-
1
-
-
0024337144
-
Studies of the HER-2/neu protooncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science 1989;244:707-12
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
2
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER- 2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER- 2/neu oncogene. Science 1987;235:177-82
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
3
-
-
84856340091
-
HER2 shedding and serum HER2 extracellular domain: Biology and clinical utility in breast cancer
-
Tsé C, Gauchez AS, Jacot W, Lamy PJ. HER2 shedding and serum HER2 extracellular domain: biology and clinical utility in breast cancer. Cancer Treat Rev 2012;38:133-42
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 133-142
-
-
Tsé, C.1
Gauchez, A.S.2
Jacot, W.3
Lamy, P.J.4
-
4
-
-
0029991439
-
Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
-
Baselga J, Tripathy D, Mendelsohn J, et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 1996;14:737-44
-
(1996)
J Clin Oncol
, vol.14
, pp. 737-744
-
-
Baselga, J.1
Tripathy, D.2
Mendelsohn, J.3
-
5
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER-2 overexpressing metastatic breast cancer that has progresssed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER-2 overexpressing metastatic breast cancer that has progresssed after chemotherapy for metastatic disease. J Clin Oncol 1999;17: 2639-48
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
6
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-26
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
7
-
-
33751344602
-
HER2 therapy: Molecular mechanisms of trastuzumab resistance
-
Nahta R, Esteva FJ. HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res 2006;8:215
-
(2006)
Breast Cancer Res
, vol.8
, pp. 215
-
-
Nahta, R.1
Esteva, F.J.2
-
8
-
-
0025829608
-
A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells
-
Lin YL, Clinton GM. A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells. Oncogene 1991;6:639-43
-
(1991)
Oncogene
, vol.6
, pp. 639-643
-
-
Lin, Y.L.1
Clinton, G.M.2
-
9
-
-
0027524245
-
The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage
-
Pupa SM, Menard S, Morelli D, et al. The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage. Oncogene 1993;8:2917-23
-
(1993)
Oncogene
, vol.8
, pp. 2917-2923
-
-
Pupa, S.M.1
Menard, S.2
Morelli, D.3
-
10
-
-
0026071364
-
The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3
-
Zabrecky J R, Lam T, McKenzie SJ, Carney W. The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3. J Biol Chem 1991;266:1716-20
-
(1991)
J Biol Chem
, vol.266
, pp. 1716-1720
-
-
Zabrecky, J.R.1
Lam, T.2
McKenzie, S.J.3
Carney, W.4
-
11
-
-
0036187710
-
NH (2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
-
Molina MA, Saéz R, Ramsey EE, et al. NH (2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin Cancer Res 2002;8:347-53
-
(2002)
Clin Cancer Res
, vol.8
, pp. 347-353
-
-
Molina, M.A.1
Saéz, R.2
Ramsey, E.E.3
-
12
-
-
0029593312
-
The c-erb transmembrane growth factor receptors as serum biomarkers in human cancer studies
-
Brandt-Rauf PW. The c-erb transmembrane growth factor receptors as serum biomarkers in human cancer studies. Mutat Res 1995;333:203-8
-
(1995)
Mutat Res
, vol.333
, pp. 203-208
-
-
Brandt-Rauf, P.W.1
-
13
-
-
33746290773
-
Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation
-
Anido J, Scaltriti M, Bech Serra JJ, et al. Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. EMBOJ 2006;25: 3234-44
-
(2006)
EMBOJ
, vol.25
, pp. 3234-3244
-
-
Anido, J.1
Scaltriti, M.2
Bech Serra, J.J.3
-
14
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
-
Scaltriti M, Rojo F, Ocaña A, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 2007;99:628-38
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocaña, A.3
-
15
-
-
77951744619
-
Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor
-
Scaltriti M, Chandarlapaty S, Prudkin L, et al. Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor. Clin Cancer Res 2010;16:2688-95
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2688-2695
-
-
Scaltriti, M.1
Chandarlapaty, S.2
Prudkin, L.3
-
16
-
-
33750614996
-
Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors
-
Sanderson MP, Dempsey PJ, Dunbar AJ. Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors. Growth Factors 2006;24:121-36
-
(2006)
Growth Factors
, vol.24
, pp. 121-136
-
-
Sanderson, M.P.1
Dempsey, P.J.2
Dunbar, A.J.3
-
17
-
-
67649234062
-
A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis
