메뉴 건너뛰기




Volumn 6, Issue 1, 2012, Pages 56-63

Insight into p95HER2 in breast cancer: Molecular mechanisms and targeted therapies

Author keywords

Biomarkers; Breast neoplasms; ErbB 2; Genes; Human HER2 protein; Lapatinib; Monoclonal antibodies; Neratinib; P95HER2; Pertuzumab; Pharmacogenetics; Trastuzumab; Trastuzumab DM1

Indexed keywords

CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; EVEROLIMUS; FLUOROURACIL; LAPATINIB; MAYTANSINE; METHOTREXATE; NAVELBINE; NERATINIB; P95 EPIDERMAL GROWTH FACTOR RECEPTOR 2; PACLITAXEL; PERTUZUMAB; TRASTUZUMAB; TRASTUZUMAB MAYTANSINE; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 84857126212     PISSN: 18722156     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221512799303109     Document Type: Article
Times cited : (6)

References (59)
  • 2
    • 78650320068 scopus 로고    scopus 로고
    • Concurrent breast stroma sarcoma and breast carcinoma: A case report
    • de Mello R, Figueiredo P, Marques M, et al. Concurrent breast stroma sarcoma and breast carcinoma: a case report. J Med Case Reports 2010; 4: 414.
    • (2010) J Med Case Reports , vol.4 , pp. 414
    • de Mello, R.1    Figueiredo, P.2    Marques, M.3
  • 3
    • 0036731788 scopus 로고    scopus 로고
    • Revision of the American Joint Committee on Cancer staging system for breast cancer
    • Singletary S, Allred C, Ashley P, et al. Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol 2002; 20: 3628-36.
    • (2002) J Clin Oncol , vol.20 , pp. 3628-3636
    • Singletary, S.1    Allred, C.2    Ashley, P.3
  • 4
    • 79954585183 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: A tool whose time has come of age
    • Swaby R, Cristofanilli M. Circulating tumor cells in breast cancer: a tool whose time has come of age. BMC Med 2011; 9: 43.
    • (2011) BMC Med , vol.9 , pp. 43
    • Swaby, R.1    Cristofanilli, M.2
  • 6
    • 0021688634 scopus 로고
    • The neu oncogene: An erb-B-related gene encoding a 185,000-Mr tumour antigen
    • Schechter A, Stem D, Vaidyananthan L, et al. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature 1984; 312: 513-6.
    • (1984) Nature , vol.312 , pp. 513-516
    • Schechter, A.1    Stem, D.2    Vaidyananthan, L.3
  • 7
    • 19044380618 scopus 로고    scopus 로고
    • Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
    • Agus D, Akita R, Fox W, et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2002; 2:127-37.
    • (2002) Cancer Cell , vol.2 , pp. 127-137
    • Agus, D.1    Akita, R.2    Fox, W.3
  • 8
    • 0033608993 scopus 로고    scopus 로고
    • The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors
    • Klappler L, Glathe S, Vaisman N, et al. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci USA 1999; 96: 4995-5000.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4995-5000
    • Klappler, L.1    Glathe, S.2    Vaisman, N.3
  • 9
    • 0033992633 scopus 로고    scopus 로고
    • Biochemical and clinical implications of ErbB/HR signaling network of growth factor receptors
    • Klapper L, Kirschbaum M, Sela M, Yarden Y. Biochemical and clinical implications of ErbB/HR signaling network of growth factor receptors. Adv Cancer Res 2000; 77: 25-79.
    • (2000) Adv Cancer Res , vol.77 , pp. 25-79
    • Klapper, L.1    Kirschbaum, M.2    Sela, M.3    Yarden, Y.4
  • 10
    • 0036792117 scopus 로고    scopus 로고
    • Inhibition of Ligand-mediated HER2 Activation in Androgenindependent Prostate Cancer
    • Mendoza N, Phillips G, Silva J, Schwall R, Wickramasinghe D. Inhibition of Ligand-mediated HER2 Activation in Androgenindependent Prostate Cancer. Cancer Res 2002; 62: 5485-8.
