. An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance. Mol Cancer Ther. 2009; 8: 2152-62.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2152-2162
    • Mitra, D.1    Brumlik, M.J.2    Okamgba, S.U.3
  • 55
    • 84939416055 scopus 로고    scopus 로고
    • Circulating her-2/neu extracellular domain in breast cancer patients-correlation with prognosis and clinicopathological parameters including steroid receptor, her-2/neu receptor coexpression
    • Barić M, Kulić A, Sirotković-Skerlev M, et al. Circulating her-2/neu extracellular domain in breast cancer patients-correlation with prognosis and clinicopathological parameters including steroid receptor, her-2/neu receptor coexpression. Pathol Oncol Res. 2014; 21: 1-7.
    • (2014) Pathol Oncol Res , vol.21 , pp. 1-7
    • Barić, M.1    Kulić, A.2    Sirotković-Skerlev, M.3
  • 56
    • 84880868333 scopus 로고    scopus 로고
    • Clinical significance of HER-2 splice variants in breast cancer progression and drug resistance
    • Jackson C, Browell D, Gautrey H, et al. Clinical significance of HER-2 splice variants in breast cancer progression and drug resistance. Int J Cell Biol. 2013; 2013: 973584.
    • (2013) Int J Cell Biol , vol.2013 , pp. 973584
    • Jackson, C.1    Browell, D.2    Gautrey, H.3
  • 57
    • 43949138899 scopus 로고    scopus 로고
    • Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer
    • Coley HM. Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev. 2008; 34: 378-90.
    • (2008) Cancer Treat Rev , vol.34 , pp. 378-390
    • Coley, H.M.1
  • 58
    • 79960255931 scopus 로고    scopus 로고
    • Targeted therapy in breast cancer: what's new
    • Fang L, Barekati Z, Zhang B, et al. Targeted therapy in breast cancer: what's new. Swiss Med Wkly. 2011; 141: w13231.
    • (2011) Swiss Med Wkly , vol.141 , pp. w13231
    • Fang, L.1    Barekati, Z.2    Zhang, B.3
  • 59
    • 84861598810 scopus 로고    scopus 로고
    • Advances in first-line treatment for patients with HER-2+ metastatic breast cancer
    • De Mattos-Arruda L, Cortes J. Advances in first-line treatment for patients with HER-2+ metastatic breast cancer. Oncologist. 2012; 17: 631-44.
    • (2012) Oncologist , vol.17 , pp. 631-644
    • De Mattos-Arruda, L.1    Cortes, J.2
  • 60
    • 84896696101 scopus 로고    scopus 로고
    • Resistance to human epidermal growth factor receptor type 2-targeted therapies
    • Thery J-C, Spano J-P, Azria D, et al. Resistance to human epidermal growth factor receptor type 2-targeted therapies. Eur J Cancer. 2014; 50: 892-901.
    • (2014) Eur J Cancer , vol.50 , pp. 892-901
    • Thery, J.-C.1    Spano, J.-P.2    Azria, D.3
  • 61
    • 79955712254 scopus 로고    scopus 로고
    • The human splice variant Delta16HER2 induces rapid tumor onset in a reporter transgenic mouse
    • Marchini C, Gabrielli F, Iezzi M, et al. The human splice variant Delta16HER2 induces rapid tumor onset in a reporter transgenic mouse. PLoS ONE. 2011; 6: e18727.
    • (2011) PLoS ONE , vol.6 , pp. e18727
    • Marchini, C.1    Gabrielli, F.2    Iezzi, M.3
  • 63
    • 78449276234 scopus 로고    scopus 로고
    • A major role of p95/611-CTF, a carboxy-terminal fragment of HER2, in the down-modulation of the estrogen receptor in HER2-positive breast cancers
    • Parra-Palau JL, Pedersen K, Peg V, et al. A major role of p95/611-CTF, a carboxy-terminal fragment of HER2, in the down-modulation of the estrogen receptor in HER2-positive breast cancers. Cancer Res. 2010; 70: 8537-46.
    • (2010) Cancer Res , vol.70 , pp. 8537-8546
    • Parra-Palau, J.L.1    Pedersen, K.2    Peg, V.3
  • 64
    • 77955753644 scopus 로고    scopus 로고
    • Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients
    • Sperinde J, Jin X, Banerjee J, et al. Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients. Clin Cancer Res. 2010; 16: 4226-35.
