-
1
-
-
77951945506
-
Status of PI3K inhibition and biomarker development in cancer therapeutics
-
PMID:19713247
-
Markman B, Atzori F, Perez-Garcia J, Tabernero J, Baselga J. Status of PI3K inhibition and biomarker development in cancer therapeutics. Ann Oncol 2010; 21:683-91 PMID:19713247; http://dx.doi.org/10.1093/annonc/mdp347.
-
(2010)
Ann Oncol
, vol.21
, pp. 683-691
-
-
Markman, B.1
Atzori, F.2
Perez-Garcia, J.3
Tabernero, J.4
Baselga, J.5
-
2
-
-
44449161481
-
The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
-
PMID:18466115
-
Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 2008; 412:179-90 PMID:18466115; http://dx.doi.org/10.1042/BJ20080281.
-
(2008)
Biochem J
, vol.412
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
3
-
-
34249679614
-
MTOR Complex1- S6K1 signaling: At the crossroads of obesity, diabetes and cancer
-
PMID:17452018
-
Dann SG, Selvaraj A, Thomas G. mTOR Complex1- S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 2007; 13:252-9 PMID:17452018; http://dx.doi.org/10.1016/j.molmed.2007.04.002.
-
(2007)
Trends Mol Med
, vol.13
, pp. 252-259
-
-
Dann, S.G.1
Selvaraj, A.2
Thomas, G.3
-
4
-
-
0041356888
-
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
-
PMID:12842888
-
Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem 2003; 278:32493-6 PMID:12842888; http://dx.doi.org/10.1074/jbc.C300226200.
-
(2003)
J Biol Chem
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.J.3
Quilliam, L.A.4
-
5
-
-
78650305038
-
Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: Implications for cell proliferation and tumorigenesis
-
PMID:20818424
-
Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis. Oncogene 2010; 29:6543-56 PMID:20818424; http://dx.doi.org/10.1038/onc.2010.393.
-
(2010)
Oncogene
, vol.29
, pp. 6543-6556
-
-
Lacher, M.D.1
Pincheira, R.2
Zhu, Z.3
Camoretti-Mercado, B.4
Matli, M.5
Warren, R.S.6
-
6
-
-
50049091255
-
AMPK: A key regulator of energy balance in the single cell and the whole organism
-
PMID:18719601
-
Hardie DG. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond) 2008; 32:7-12 PMID:18719601; http://dx.doi.org/10.1038/ijo.2008.116.
-
(2008)
Int J Obes (Lond)
, vol.32
, pp. 7-12
-
-
Hardie, D.G.1
-
7
-
-
61449106744
-
AMPK and the biochemistry of exercise: Implications for human health and disease
-
PMID:19196246
-
Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J 2009; 418:261-75 PMID:19196246; http://dx.doi.org/10.1042/BJ20082055.
-
(2009)
Biochem J
, vol.418
, pp. 261-275
-
-
Richter, E.A.1
Ruderman, N.B.2
-
8
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
PMID:18281291
-
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 2008; 283:10892-903 PMID:18281291; http://dx.doi.org/10.1074/jbc.M800102200.
-
(2008)
J Biol Chem
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
-
9
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
PMID:15058305
-
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428:569-74 PMID:15058305; http://dx.doi.org/10.1038/nature02440.
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
Kim, Y.B.4
Lee, A.5
Xue, B.6
-
10
-
-
77952116629
-
Metformin in cancer therapy: A new perspective for an old antidiabetic drug?
-
PMID:20442309
-
Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F. Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 2010; 9:1092-9 PMID:20442309; http://dx.doi.org/10.1158/1535-7163.MCT-09-1186.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1092-1099
-
-
Ben, S.I.1
Le Marchand-Brustel, Y.2
Tanti, J.F.3
Bost, F.4
-
11
-
-
53049083680
-
AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27
-
PMID:18701472
-
Short JD, Houston KD, Dere R, Cai SL, Kim J, Johnson CL, et al. AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res 2008; 68:6496-506 PMID:18701472; http://dx.doi.org/10.1158/0008-5472.CAN-07-5756.