    • (2002) Cancer Res , vol.62 , pp. 5485-5488
    • Mendoza, N.1    Phillips, G.2    Silva, J.3    Schwall, R.4    Wickramasinghe, D.5
  • 11
    • 84856223809 scopus 로고    scopus 로고
    • Dual HER2-targeted approaches in HER2- positive breast cancer
    • DOI 10.1007/s10549-011-1781-y
    • Ahn E, Vogel C. Dual HER2-targeted approaches in HER2- positive breast cancer. Breast Cancer Res Treat 2011; DOI 10.1007/s10549-011-1781-y.
    • (2011) Breast Cancer Res Treat
    • Ahn, E.1    Vogel, C.2
  • 12
    • 84857125224 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies
    • de Mello R, Marques D, Medeiros R, Araújo A. Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies. World J Clin Oncol 2011; 2: 367-76.
    • (2011) World J Clin Oncol , vol.2 , pp. 367-376
    • de Mello, R.1    Marques, D.2    Medeiros, R.3    Araújo, A.4
  • 13
    • 78650208364 scopus 로고    scopus 로고
    • Mechanisms of resistance to anti-human epidermal growth factor receptor 2 agents in breast cancer
    • Mukohara T. Mechanisms of resistance to anti-human epidermal growth factor receptor 2 agents in breast cancer. Cancer Sci 2011; 102: 1-8.
    • (2011) Cancer Sci , vol.102 , pp. 1-8
    • Mukohara, T.1
  • 14
    • 78651387936 scopus 로고    scopus 로고
    • Resistance to HER2- targeted therapy: Mechanisms of trastuzumab resistance and possible strategies to overcome unresponsiveness to treatment
    • Hubalek M, Brunner C, Matthä K, Marth C. Resistance to HER2- targeted therapy: mechanisms of trastuzumab resistance and possible strategies to overcome unresponsiveness to treatment. Wien Med Wochenschr. 2010; 160: 506-12.
    • (2010) Wien Med Wochenschr , vol.160 , pp. 506-512
    • Hubalek, M.1    Brunner, C.2    Matthä, K.3    Marth, C.4
  • 15
    • 70349349043 scopus 로고    scopus 로고
    • Optimizing the Use of Her-2/neu Targeting Agents in Breast Cancer: A Developing Nation Perspective
    • Azim H, Azim HJ. Optimizing the Use of Her-2/neu Targeting Agents in Breast Cancer: A Developing Nation Perspective. J Egypt Natl Canc Inst 2007;19: 225-30.
    • (2007) J Egypt Natl Canc Inst , vol.19 , pp. 225-230
    • Azim, H.1    Azim, H.J.2
  • 16
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti M, Rojo F, Ocaña A, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst. 2007; 99: 628-38.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocaña, A.3
  • 18
    • 78449276234 scopus 로고    scopus 로고
    • A major role of p95/611- CTF, a carboxy-terminal fragment of HER2, in the downmodulation of the estrogen receptor in HER2-positive breast cancers
    • Parra-Palau J, Pedersen K, Peg V, et al. A major role of p95/611- CTF, a carboxy-terminal fragment of HER2, in the downmodulation of the estrogen receptor in HER2-positive breast cancers. Cancer Res 2010; 70: 8537-46.
    • (2010) Cancer Res , vol.70 , pp. 8537-8546
    • Parra-Palau, J.1    Pedersen, K.2    Peg, V.3
  • 19
    • 77955753644 scopus 로고    scopus 로고
    • Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer
    • Sperinde J, Jin X, Banerjee J, et al. Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer. Clin Cancer Res. 2010; 15: 4226-35.
    • (2010) Clin Cancer Res , vol.15 , pp. 4226-4235
    • Sperinde, J.1    Jin, X.2    Banerjee, J.3
  • 20
    • 31544465529 scopus 로고    scopus 로고
    • p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer
    • Sáez R, Molina MA, Ramsey EE, et al. p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer. Clin Cancer Res 2006; 12: 424-31.
