Protein engineering of the quaternary sulfiredoxin-peroxiredoxin enzyme-substrate complex reveals the molecular basis for cysteine sulfinic acid phosphorylation

Journal of Biological Chemistry

Volumn 284, Issue 48, 2009, Pages 33305-33310

  Jönsson, Thomas J ^a   Johnson, Lynnette C ^a   Lowther, W Todd ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A-CARBON; ACTIVE SITE; ANTIOXIDANT ENZYME; DISULFIDE BOND FORMATION; ENZYME-SUBSTRATE COMPLEXES; HYDROPHOBIC POCKETS; MOLECULAR BASIS; OXYGEN ATOM; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; STRUCTURAL CHANGE; STRUCTURAL REARRANGEMENT; SULFINIC ACID; SULFUR ATOMS;

ACIDS; ATOMS; BIOCHEMICAL ENGINEERING; CHEMICAL BONDS; ENZYMES; GENETIC ENGINEERING; OXYGEN; PHOSPHORYLATION; SULFUR;

CRYSTAL ATOMIC STRUCTURE;

ADENOSINE TRIPHOSPHATE; ASPARTIC ACID; CARBON; CYSTEINE SULFINIC ACID; MAGNESIUM ION; OXIDOREDUCTASE; PEROXIREDOXIN; SULFIREDOXIN; SULFUR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISULFIDES; HUMANS; MAGNESIUM; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDOREDUCTASES ACTING ON SULFUR GROUP DONORS; PEROXIREDOXINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; SULFINIC ACIDS;

EID: 70450227268     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.036400     Document Type: Article

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