-
(2008)
Cancer Res
, vol.68
, pp. 6496-6506
-
-
Short, J.D.1
Houston, K.D.2
Dere, R.3
Cai, S.L.4
Kim, J.5
Johnson, C.L.6
-
12
-
-
66449117931
-
AMP-activated protein kinase promotes human prostate cancer cell growth and survival
-
PMID:19372545
-
Park HU, Suy S, Danner M, Dailey V, Zhang Y, Li H, et al. AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther 2009; 8:733-41 PMID:19372545; http://dx.doi.org/10.1158/1535-7163.MCT-08-0631.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 733-741
-
-
Park, H.U.1
Suy, S.2
Danner, M.3
Dailey, V.4
Zhang, Y.5
Li, H.6
-
13
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
PMID:17237771
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007; 9:218-24 PMID:17237771; http://dx.doi.org/10.1038/ncb1537.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
-
15
-
-
41149150219
-
The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
-
PMID:18354415
-
Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008; 8:253-67 PMID:18354415; http://dx.doi.org/10.1038/nrc2347.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 253-267
-
-
Chu, I.M.1
Hengst, L.2
Slingerland, J.M.3
-
16
-
-
73649145175
-
KIP1 during tumor development
-
PMID:19887899
-
KIP1 during tumor development. Exp Mol Med 2009; 41:765-71 PMID:19887899; http://dx.doi.org/10.3858/emm.2009.41.11.102.
-
(2009)
Exp Mol Med
, vol.41
, pp. 765-771
-
-
Lee, J.1
Kim, S.S.2
-
18
-
-
77953035951
-
AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability
-
PMID:20146253
-
Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, et al. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 2010; 49:429-39 PMID:20146253.
-
(2010)
Mol Carcinog
, vol.49
, pp. 429-439
-
-
Short, J.D.1
Dere, R.2
Houston, K.D.3
Cai, S.L.4
Kim, J.5
Bergeron, J.M.6
-
19
-
-
77950509348
-
Autophagy and tumorigenesis
-
PMID:20035753
-
Chen N, Debnath J. Autophagy and tumorigenesis. FEBS Lett 2010; 584:1427-35 PMID:20035753; http://dx.doi.org/10.1016/j.febslet.2009.12.034.
-
(2010)
FEBS Lett
, vol.584
, pp. 1427-1435
-
-
Chen, N.1
Debnath, J.2
-
20
-
-
77951649035
-
The role of autophagy in tumour development and cancer therapy
-
PMID:19951459
-
Rosenfeldt MT, Ryan KM. The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med 2009; 11:36 PMID:19951459; http://dx.doi.org/10.1017/S1462399409001306.
-
(2009)
Expert Rev Mol Med
, vol.11
, pp. 36
-
-
Rosenfeldt, M.T.1
Ryan, K.M.2
-
21
-
-
34249863298
-
Autophagy suppresses tumor pro gression by limiting chromosomal instability
-
PMID:17510285
-
Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, et al. Autophagy suppresses tumor pro gression by limiting chromosomal instability. Genes Dev 2007; 21:1367-81 PMID:17510285; http://dx.doi.org/10.1101/gad.1545107.
-
(2007)
Genes Dev
, vol.21
, pp. 1367-1381
-
-
Mathew, R.1
Kongara, S.2
Beaudoin, B.3
Karp, C.M.4
Bray, K.5
Degenhardt, K.6
-
22
-
-
34347404887
-
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
-
PMID:17606641
-
Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21:1621-35 PMID:17606641; http://dx.doi.org/10.1101/gad.1565707.
-
(2007)
Genes Dev
, vol.21
, pp. 1621-1635
-
-
Karantza-Wadsworth, V.1
Patel, S.2
Kravchuk, O.3
Chen, G.4
Mathew, R.5
Jin, S.6
-
23
-
-
57049186623
-
How to live long and prosper: Autophagy, mitochondria and aging
-
PMID:18927201
-
Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria and aging. Physiology (Bethesda) 2008; 23:248-62 PMID:18927201; http://dx.doi.org/10.1152/physiol.00013.2008.
-
(2008)
Physiology (Bethesda)
, vol.23
, pp. 248-262
-
-
Yen, W.L.1
Klionsky, D.J.2
-
24
-
-
55949087699
-
Role of the metabolic stress responses of apoptosis and autophagy in tumor suppression
-
White E. Role of the metabolic stress responses of apoptosis and autophagy in tumor suppression. Ernst Schering Found Symp Proc 2007; 23-34.
-
(2007)
Ernst Schering Found Symp Proc
, pp. 23-34
-
-
White, E.1
-
25
-
-
77951228508
-
Hypoxia-induced autophagy: Cell death or cell survival?
