Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system

Life Sciences

Volumn 146, Issue , 2016, Pages 163-173

  Amir Aslani, Banafsheh ^a   Ghobadi, Sirous ^b  

^a PAYAME NOOR UNIVERSITY   (Iran)

^b RAZI UNIVERSITY   (Iran)

Author keywords

Antioxidants; Free radicals; Immune system; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CAROTENOID; CATALASE; FREE RADICAL; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MELATONIN; METAL CHELATE; OXIDIZING AGENT; PEROXIREDOXIN; POLYPHENOL; SUPEROXIDE DISMUTASE; TRACE ELEMENT; UBIQUINONE;

CARCINOGENESIS; CARDIOVASCULAR DISEASE; CELL DAMAGE; CELL METABOLISM; DEGENERATIVE DISEASE; IMMUNE SYSTEM; OXIDATIVE STRESS; REVIEW; TISSUE INJURY; ANIMAL; BLOOD; HUMAN; METABOLISM;

ANIMALS; ANTIOXIDANTS; FREE RADICALS; HUMANS; IMMUNE SYSTEM; OXIDANTS;

EID: 84955154004     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2016.01.014     Document Type: Review

References (133)

1. M. Valko, D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur, and J. Telser Free radicals and antioxidants in normal physiological functions and human disease Int. J. Biochem. Cell Biol. 39 2007 44 84
2. M. Carocho, and I.C. Ferreira A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives Food Chem. Toxicol. 21 2013 15 25
3. L.J. Machlin, and A. Bendich Free radical tissue damage: protective role of antioxidant nutrients FASEB J. 1 1987 441 445
4. Y.Z. Fang, S. Yang, and G. Wu Free radicals, antioxidants, and nutrition Nutrition 18 2002 872 879
5. S.S. Gropper, and J.L. Smith Advanced Nutrition and Human Metabolism sixth ed. 2013 Wadsworth Cengage Learning Belmont, Ca, USA
6. L.A. Pham-Huy, H. He, and C. Pham-Huy Free radicals, antioxidants in disease and health Int. J. Biomed. Sci. 4 2008 89 96
7. E.E. Battin, and J.L. Brumaghim Antioxidant activity of sulfur and selenium: a review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms Cell Biochem. Biophys. 55 2009 1 23
8. J. Nordberg, and E.S. Arner Reactive oxygen species, antioxidants, and the mammalian thioredoxin system Free Radic. Biol. Med. 31 2001 1287 1312
9. I.S. Young, and J.V. Woodside Antioxidants in health and disease J. Clin. Pathol. 54 2001 176 186
10. M. Jastroch, A.S. Divakaruni, S. Mookerjee, J.R. Treberg, and M.D. Brand Mitochondrial proton and electron leaks Essays Biochem. 47 2010 53 67
11. J.F. Turrens Mitochondrial formation of reactive oxygen species J. Physiol. 552 2003 335 344
12. S. Moncada, and J.P. Bolanos Nitric oxide, cell bioenergetics and neurodegeneration J. Neurochem. 97 2006 1676 1689
13. K. Rahman Studies on free radicals, antioxidants, and co-factors Clin. Interv. Aging 2 2007 219 236
14. M. Valko, C.J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem. Biol. Interact. 160 2006 1 40
15. M. Mari, A. Morales, A. Colell, C. Garcia-Ruiz, and J.C. Fernandez-Checa Mitochondrial glutathione, a key survival antioxidant Antioxid. Redox Signal. 11 2009 2685 2700
16. V. Cecarini, J. Gee, E. Fioretti, M. Amici, M. Angeletti, A.M. Eleuteri, and J.N. Keller Protein oxidation and cellular homeostasis: emphasis on metabolism Biochim. Biophys. Acta 1773 2007 93 104
17. L.A. Goodglick, and A.B. Kane Membrane perturbation by asbestos fibers and disease S.T. Ohnishi, T. Ohnishi, Cellular Membrane: A Key to Disease Processes first ed. 1992 CRC Press London 123 139
18. A. Terman, and U.T. Brunk Lipofuscin Int. J. Biochem. Cell Biol. 36 2004 1400 1404
19. S.K. Ardestani, M. Ahadian, and R.R. Watson Antioxidant nutrients and breast cancer S.I. Mufti, Nutrition and Cancer Prevention first ed. 1995 CRC Press London 173 204