    • (2010) Clin Cancer Res , vol.16 , pp. 4226-4235
    • Sperinde, J.1    Jin, X.2    Banerjee, J.3
  • 66
    • 84906685211 scopus 로고    scopus 로고
    • P95 HER2 fragments and breast cancer outcome
    • Tural D, Akar E, Mutlu H, et al. P95 HER2 fragments and breast cancer outcome. Expert Rev Anticancer Ther. 2014; 14: 1089-96.
    • (2014) Expert Rev Anticancer Ther , vol.14 , pp. 1089-1096
    • Tural, D.1    Akar, E.2    Mutlu, H.3
  • 67
    • 67649234062 scopus 로고    scopus 로고
    • A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis
    • Pedersen K, Angelini P-D, Laos S, et al. A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Mol Cell Biol. 2009; 29: 3319-31.
    • (2009) Mol Cell Biol , vol.29 , pp. 3319-3331
    • Pedersen, K.1    Angelini, P.-D.2    Laos, S.3
  • 68
    • 31544465529 scopus 로고    scopus 로고
    • p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer
    • Sáez R, Molina MA, Ramsey EE, et al. p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer. Clin Cancer Res. 2006; 12: 424-31.
    • (2006) Clin Cancer Res , vol.12 , pp. 424-431
    • Sáez, R.1    Molina, M.A.2    Ramsey, E.E.3
  • 69
    • 84901044363 scopus 로고    scopus 로고
    • Quantitative measurements of tumoral p95HER2 protein expression in metastatic breast cancer patients treated with trastuzumab: independent validation of the p95HER2 clinical cutoff
    • Duchnowska R, Sperinde J, Chenna A, et al. Quantitative measurements of tumoral p95HER2 protein expression in metastatic breast cancer patients treated with trastuzumab: independent validation of the p95HER2 clinical cutoff. Clin Cancer Res. 2014; 20: 2805-13.
    • (2014) Clin Cancer Res , vol.20 , pp. 2805-2813
    • Duchnowska, R.1    Sperinde, J.2    Chenna, A.3
  • 70
    • 84857126212 scopus 로고    scopus 로고
    • Insight into p95HER2 in breast cancer: molecular mechanisms and targeted therapies
    • Andrade de Mello R, de Vasconcelos A, Ribeiro RA, et al. Insight into p95HER2 in breast cancer: molecular mechanisms and targeted therapies. Recent Pat DNA Gene Seq. 2012; 6: 56-63.
    • (2012) Recent Pat DNA Gene Seq , vol.6 , pp. 56-63
    • Andrade de Mello, R.1    de Vasconcelos, A.2    Ribeiro, R.A.3
  • 71
    • 0035939791 scopus 로고    scopus 로고
    • Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor
    • Azios NG, Romero FJ, Denton MC, et al. Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor. Oncogene. 2001; 20: 5199-209.
    • (2001) Oncogene , vol.20 , pp. 5199-5209
    • Azios, N.G.1    Romero, F.J.2    Denton, M.C.3
  • 72
    • 84878876128 scopus 로고    scopus 로고
    • HER1 R497K and HER2 I655V polymorphisms are linked to development of breast cancer
    • AbdRaboh NR, Shehata HH, Ahmed MB, et al. HER1 R497K and HER2 I655V polymorphisms are linked to development of breast cancer. Dis Markers. 2013; 34: 407-17.
    • (2013) Dis Markers , vol.34 , pp. 407-417
    • AbdRaboh, N.R.1    Shehata, H.H.2    Ahmed, M.B.3
  • 73
    • 18444372055 scopus 로고    scopus 로고
    • HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses
    • Millikan RC, Hummer AJ, Wolff MS, et al. HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses. Breast Cancer Res Treat. 2005; 89: 309-12.