-
PMID:20022734
-
Mazure NM, Pouyssegur J. Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol 2010; 22:177-80 PMID:20022734; http://dx.doi.org/10.1016/j.ceb.2009.11.015.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 177-180
-
-
Mazure, N.M.1
Pouyssegur, J.2
-
26
-
-
52149101812
-
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L
-
PMID:18551130
-
Papandreou I, Lim AL, Laderoute K, Denko NC. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L. Cell Death Differ 2008; 15:1572-81; PMID:18551130; http://dx.doi.org/10.1038/cdd.2008.84.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1572-1581
-
-
Papandreou, I.1
Lim, A.L.2
Laderoute, K.3
Denko, N.C.4
-
27
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
PMID:19460998
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33 PMID:19460998; http://dx.doi.org/10.1126/science.1160809.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander, H.M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
28
-
-
55849109650
-
Hypoxiainduced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma
-
PMID:18953439
-
Schneider A, Younis RH, Gutkind JS. Hypoxiainduced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia 2008; 10:1295-302 PMID:18953439.
-
(2008)
Neoplasia
, vol.10
, pp. 1295-1302
-
-
Schneider, A.1
Younis, R.H.2
Gutkind, J.S.3
-
29
-
-
64449087671
-
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ ATP ratio
-
PMID:19268526
-
Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, et al. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ ATP ratio. Free Radic Biol Med 2009; 46:1386-91 PMID:19268526; http://dx.doi.org/10.1016/j.freeradbiomed.2009.02.019.
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 1386-1391
-
-
Emerling, B.M.1
Weinberg, F.2
Snyder, C.3
Burgess, Z.4
Mutlu, G.M.5
Viollet, B.6
-
30
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
PMID:19211835
-
Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20:1981-91 PMID:19211835; http://dx.doi.org/10.1091/mbc.E08-12-1248.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
Miura, Y.6
-
31
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
PMID:18439900
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 30:214-26 PMID:18439900; http://dx.doi.org/10.1016/j.molcel.2008.03.003.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
32
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
PMID:21258367
-
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132-41 PMID:21258367; http://dx.doi.org/10.1038/ncb2152.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
33
-
-
79959963047
-
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
-
PMID:21460634
-
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, et al. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy 2011; 7:696-706 PMID:21460634.
-
(2011)
Autophagy
, vol.7
, pp. 696-706
-
-
Löffler, A.S.1
Alers, S.2
Dieterle, A.M.3
Keppeler, H.4
Franz-Wachtel, M.5
Kundu, M.6
-
34
-
-
0035835828
-
P27(Kip1): Regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer
-
PMID:11237531
-
Philipp-Staheli J, Payne SR, Kemp CJ. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res 2001; 264:148-68 PMID:11237531; http://dx.doi.org/10.1006/excr.2000.5143.
-
(2001)
Exp Cell Res
, vol.264
, pp. 148-168
-
-
Philipp-Staheli, J.1
Payne, S.R.2
Kemp, C.J.3
-
35
-
-
78650174233
-
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stressinduced apoptosis
-
PMID:20616807
-
Kang YJ, Lu MK, Guan KL. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stressinduced apoptosis. Cell Death Differ 2011; 18:133-44 PMID:20616807; http://dx.doi.org/10.1038/cdd.2010.82.
-
(2011)
Cell Death Differ
, vol.18
, pp. 133-144
-
-
Kang, Y.J.1
Lu, M.K.2
Guan, K.L.3
-
36
-
-
57049121039
-
Signal transduction molecules in gliomas of all grades
-
PMID:18759130
-
Ermoian RP, Kaprealian T, Lamborn KR, Yang X, Jelluma N, Arvold ND, et al. Signal transduction molecules in gliomas of all grades. J Neurooncol 2009; 91:19-26 PMID:18759130; http://dx.doi.org/10.1007/s11060-008-9683-5.