    • (2006) Clin Cancer Res , vol.12 , pp. 424-431
    • Sáez, R.1    Molina, M.A.2    Ramsey, E.E.3
  • 22
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti M, Rojo F, Ocaña A, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 2007; 99: 628-38.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocaña, A.3
  • 23
    • 77951744619 scopus 로고    scopus 로고
    • Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor
    • Scaltriti M, Chandarlapaty S, Prudkin L, et al. Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor. Clin Cancer Res 2010; 16: 2688-95.
    • (2010) Clin Cancer Res , vol.16 , pp. 2688-2695
    • Scaltriti, M.1    Chandarlapaty, S.2    Prudkin, L.3
  • 24
    • 78649390831 scopus 로고    scopus 로고
    • Treatment of HER2-overexpressing breast cancer
    • Baselga J. Treatment of HER2-overexpressing breast cancer. Ann Oncol 2010; 21: vii36-vii40.
    • (2010) Ann Oncol , vol.21
    • Baselga, J.1
  • 25
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • Hudis C. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med 2007; 357: 39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.1
  • 26
    • 79952162826 scopus 로고    scopus 로고
    • HER2-amplified breast cancer: Mechanisms of trastuzumab resistance and novel targeted therapies
    • Gajria D, Chandarlapaty S. HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies. Expert Rev Anticancer Ther 2011; 11: 263-75.
    • (2011) Expert Rev Anticancer Ther , vol.11 , pp. 263-275
    • Gajria, D.1    Chandarlapaty, S.2
  • 28
    • 79952041937 scopus 로고    scopus 로고
    • Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial
    • Gianni L, Dafni U, Gelber R, et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial. Lancet Oncol 2011; 12: 236-44.
    • (2011) Lancet Oncol , vol.12 , pp. 236-244
    • Gianni, L.1    Dafni, U.2    Gelber, R.3
  • 29
    • 80052728749 scopus 로고    scopus 로고
    • Four-Year Follow-Up of Trastuzumab Plus Adjuvant Chemotherapy for Operable Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Joint Analysis of Data From NCCTG N9831 and NSABP B-31
    • Perez EA, Romond EH, Suman VJ, et al. Four-Year Follow-Up of Trastuzumab Plus Adjuvant Chemotherapy for Operable Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Joint Analysis of Data From NCCTG N9831 and NSABP B-31. J Clin Oncol 2011; 29: 3366-73.
    • (2011) J Clin Oncol , vol.29 , pp. 3366-3373
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3
  • 30
    • 77957300459 scopus 로고    scopus 로고
    • BCIRG 006: Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→ T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC→ TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 Study
    • San Antonio, TX: Cancer Res
    • Slamon D, Eiermann W, Robert N. BCIRG 006: Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→ T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC→ TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 Study. 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, 2009; San Antonio, TX: Cancer Res; 2009.
    • (2009) 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, 2009
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 31
    • 74949141693 scopus 로고    scopus 로고
    • Trastuzumab for patients with axillary-node-positive breast cancer: Results of the FNCLCCPACS 04 trial
    • Spielmann M, Roché H, Delozier T, et al. Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCCPACS 04 trial. J Clin Oncol 2009; 27: 6129-34.
    • (2009) J Clin Oncol , vol.27 , pp. 6129-6134
    • Spielmann, M.1    Roché, H.2    Delozier, T.3
  • 32
    • 73349115249 scopus 로고    scopus 로고
    • Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: Final results of the FinHer Trial
    • Joensuu H, Bono P, Kataja V, et al. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial. J Clin Oncol 2009; 27: 5685-92.
    • (2009) J Clin Oncol , vol.27 , pp. 5685-5692
    • Joensuu, H.1    Bono, P.2    Kataja, V.3
  • 33
    • 58849094563 scopus 로고    scopus 로고
    • Docetaxel in the adjuvant therapy of HER-2 positive breast cancer patients
    • Vici P, Viola G, Botti C, et al. Docetaxel in the adjuvant therapy of HER-2 positive breast cancer patients. Clin Ter 2008; 159: 449-52.