20. V.M. Victor, M. Rocha, and M. De la Fuente Immune cells: free radicals and antioxidants in sepsis Int. Immunopharmacol. 4 2004 327 347
21. P.J.H. Jones, and S. Kubow Lipids, sterols, and their metabolites M.E. Shils, M. Shike, A.C. Ross, B. Caballero, R.J. Cousins, Modern Nutrition in Health and Disease tenth ed. 2005 Lippincott Williams & Wilkins New York 92 122
22. A. Negre-Salvayre, C. Coatrieux, C. Ingueneau, and R. Salvayre Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors Br. J. Pharmacol. 153 2008 6 20
23. V. Sudhahar, and T. Fukai Antioxidant supplementation and therapies H. Tsukahara, K. Kaneko, Studies on Pediatric Disorders (Oxidative Stress in Applied Basic Research and Clinical Practice) 2014 ed. 2014 Springer New York 183 209
24. T.J. Jonsson, L.C. Johnson, and W.T. Lowther Protein engineering of the quaternary sulfiredoxin.peroxiredoxin enzyme-substrate complex reveals the molecular basis for cysteine sulfinic acid phosphorylation J. Biol. Chem. 284 2009 33305 33310
25. K. Goncalves, K. Sullivan, and S. Phelan Differential expression and function of peroxiredoxin 1 and peroxiredoxin 6 in cancerous MCF-7 and noncancerous MCF-10A breast epithelial cells Cancer Investig. 30 2012 38 47
26. J. Chaudiere, and R. Ferrari-Iliou Intracellular antioxidants: from chemical to biochemical mechanisms Food Chem. Toxicol. 37 1999 949 962
27. D.A. Dickinson, and H.J. Forman Cellular glutathione and thiols metabolism Biochem. Pharmacol. 64 2002 1019 1026
28. G. Mugesh, A. Panda, H.B. Singh, N.S. Punekar, and R.J. Butcher Glutathione peroxidase-like antioxidant activity of diaryl diselenides: a mechanistic study J. Am. Chem. Soc. 123 2001 839 850
29. G. Casi, and D. Hilvert Reinvestigation of a selenopeptide with purportedly high glutathione peroxidase activity J. Biol. Chem. 282 2007 30518 30522
30. G. Mugesh, and W.W. du Mont Structure-activity correlation between natural glutathione peroxidase (GPx) and mimics: a biomimetic concept for the design and synthesis of more efficient GPx mimics Chemistry 7 2001 1365 1370
31. S.E. Espinoza, H. Guo, N. Fedarko, A. DeZern, L.P. Fried, Q.L. Xue, S. Leng, B. Beamer, and J.D. Waiston Glutathione peroxidase enzyme activity in aging J. Gerontol. A Biol. Sci. Med. Sci. 63 2008 505 509
32. J.M. Mates, C. Perez-Gomez, and I. Nunez de Castro Antioxidant enzymes and human diseases Clin. Biochem. 32 1999 595 603
33. L. Forsberg, U. de Faire, and R. Morgenstern Oxidative stress, human genetic variation, and disease Arch. Biochem. Biophys. 389 2001 84 93
34. S.A. Comhair, and S.C. Erzurum Redox control of asthma: molecular mechanisms and therapeutic opportunities Antioxid. Redox Signal. 12 2010 93 124
35. J.W. Whittaker Metal uptake by manganese superoxide dismutase Biochim. Biophys. Acta 1804 2010 298 307
36. J.A. Johnston, M.J. Dalton, M.E. Gurney, and R.R. Kopito Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U. S. A. 97 2000 12571 12576
37. J.M. Mates Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology Toxicology 153 2000 83 104
38. I.N. Zelko, T.J. Mariani, and R.J. Folz Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression Free Radic. Biol. Med. 33 2002 337 349
39. S.G. Rhee, S.W. Kang, T.S. Chang, W. Jeong, and K. Kim Peroxiredoxin, a novel family of peroxidases IUBMB Life 52 2001 35 41
40. S.G. Rhee, H.A. Woo, I.S. Kil, and S.H. Bae Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides J. Biol. Chem. 287 2012 4403 4410
41. 2 J. Biol. Chem. 287 2012 81 89