-
Pedersen K, Angelini PD, Laos S, et al. A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Mol Cell Biol 2009;29:3319-31
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3319-3331
-
-
Pedersen, K.1
Angelini, P.D.2
Laos, S.3
-
18
-
-
0032532950
-
NH2-terminally truncated HER-2/neu protein: Relationship with shedding of the extracellular domain and with prognostic factors in breast cancer
-
Christianson TA, Doherty JK, Lin YJ, et al. NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer. Cancer Res 1998;58:5123-9
-
(1998)
Cancer Res
, vol.58
, pp. 5123-5129
-
-
Christianson, T.A.1
Doherty, J.K.2
Lin, Y.J.3
-
19
-
-
0035874981
-
Trastuzumab (HerceptinR), a humanized anti-HER-2 receptor monoclonal antibody, inhibits basal and activated HER-2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, et al. Trastuzumab (HerceptinR), a humanized anti-HER-2 receptor monoclonal antibody, inhibits basal and activated HER-2 ectodomain cleavage in breast cancer cells. Cancer Res 2001;15: 4744-9
-
(2001)
Cancer Res
, vol.15
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
-
20
-
-
11344287012
-
Herstatin, an autoinhibitor of the epidermal growth factor receptor family, blocks the intracranial growth of glioblastoma
-
Staverosky JA, Muldoon LL, Guo S, et al. Herstatin, an autoinhibitor of the epidermal growth factor receptor family, blocks the intracranial growth of glioblastoma. Clin Cancer Res 2005;11:335-40
-
(2005)
Clin Cancer Res
, vol.11
, pp. 335-340
-
-
Staverosky, J.A.1
Muldoon, L.L.2
Guo, S.3
-
21
-
-
0032850779
-
The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor
-
Doherty JK, Bond C, Jardim A, et al. The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor. Proc Natl Acad Sci USA 1999;96:10869-74
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10869-10874
-
-
Doherty, J.K.1
Bond, C.2
Jardim, A.3
-
22
-
-
0035912086
-
Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation
-
Aigner A, Juhl H, Malerczyk C, et al. Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation. Oncogene 2001;20:2101-11
-
(2001)
Oncogene
, vol.20
, pp. 2101-2111
-
-
Aigner, A.1
Juhl, H.2
Malerczyk, C.3
-
23
-
-
0037047402
-
Identification of a region within the ErbB2/ HER2 intracellular domain that is necessary for ligand-independent association
-
Penuel E, Akita RW, Sliwkowski MX. Identification of a region within the ErbB2/ HER2 intracellular domain that is necessary for ligand-independent association. J Biol Chem 2002;277:28468-73
-
(2002)
J Biol Chem
, vol.277
, pp. 28468-28473
-
-
Penuel, E.1
Akita, R.W.2
Sliwkowski, M.X.3
-
25
-
-
38149074027
-
Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations
-
Burns DM, He C, Li Y, et al. Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett 2008;18:560-4
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 560-564
-
-
Burns, D.M.1
He, C.2
Li, Y.3
-
26
-
-
84872971201
-
Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines
-
Recupero D, Daniele L, Marchiò C, et al. Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines. J Pathol 2013;229:390-9
-
(2013)
J Pathol
, vol.229
, pp. 390-399
-
-
Recupero, D.1
Daniele, L.2
Marchiò, C.3
-
27
-
-
10744230127
-
An openand-shut case? Recent insights into the activation of EGF/ErbB receptors
-
Burgess AW, Cho HS, Eigenbrot C, et al. An openand-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell 2003;12:541-52
-
(2003)
Mol Cell
, vol.12
, pp. 541-552
-
-
Burgess, A.W.1
Cho, H.S.2
Eigenbrot, C.3
-
28
-
-
62649159075
-
Ligand-induced ErbB receptor dimerization
-
Lemmon MA. Ligand-induced ErbB receptor dimerization. Exp Cell Res 2009;315:638-48
-
(2009)
Exp Cell Res
, vol.315
, pp. 638-648
-
-
Lemmon, M.A.1
-
29
-
-
0141615794
-
Potential clinical utility of serum HER-2/ neu oncoprotein concentrations in patients with breast cancer
-
Carney WP, Neumann R, Lipton A, et al. Potential clinical utility of serum HER-2/ neu oncoprotein concentrations in patients with breast cancer. Clin Chem 2003;49: 1579-98
-
(2003)
Clin Chem
, vol.49
, pp. 1579-1598
-
-
Carney, W.P.1
Neumann, R.2
Lipton, A.3
-
30
-
-
53149107465
-
Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer
-
Ali SM, Carney WP, Esteva FJ, et al. Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer. Cancer 2008;113: 1294-301
-
(2008)
Cancer
, vol.113
, pp. 1294-1301
-
-
Ali, S.M.1
Carney, W.P.2
Esteva, F.J.3
-
31
-
-
84890679006
-
Circulating HER2 extra cellular domain: A specific and quantitative biomarker of prognostic value in all breast cancer patients?