    • (2008) Clin Ter , vol.159 , pp. 449-452
    • Vici, P.1    Viola, G.2    Botti, C.3
  • 34
    • 13744257860 scopus 로고    scopus 로고
    • Neoadjuvant versus adjuvant systemic treatment in breast cancer: A meta-analysis
    • Mauri D, Pavlidis N, Ioannidis JPA. Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis. J Natl Cancer Inst 2005; 97: 188-94.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 188-194
    • Mauri, D.1    Pavlidis, N.2    Ioannidis, J.P.A.3
  • 35
    • 20544460650 scopus 로고    scopus 로고
    • Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: Results of a randomized trial in human epidermal growth factor receptor 2- positive operable breast cancer
    • Buzdar AU, Ibrahim NK, Francis D, et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: Results of a randomized trial in human epidermal growth factor receptor 2- positive operable breast cancer. J Clin Oncol 2005; 23: 3676-85.
    • (2005) J Clin Oncol , vol.23 , pp. 3676-3685
    • Buzdar, A.U.1    Ibrahim, N.K.2    Francis, D.3
  • 36
    • 33846297680 scopus 로고    scopus 로고
    • Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: An update of the initial randomized study population and data of additional patients treated with the same regimen
    • Buzdar AU, Valero V, Ibrahim NK, et al. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 2007; 13: 228-33.
    • (2007) Clin Cancer Res , vol.13 , pp. 228-233
    • Buzdar, A.U.1    Valero, V.2    Ibrahim, N.K.3
  • 37
    • 75149145066 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2- positive locally advanced breast cancer (the NOAH trial): A randomised controlled superiority trial with a parallel HER2- negative cohort
    • Gianni L, Eiermann W, Semiglazov V, et al. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2- positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2- negative cohort. Lancet 2010; 375: 377-84.
    • (2010) Lancet , vol.375 , pp. 377-384
    • Gianni, L.1    Eiermann, W.2    Semiglazov, V.3
  • 38
    • 77951624086 scopus 로고    scopus 로고
    • Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: Results from the Gepar Quattro study
    • Untch M, Rezai M, Loibl S, et al. Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the Gepar Quattro study. J Clin Oncol 2010; 28: 2024-31.
    • (2010) J Clin Oncol , vol.28 , pp. 2024-2031
    • Untch, M.1    Rezai, M.2    Loibl, S.3
  • 39
    • 80051648150 scopus 로고    scopus 로고
    • Phase I Study of S-1 in Combination with Trastuzumab for HER2-positive Metastatic Breast Cancer
    • Nakayama T, Morita S, Takashima T, et al. Phase I Study of S-1 in Combination with Trastuzumab for HER2-positive Metastatic Breast Cancer. Anticancer Res 2011; 31: 3035-9.
    • (2011) Anticancer Res , vol.31 , pp. 3035-3039
    • Nakayama, T.1    Morita, S.2    Takashima, T.3
  • 40
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011; 29: 3126-32.
    • (2011) J Clin Oncol , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 41
    • 77953724897 scopus 로고    scopus 로고
    • Inhibition of the PI3K pathway: Hope we can believe in?
    • van der Heijden MS, Bernards R. Inhibition of the PI3K pathway: hope we can believe in? Clin Cancer Res 2010; 16: 3094-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 3094-3099
    • van der Heijden, M.S.1    Bernards, R.2
  • 42
    • 78649701154 scopus 로고    scopus 로고
    • Evolving strategies for overcoming resistance to HER2-directed therapy: Targeting the PI3K/Akt/ mTOR pathway
    • Nahta R, O'Regan RM. Evolving strategies for overcoming resistance to HER2-directed therapy: targeting the PI3K/Akt/ mTOR pathway. Clin Breast Cancer 2010; 10: 72-8.
    • (2010) Clin Breast Cancer , vol.10 , pp. 72-78
    • Nahta, R.1    O'Regan, R.M.2
  • 43
    • 84856227263 scopus 로고    scopus 로고
    • Phase II trial of a novel capecitabine dosing schedule in combination with lapatinib for the treatment of patients with HER2-positive metastatic breast cancer
    • DOI 10.1007/s10549-011-1749-y
    • Gajria D, Gonzalez J, Feigin K, et al. Phase II trial of a novel capecitabine dosing schedule in combination with lapatinib for the treatment of patients with HER2-positive metastatic breast cancer. Breast Cancer Res Treat 2011:DOI 10.1007/s10549-011-1749-y.