42. G. Wu, Y.Z. Fang, S. Yang, J.R. Lupton, and N.D. Turner Glutathione metabolism and its implications for health J. Nutr. 134 2004 489 492
43. R. Franco, and J.A. Cidlowski Apoptosis and glutathione: beyond an antioxidant Cell Death Differ. 16 2009 1303 1314
44. H. Jaeschke Antioxidant defense mechanisms C.A. McQueen, Comprehensive Toxicology second ed. 9 2010 Academic Press New York 319 337
45. M.K. Ahsan, I. Lekli, D. Ray, J. Yodoi, and D.K. Das Redox regulation of cell survival by the thioredoxin superfamily: an implication of redox gene therapy in the heart Antioxid. Redox Signal. 11 2009 2741 2758
46. Y. Munemasa, S.H. Kim, J.H. Ahn, J.M. Kwong, J. Caprioli, and N. Piri Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress Invest. Ophthalmol. Vis. Sci. 49 2008 3535 3543
47. J. Zhou, A.E. Damdimopoulos, G. Spyrou, and B. Brune Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1 alpha J. Biol. Chem. 282 2007 7482 7490
48. A. Holmgren, C. Johansson, C. Berndt, M.E. Lonn, C. Hudemann, and C.H. Lillig Thiol redox control via thioredoxin and glutaredoxin systems Biochem. Soc. Trans. 33 2005 1375 1377
49. M. Wallenberg, E. Olm, C. Hebert, M. Bjornstedt, and A.P. Fernandes Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity Biochem. J. 429 2010 85 93
50. M. Fladvad, M. Bellanda, A.P. Fernandes, S. Mammi, A. Vlamis-Gardikas, A. Holmgren, and M. Sunnerhagen Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli J. Biol. Chem. 280 2005 24553 24561
51. C. Berndt, C.H. Lillig, and A. Holmgren Thioredoxins and glutaredoxins as facilitators of protein folding Biochim. Biophys. Acta 1783 2008 641 650
52. N. Mesecke, A. Spang, M. Deponte, and J.M. Herrmann A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance Mol. Biol. Cell 19 2008 2673 2680
53. L. Bräutigam, L.D. Jensen, G. Poschmann, S. Nystrom, S. Bannenberg, K. Dreij, K. Lepka, T. Prozorovski, S.J. Montano, O. Aktas, P. Uhlén, K. Stühler, Y. Cao, A. Holmgren, and C. Berndt Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1 Proc. Natl. Acad. Sci. U. S. A. 110 2013 20057 20062
54. L. Packer, and E. Cadenas Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling J. Clin. Biochem. Nutr. 48 2011 26 32
55. P. Atukeren, S. Aydin, E. Uslu, M.K. Gumustas, and U. Cakatay Redox homeostasis of albumin in relation to alpha-lipoic acid and dihydrolipoic acid Oxidative Med. Cell. Longev. 3 2010 206 213
56. H. Kim, H.J. Kim, K. Lee, J.M. Kim, H.S. Kim, J.R. Kim, C.M. Ha, Y.K. Choi, S.J. Lee, J.Y. Kim, R.A. Harris, D. Jeong, and I.K. Lee α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway J. Cell. Mol. Med. 16 2012 273 286
57. V.N. Anisimov, I.G. Popovich, M.A. Zabezhinski, S.V. Anisimov, G.M. Vesnushkin, and I.A. Vinogradova Melatonin as antioxidant, geroprotector and anticarcinogen Biochim. Biophys. Acta 1757 2006 573 589
58. R.J. Reiter, D.X. Tan, J.C. Mayo, R.M. Sainz, J. Leon, and Z. Czarnocki Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans Acta Biochim. Pol. 50 2003 1129 1146
59. C.Q. Chen, J. Fichna, M. Bashashati, Y.Y. Li, and M. Storr Distribution, function and physiological role of melatonin in the lower gut World J. Gastroenterol. 17 2011 3888 3898
60. A. Korkmaz, R.J. Reiter, T. Topal, L.C. Manchester, S. Oter, and D.X. Tan Melatonin: an established antioxidant worthy of use in clinical trials Mol. Med. 15 2009 43 50
61. F. Radogna, M. Diederich, and L. Ghibelli Melatonin: a pleiotropic molecule regulating inflammation Biochem. Pharmacol. 80 2010 1844 1852
62. E. Miller, M. Mrowicka, K. Malinowska, J. Mmrowicki, J. Saluk-Juszczak, and J. Kedziora The effects of whole-body cryotherapy on oxidative stress in multiple sclerosis patients J. Therm. Biol. 35 2010 406 410
