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Volumn 14, Issue 9, 2014, Pages 1089-1096

P95 HER2 fragments and breast cancer outcome

Author keywords

breast cancer outcome; p185HER2; p95HER2 fragment; proteolytic shedding and translation of HER2

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GROWTH FACTOR RECEPTOR; MESSENGER RNA; P95HER2 PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; LAPATINIB; MONOCLONAL ANTIBODY; QUINAZOLINE DERIVATIVE; TRASTUZUMAB; TUMOR MARKER;

EID: 84906685211     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.2014.929946     Document Type: Review
Times cited : (31)

References (43)
  • 1
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu protooncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science 1989;244:707-12
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER- 2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER- 2/neu oncogene. Science 1987;235:177-82
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 3
    • 84856340091 scopus 로고    scopus 로고
    • HER2 shedding and serum HER2 extracellular domain: Biology and clinical utility in breast cancer
    • Tsé C, Gauchez AS, Jacot W, Lamy PJ. HER2 shedding and serum HER2 extracellular domain: biology and clinical utility in breast cancer. Cancer Treat Rev 2012;38:133-42
    • (2012) Cancer Treat Rev , vol.38 , pp. 133-142
    • Tsé, C.1    Gauchez, A.S.2    Jacot, W.3    Lamy, P.J.4
  • 4
    • 0029991439 scopus 로고    scopus 로고
    • Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
    • Baselga J, Tripathy D, Mendelsohn J, et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 1996;14:737-44
    • (1996) J Clin Oncol , vol.14 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3
  • 5
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER-2 overexpressing metastatic breast cancer that has progresssed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER-2 overexpressing metastatic breast cancer that has progresssed after chemotherapy for metastatic disease. J Clin Oncol 1999;17: 2639-48
    • (1999) J Clin Oncol , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 6
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-26
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 7
    • 33751344602 scopus 로고    scopus 로고
    • HER2 therapy: Molecular mechanisms of trastuzumab resistance
    • Nahta R, Esteva FJ. HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res 2006;8:215
    • (2006) Breast Cancer Res , vol.8 , pp. 215
    • Nahta, R.1    Esteva, F.J.2
  • 8
    • 0025829608 scopus 로고
    • A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells
    • Lin YL, Clinton GM. A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells. Oncogene 1991;6:639-43
    • (1991) Oncogene , vol.6 , pp. 639-643
    • Lin, Y.L.1    Clinton, G.M.2
  • 9
    • 0027524245 scopus 로고
    • The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage
    • Pupa SM, Menard S, Morelli D, et al. The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage. Oncogene 1993;8:2917-23
    • (1993) Oncogene , vol.8 , pp. 2917-2923
    • Pupa, S.M.1    Menard, S.2    Morelli, D.3
  • 10
    • 0026071364 scopus 로고
    • The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3
    • Zabrecky J R, Lam T, McKenzie SJ, Carney W. The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3. J Biol Chem 1991;266:1716-20
    • (1991) J Biol Chem , vol.266 , pp. 1716-1720
    • Zabrecky, J.R.1    Lam, T.2    McKenzie, S.J.3    Carney, W.4
  • 11
    • 0036187710 scopus 로고    scopus 로고
    • NH (2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
    • Molina MA, Saéz R, Ramsey EE, et al. NH (2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin Cancer Res 2002;8:347-53
    • (2002) Clin Cancer Res , vol.8 , pp. 347-353
    • Molina, M.A.1    Saéz, R.2    Ramsey, E.E.3
  • 12
    • 0029593312 scopus 로고
    • The c-erb transmembrane growth factor receptors as serum biomarkers in human cancer studies