    • (2011) Breast Cancer Res Treat
    • Gajria, D.1    Gonzalez, J.2    Feigin, K.3
  • 44
    • 78650802161 scopus 로고    scopus 로고
    • Lapatinib in breast cancer - the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma levela assessment
    • Bouchalovaa K, Cizkovaa M, Cwiertkab K, et al. Lapatinib in breast cancer - the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma levela assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2010; 154: 281-8.
    • (2010) Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , vol.154 , pp. 281-288
    • Bouchalovaa, K.1    Cizkovaa, M.2    Cwiertkab, K.3
  • 45
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006; 355: 2733-43.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 46
    • 42049121934 scopus 로고    scopus 로고
    • Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: Molecular mechanism and clinical implications for endocrine therapy resistance
    • Arpino G, Wiechmann L, Osborne CK, Schiff R. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocr Rev 2008; 29: 217-33.
    • (2008) Endocr Rev , vol.29 , pp. 217-233
    • Arpino, G.1    Wiechmann, L.2    Osborne, C.K.3    Schiff, R.4
  • 47
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen Jr J, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009; 27: 5538-46.
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen, J.2    Pivot, X.3
  • 48
  • 49
    • 73649149433 scopus 로고    scopus 로고
    • Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
    • Scheuer W, Friess T, Burtscher H, et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 2009; 69: 9330-6.
    • (2009) Cancer Res , vol.69 , pp. 9330-9336
    • Scheuer, W.1    Friess, T.2    Burtscher, H.3
  • 51
    • 79952276644 scopus 로고    scopus 로고
    • CLEOPATRA: A phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer
    • Baselga J, Swain S. CLEOPATRA: a phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer. Clin Breast Cancer. 2010;10:489-91.
    • (2010) Clin Breast Cancer , vol.10 , pp. 489-491
    • Baselga, J.1    Swain, S.2
  • 53
    • 79955475247 scopus 로고    scopus 로고
    • Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer
    • Barok M, Tanner M, Köninki K, Isola J. Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer. Cancer Lett 2011; 306: 171-9.
    • (2011) Cancer Lett , vol.306 , pp. 171-179
    • Barok, M.1    Tanner, M.2    Köninki, K.3    Isola, J.4
  • 54
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
    • Lewis PG, Li G, Dugger D, et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 2008; 68: 9280-90.
    • (2008) Cancer Res , vol.68 , pp. 9280-9290
    • Lewis, P.G.1    Li, G.2    Dugger, D.3
  • 55
    • 77954031486 scopus 로고    scopus 로고
    • Phase I study of trastuzumab- DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
    • Krop IE, Beeram M, Modi S, et al. Phase I study of trastuzumab- DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol 2010; 28: 2698-704.
    • (2010) J Clin Oncol , vol.28 , pp. 2698-2704
    • Krop, I.E.1    Beeram, M.2    Modi, S.3
  • 56
    • 79952092706 scopus 로고    scopus 로고
    • Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer After Prior HER2-Directed Therapy
    • Burris HA, Rugo HS, Vukelja SJ, et al. Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer After Prior HER2-Directed Therapy. J Clin Oncol 2011; 29: 398-405.
    • J Clin Oncol 2011; , vol.29 , pp. 398-405
    • Burris, H.A.1    Rugo, H.S.2    Vukelja, S.J.3
  • 57
    • 2542582261 scopus 로고    scopus 로고
    • Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
    • Rabindran S, Discafani C, Rosfjord E, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 2004; 64: 3958-65.
    • (2004) Cancer Res , vol.64 , pp. 3958-3965
    • Rabindran, S.1    Discafani, C.2    Rosfjord, E.3
  • 58
    • 77950497981 scopus 로고    scopus 로고
    • Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2- positive breast cancer
    • Burstein HJ, Sun Y, Dirix LY, et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2- positive breast cancer. J Clin Oncol 2010; 28:1301-7.
    • (2010) J Clin Oncol , vol.28 , pp. 1301-1307
    • Burstein, H.J.1    Sun, Y.2    Dirix, L.Y.3
  • 59


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.