Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D

Neuropharmacology

Volumn 105, Issue , 2016, Pages 84-95

  Penazzi, Lorène ^a   Tackenberg, Christian ^a,d   Ghori, Adnan ^a   Golovyashkina, Nataliya ^a   Niewidok, Benedikt ^a   Selle, Karolin ^a   Ballatore, Carlo ^b,c   Smith, Amos B ^b   Bakota, Lidia ^a   Brandt, Roland ^a  

^a UNIVERSITY OF OSNABRÜCK   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Alzheimer's disease; Amyloid beta; Dendritic spine; Epothilone; Microtubules

Indexed keywords

AMYLOID BETA PROTEIN; EPOTHILONE D; 24-DIAMINO-5-PHENYLTHIAZOLE; AMYLOID PRECURSOR PROTEIN; DESOXYEPOTHILONE B; DIAMINE; EPOTHILONE DERIVATIVE; NOCODAZOLE; THIAZOLE DERIVATIVE; TUBULIN MODULATOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL LOSS; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITIC SPINE; EX VIVO STUDY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PC12 CELL LINE; RAT; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELLS, CULTURED; DENDRITIC SPINES; DIAMINES; EPOTHILONES; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NOCODAZOLE; PC12 CELLS; RATS; THIAZOLES; TUBULIN MODULATORS;

EID: 84955161706     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.01.002     Document Type: Article

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