    • Brandt-Rauf PW. The c-erb transmembrane growth factor receptors as serum biomarkers in human cancer studies. Mutat Res 1995;333:203-8
    • (1995) Mutat Res , vol.333 , pp. 203-208
    • Brandt-Rauf, P.W.1
  • 13
    • 33746290773 scopus 로고    scopus 로고
    • Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation
    • Anido J, Scaltriti M, Bech Serra JJ, et al. Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. EMBOJ 2006;25: 3234-44
    • (2006) EMBOJ , vol.25 , pp. 3234-3244
    • Anido, J.1    Scaltriti, M.2    Bech Serra, J.J.3
  • 14
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti M, Rojo F, Ocaña A, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 2007;99:628-38
    • (2007) J Natl Cancer Inst , vol.99 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocaña, A.3
  • 15
    • 77951744619 scopus 로고    scopus 로고
    • Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor
    • Scaltriti M, Chandarlapaty S, Prudkin L, et al. Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor. Clin Cancer Res 2010;16:2688-95
    • (2010) Clin Cancer Res , vol.16 , pp. 2688-2695
    • Scaltriti, M.1    Chandarlapaty, S.2    Prudkin, L.3
  • 16
    • 33750614996 scopus 로고    scopus 로고
    • Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors
    • Sanderson MP, Dempsey PJ, Dunbar AJ. Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors. Growth Factors 2006;24:121-36
    • (2006) Growth Factors , vol.24 , pp. 121-136
    • Sanderson, M.P.1    Dempsey, P.J.2    Dunbar, A.J.3
  • 17
    • 67649234062 scopus 로고    scopus 로고
    • A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis
    • Pedersen K, Angelini PD, Laos S, et al. A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Mol Cell Biol 2009;29:3319-31
    • (2009) Mol Cell Biol , vol.29 , pp. 3319-3331
    • Pedersen, K.1    Angelini, P.D.2    Laos, S.3
  • 18
    • 0032532950 scopus 로고    scopus 로고
    • NH2-terminally truncated HER-2/neu protein: Relationship with shedding of the extracellular domain and with prognostic factors in breast cancer
    • Christianson TA, Doherty JK, Lin YJ, et al. NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer. Cancer Res 1998;58:5123-9
    • (1998) Cancer Res , vol.58 , pp. 5123-5129
    • Christianson, T.A.1    Doherty, J.K.2    Lin, Y.J.3
  • 19
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (HerceptinR), a humanized anti-HER-2 receptor monoclonal antibody, inhibits basal and activated HER-2 ectodomain cleavage in breast cancer cells
    • Molina MA, Codony-Servat J, Albanell J, et al. Trastuzumab (HerceptinR), a humanized anti-HER-2 receptor monoclonal antibody, inhibits basal and activated HER-2 ectodomain cleavage in breast cancer cells. Cancer Res 2001;15: 4744-9
    • (2001) Cancer Res , vol.15 , pp. 4744-4749
    • Molina, M.A.1    Codony-Servat, J.2    Albanell, J.3
  • 20
    • 11344287012 scopus 로고    scopus 로고
    • Herstatin, an autoinhibitor of the epidermal growth factor receptor family, blocks the intracranial growth of glioblastoma
    • Staverosky JA, Muldoon LL, Guo S, et al. Herstatin, an autoinhibitor of the epidermal growth factor receptor family, blocks the intracranial growth of glioblastoma. Clin Cancer Res 2005;11:335-40
    • (2005) Clin Cancer Res , vol.11 , pp. 335-340
    • Staverosky, J.A.1    Muldoon, L.L.2    Guo, S.3
  • 21
    • 0032850779 scopus 로고    scopus 로고
    • The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor
    • Doherty JK, Bond C, Jardim A, et al. The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor. Proc Natl Acad Sci USA 1999;96:10869-74
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10869-10874
    • Doherty, J.K.1    Bond, C.2    Jardim, A.3
  • 22
    • 0035912086 scopus 로고    scopus 로고
    • Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation
    • Aigner A, Juhl H, Malerczyk C, et al. Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation. Oncogene 2001;20:2101-11
    • (2001) Oncogene , vol.20 , pp. 2101-2111
    • Aigner, A.1    Juhl, H.2    Malerczyk, C.3
  • 23