63. D. Solkoff, W.T. Cummings, B. Liang, P. Inserra, and R.R. Watson The antioxidant properties of melatonin R.R. Watson, Melatonin in the Promotion of Health 1998 CRC Press London 41 58
64. F.L. Crane Biochemical functions of coenzyme Q10 J. Am. Coll. Nutr. 20 2001 591 598
65. M.D. Cordero, E. Alcocer-Gómez, M. de Miguel, F.J. Cano-Garcia, C.M. Luque, P. Fernández-Riejo, A.M. Fernández, and J.A. Sánchez-Alcazar Coenzyme Q(10): a novel therapeutic approach for fibromyalgia? Case series with 5 patients Mitochondrion 11 2011 623 625
66. B.J. Lee, Y.C. Lin, Y.C. Huang, Y.W. Ko, S. Hsia, and P.T. Lin The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease Sci. World J. 2012 2012 792756
67. G.F. Watts, D.A. Playford, K.D. Croft, N.C. Ward, T.A. Mori, and V. Burke Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in type II diabetes mellitus Diabetologia 45 2002 420 426
68. A. Valente, T.G. Albuquerque, A. Sanches-Silva, and H.S. Costa Ascorbic acid content in exotic fruits: a contribution to produce quality data for food composition databases Food Res. Int. 44 2011 2237 2242
69. K.A. Naidu Vitamin C in human health and disease is still a mystery? An overview Nutr. J. 2 2003 7
70. S.J. Padayatty, A. Katz, Y. Wang, P. Eck, O. Kwon, J.H. Lee, S. Chen, C. Corpe, A. Dutta, S.K. Dutta, and M. Levine Vitamin C as an antioxidant: evaluation of its role in disease prevention J. Am. Coll. Nutr. 22 2003 18 35
71. A. Freyschuss, R.J. Xiu, J. Zhang, X. Ying, U. Diczfalusy, T. Jogestrand, P. Henriksson, and I. Björkhem Vitamin C reduces cholestrol-induced microcirculatory changes in rabbits Arterioscler. Thromb. Vasc. Biol. 17 1997 1178 1184
72. L. Packer, S.U. Weber, and G. Rimbach Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling J. Nutr. 131 2001 369S 373S
73. C.K. Sen, S. Khanna, and S. Roy Tocotrienols: vitamin E beyond tocopherols Life Sci. 78 2006 2088 2098
74. G. Tahan, E. Aytac, H. Aytekin, F. Gunduz, G. Dogusoy, S. Aydin, V. Tahan, and H. Uzum Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid-induced ulcerative colitis in rats Can. J. Surg. 54 2011 333 338
75. A.C. Romero, E.G.O. Hernández, T.F. Cerón, and A.Á. Chávez The exogenous antioxidants J.A. Morales-González, Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants 2013 InTech Croatia 33 57
76. G. Britton Structure and properties of carotenoids in relation to function FASEB J. 9 1995 1551 1558
77. J. Fiedor, and K. Burda Potential role of carotenoids as antioxidants in human health and disease Nutrients 6 2014 466 488
78. A.V. Rao, and L.G. Rao Carotenoids and human health Pharmacol. Res. 55 2007 207 216
79. The International Agency for Research and Cancer, Carotenoids (IARC Handbooks of Cancer Prevention) 2 1998 World Health Organization Lyon, France
80. D. Prakash, and C. Gupta Carotenoids: chemistry and health benefits D. Prakash, G. Sharma, Phytochemicals of Nutraceutical Importance 2014 CABI Boston 181 195
81. A.V. Rao, and S. Agarwal Role of antioxidant lycopene in cancer and heart disease J. Am. Coll. Nutr. 19 2000 563 569
82. N.I. Krinsky, and E.J. Johnson Carotenoid actions and their relation to health and disease Mol. Asp. Med. 26 2005 459 516
83. K.B. Pandey, and S.I. Rizvi Plant polyphenols as dietary antioxidants in human health and disease Oxidative Med. Cell. Longev. 2 2009 270 278
84. H. Palafox-Carlos, J.F. Ayala-Zavala, and G.A. Gonzalez-Aguilar The role of dietary fiber in the bioaccessibility and bioavailability of fruit and vegetable antioxidants J. Food Sci. 76 2011 R6 R15