-
Carney WP, Bernhardt D, Jasani B. Circulating HER2 extra cellular domain: a specific and quantitative biomarker of prognostic value in all breast cancer patients? Biomark Cancer 2013;5:31-9
-
(2013)
Biomark Cancer
, vol.5
, pp. 31-39
-
-
Carney, W.P.1
Bernhardt, D.2
Jasani, B.3
-
32
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang X, Gureasko J, Shen K, et al. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 2006;125:1137-49
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
-
33
-
-
1242273590
-
Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
-
Xia W, Liu LH, Ho P, Spector NL. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene 2004;23:646-53
-
(2004)
Oncogene
, vol.23
, pp. 646-653
-
-
Xia, W.1
Liu, L.H.2
Ho, P.3
Spector, N.L.4
-
34
-
-
31544465529
-
P95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer
-
Saéz R, Molina MA, Ramsey EE, et al. Albanell J. p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer. Clin Cancer Res 2006;12: 424-31
-
(2006)
Clin Cancer Res
, vol.12
, pp. 424-431
-
-
Saéz, R.1
Molina, M.A.2
Ramsey, E.E.3
-
35
-
-
84892965940
-
Potential biomarkers of long-term benefit from single-agent trastuzumab or lapatinib in HER2-positive metastatic breast cancer
-
Montemurro F, Prat A, Rossi V, et al. Potential biomarkers of long-term benefit from single-agent trastuzumab or lapatinib in HER2-positive metastatic breast cancer. Mol Oncol 2014;8:20-6
-
(2014)
Mol Oncol
, vol.8
, pp. 20-26
-
-
Montemurro, F.1
Prat, A.2
Rossi, V.3
-
36
-
-
77955753644
-
Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients
-
Sperinde J, Jin X, Banerjee J, et al. Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients. Clin Cancer Res 2010;16:4226-35
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4226-4235
-
-
Sperinde, J.1
Jin, X.2
Banerjee, J.3
-
37
-
-
84901044363
-
Quantitative measurements of tumoral p95her2 protein expression in metastatic breast cancer patients treated with trastuzumab: Independent validation of the p95her2 clinical cutoff
-
Epub ahead of print
-
Duchnowska R, Sperinde J, Chenna A, et al. Quantitative measurements of tumoral p95her2 protein expression in metastatic breast cancer patients treated with trastuzumab: independent validation of the p95her2 clinical cutoff. Clin Cancer Res 2014. Epub ahead of print
-
(2014)
Clin Cancer Res
-
-
Duchnowska, R.1
Sperinde, J.2
Chenna, A.3
-
38
-
-
84898849134
-
Serdarturhal N. P95-HER2 and trastuzumab resistance in metastatic breast cancer; Is immunohistochemistry appropriate?
-
Kocar M, Bozkurtlar E, Telli F, et al. Serdarturhal N. p95-HER2 and trastuzumab resistance in metastatic breast cancer; is immunohistochemistry appropriate? J BUON 2014;19:245-9
-
(2014)
J BUON
, vol.19
, pp. 245-249
-
-
Kocar, M.1
Bozkurtlar, E.2
Telli, F.3
-
39
-
-
84884279586
-
HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
-
Lipton A, Goodman L, Leitzel K, et al. HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer. Breast Cancer Res Treat 2013;141:43-53
-
(2013)
Breast Cancer Res Treat
, vol.141
, pp. 43-53
-
-
Lipton, A.1
Goodman, L.2
Leitzel, K.3
-
40
-
-
84864398790
-
Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer
-
Han SW, Cha Y, Paquet A, et al. Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer. PLoS One 2012;7: e39943
-
(2012)
PLoS One
, vol.7
-
-
Han, S.W.1
Cha, Y.2
Paquet, A.3
-
41
-
-
80052905474
-
Validation of p95 as a predictive marker for trastuzumab-based therapy in primary HER2-positive breast cancer: A translational investigation from the neoadjuvant GeparQuattro study
-
German Breast Group abstr 530
-
Loibl S, Bruey J, Von Minckwitz G, German Breast Group. Validation of p95 as a predictive marker for trastuzumab-based therapy in primary HER2-positive breast cancer: A translational investigation from the neoadjuvant GeparQuattro study. J Clin Oncol 2011;29:suppl;abstr 530
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Loibl, S.1
Bruey, J.2
Von Minckwitz, G.3
-
42
-
-
33749011681
-
A phase i study of cetuximab/paclitaxel in patients with advanced-stage breast cancer
-
Modi S, D' Andrea G, Norton L, et al. A phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer. Clin Breast Cancer 2006;7:270-7
-
(2006)
Clin Breast Cancer
, vol.7
, pp. 270-277
-
-
Modi, S.1
Andrea G, D.'.2
Norton, L.3
-
43
-
-
75149123144
-
Inhibitors of HSP90 block p95-HER2 signaling in trastuzumab-resistant tumors and suppress their growth
-
Chandarlapaty S, Scaltriti M, Angelini P, et al. Inhibitors of HSP90 block p95-HER2 signaling in trastuzumab-resistant tumors and suppress their growth. Oncogene 2010;29:325-34
-
(2010)
Oncogene
, vol.29
, pp. 325-334
-
-
Chandarlapaty, S.1
Scaltriti, M.2
Angelini, P.3
|