Experimental epothilone B neurotoxicity: Results of in vitro and in vivo studies

Neurobiology of Disease

Volumn 35, Issue 2, 2009, Pages 270-277

  Chiorazzi, Alessia ^a   Nicolini, Gabriella ^a   Canta, Annalisa ^a   Oggioni, Norberto ^a   Rigolio, Roberta ^a   Cossa, Giacomo ^a   Lombardi, Raffaella ^b   Roglio, Ilaria ^c   Cervellini, Ilaria ^d   Lauria, Giuseppe ^b   Melcangi, Roberto Cosimo ^c   Bianchi, Roberto ^d   Crippa, Donatella ^e   Cavaletti, Guido ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e Bayer Health Care Bayer Schering Pharma   (Italy)

Author keywords

Epothilone B; In vitro; In vivo; Peripheral neuropathy; Toxicity; Tubulin

Indexed keywords

EPOTHILONE B; TUBULIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG TARGETING; EMBRYO; FEMALE; FISCHER 344 RAT; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE; NERVE FIBER GROWTH; NEUROPHYSIOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; RAT; SCIATIC NERVE; STRAIN DIFFERENCE; TREATMENT DURATION; WISTAR RAT;

ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOTHILONES; FEMALE; GANGLIA, SPINAL; MYELIN SHEATH; NEURAL CONDUCTION; NEURITES; NEURONS; NEUROTOXINS; PAIN THRESHOLD; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RNA, MESSENGER; SCIATIC NERVE; SKIN; TUBULIN;

EID: 67649467279     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.05.006     Document Type: Article

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