85. C. Manach, A. Scalbert, C. Morand, C. Remesy, and L. Jimenez Polyphenols: food sources and bioavailability Am. J. Clin. Nutr. 79 2004 727 747
86. D. Grassi, G. Desideri, and C. Ferri Flavonoids: antioxidants against atherosclerosis Nutrients 2 2010 889 902
87. P.G. Pietta Flavonoids as antioxidants J. Nat. Prod. 63 2000 1035 1042
88. H. Halbwrith The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway Int. J. Mol. Sci. 11 2010 595 621
89. S. Kumar, and A.K. Pandey Chemistry and biological activities of flavonoids: an overview Sci. World J. 2013 2013 162750
90. S. Cimino, G. Sortino, V. Favilla, T. Castelli, M. Madonia, S. Sansalone, G.I. Russo, and G. Morgia Polyphenols: key issues involved in chemoprevention of prostate cancer Oxidative Med. Cell. Longev. 2012 2012 632959
91. Y. Tanaka, N. Sasaki, and A. Ohmiya Biosynthesis of plant pigments: anthocyanins, betalains and carotenoids Plant J. 554 2008 733 749
92. L.S. Wang, and G.D. Stoner Anthocyanins and their role in cancer prevention Cancer Lett. 269 2008 281 290
93. R.A.S. Hemat Principles of Orthomolecularism Urotext 2004
94. R.R. Ramoutar, and J.L. Brumaghim Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds Cell Biochem. Biophys. 58 2010 1 23
95. L.A. Komarnisky, and T.K. Basu Biological and toxicological considerations of dietary sulfur V.R. Preedy, R.R. Watson, Reviews in Food and Nutrition Toxicity first ed. 4 2005 Taylor & Francis London 85 104
96. C. Borek Antioxidant health effects of aged garlic extract J. Nutr. 131 2001 1010S 1015S
97. L. Patrick Selenium biochemistry and cancer: a review of the literature Altern. Med. Rev. 9 2004 239 258
98. J. Lu, and A. Holmgren Selenoproteins J. Biol. Chem. 284 2009 723 727
99. J.R. Arthur, R.C. McKenzie, and G.J. Beckett Selenium in the immune system J. Nutr. 133 2003 1457S 1459S
100. B. Frei, R. Stocker, and B.N. Ames Antioxidant defenses and lipid peroxidation in human blood plasma Proc. Natl. Acad. Sci. U. S. A. 85 1988 9748 9752
101. D.E. Baranano, M. Rao, C.D. Ferris, and S.H. Snyder Biliverdin reductase: a major physiologic cytoprotectant Proc. Natl. Acad. Sci. U. S. A. 99 2002 16093 16098
102. M. Taverna, A.L. Marie, J.P. Mira, and B. Guidet Specific antioxidant properties of human serum albumin Ann. Intensive Care 3 2013 4
103. M. Roche, P. Rondeau, N.R. Singh, E. Tarnus, and E. Bourdon The antioxidant properties of serum albumin FEBS Lett. 582 2008 1783 1787
104. S. Ranjbar, Y. Shokoohinia, S. Ghobadi, N. Bijari, S. Gholamzadeh, N. Moradi, M.R. Ashrafi-Kooshk, A. Bagheri, and R. Khodarahmi Studies of the interaction between isoimperatorin and human serum albumin by multispectroscopic method: identification of possible binding site of the compound using esterase activity of the protein Sci. World J. 2013 2013 305081
105. R. Garcia-Martinez, P. Caraceni, M. Bernardi, P. Gines, V. Arroyo, and R. Jalan Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complications Hepatology 58 2013 1836 1846
106. Y.Y. Sautin, and R.J. Johnson Uric acid: the oxidant-antioxidant paradox Nucleosides Nucleotides Nucleic 27 2008 608 619
107. W.S. Waring, A. Convery, V. Mishra, A. Shenkin, D.J. Webb, and S.R. Maxwell Uric acid reduces exercise-induced oxidative stress in healthy adults Clin. Sci. 105 2003 425 430
108. W.S. Waring Uric acid: an important antioxidant in acute ischaemic stroke Q. J. Med. 95 2002 691 693
109. H. Kaur, M.N. Hughes, C.J. Green, P. Naughton, R. Foresti, and R. Motterlini Interaction of bilirubin and biliverdin with reactive nitrogen species FEBS Lett. 543 2003 113 119