-
(2009)
J Neurooncol
, vol.91
, pp. 19-26
-
-
Ermoian, R.P.1
Kaprealian, T.2
Lamborn, K.R.3
Yang, X.4
Jelluma, N.5
Arvold, N.D.6
-
37
-
-
0037864520
-
Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours
-
PMID:12773163
-
Knowles MA, Hornigold N, Pitt E. Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours. Biochem Soc Trans 2003; 31:597-602 PMID:12773163; http://dx.doi.org/10.1042/BST0310597.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 597-602
-
-
Knowles, M.A.1
Hornigold, N.2
Pitt, E.3
-
38
-
-
45949107072
-
Involvement of TSC genes and differentialexpression of other members of the mTOR signaling pathway in oral squamous cell carcinoma
-
PMID:18538015
-
Chakraborty S, Mohiyuddin SM, Gopinath KS, Kumar A. Involvement of TSC genes and differentialexpression of other members of the mTOR signaling pathway in oral squamous cell carcinoma. BMC Cancer 2008; 8:163 PMID:18538015; http://dx.doi.org/10.1186/1471-2407-8-163.
-
(2008)
BMC Cancer
, vol.8
, pp. 163
-
-
Chakraborty, S.1
Mohiyuddin, S.M.2
Gopinath, K.S.3
Kumar, A.4
-
39
-
-
22144438660
-
Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: The role of promoter methylation of TSC genes
-
PMID:15951164
-
Jiang WG, Sampson J, Martin TA, Lee-Jones L, Watkins G, Douglas-Jones A, et al. Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes. Eur J Cancer 2005; 41:1628-36 PMID:15951164; http://dx.doi.org/10.1016/j.ejca.2005.03.023.
-
(2005)
Eur J Cancer
, vol.41
, pp. 1628-1636
-
-
Jiang, W.G.1
Sampson, J.2
Martin, T.A.3
Lee-Jones, L.4
Watkins, G.5
Douglas-Jones, A.6
-
40
-
-
49849087494
-
Loss of tuberous sclerosis complex- 2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
-
Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, et al. Loss of tuberous sclerosis complex- 2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. Clinical cancer research: an official journal of the American Association for Cancer Research 2008; 14:2543-50.
-
(2008)
Clinical Cancer Research: An Official Journal of the American Association For Cancer Research
, vol.14
, pp. 2543-2550
-
-
Lu, K.H.1
Wu, W.2
Dave, B.3
Slomovitz, B.M.4
Burke, T.W.5
Munsell, M.F.6
-
41
-
-
79955566182
-
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling
-
PMID:21289294
-
Winter JN, Jefferson LS, Kimball SR. ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. Am J Physiol Cell Physiol 2011; 300:1172-80 PMID:21289294;http://dx.doi.org/10.1152/ajpcell.00504.2010.
-
(2011)
Am J Physiol Cell Physiol
, vol.300
, pp. 1172-1180
-
-
Winter, J.N.1
Jefferson, L.S.2
Kimball, S.R.3
-
42
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
PMID:16959574
-
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006; 126:955-68 PMID:16959574; http://dx.doi.org/10.1016/j.cell.2006.06.055.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
-
43
-
-
33745213627
-
AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer
-
PMID:16613876
-
Motoshima H, Goldstein BJ, Igata M, Araki E. AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol 2006; 574:63-71 PMID:16613876; http://dx.doi.org/10.1113/jphysiol.2006.108324.
-
(2006)
J Physiol
, vol.574
, pp. 63-71
-
-
Motoshima, H.1
Goldstein, B.J.2
Igata, M.3
Araki, E.4
-
44
-
-
33750072949
-
MTOR and cancer therapy
-
PMID:17041628
-
Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006; 25:6436-46 PMID:17041628; http://dx.doi.org/10.1038/sj.onc.1209886.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
45
-
-
79952495236
-
Mammalian target of rapamycin: Biological function and target for novel anticancer agents
-
PMID:21116000
-
Borders EB, Bivona C, Medina PJ. Mammalian target of rapamycin: biological function and target for novel anticancer agents. Am J Health Syst Pharm 2010; 67:2095-106 PMID:21116000; http://dx.doi.org/10.2146/ajhp100020.
-
(2010)
Am J Health Syst Pharm
, vol.67
, pp. 2095-2106
-
-
Borders, E.B.1
Bivona, C.2
Medina, P.J.3
-
46
-
-
38049169557
-
Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis
-
PMID:18184966
-
Paul E, Thiele E. Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis. N Engl J Med 2008; 358:190-2 PMID:18184966; http://dx.doi.org/10.1056/NEJMe0707153.
-
(2008)
N Engl J Med
, vol.358
, pp. 190-192
-
-
Paul, E.1
Thiele, E.2
|