    • (2005) Breast Cancer Res Treat , vol.89 , pp. 309-312
    • Millikan, R.C.1    Hummer, A.J.2    Wolff, M.S.3
  • 74
    • 0034163421 scopus 로고    scopus 로고
    • Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk
    • Xie D, Shu X-O, Deng Z, et al. Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk. J Natl Cancer Inst. 2000; 92: 412-7.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 412-417
    • Xie, D.1    Shu, X.-O.2    Deng, Z.3
  • 75
    • 78649324359 scopus 로고    scopus 로고
    • HER2 Ile655Val polymorphism contributes to breast cancer risk: evidence from 27 case-control studies
    • Lu S, Wang Z, Liu H, et al. HER2 Ile655Val polymorphism contributes to breast cancer risk: evidence from 27 case-control studies. Breast Cancer Res Treat. 2010; 124: 771-8.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 771-778
    • Lu, S.1    Wang, Z.2    Liu, H.3
  • 76
    • 78651076978 scopus 로고    scopus 로고
    • Lack of association between HER2 codon 655 polymorphism and breast cancer susceptibility: meta-analysis of 22 studies involving 19,341 subjects
    • Ma Y, Yang J, Zhang P, et al. Lack of association between HER2 codon 655 polymorphism and breast cancer susceptibility: meta-analysis of 22 studies involving 19, 341 subjects. Breast Cancer Res Treat. 2011; 125: 237-41.
    • (2011) Breast Cancer Res Treat , vol.125 , pp. 237-241
    • Ma, Y.1    Yang, J.2    Zhang, P.3
  • 77
    • 84921519339 scopus 로고    scopus 로고
    • Updated meta-analysis on HER2 polymorphisms and risk of breast cancer: evidence from 32 studies
    • Chen W, Yang H, Tang WR, et al. Updated meta-analysis on HER2 polymorphisms and risk of breast cancer: evidence from 32 studies. Asian Pac J Cancer Prev. 2014; 15: 9643-7.
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 9643-9647
    • Chen, W.1    Yang, H.2    Tang, W.R.3
  • 78
    • 1542787627 scopus 로고    scopus 로고
    • The HER2 I655V polymorphism and breast cancer risk in ashkenazim
    • Rutter JL, Chatterjee N, Wacholder S, et al. The HER2 I655V polymorphism and breast cancer risk in ashkenazim. Epidemiology. 2003; 14: 694-700.
    • (2003) Epidemiology , vol.14 , pp. 694-700
    • Rutter, J.L.1    Chatterjee, N.2    Wacholder, S.3
  • 79
    • 0037899640 scopus 로고    scopus 로고
    • HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites
    • Millikan R, Eaton A, Worley K, et al. HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites. Breast Cancer Res Treat. 2003; 79: 355-64.
    • (2003) Breast Cancer Res Treat , vol.79 , pp. 355-364
    • Millikan, R.1    Eaton, A.2    Worley, K.3
  • 80
    • 77950858179 scopus 로고    scopus 로고
    • HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma
    • Kruszyna L, Lianeri M, Roszak A, et al. HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma. Clin Biochem. 2010; 43: 545-8.
    • (2010) Clin Biochem , vol.43 , pp. 545-548
    • Kruszyna, L.1    Lianeri, M.2    Roszak, A.3
  • 81
    • 16244422364 scopus 로고    scopus 로고
    • The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk
    • Frank B, Hemminki K, Wirtenberger M, et al. The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk. Carcinogenesis. 2005; 26: 643-7.
    • (2005) Carcinogenesis , vol.26 , pp. 643-647
    • Frank, B.1    Hemminki, K.2    Wirtenberger, M.3
  • 82
    • 77956292811 scopus 로고    scopus 로고
    • The role of HER2 in cancer therapy and targeted drug delivery
    • Tai W, Mahato R, Cheng K. The role of HER2 in cancer therapy and targeted drug delivery. J Controlled Release. 2010; 146: 264-75.
    • (2010) J Controlled Release , vol.146 , pp. 264-275
    • Tai, W.1    Mahato, R.2    Cheng, K.3
  • 83
    • 84888307687 scopus 로고    scopus 로고
    • A systematic review of dual targeting in HER2-positive breast cancer
    • Kümler I, Tuxen MK, Nielsen DL. A systematic review of dual targeting in HER2-positive breast cancer. Cancer Treat Rev. 2014; 40: 259-70.
    • (2014) Cancer Treat Rev , vol.40 , pp. 259-270
    • Kümler, I.1    Tuxen, M.K.2    Nielsen, D.L.3
  • 84
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • GrausPorta D, Beerli RR, Daly JM, et al. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 1997; 16: 1647-55.
