EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation

Clinical Cancer Research

Volumn 14, Issue 8, 2008, Pages 2465-2475

  Trowe, Torsten ^a   Boukouvala, Sotiria ^a   Calkins, Keith ^a   Cutler Jr , Richard E ^a   Fong, Ryan ^a   Funke, Roel ^a   Gendreau, Steven B ^a   Kim, Yong D ^a   Miller, Nicole ^a   Woolfrey, John R ^a   Vysotskaia, Valentina ^a   Jing, Ping Yang ^a   Gerritsen, Mary E ^a   Matthews, David J ^a   Lamb, Peter ^a   Heuer, Timothy S ^a  

^a EXELIXIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EXEL 7647; IMATINIB; LAPATINIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; IN VITRO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DRUG RESISTANCE, NEOPLASM; HUMANS; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, ERBB-2;

EID: 42249109014     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-4367     Document Type: Article

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