-
1
-
-
33744938412
-
Trends in breast cancer by race and ethnicity: Update 2006
-
Smigal C, Jemal A, Ward E et al. Trends in breast cancer by race and ethnicity: Update 2006. CA Cancer J Clin 2006;56:168-183.
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 168-183
-
-
Smigal, C.1
Jemal, A.2
Ward, E.3
-
2
-
-
33846436108
-
Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) program
-
Hayat MJ, Howlader N, Reichman ME et al. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) program. The Oncologist 2007;12:20-37.
-
(2007)
The Oncologist
, vol.12
, pp. 20-37
-
-
Hayat, M.J.1
Howlader, N.2
Reichman, M.E.3
-
3
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003;21:2787-2799.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
5
-
-
0141725532
-
Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer
-
Atalay G, Cardoso F, Awada A et al Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer. Ann Oncol 2003;14:1346-1363.
-
(2003)
Ann Oncol
, vol.14
, pp. 1346-1363
-
-
Atalay, G.1
Cardoso, F.2
Awada, A.3
-
6
-
-
37049183697
-
Human breast cancer: Corelation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: Corelation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
7
-
-
25144517586
-
Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab
-
Mass RD, Press MF, Anderson S et al. Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab. Clin Breast Cancer 2005;6:240-246.
-
(2005)
Clin Breast Cancer
, vol.6
, pp. 240-246
-
-
Mass, R.D.1
Press, M.F.2
Anderson, S.3
-
8
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001.344:783-792.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
9
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 2005;23:4265-427Marty M, Cognetti F, Maraninchi D et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 2005;23:4265-4274.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
10
-
-
34249342246
-
HER-2-positive metastatic breast cancer: Optimizing trastuzumab-based therapy
-
Jackisch C. HER-2-positive metastatic breast cancer: Optimizing trastuzumab-based therapy. The Oncologist 2006;11(suppl 1):34-41.
-
(2006)
The Oncologist
, vol.11
, Issue.SUPPL. 1
, pp. 34-41
-
-
Jackisch, C.1
-
11
-
-
73949090721
-
Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutional-based review
-
Dawood S, Broglio K, Buzdar AU et al. Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutional-based review. J Clin Oncol 2010;28:92-98.
-
(2010)
J Clin Oncol
, vol.28
, pp. 92-98
-
-
Dawood, S.1
Broglio, K.2
Buzdar, A.U.3
-
12
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-726.
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
13
-
-
17144371333
-
Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
-
Baselga J, Carbonell X, Castaneda-Soto NJ et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 2005;23:2162-2171.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2162-2171
-
-
Baselga, J.1
Carbonell, X.2
Castaneda-Soto, N.J.3
-
14
-
-
84872758982
-
Superior long-term survival benefits of trastuzumab plus docetaxel compared to docetaxel alone in patients with HER2-positive metastatic breast cancer: Patients surviving more than 4 years in the M77001 study
-
San Antonio, TX, December
-
Marty M, Cognetti F, Maraninchi D et al. Superior long-term survival benefits of trastuzumab plus docetaxel compared to docetaxel alone in patients with HER2-positive metastatic breast cancer: Patients surviving more than 4 years in the M77001 study. Presented at the 29th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 14-17, 2006.
-
(2006)
Presented At the 29th Annual San Antonio Breast Cancer Symposium
, pp. 14-17
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
15
-
-
80051766451
-
Randomized phase II study comparing efficacy and safety of combination-therapy trastuzumab and docetaxel vs. sequential therapy of trastuzumab followed by docetaxel alone at progression as first-line chemotherapy in patients with HER2+ metastatic breast cancer: HERTAX trial
-
Hamberg P, Bos MM, Braun HJ et al. Randomized phase II study comparing efficacy and safety of combination-therapy trastuzumab and docetaxel vs. sequential therapy of trastuzumab followed by docetaxel alone at progression as first-line chemotherapy in patients with HER2+ metastatic breast cancer: HERTAX trial. Clin Breast Cancer 2011;11:103-113.
-
(2011)
Clin Breast Cancer
, vol.11
, pp. 103-113
-
-
Hamberg, P.1
Bos, M.M.2
Braun, H.J.3
-
16
-
-
34548178720
-
Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study
-
Burstein HJ, Keshaviah A, Baron AD et al. Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study. Cancer 2007;110:965-972.
-
(2007)
Cancer
, vol.110
, pp. 965-972
-
-
Burstein, H.J.1
Keshaviah, A.2
Baron, A.D.3
-
17
-
-
79951974161
-
Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The HERNATA study
-
Andersson M, Lidbrink E, Bjerre K et al. Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The HERNATA study. J Clin Oncol 2011;29:264-271.
-
(2011)
J Clin Oncol
, vol.29
, pp. 264-271
-
-
Andersson, M.1
Lidbrink, E.2
Bjerre, K.3
-
18
-
-
73349115249
-
Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: Final results of the FinHer Trial
-
Joensuu H, Bono P, Kataja V et al. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: Final results of the FinHer Trial. J Clin Oncol 2009;27:5685-5692.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5685-5692
-
-
Joensuu, H.1
Bono, P.2
Kataja, V.3
-
19
-
-
2942659576
-
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer
-
Pegram MD, Konecny GE, O'Callaghan C et al. Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst 2004;96:739-749.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 739-749
-
-
Pegram, M.D.1
Konecny, G.E.2
O'Callaghan, C.3
-
20
-
-
33745530224
-
Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer
-
Robert N, Leyland-Jones B, Asmar L et al. Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2006;24:2786-2792.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2786-2792
-
-
Robert, N.1
Leyland-Jones, B.2
Asmar, L.3
-
21
-
-
79951982754
-
Multicenter phase 111 randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-geneamplified metastatic breast cancer (BCIRG 007 study): Two highly active therapeutic regimens
-
Valero V, Forbes J, Pegram MD et al. Multicenter phase 111 randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-geneamplified metastatic breast cancer (BCIRG 007 study): Two highly active therapeutic regimens. J Clin Oncol 2011;29:149-156.