110. T.W. Sedlak, M. Saleh, D.S. Higginson, B.D. Paul, K.R. Juluri, and S.H. Snyder Bilirubin and glutathione have complementary antioxidant and cytoprotective roles Proc. Natl. Acad. Sci. U. S. A. 106 2009 5171 5176
111. P.L.M. Jansen, and E.E. Bittar Bilirubin metabolism E.E. Bittar, The Liver in Biology and Disease 2004 Elsevier Amsterdam 257 290
112. J. Wu, J. Ma, S.T. Fan, H.J. Schlitt, and T.Y. Tsui Bilirubin derived from heme degradation suppresses MHC class II expression in endothelial cells Biochem. Biophys. Res. Commun. 338 2005 890 896
113. J. Fevery Bilirubin in clinical practice: a review Liver Int. 28 2008 592 605
114. M. Inoue Protective mechanisms against reactive oxygen species I.M. Arias, J.L. Boyer, F.V. Chisari, N. Fausto, D. Schachter, D.A. Shafritz, The Liver: Biology and Pathobiology forth ed. 2001 Lippincott Williams & Wilkins Philadelphia, Pennsylvania 281 290
115. R. Stocker, A.N. Glazer, and B.N. Ames Antioxidant activity of albumin-bound bilirubin Proc. Natl. Acad. Sci. U. S. A. 84 1987 5918 5922
116. R.L. Levine Fluorescence-quenching studies of the binding of bilirubin to albumin Clin. Chem. 23 1977 2292 2301
117. M. Rayman, and A. Callaghan Nutrition and Arthritis 2006 Blackwell Publishing Oxford
118. C. Rice-Evans Free radicals and antioxidants in atherosclerosis C. Page, D. Blake, P.G. Winyard, Immunopharmacology of Free Radical Species 1995 Academic Press New York 39 52
119. M. De la Fuente Effects of antioxidants on immune system ageing Eur. J. Clin. Nutr. 56 Suppl. 3 2002 S5 S8
120. D.A. Hughes Effects of dietary antioxidants on the immune function of middle-aged adults Proc. Nutr. Soc. 58 1999 79 84
121. D. Brambilla, C. Mancuso, M.R. Scuderi, P. Bosco, G. Cantarella, L. Lempereur, G.D. Benedetto, S. Pezzino, and R. Bernardini The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile Nutr. J. 7 2008 29
122. B.P. Chew, and J.S. Park Carotenoid action on the immune response J. Nutr. 134 2004 257S 261S
123. R. Spooner, and O. Yilmaz The role of reactive-oxygen-species in microbial persistence and inflammation Int. J. Mol. Sci. 12 2011 334 352
124. S. Maggini, E.S. Wintergerst, S. Beveridge, and D.H. Hornig Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses Br. J. Nutr. 98 2007 S29 S35
125. K.L. Erickson, E.A. Medina, and N.E. Hubbard Micronutrients and innate immunity J. Infect. Dis. 182 2000 5 10
126. K.H. Ibs, and L. Rink Zinc-altered immune function J. Nutr. 133 2003 1452s 1456s
127. R.F. Grimble Anti-oxidant modulation in immune function G. Rimbach, J. Fuchs, L. Packer, Nutrigenomics 2005 CRC Press London 97 122
128. J.M. Cruse, and R.E. Lewis Illustrated Dictionary of Immunology third ed. 2009 CRC Press London
129. K.-H. Wagner Antioxidants in sport nutrition: all the same effectiveness? M. Lamprecht, Antioxidants in Sport Nutrition 2014 CRC Press London 67 78
130. S.N. Meydani, S.N. Han, and D. Wu Vitamin E and immune response in the aged: molecular mechanisms and clinical implications Immunol. Rev. 205 2005 269 284
131. M. Zimmermann Burgerstein's Handbook of Nutrition: Micronutrients in the Prevention and Therapy of Disease 2001 Thieme New York New York
132. C.J. Field, I.R. Johnson, and P.D. Schley Nutrients and their role in host resistance to infection J. Leukoc. Biol. 71 2002 16 32
133. S.N. Meydani, M.P. Barklund, S. Liu, M. Meydani, R.A. Miller, J.G. Cannon, F.D. Morrow, R. Rocklin, and J.B. Blumberg Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects Am. J. Clin. Nutr. 52 1990 557 563