    • (1997) EMBO J , vol.16 , pp. 1647-1655
    • GrausPorta, D.1    Beerli, R.R.2    Daly, J.M.3
  • 85
    • 0029053716 scopus 로고
    • Cooperative signaling of Erbb3 and Erbb2 in neoplastic transformation and human mammary carcinomas
    • Alimandi M, Romano A, Curia MC, et al. Cooperative signaling of Erbb3 and Erbb2 in neoplastic transformation and human mammary carcinomas. Oncogene. 1995; 10: 1813-21.
    • (1995) Oncogene , vol.10 , pp. 1813-1821
    • Alimandi, M.1    Romano, A.2    Curia, M.C.3
  • 87
    • 0042307325 scopus 로고    scopus 로고
    • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    • Holbro T, Beerli RR, Maurer F, et al. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci USA. 2003; 100: 8933-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3
  • 88
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: towards the systems level
    • Citri A, Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol. 2006; 7: 505-16.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 89
    • 84898703624 scopus 로고    scopus 로고
    • Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study
    • Slattery ML, John EM, Stern MC, et al. Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study. Breast Cancer Res Treat. 2013; 140: 587-601.
    • (2013) Breast Cancer Res Treat , vol.140 , pp. 587-601
    • Slattery, M.L.1    John, E.M.2    Stern, M.C.3
  • 90
    • 37049183697 scopus 로고
    • Human-breast cancer - correlation of relapse and survival with amplification of the her-2 neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human-breast cancer - correlation of relapse and survival with amplification of the her-2 neu oncogene. Science. 1987; 235: 177-82.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 91
    • 61749088975 scopus 로고    scopus 로고
    • HER2-targeted therapy in breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors
    • Nielsen DL, Andersson M, Kamby C. HER2-targeted therapy in breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors. Cancer Treat Rev. 2009; 35: 121-36.
    • (2009) Cancer Treat Rev , vol.35 , pp. 121-136
    • Nielsen, D.L.1    Andersson, M.2    Kamby, C.3
  • 92
    • 58149250652 scopus 로고    scopus 로고
    • Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors
    • Chen FL, Xia W, Spector NL. Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors. Clin Cancer Res. 2008; 14: 6730-4.
    • (2008) Clin Cancer Res , vol.14 , pp. 6730-6734
    • Chen, F.L.1    Xia, W.2    Spector, N.L.3
  • 93
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
    • Spector NL, Blackwell KL. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2009; 27: 5838-47.
    • (2009) J Clin Oncol , vol.27 , pp. 5838-5847
    • Spector, N.L.1    Blackwell, K.L.2
  • 94
    • 84855177710 scopus 로고    scopus 로고
    • Mechanisms of resistance to HER2 target therapy
    • Tortora G. Mechanisms of resistance to HER2 target therapy. J Natl Cancer Inst Monogr. 2011; 2011: 95-8.
    • (2011) J Natl Cancer Inst Monogr , vol.2011 , pp. 95-98
    • Tortora, G.1
  • 95
    • 84861516765 scopus 로고    scopus 로고
    • Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications
    • Rexer BN, Arteaga CL. Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications. Crit Rev Oncog. 2012; 17: 1-16.
    • (2012) Crit Rev Oncog , vol.17 , pp. 1-16
    • Rexer, B.N.1    Arteaga, C.L.2
  • 96
    • 79957916527 scopus 로고    scopus 로고
    • Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
    • Wu JY, Yu CJ, Chang YC, et al. Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res. 2011; 17: 3812-21.
    • (2011) Clin Cancer Res , vol.17 , pp. 3812-3821
    • Wu, J.Y.1    Yu, C.J.2    Chang, Y.C.3
  • 97
    • 84886442748 scopus 로고    scopus 로고
    • Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2
    • Rexer BN, Ghosh R, Narasanna A, et al. Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2. Clin Cancer Res. 2013; 19: 5390-401.
    • (2013) Clin Cancer Res , vol.19 , pp. 5390-5401
    • Rexer, B.N.1    Ghosh, R.2    Narasanna, A.3
  • 98
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005; 2: 225-35.