-
(2011)
J Clin Oncol
, vol.29
, pp. 149-156
-
-
Valero, V.1
Forbes, J.2
Pegram, M.D.3
-
22
-
-
30544441239
-
Two concurrent phase II trials of paclitaxel/carboplatin/trastuzumab (weekly or every-3-week schedule) as first-line therapy in women with HER2-overexpressing metastatic breast cancer: NCCTG study 983252
-
Perez EA, Suman VJ, Rowland KM et al. Two concurrent phase II trials of paclitaxel/carboplatin/trastuzumab (weekly or every-3-week schedule) as first-line therapy in women with HER2-overexpressing metastatic breast cancer: NCCTG study 983252. Clin Breast Cancer 2005;6:425-432.
-
(2005)
Clin Breast Cancer
, vol.6
, pp. 425-432
-
-
Perez, E.A.1
Suman, V.J.2
Rowland, K.M.3
-
23
-
-
19944428805
-
Paclitaxel and gemcitabine, as first-line chemotherapy, combined with trastuzumab in patients with advanced breast cancer: A phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG)
-
Fountzilas G, Christodoulou C, Tsavdaridis D et al. Paclitaxel and gemcitabine, as first-line chemotherapy, combined with trastuzumab in patients with advanced breast cancer: A phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG). Cancer Invest 2004;22:655-662.
-
(2004)
Cancer Invest
, vol.22
, pp. 655-662
-
-
Fountzilas, G.1
Christodoulou, C.2
Tsavdaridis, D.3
-
24
-
-
58149250717
-
A phase II trial of gemcitabine/carboplatin with or without trastuzumab in the first-line treatment of patients with metastatic breast cancer
-
Yardley DA, Burris HA 3rd, Simons L et al. A phase II trial of gemcitabine/carboplatin with or without trastuzumab in the first-line treatment of patients with metastatic breast cancer. Clin Breast Cancer 2008;8: 425-431.
-
(2008)
Clin Breast Cancer
, vol.8
, pp. 425-431
-
-
Yardley, D.A.1
Burris III, H.A.2
Simons, L.3
-
25
-
-
77949893849
-
Randomized phase II trial of first-line trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer
-
Wardley AM, Pivot X, Morales-Vasquez F et al. Randomized phase II trial of first-line trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer. J Clin Oncol 2010;28:976-983.
-
(2010)
J Clin Oncol
, vol.28
, pp. 976-983
-
-
Wardley, A.M.1
Pivot, X.2
Morales-Vasquez, F.3
-
26
-
-
38049103907
-
HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials
-
Gennari A, Sormani MP, Pronzato P et al. HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials. J Natl Cancer Inst 2008;100:14-20.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 14-20
-
-
Gennari, A.1
Sormani, M.P.2
Pronzato, P.3
-
27
-
-
0036498781
-
Cardiac dysfunction in the trastuzumab clinical trials experience
-
Seidman A, Hudis C, Pierri MK et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol 2002;20:1215-1221.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1215-1221
-
-
Seidman, A.1
Hudis, C.2
Pierri, M.K.3
-
28
-
-
36849016904
-
Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC)→paclitaxel (T) vs. AC→T with trastuzumab(H)
-
LBA513
-
Rastogi P, Jeong J, Geyer CE et al. Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC)→paclitaxel (T) vs. AC→T with trastuzumab(H). J Clin Oncol 2007;25(18 suppl):LBA513.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 18
-
-
Rastogi, P.1
Jeong, J.2
Geyer, C.E.3
-
29
-
-
41649083764
-
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial
-
Perez EA, Suman VJ, Davidson NE et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol 2008;26:1231-1238.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1231-1238
-
-
Perez, E.A.1
Suman, V.J.2
Davidson, N.E.3
-
30
-
-
77955284228
-
Longer-term assessment of trastuzumab-related cardiac adverse events in the Herceptin Adjuvant (HERA) trial
-
Procter M, Suter TM, de Azambuja E et al. Longer-term assessment of trastuzumab-related cardiac adverse events in the Herceptin Adjuvant (HERA) trial. J Clin Oncol 2010;28:3422-3428.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3422-3428
-
-
Procter, M.1
Suter, T.M.2
de Azambuja, E.3
-
31
-
-
80053539103
-
Adjuvant trastuzumab in HER2-positive breast cancer
-
Slamon D, Eiermann W, Robert N et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011;365:1273-1283.
-
(2011)
N Engl J Med
, vol.365
, pp. 1273-1283
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
32
-
-
74949141693
-
Trastuzumab for patients with axillary-node-positive breast cancer: Results of the FNCLCC-PACS 04 trial
-
Spielmann M, Roché H, Delozier T et al. Trastuzumab for patients with axillary-node-positive breast cancer: Results of the FNCLCC-PACS 04 trial. J Clin Oncol 2009;27:6129-6134.
-
(2009)
J Clin Oncol
, vol.27
, pp. 6129-6134
-
-
Spielmann, M.1
Roché, H.2
Delozier, T.3
-
33
-
-
77955284952
-
Independent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamide followed by trastuzumab adjuvant therapy: A combined review of cardiac data from the National Surgical Adjuvant Breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 clinical trials
-
Russell SD, Blackwell KL, Lawrence J et al., Independent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamide followed by trastuzumab adjuvant therapy: A combined review of cardiac data from the National Surgical Adjuvant Breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 clinical trials. J Clin Oncol 2010;28:3416-3421.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3416-3421
-
-
Russell, S.D.1
Blackwell, K.L.2
Lawrence, J.3
-
34
-
-
0036142158
-
Liposome-encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first-line therapy of metastatic breast carcinoma
-
Harris L, Batist G, Belt R et al. Liposome-encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first-line therapy of metastatic breast carcinoma. Cancer 2002;94: 25-36.