    • 0037047402 scopus 로고    scopus 로고
    • Identification of a region within the ErbB2/ HER2 intracellular domain that is necessary for ligand-independent association
    • Penuel E, Akita RW, Sliwkowski MX. Identification of a region within the ErbB2/ HER2 intracellular domain that is necessary for ligand-independent association. J Biol Chem 2002;277:28468-73
    • (2002) J Biol Chem , vol.277 , pp. 28468-28473
    • Penuel, E.1    Akita, R.W.2    Sliwkowski, M.X.3
  • 25
    • 38149074027 scopus 로고    scopus 로고
    • Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations
    • Burns DM, He C, Li Y, et al. Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett 2008;18:560-4
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 560-564
    • Burns, D.M.1    He, C.2    Li, Y.3
  • 26
    • 84872971201 scopus 로고    scopus 로고
    • Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines
    • Recupero D, Daniele L, Marchiò C, et al. Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines. J Pathol 2013;229:390-9
    • (2013) J Pathol , vol.229 , pp. 390-399
    • Recupero, D.1    Daniele, L.2    Marchiò, C.3
  • 27
    • 10744230127 scopus 로고    scopus 로고
    • An openand-shut case? Recent insights into the activation of EGF/ErbB receptors
    • Burgess AW, Cho HS, Eigenbrot C, et al. An openand-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell 2003;12:541-52
    • (2003) Mol Cell , vol.12 , pp. 541-552
    • Burgess, A.W.1    Cho, H.S.2    Eigenbrot, C.3
  • 28
    • 62649159075 scopus 로고    scopus 로고
    • Ligand-induced ErbB receptor dimerization
    • Lemmon MA. Ligand-induced ErbB receptor dimerization. Exp Cell Res 2009;315:638-48
    • (2009) Exp Cell Res , vol.315 , pp. 638-648
    • Lemmon, M.A.1
  • 29
    • 0141615794 scopus 로고    scopus 로고
    • Potential clinical utility of serum HER-2/ neu oncoprotein concentrations in patients with breast cancer
    • Carney WP, Neumann R, Lipton A, et al. Potential clinical utility of serum HER-2/ neu oncoprotein concentrations in patients with breast cancer. Clin Chem 2003;49: 1579-98
    • (2003) Clin Chem , vol.49 , pp. 1579-1598
    • Carney, W.P.1    Neumann, R.2    Lipton, A.3
  • 30
    • 53149107465 scopus 로고    scopus 로고
    • Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer
    • Ali SM, Carney WP, Esteva FJ, et al. Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer. Cancer 2008;113: 1294-301
    • (2008) Cancer , vol.113 , pp. 1294-1301
    • Ali, S.M.1    Carney, W.P.2    Esteva, F.J.3
  • 31
    • 84890679006 scopus 로고    scopus 로고
    • Circulating HER2 extra cellular domain: A specific and quantitative biomarker of prognostic value in all breast cancer patients?
    • Carney WP, Bernhardt D, Jasani B. Circulating HER2 extra cellular domain: a specific and quantitative biomarker of prognostic value in all breast cancer patients? Biomark Cancer 2013;5:31-9
    • (2013) Biomark Cancer , vol.5 , pp. 31-39
    • Carney, W.P.1    Bernhardt, D.2    Jasani, B.3
  • 32
    • 33745002702 scopus 로고    scopus 로고
    • An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
    • Zhang X, Gureasko J, Shen K, et al. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 2006;125:1137-49
    • (2006) Cell , vol.125 , pp. 1137-1149
    • Zhang, X.1    Gureasko, J.2    Shen, K.3
  • 33
    • 1242273590 scopus 로고    scopus 로고
    • Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
    • Xia W, Liu LH, Ho P, Spector NL. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene 2004;23:646-53
    • (2004) Oncogene , vol.23 , pp. 646-653
    • Xia, W.1    Liu, L.H.2    Ho, P.3    Spector, N.L.4
  • 34
    • 31544465529 scopus 로고    scopus 로고
    • P95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer
    • Saéz R, Molina MA, Ramsey EE, et al. Albanell J. p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer. Clin Cancer Res 2006;12: 424-31
    • (2006) Clin Cancer Res , vol.12 , pp. 424-431
    • Saéz, R.1    Molina, M.A.2    Ramsey, E.E.3
  • 35
    • 84892965940 scopus 로고    scopus 로고
