Activating mutations in ERBB2 and their impact on diagnostics and treatment

Frontiers in Oncology

Volumn 3 APR, Issue , 2013, Pages

  Herter Sprie, Grit S ^a,b   Greulich, Heidi ^a,b,c,d   Wong, Kwok Kin ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Activating somatic mutation; Breast cancer; ERBB2 HER2; Lung cancer; Resistance; Reversible and irreversible tyrosine kinase inhibitors; Targeted therapies

Indexed keywords

AFATINIB; BCR ABL PROTEIN; DACOMITINIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ERLOTINIB; ERTUMAXOMAB; GEFITINIB; IMATINIB; INK 128; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN 4; NERATINIB; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 13; PACLITAXEL; PELITINIB; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; RAPAMYCIN; RAS PROTEIN; TANESPIMYCIN; TEMSIROLIMUS; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BREAST CANCER; BREAST CARCINOGENESIS; BREAST METASTASIS; GENE MUTATION; HUMAN; LUNG NON SMALL CELL CANCER; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROSTATE CANCER; REVIEW;

EID: 84890767985     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00086     Document Type: Review

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