-
(2002)
Cancer
, vol.94
, pp. 25-36
-
-
Harris, L.1
Batist, G.2
Belt, R.3
-
35
-
-
0035282073
-
Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer
-
Batist G, Ramakrishnan G, Rao CS et al. Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer. J Clin Oncol 2001;19:1444-1454.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1444-1454
-
-
Batist, G.1
Ramakrishnan, G.2
Rao, C.S.3
-
36
-
-
11144357506
-
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCI (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
-
O'Brien ME, Wigler N, Inbar M et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCI (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol 2004;15:440-449.
-
(2004)
Ann Oncol
, vol.15
, pp. 440-449
-
-
O'Brien, M.E.1
Wigler, N.2
Inbar, M.3
-
37
-
-
0003291391
-
TLC D99 (D, Myocet) and Herceptin (H) is safe in advanced breast cancer (ABC): Final cardiac safety and efficacy analysis
-
Theodoulou M, Campos SM, Batist G et al. TLC D99 (D, Myocet) and Herceptin (H) is safe in advanced breast cancer (ABC): Final cardiac safety and efficacy analysis. Proc Am Soc Clin Oncol 2002;21:216.
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 216
-
-
Theodoulou, M.1
Campos, S.M.2
Batist, G.3
-
38
-
-
80052516749
-
A phase I/II trial of non-pegylated liposomal doxorubicin, docetaxel and trastuzumab as first-line treatment in HER-2-positive locally advanced or metastatic breast cancer
-
Amadori D, Milandri C, Comella G et al. A phase I/II trial of non-pegylated liposomal doxorubicin, docetaxel and trastuzumab as first-line treatment in HER-2-positive locally advanced or metastatic breast cancer. EurJ Cancer 2011;47:2091-2098.
-
(2011)
EurJ Cancer
, vol.47
, pp. 2091-2098
-
-
Amadori, D.1
Milandri, C.2
Comella, G.3
-
39
-
-
58849110946
-
Nonpegylated liposomal doxorubicin (TLC-D99), paclitaxel, and trastuzumab in HER-2-overexpressing breast cancer: A multicenter phase I/II study
-
Cones J, Di Cosimo S, Climent MA et al. Nonpegylated liposomal doxorubicin (TLC-D99), paclitaxel, and trastuzumab in HER-2-overexpressing breast cancer: A multicenter phase I/II study. Clin Cancer Res 2009;15:307-314.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 307-314
-
-
Cones, J.1
Di Cosimo, S.2
Climent, M.A.3
-
40
-
-
33745552216
-
Pegylated liposomal doxorubicin and trastuzumab in HER-2 overexpressing metastatic breast cancer: A multicenter phase II trial
-
Chia S, Clemons M, Martin LA et al. Pegylated liposomal doxorubicin and trastuzumab in HER-2 overexpressing metastatic breast cancer: A multicenter phase II trial. J Clin Oncol 2006;24:2773-2778.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2773-2778
-
-
Chia, S.1
Clemons, M.2
Martin, L.A.3
-
41
-
-
77951294720
-
Phase II trial of pegylated liposomal doxorubicin plus docetaxel with and without trastuzumab in metastatic breast cancer: Eastern Cooperative Oncology Group trial E3198
-
Wolff AC, Wang M, Li H et al. Phase II trial of pegylated liposomal doxorubicin plus docetaxel with and without trastuzumab in metastatic breast cancer: Eastern Cooperative Oncology Group trial E3198. Breast Cancer Res Treat 2010;121:111-120.
-
(2010)
Breast Cancer Res Treat
, vol.121
, pp. 111-120
-
-
Wolff, A.C.1
Wang, M.2
Li, H.3
-
42
-
-
35948976685
-
Paclitaxel(P), pegylated liposomal doxorubicin (PLD) and trastuzumab as 1st-line chemotherapy (chemo) in HER2/ neu-positive (+) metastatic breast cancer (MBC)
-
Karabelis A, Kosmas C, Mylonakis N et al. Paclitaxel(P), pegylated liposomal doxorubicin (PLD) and trastuzumab as 1st-line chemotherapy (chemo) in HER2/ neu-positive (+) metastatic breast cancer (MBC). J Clin Oncol 2006;24(18 suppl):10663.
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 29
, pp. 10663
-
-
Karabelis, A.1
Kosmas, C.2
Mylonakis, N.3
-
43
-
-
33646712747
-
Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
-
Nahta R, Yu D, Hung MC et al. Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006; 3:269-280.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.C.3
-
44
-
-
77951744619
-
Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor
-
Scaltriti M, Chandarlapaty S, Prudkin L et al. Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor. Clin Cancer Res 2010;16:2688-2695.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2688-2695
-
-
Scaltriti, M.1
Chandarlapaty, S.2
Prudkin, L.3
-
45
-
-
12544250996
-
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a Herceptin-resistant, MUC4-expressing breast cancer cell line
-
Nagy P, Friedlander E, Tanner M et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a Herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res 2005;65:473-482.
-
(2005)
Cancer Res
, vol.65
, pp. 473-482
-
-
Nagy, P.1
Friedlander, E.2
Tanner, M.3
-
46
-
-
35448969823
-
Hyaluronaninduced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer
-
Pàlyi-Krekk Z, Barok M, Isola J et al. Hyaluronaninduced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer. Eur J Cancer 2007;43:2423-2433.
