Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: A mechanistic distinct event from other neurodegenerative processes

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Golovyashkina, Nataliya ^a   Penazzi, Lorène ^a   Ballatore, Carlo ^b,c   Smith, Amos B ^b   Bakota, Lidia ^a   Brandt, Roland ^a  

^a UNIVERSITY OF OSNABRÜCK   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; Dendritic simplification; Epothilone D; Microtubules; Tau protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ENHANCED GREEN FLUORESCENT PROTEIN; EPOTHILONE D; GAMMA SECRETASE; TAU PROTEIN;

ALGORITHM; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DISRUPTION; CONTROLLED STUDY; DENDRITE; EX VIVO STUDY; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL SLICE; MALE; MICROTUBULE; MOLECULAR STABILITY; MOUSE; NERVE DEGENERATION; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PYRAMIDAL NERVE CELL; ANIMAL; DENDRITIC SPINE; HIPPOCAMPUS; METABOLISM; NERVE CELL; PATHOLOGY; SYNAPSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DENDRITES; DENDRITIC SPINES; FEMALE; HIPPOCAMPUS; MALE; MICE; MICROTUBULES; NERVE DEGENERATION; NEURONS; SYNAPSES; TAU PROTEINS;

EID: 84960089794     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0049-0     Document Type: Article

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