    • Potential biomarkers of long-term benefit from single-agent trastuzumab or lapatinib in HER2-positive metastatic breast cancer
    • Montemurro F, Prat A, Rossi V, et al. Potential biomarkers of long-term benefit from single-agent trastuzumab or lapatinib in HER2-positive metastatic breast cancer. Mol Oncol 2014;8:20-6
    • (2014) Mol Oncol , vol.8 , pp. 20-26
    • Montemurro, F.1    Prat, A.2    Rossi, V.3
  • 36
    • 77955753644 scopus 로고    scopus 로고
    • Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients
    • Sperinde J, Jin X, Banerjee J, et al. Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients. Clin Cancer Res 2010;16:4226-35
    • (2010) Clin Cancer Res , vol.16 , pp. 4226-4235
    • Sperinde, J.1    Jin, X.2    Banerjee, J.3
  • 37
    • 84901044363 scopus 로고    scopus 로고
    • Quantitative measurements of tumoral p95her2 protein expression in metastatic breast cancer patients treated with trastuzumab: Independent validation of the p95her2 clinical cutoff
    • Epub ahead of print
    • Duchnowska R, Sperinde J, Chenna A, et al. Quantitative measurements of tumoral p95her2 protein expression in metastatic breast cancer patients treated with trastuzumab: independent validation of the p95her2 clinical cutoff. Clin Cancer Res 2014. Epub ahead of print
    • (2014) Clin Cancer Res
    • Duchnowska, R.1    Sperinde, J.2    Chenna, A.3
  • 38
    • 84898849134 scopus 로고    scopus 로고
    • Serdarturhal N. P95-HER2 and trastuzumab resistance in metastatic breast cancer; Is immunohistochemistry appropriate?
    • Kocar M, Bozkurtlar E, Telli F, et al. Serdarturhal N. p95-HER2 and trastuzumab resistance in metastatic breast cancer; is immunohistochemistry appropriate? J BUON 2014;19:245-9
    • (2014) J BUON , vol.19 , pp. 245-249
    • Kocar, M.1    Bozkurtlar, E.2    Telli, F.3
  • 39
    • 84884279586 scopus 로고    scopus 로고
    • HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
    • Lipton A, Goodman L, Leitzel K, et al. HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer. Breast Cancer Res Treat 2013;141:43-53
    • (2013) Breast Cancer Res Treat , vol.141 , pp. 43-53
    • Lipton, A.1    Goodman, L.2    Leitzel, K.3
  • 40
    • 84864398790 scopus 로고    scopus 로고
    • Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer
    • Han SW, Cha Y, Paquet A, et al. Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer. PLoS One 2012;7: e39943
    • (2012) PLoS One , vol.7
    • Han, S.W.1    Cha, Y.2    Paquet, A.3
  • 41
    • 80052905474 scopus 로고    scopus 로고
    • Validation of p95 as a predictive marker for trastuzumab-based therapy in primary HER2-positive breast cancer: A translational investigation from the neoadjuvant GeparQuattro study
    • German Breast Group abstr 530
    • Loibl S, Bruey J, Von Minckwitz G, German Breast Group. Validation of p95 as a predictive marker for trastuzumab-based therapy in primary HER2-positive breast cancer: A translational investigation from the neoadjuvant GeparQuattro study. J Clin Oncol 2011;29:suppl;abstr 530
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Loibl, S.1    Bruey, J.2    Von Minckwitz, G.3
  • 42
    • 33749011681 scopus 로고    scopus 로고
    • A phase i study of cetuximab/paclitaxel in patients with advanced-stage breast cancer
    • Modi S, D' Andrea G, Norton L, et al. A phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer. Clin Breast Cancer 2006;7:270-7
    • (2006) Clin Breast Cancer , vol.7 , pp. 270-277
    • Modi, S.1    Andrea G, D.'.2    Norton, L.3
  • 43
    • 75149123144 scopus 로고    scopus 로고
    • Inhibitors of HSP90 block p95-HER2 signaling in trastuzumab-resistant tumors and suppress their growth
    • Chandarlapaty S, Scaltriti M, Angelini P, et al. Inhibitors of HSP90 block p95-HER2 signaling in trastuzumab-resistant tumors and suppress their growth. Oncogene 2010;29:325-34
    • (2010) Oncogene , vol.29 , pp. 325-334
    • Chandarlapaty, S.1    Scaltriti, M.2    Angelini, P.3


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