-
(2007)
Eur J Cancer
, vol.43
, pp. 2423-2433
-
-
Pàlyi-Krekk, Z.1
Barok, M.2
Isola, J.3
-
47
-
-
34548546535
-
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab
-
Lu Y, Li X, Liang K et al. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Cancer Res 2007;67: 8240-8247.
-
(2007)
Cancer Res
, vol.67
, pp. 8240-8247
-
-
Lu, Y.1
Li, X.2
Liang, K.3
-
48
-
-
33746290773
-
Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation
-
Anido J, Scaltriti M, Bech Serra JJ et al. Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. EMBO J 2006;25: 3234-3244.
-
(2006)
EMBO J
, vol.25
, pp. 3234-3244
-
-
Anido, J.1
Scaltriti, M.2
Bech Serra, J.J.3
-
49
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
-
Scaltriti M, Rojo F, Ocaña A et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 2007;99:628-638.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocaña, A.3
-
50
-
-
65349101151
-
Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
-
Junttila TT, Akita RW, Parsons K et al. Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 2009;15:429-440.
-
(2009)
Cancer Cell
, vol.15
, pp. 429-440
-
-
Junttila, T.T.1
Akita, R.W.2
Parsons, K.3
-
51
-
-
78650984926
-
Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
-
Andre F, Campone M, O'Regan R et al. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 2010;28:5110-5115.
-
(2010)
J Clin Oncol
, vol.28
, pp. 5110-5115
-
-
Andre, F.1
Campone, M.2
O'Regan, R.3
-
52
-
-
43049107243
-
A phase 2 study of perifosine in advanced or metastatic breast cancer
-
Leighl NB, Dent S, Clemons M et al. A phase 2 study of perifosine in advanced or metastatic breast cancer. Breast Cancer Res Treat 2008;108:87-92.
-
(2008)
Breast Cancer Res Treat
, vol.108
, pp. 87-92
-
-
Leighl, N.B.1
Dent, S.2
Clemons, M.3
-
53
-
-
28244432561
-
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R, Yuan LX, Zhang B et al. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005;65: 11118-11128.
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
-
54
-
-
40449113978
-
Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
-
Shattuck DL, Miller JK, Carraway KL 3rd et al. Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res 2008;68:1471-1477.
-
(2008)
Cancer Res
, vol.68
, pp. 1471-1477
-
-
Shattuck, D.L.1
Miller, J.K.2
Carraway III, K.L.3
-
55
-
-
84872749317
-
Targeting of the chemokine receptor CXCR4 in acquired trastuzumab resistance
-
San Antonio, TX, December
-
Tripathy D, Mukhopadhyay P, Verma U et al. Targeting of the chemokine receptor CXCR4 in acquired trastuzumab resistance. Presented at the 30th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 13-16,2007.
-
(2007)
Presented At the 30th Annual San Antonio Breast Cancer Symposium
, pp. 13-16
-
-
Tripathy, D.1
Mukhopadhyay, P.2
Verma, U.3
-
56
-
-
34247345082
-
PC cell-derived growth factor stimulates proliferation and confers trastuzumab resistance to Her-2-overexpressing breast cancer cells
-
Kim WE, Serrero G. PC cell-derived growth factor stimulates proliferation and confers trastuzumab resistance to Her-2-overexpressing breast cancer cells. Clin Cancer Res 2006;12:4192-4199.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4192-4199
-
-
Kim, W.E.1
Serrero, G.2
-
57
-
-
84872754819
-
Increased b1 integrin expression is a predictor of trastuzumab resistance in HER-2 overexpressing metastatic breast cancer patients
-
San Antonio, TX, December
-
Thorns J, Sabri S, Deschenes J et al. Increased b1 integrin expression is a predictor of trastuzumab resistance in HER-2 overexpressing metastatic breast cancer patients. Presented at the 30th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 13-16,2007.
-
(2007)
Presented At the 30th Annual San Antonio Breast Cancer Symposium
, pp. 13-16
-
-
Thorns, J.1
Sabri, S.2
Deschenes, J.3
-
58
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2002;2:127-137.
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
59
-
-
57149096463
-
Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
-
Di Leo A, Gomez HL, Aziz Z et al. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol 2008;26: 5544-5552.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5544-5552
-
-
Di Leo, A.1
Gomez, H.L.2
Aziz, Z.3
-
60
-
-
65249170861
-
A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors
-
Wong KK, Fracasso PM, Bukowski RM et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res 2009;15:2552-2558.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2552-2558
-
-
Wong, K.K.1
Fracasso, P.M.2
Bukowski, R.M.3
-
61
-
-
75449089516
-
Beyond trastuzumab: Small molecule tyrosine kinase inhibitors in HER-2-positive breast cancer
-
Roy V, Perez EA. Beyond trastuzumab: Small molecule tyrosine kinase inhibitors in HER-2-positive breast cancer. The Oncologist 2009;14:1061-1069.
-
(2009)
The Oncologist
, vol.14
, pp. 1061-1069
-
-
Roy, V.1
Perez, E.A.2
-
62
-
-
78651458656
-
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
-
Chandarlapaty S, Sawai A, Scaltriti M et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 2011;19:58-71.
-
(2011)
Cancer Cell
, vol.19
, pp. 58-71
-
-
Chandarlapaty, S.1
Sawai, A.2
Scaltriti, M.3
-
63
-
-
82355164794
-
Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2+ metastatic breast cancer
-
Wong H, Leung R, Kwong A et al. Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2+ metastatic breast cancer. The Oncologist 2011;16:1535-1546.
-
(2011)
The Oncologist
, vol.16
, pp. 1535-1546
-
-
Wong, H.1
Leung, R.2
Kwong, A.3
-
64
-
-
33644694046
-
Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1
-
Zsebik B, Citri A, Isola J et al. Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. Immunol Lett 2006;104:146-155.