    • (2005) PLoS Med , vol.2 , pp. 225-235
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 99
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002; 2: 117-25.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 100
    • 20344393896 scopus 로고    scopus 로고
    • Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation
    • Antonescu CR, Besmer P, Guo TH, et al. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res. 2005; 11: 4182-90.
    • (2005) Clin Cancer Res , vol.11 , pp. 4182-4190
    • Antonescu, C.R.1    Besmer, P.2    Guo, T.H.3
  • 101
    • 42249109014 scopus 로고    scopus 로고
    • EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation
    • Trowe T, Boukouvala S, Calkins K, et al. EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation. Clin Cancer Res. 2008; 14: 2465-75.
    • (2008) Clin Cancer Res , vol.14 , pp. 2465-2475
    • Trowe, T.1    Boukouvala, S.2    Calkins, K.3
  • 102
    • 84907200604 scopus 로고    scopus 로고
    • Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 mutations and PHLDA1
    • Li G, Wang X, Hibshoosh H, et al. Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 mutations and PHLDA1. PLoS ONE. 2014; 9: e106349.
    • (2014) PLoS ONE , vol.9 , pp. e106349
    • Li, G.1    Wang, X.2    Hibshoosh, H.3
  • 103
    • 80055032877 scopus 로고    scopus 로고
    • Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
    • Kancha RK, von Bubnoff N, Bartosch N, et al. Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS ONE. 2011; 6: e26760.
    • (2011) PLoS ONE , vol.6 , pp. e26760
    • Kancha, R.K.1    von Bubnoff, N.2    Bartosch, N.3
  • 104
    • 34547096751 scopus 로고    scopus 로고
    • Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu
    • Piechocki MP, Yoo GH, Dibbley SK, et al. Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu. Cancer Res. 2007; 67: 6825-43.
    • (2007) Cancer Res , vol.67 , pp. 6825-6843
    • Piechocki, M.P.1    Yoo, G.H.2    Dibbley, S.K.3
  • 105
    • 77953479867 scopus 로고    scopus 로고
    • Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators
    • Wang SE, Yu Y, Criswell TL, et al. Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Oncogene. 2010; 29: 3335-48.
    • (2010) Oncogene , vol.29 , pp. 3335-3348
    • Wang, S.E.1    Yu, Y.2    Criswell, T.L.3
  • 106
    • 84873830350 scopus 로고    scopus 로고
    • Non-small-cell lung cancer with HER2 exon 20 mutation regression with dual HER2 inhibition and anti-VEGF combination treatment
    • Falchook GS, Janku F, Tsao AS, et al. Non-small-cell lung cancer with HER2 exon 20 mutation regression with dual HER2 inhibition and anti-VEGF combination treatment. J Thorac Oncol. 2013; 8: E19-20.
    • (2013) J Thorac Oncol , vol.8 , pp. E19-E20
    • Falchook, G.S.1    Janku, F.2    Tsao, A.S.3
  • 107
    • 58849132314 scopus 로고    scopus 로고
    • HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy
    • Perera SA, Li D, Shimamura T, et al. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci USA. 2009; 106: 474-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 474-479
    • Perera, S.A.1    Li, D.2    Shimamura, T.3
  • 108
    • 84880661427 scopus 로고    scopus 로고
    • Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives
    • 1997-U307
    • Mazieres J, Peters S, Lepage B, et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol. 2013; 31: 1997-U307.
    • (2013) J Clin Oncol , vol.31
    • Mazieres, J.1    Peters, S.2    Lepage, B.3
  • 109
    • 33745057881 scopus 로고    scopus 로고
    • HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer
    • Cappuzzo F, Bemis L, Varella-Garcia M. HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N Engl J Med. 2006; 354: 2619-21.
    • (2006) N Engl J Med , vol.354 , pp. 2619-2621
    • Cappuzzo, F.1    Bemis, L.2    Varella-Garcia, M.3
  • 110
    • 84903387504 scopus 로고    scopus 로고
    • HER2 mutation status in Japanese HER2-negative breast cancer patients
    • Endo Y, Dong Y, Yoshimoto N, et al. HER2 mutation status in Japanese HER2-negative breast cancer patients. Jpn J Clin Oncol. 2014; 44: 619-23.
    • (2014) Jpn J Clin Oncol , vol.44 , pp. 619-623
    • Endo, Y.1    Dong, Y.2    Yoshimoto, N.3


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