-
(2006)
Immunol Lett
, vol.104
, pp. 146-155
-
-
Zsebik, B.1
Citri, A.2
Isola, J.3
-
65
-
-
79960985354
-
HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
-
Modi S, Stopeck A, Linden H et al. HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res 2011;17:5132-5139.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5132-5139
-
-
Modi, S.1
Stopeck, A.2
Linden, H.3
-
66
-
-
4544252430
-
Humoral epitope-spreading following immunization with a HER-2/neu peptide based vaccine in cancer patients
-
Disis ML, Goodell V, Schiffman K et al. Humoral epitope-spreading following immunization with a HER-2/neu peptide based vaccine in cancer patients. J Clin Immunol 2004;24:571-578.
-
(2004)
J Clin Immunol
, vol.24
, pp. 571-578
-
-
Disis, M.L.1
Goodell, V.2
Schiffman, K.3
-
67
-
-
33744803712
-
Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer
-
Kiewe P, Hasmïler S, Kahlert S et al. Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer. Clin Cancer Res 2006;12:3085-3091.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3085-3091
-
-
Kiewe, P.1
Hasmïler, S.2
Kahlert, S.3
-
68
-
-
33645218704
-
Engineered antibody Fc variants with enhanced effector function
-
Lazar GA, Dang W, Karki S et al. Engineered antibody Fc variants with enhanced effector function. Proc Natl Acad Sci USA 2006;103:4005-4010.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4005-4010
-
-
Lazar, G.A.1
Dang, W.2
Karki, S.3
-
69
-
-
79952092706
-
Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
-
Burris HA 3rd, Rugo HS, Vukelja SJ et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 2011;29:398-405.
-
(2011)
J Clin Oncol
, vol.29
, pp. 398-405
-
-
Burris III, H.A.1
Rugo, H.S.2
Vukelja, S.J.3
-
70
-
-
1642490813
-
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, Taxotere, gemcitabine, and epothilone B
-
Fuino L, Bali P, Wittmann S et al. Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, Taxotere, gemcitabine, and epothilone B. Mol Cancer Ther 2003; 2:971-984.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 971-984
-
-
Fuino, L.1
Bali, P.2
Wittmann, S.3
-
71
-
-
33846216907
-
Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner
-
Cardoso F, Durbecq V, Laes JF et al. Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner. Mol Cancer Ther 2006;5:3042-3051.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 3042-3051
-
-
Cardoso, F.1
Durbecq, V.2
Laes, J.F.3
-
72
-
-
80054100462
-
Final results of a phase II randomized trial of neoadjuvant anthracycline-taxane chemotherapy plus lapatinib, trastuzumab, or both in HER2-positive breast cancer (CHER-LOB trial)
-
Guarneri V, Frassoldati A, Bottini A et al. Final results of a phase II randomized trial of neoadjuvant anthracycline-taxane chemotherapy plus lapatinib, trastuzumab, or both in HER2-positive breast cancer (CHER-LOB trial). J Clin Oncol 2011;(20 suppl):507.
-
(2011)
J Clin Oncol
, Issue.SUPPL. 29
, pp. 507
-
-
Guarneri, V.1
Frassoldati, A.2
Bottini, A.3
-
73
-
-
80052905474
-
Validation of p95 as a predictive marker for trastuzumab-based therapy in primary HER2-positive breast cancer: A translational investigation from the neoadjuvant Gepar-Quattro study
-
Loibl S, Bruey J, Von Minckwitz G et al. Validation of p95 as a predictive marker for trastuzumab-based therapy in primary HER2-positive breast cancer: A translational investigation from the neoadjuvant Gepar-Quattro study. J Clin Oncol 2011;(29 suppl):530.
-
(2011)
J Clin Oncol
, Issue.SUPPL. 29
, pp. 530
-
-
Loibl, S.1
Bruey, J.2
von Minckwitz, G.3
-
74
-
-
46449113024
-
Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
-
Gomez HL, Doval DC, Chavez MA et al. Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 2008;26:2999-3005.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2999-3005
-
-
Gomez, H.L.1
Doval, D.C.2
Chavez, M.A.3
-
75
-
-
40949159086
-
Safety and tolerability of lapatinib in combination with taxanes (T) in patients with breast cancer (BC)
-
Crown JP, Burris HA, Jones S et al. Safety and tolerability of lapatinib in combination with taxanes (T) in patients with breast cancer (BC). J Clin Oncol 2007; 25(18 suppl):1027.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 18
, pp. 1027
-
-
Crown, J.P.1
Burris, H.A.2
Jones, S.3
-
76
-
-
27344435038
-
Lapatinib (an oral dual kinase inhibitor) plus weekly or every 3 week paclitaxel
-
San Antonio, TX, December 8-11
-
Jones SF, Burris HA 3rd, Yardley DA et al. Lapatinib (an oral dual kinase inhibitor) plus weekly or every 3 week paclitaxel. Presented at the 27th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 8-11, 2004.
-
(2004)
Presented At the 27th Annual San Antonio Breast Cancer Symposium
-
-
Jones, S.F.1
Burris III, H.A.2
Yardley, D.A.3
-
77
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
Konecny GE, Pegram MD, Venkatesan N et al. Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res 2006;66:1630-1639.
-
(2006)
Cancer Res
, vol.66
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
Venkatesan, N.3
-
78
-
-
60149109196
-
Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumabdependent cell cytotoxicity
-
Scaltriti M, Verma C, Guzman M et al. Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumabdependent cell cytotoxicity. Oncogene 2009;28:803-814.
-
(2009)
Oncogene
, vol.28
, pp. 803-814
-
-
Scaltriti, M.1
Verma, C.2
Guzman, M.3
-
79
-
-
77949884661
-
Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
Blackwell KL, Burstein HJ, Stomiolo AM et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 2010;28:1124-1130.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Stomiolo, A.M.3
-
80
-
-
84856029331
-
Updated efficacy and safety assessment of first-line therapy with lapatinib, trastuzumab, and paclitaxel in HER2+ metastatic breast cancer
-
Esteva FJ, Franco S, Hagan MK et al. Updated efficacy and safety assessment of first-line therapy with lapatinib, trastuzumab, and paclitaxel in HER2+ metastatic breast cancer. J Clin Oncol 2010;28(15 suppl): 1046.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 15
, pp. 1046
-
-
Esteva, F.J.1
Franco, S.2
Hagan, M.K.3
-
81
-
-
0037440261
-
Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer
-
Konecny G, Pauletti G, Pegram M et al. Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. J Natl Cancer Inst 2003;95:142-153.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 142-153
-
-
Konecny, G.1
Pauletti, G.2
Pegram, M.3
-
82
-
-
33847147996
-
The combination of letrozole and trastuzumab as first or secondline biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers
-
Marcom PK, Isaacs C, Harris L et al. The combination of letrozole and trastuzumab as first or secondline biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers. Breast Cancer Res Treat 2007;102:43-49.
-
(2007)
Breast Cancer Res Treat
, vol.102
, pp. 43-49
-
-
Marcom, P.K.1
Isaacs, C.2
Harris, L.3
-
83
-
-
12144269500
-
Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer
-
Osborne CK, Shou J, Massarweh S et al. Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin Cancer Res 2005;11:865s-870s.
-
(2005)
Clin Cancer Res
, vol.11
-
-
Osborne, C.K.1
Shou, J.2
Massarweh, S.3
-
84
-
-
42049121934
-
Cross-talk between the estrogen receptor and the HER tyrosine kinase receptor family: Molecular mechanism and clinical implications for endocrine therapy resistance
-
Arpino G, Wiechmann L, Osborne CK et al. Cross-talk between the estrogen receptor and the HER tyrosine kinase receptor family: Molecular mechanism and clinical implications for endocrine therapy resistance. Endocr Rev 2008;29:217-233.
-
(2008)
Endocr Rev
, vol.29
, pp. 217-233
-
-
Arpino, G.1
Wiechmann, L.2
Osborne, C.K.3
-
85
-
-
73149115341
-
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
-
Johnston S, Pippen J Jr, Pivot X et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27: 5538-5546.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5538-5546
-
-
Johnston, S.1
Pippen Jr., J.2
Pivot, X.3
-
86
-
-
77649100030
-
Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer
-
Schwartzberg LS, Franco SX, Florance A et al. Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer. The Oncologist 2011;15:122-129.
-
(2011)
The Oncologist
, vol.15
, pp. 122-129
-
-
Schwartzberg, L.S.1
Franco, S.X.2
Florance, A.3
-
87
-
-
73949105921
-
Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
-
Kaufman B, Mackey JR, Clemens MR et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study. J Clin Oncol 2009;27:5529-5537.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5529-5537
-
-
Kaufman, B.1
Mackey, J.R.2
Clemens, M.R.3
-
88
-
-
77949904451
-
Intensive loading dose of trastuzumab achieves higher-than-steady-state serum concentrations and is well tolerated
-
Leyland-Jones B, Colomer R, Trudeau ME et al. Intensive loading dose of trastuzumab achieves higher-than-steady-state serum concentrations and is well tolerated. J Clin Oncol 2010;28:960-966.
-
(2010)
J Clin Oncol
, vol.28
, pp. 960-966
-
-
Leyland-Jones, B.1
Colomer, R.2
Trudeau, M.E.3
-
89
-
-
80051718778
-
Targeted therapy for human epidermal growth factor receptor 2-positive breast cancer: Can there be too many active drugs?
-
Chandarlapaty S, Modi S. Targeted therapy for human epidermal growth factor receptor 2-positive breast cancer: Can there be too many active drugs? J Clin Oncol 2011;29:3111-3113.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3111-3113
-
-
Chandarlapaty, S.1
Modi, S.2
-
91
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortes J, Kim SB et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012;366:109-119.
-
(2012)
N Engl J Med
, vol.366
, pp. 109-119
-
-
Baselga, J.1
Cortes, J.2
Kim, S.B.3
-
94
-
-
84856806836
-
First results of AVEREL, a randomized phase III trial to evaluate bevacizumab (BEV) in combination with trastuzumab (H) + docetaxel (DOC) as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer (LR/mBC)
-
San Antonio, TX, December 6-10
-
Gianni L, Romieu G, Lichinitser M et al. First results of AVEREL, a randomized phase III trial to evaluate bevacizumab (BEV) in combination with trastuzumab (H) + docetaxel (DOC) as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer (LR/mBC). Presented at the 34th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 6-10, 2011.
-
(2011)
Presented At the 34th Annual San Antonio Breast Cancer Symposium
-
-
Gianni, L.1
Romieu, G.2
Lichinitser, M.3
-
95
-
-
77950497981
-
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer
-
Burstein HJ, Sun Y, Dirix LY et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 2010;28:1301-1307.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1301-1307
-
-
Burstein, H.J.1
Sun, Y.2
Dirix, L.Y.3
-
96
-
-
70449728711
-
Use of BIBW 2992, a novel irreversible EGFR/HER2 tyrosine kinase inhibitor (TM), to treat patients with HER2-positive metastatic breast cancer after failure of treatment with trastuzumab
-
Hickish T, Wheatley D, Lin N et al. Use of BIBW 2992, a novel irreversible EGFR/HER2 tyrosine kinase inhibitor (TM), to treat patients with HER2-positive metastatic breast cancer after failure of treatment with trastuzumab. J Clin Oncol 2009;7(15 suppl):1023.
-
(2009)
J Clin Oncol
, vol.7
, Issue.SUPPL. 15
, pp. 1023
-
-
Hickish, T.1
Wheatley, D.2
Lin, N.3
-
97
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Baselga J, Gelmon KA, Verma S et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010;28:1138-1144.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.A.2
Verma, S.3
-
98
-
-
79952274439
-
Neoadjuvant pertuzumab (P) and trastuzumab (H): Antitumor and safety analysis of a randomized phase II study ('Neo-Sphere')
-
San Antonio, TX, December 8-12
-
Gianni L, Pienkowski T, Im Y-H et al. Neoadjuvant pertuzumab (P) and trastuzumab (H): Antitumor and safety analysis of a randomized phase II study ('Neo-Sphere'). Presented at the 33rd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 8-12, 2010.
-
(2010)
Presented At the 33rd Annual San Antonio Breast Cancer Symposium
-
-
Gianni, L.1
Pienkowski, T.2
Im, Y.-H.3
-
99
-
-
79952258750
-
First results of the NeoALTTO trial (BIG 01-06 / EGF 106903): A phase III, randomized, open label. neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer
-
San Antonio, TX, December 8-12
-
Baselga J, Bradbury I, Eidtmann H et al. First results of the NeoALTTO trial (BIG 01-06 / EGF 106903): A phase III, randomized, open label. neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer. Presented at the 33rd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 8-12, 2010.
-
(2010)
Presented At the 33rd Annual San Antonio Breast Cancer Symposium
-
-
Baselga, J.1
Bradbury, I.2
Eidtmann, H.3
-
100
-
-
79953772036
-
Lapatinib vs trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy: Primary efficacy endpoint analysis of the GEPARQUINTO study (GBG 44)
-
San Antonio, TX, December 8-12
-
Untch M, Loibl S, Bischoff J et al. Lapatinib vs trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy: Primary efficacy endpoint analysis of the GEPARQUINTO study (GBG 44). Presented at the 33rd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 8-12, 2010.
-
(2010)
Presented At the 33rd Annual San Antonio Breast Cancer Symposium
-
-
Untch, M.1
Loibl, S.2
Bischoff, J.3
-
101
-
-
84856700379
-
Neoadjuvant pertuzumab and trastuzumab concurrent or sequential with an anthracycline-containing or concurrent with an anthracycline-free standard regimen: A randomized phase II study (TRYPHAENA)
-
San Antonio, TX, December 6-10
-
Schneeweiss A, Chia S, Hickish T et al. Neoadjuvant pertuzumab and trastuzumab concurrent or sequential with an anthracycline-containing or concurrent with an anthracycline-free standard regimen: A randomized phase II study (TRYPHAENA). Presented at the 34th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 6-10, 2011.
-
(2011)
Presented At the 34th Annual San Antonio Breast Cancer Symposium
-
-
Schneeweiss, A.1
Chia, S.2
Hickish, T.3
-
102
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumabDM 1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips GD, Li G, Dugger DL et al. Targeting HER2-positive breast cancer with trastuzumabDM 1, an antibody-cytotoxic drug conjugate. Cancer Res 2008;68:9280-9290.
-
(2008)
Cancer Res
, vol.68
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
Li, G.2
Dugger, D.L.3
-
103
-
-
84856617116
-
Trastuzumab emtansine (T-DM I) versus trastuzumab + docetaxel in previously untreated HER2-positive metastatic breast cancer (MBC): Primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976) [abstract 5.001]
-
Stockholm, Sweden, September 23-27
-
Hurvitz SA, Dirix L, Kocsis J et al. Trastuzumab emtansine (T-DM I) versus trastuzumab + docetaxel in previously untreated HER2-positive metastatic breast cancer (MBC): Primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976) [abstract 5.001]. Presented at the ESMO-ECCO European Multidisciplinary Cancer Congress, Stockholm, Sweden, September 23-27, 2011.
-
(2011)
Presented At the ESMO-ECCO European Multidisciplinary Cancer Congress
-
-
Hurvitz, S.A.1
Dirix, L.2
Kocsis, J.3
-
104
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006; 441:424-430.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
105
-
-
77955879325
-
Everolimus in combination with weekly paclitaxel and trastuzumab in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC) with prior resistance to trastuzumab and taxanes: A multicenter phase II clinical trial
-
Dalenc F, Campone M, Hupperets P et al. Everolimus in combination with weekly paclitaxel and trastuzumab in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC) with prior resistance to trastuzumab and taxanes: A multicenter phase II clinical trial. J Clin Oncol 2010;28(15 suppl):1013.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 15
, pp. 1013
-
-
Dalenc, F.1
Campone, M.2
Hupperets, P.3
-
106
-
-
80051751593
-
Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
-
Morrow PK, Wulf GM, Ensor J et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011;29:3126-3132.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3126-3132
-
-
Morrow, P.K.1
Wulf, G.M.2
Ensor, J.3
-
107
-
-
12144291334
-
Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
-
Konecny GE, Meng YG, Untch M et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004; 10:1706-1716.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1706-1716
-
-
Konecny, G.E.1
Meng, Y.G.2
Untch, M.3
-
108
-
-
77649134730
-
Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer
-
San Antonio, TX, December 2009;9-13
-
Hurvitz SA, Pegram MD, Lin L-S et al. Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer. Presented at the 32nd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 2009;9-13.
-
Presented At the 32nd Annual San Antonio Breast Cancer Symposium
-
-
Hurvitz, S.A.1
Pegram, M.D.2
Lin, L.-S.3
-
109
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353: 1659-1672.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
110
-
-
79952041937
-
Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial
-
Gianni L, Dafni U, Gelber RD et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial. Lancet Oncol 2011;12:236-244.
-
(2011)
Lancet Oncol
, vol.12
, pp. 236-244
-
-
Gianni, L.1
Dafni, U.2
Gelber, R.D.3
-
111
-
-
80052728749
-
Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31
-
Perez EA, Romond EH, Suman VJ et al. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol 2011;29:3366-3373.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3366-3373
-
-
Perez, E.A.1
Romond, E.H.2
Suman, V.J.3
-
112
-
-
26944465031
-
Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease
-
Zidan J, Dashkovsky I, Stayerman C et al. Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease. Br J Cancer 2005;93:552-556.
-
(2005)
Br J Cancer
, vol.93
, pp. 552-556
-
-
Zidan, J.1
Dashkovsky, I.2
Stayerman, C.3
-
113
-
-
17644393853
-
Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinoma
-
Gong Y, Booser DJ, Sneige N. Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinoma. Cancer 2005;103:1763-1769.
-
(2005)
Cancer
, vol.103
, pp. 1763-1769
-
-
Gong, Y.1
Booser, D.J.2
Sneige, N.3
-
114
-
-
38749140648
-
HER-2 status discrepancy between primary breast cancer and metastatic sites. Impact on target therapy
-
Santinelli A, Pisa E, Stramazzotti D et al. HER-2 status discrepancy between primary breast cancer and metastatic sites. Impact on target therapy. Int J Cancer 2008;122:999-1004.
-
(2008)
Int J Cancer
, vol.122
, pp. 999-1004
-
-
Santinelli, A.1
Pisa, E.2
Stramazzotti, D.3
-
115
-
-
50649119930
-
Comparison of HER-2 and hormone receptor expression in primary breast cancers and asynchronous paired metastases: Impact on patient management
-
Guarneri V, Giovannelli S, Ficarra G et al. Comparison of HER-2 and hormone receptor expression in primary breast cancers and asynchronous paired metastases: Impact on patient management. The Oncologist 2008;13:838-844.
-
(2008)
The Oncologist
, vol.13
, pp. 838-844
-
-
Guarneri, V.1
Giovannelli, S.2
Ficarra, G.3
-
116
-
-
79954431896
-
Detection of HER2 amplification in circulating free DNA in patients with breast cancer
-
Page K, Hava N, Ward B et al. Detection of HER2 amplification in circulating free DNA in patients with breast cancer. Br J Cancer 2011;104:1342-1348.
-
(2011)
Br J Cancer
, vol.104
, pp. 1342-1348
-
-
Page, K.1
Hava, N.2
Ward, B.3
-
117
-
-
79951610766
-
Hitting multiple targets in HER2-positive breast cancer: Proof of principle or therapeutic opportunity?
-
Geuna E, Milani A, Redana S et al. Hitting multiple targets in HER2-positive breast cancer: Proof of principle or therapeutic opportunity? Expert Opin Pharmacother 2011;12:549-565.
-
(2011)
Expert Opin Pharmacother
, vol.12
, pp. 549-565
-
-
Geuna, E.1
Milani, A.2
Redana, S.3
-
118
-
-
77950682786
-
Management of metastatic HER2-positive breast cancer progression after adjuvant trastuzumab therapy-current evidence and future trends
-
Metzger-Filho O, Vora T, Awada A. Management of metastatic HER2-positive breast cancer progression after adjuvant trastuzumab therapy-current evidence and future trends. Expert Opin Investig Drugs 2010; 19(suppl 1):S31-S39.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, Issue.SUPPL. 1
-
-
Metzger-Filho, O.1
Vora, T.2
Awada, A.3
-
119
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355: 2733-2743.
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
120
-
-
65349110371
-
Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German Breast Group 26/Breast International Group 03-05 study
-
von Minckwitz G, du Bois A, Schmidt M et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German Breast Group 26/Breast International Group 03-05 study. J Clin Oncol 2009;27: 1999-2006.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1999-2006
-
-
von Minckwitz, G.1
du Bois, A.2
Schmidt, M.3
-
121
-
-
73949139238
-
How to treat hormone receptor-positive, human epidermal growth factor receptor 2-amplified breast cancer
-
Cortes J, Baselga J. How to treat hormone receptor-positive, human epidermal growth factor receptor 2-amplified breast cancer. J Clin Oncol 2009;27:5492-5494.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5492-5494
-
-
Cortes, J.1
Baselga, J.2
-
122
-
-
79955617130
-
HER2 and hormone receptor-positive breast cancer-blocking the right target
-
Cortés J, Saura C, Bellet M et al. HER2 and hormone receptor-positive breast cancer-blocking the right target. Nat Rev Clin Oncol 2010;8:307-311.
-
(2010)
Nat Rev Clin Oncol
, vol.8
, pp. 307-311
-
-
Cortés, J.1
Saura, C.2
Bellet, M.3
-
123
-
-
84855176565
-
Responses to subsequent anti-HER2 therapy after treatment with trastuzumab-DM 1 in women with HER2-positive metastatic breast cancer
-
Olson EM, Lin NU, Di Piro PJ et al. Responses to subsequent anti-HER2 therapy after treatment with trastuzumab-DM 1 in women with HER2-positive metastatic breast cancer. Ann Oncol 2012;23:93-97.
-
(2012)
Ann Oncol
, vol.23
, pp. 93-97
-
-
Olson, E.M.1
Lin, N.U.2
Di Piro, P.J.3
-
124
-
-
84872750150
-
Retreatment with trastuzumab-based therapy after disease progression following lapatinib in her2-positive metastatic breast cancer
-
[Oct 29 lEpub ahead of print]
-
Gori S, Montemurro F, Spazzapan S et al. Retreatment with trastuzumab-based therapy after disease progression following lapatinib in her2-positive metastatic breast cancer. Ann Oncol 2011 [Oct 29 lEpub ahead of print].
-
(2011)
Ann Oncol
-
-
Gori, S.1
Montemurro, F.2
Spazzapan, S.3
|