Pathology of the pancreas: A practical approach

Pathology of the Pancreas: A Practical Approach

Volumn , Issue , 2013, Pages 1-317

  Campbell, Fiona ^a   Verbeke, Caroline S ^b  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84954614070     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4471-2449-8     Document Type: Book

References (227)

1. Vikram R, Balachandran A, Bhosale PR, Tamm EP, Marcal LP, Chamsangavej C. Pancreas: peritoneal reflections, ligamentous connections, and pathways of disease spread. Radiographics. 2009. 29: e34.
2. Horiguchi S-I, Kamisawa T. Major duodenal papilla and its normal anatomy. Dig Surg. 2010. 27: 90-3.
3. Suda K. Histopathology of the minor duodenal papilla. Dig Surg. 2010. 27: 137-9.
4. Aimoto T, Uchida E, Nakamura Y, Yamahatsu K, Matsushita A, Katsuno A, et al. Current surgical treatment for chronic pancreatitis. J Nippon Med Sch. 2011. 78: 352-9.
5. Matsuoka L, Parekh D. The minimally invasive approach to surgical management of pancreatic diseases. Gastroenterol Clin North Am. 2012. 41: 77-101.
6. Matsuoka L, Selby R, Genyk Y. The surgical management of pancreatic cancer. Gastroenterol Clin North Am. 2012. 41: 211-21.
7. Japan Pancreas Society. Classification of pancreatic cancer. 2nd ed. Tokyo: Kanehara. 2003. English.
8. Verbeke CS, Leitch D, Menon KV, McMahon MJ, Guillou PJ, Anthoney A. Redefining the R1 resection in pancreatic cancer. Br J Surg. 2006. 93: 1232-7.
9. Esposito I, Kleeff J, Bergmann F, Reiser C, Herpel E, Friess H, et al. Most pancreatic cancer resections are R1 resections. Ann Surg Oncol. 2008. 15: 1651-60.
10. Jamieson NB, Foulis AK, Oien KA, Going JJ, Glen P, Dickson EJ, et al. Positive immobilization margins alone do not in fl uence survival following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. Ann Surg. 2010. 251: 1003-10.
11. The Royal College of Pathologists. Standards and datasets for reporting cancers. Dataset for the histopathological reporting of carcinomas of the pancreas, ampulla of Vater and common bile duct. 2nd ed. London: The Royal College of Pathologists. 2010.
12. Björnstedt M, Franzén L, Glaumann H, Nordlinder H, Palmqvist R, Rissler P, Öst Å, Verbeke C. Gastrointestinal pathology-pancreas and peri-ampullary region. Recommendations from the KVAST Study Group of the Swedish Society for Pathology. Available at: http: //svfp.se/node/240. Last accessed 21 Dec 2012.
13. Sobin LH, Gospodarowicz MK, Wittekind C, editors. UICC: TNM classification of malignant tumours. 7th ed. Oxford: Wiley-Blackwell. 2009.
14. Matsuno S, Egawa S, Fukuyama S, Motoi F, Sunamura M, Isaji S, et al. Pancreatic cancer registry in Japan. 20 years of experience. Pancreas. 2004. 28: 219-30.
15. Verbeke CS, Gladhaug IP. Resection margin involvement and tumour origin in pancreatic head cancer. Br J Surg. 2012. 99: 1036-49.
16. Washington K, Berlin J, Branton P, Burgart LJ, Carter DK, fitzgibbons P, Frankel WL, Jessup J, Kakar S, Minsky B, Nakleh R, Compton CC. Protocol for the examination of specimens from patients with carcinoma of the exocrine pancreas. College of American Pathologists. Available at: www.cap.org, web posting date June, 2012. Last accessed 21 Dec 2012.
17. Sobin LH, Gospodarowicz MK, Wittekind C. UICC: TNM classification of alignant tumours. 7th ed. Oxford: Wiley-Blackwell. 2009.
18. Rindi G, Klöppel G, Ahlman H, Caplin M, Couvelard A, de Herder WW, et al. TNM staging of foregut (neuro)endocrine tumours: a consensus proposal including a grading system. Virchows Arch. 2006. 449: 395-401.
19. Brune K, Abe T, Canto M, O'Malley L, Klein AP, Maitra A, et al. Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol. 2006. 30: 1067-76.
20. Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med. 2009. 133: 365-74.
21. Makay O, Kazimi M, Aydin U, Nart D, Yilmaz F, Zeytunlu M, et al. Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy. Int J Clin Oncol. 2010. 15: 88-92.
22. Simon P, Weiss FU, Zimmer KP, Koch HG, Lerch MM. Acute and chronic pancreatitis in patients with inborn errors of metabolism. Pancreatology. 2001. 1: 448-56.
23. Farrell PM, Rosenstein BJ, White TB, Accurso FJ, Castellani C, Cutting GR, et al. Guidelines for diagnosis of cysticfibrosis in newborns through older adults: Cysticfibrosis Foundation consensus report. J Pediatr. 2008. 153: S4-14.
24. Paterson AC, Pietrangelo A. Disorders of iron overload. In: Burt A, Portmann B, Ferrell L, editors. MacSween’s pathology of the liver. Edinburgh: Churchill Livingstone Elsevier. 2012. p. 263-75, chapter 5.
25. Lack EE. Cysticfibrosis and selected disorders with pancreatic insufficiency. In: Pathology of the pancreas, gallbladder, extrahepatic biliary tract, and ampullary region. Oxford: Oxford University Press. 2003. p. 63-80, chapter 3.
26. Comfort MW, Steinberg AG. Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology. 1952. 21: 54-63.
27. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996. 14: 141-5.
28. Le Bodic L, Bignon JD, Raguénès O, Mercier B, Georgelin T, Schnee M, et al. The hereditary pancreatitis gene maps to long arm of chromosome 7. Hum Mol Genet. 1996. 5: 549-54.
29. Kereszturi E, Szmola R, Kukor Z, Simon P, Weiss FU, Lerch MM, et al. Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism. Hum Mutat. 2009. 30: 575-82.
30. Gaiser S, Daniluk J, Liu Y, Tsou L, Chu J, Lee W, et al. Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis. Gut. 2011. 60: 1379-88.
31. Klöppel G, Detlefsen S, Feyerabend B.fibrosis of the pancreas: the initial tissue damage and the resulting pattern. Virchows Arch. 2004. 445: 1-8.
32. Felderbauer P, Stricker I, Schnekenburger J, Bulut K, Chromik AM, Belyaev O, et al. Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS mutations. Digestion. 2008. 78: 60-5.
33. Rebours V, Lévy P, Mosnier JF, Scoazec JY, Soubeyrand MS, Fléjou JF, et al. Pathology analysis reveals that dysplastic pancreatic ductal lesions are frequent in patients with hereditary pancreatitis. Clin Gastroenterol Hepatol. 2010. 8: 206-12.
34. Bartsch DK, Gress TM, Langer P. Familial pancreatic cancer-current knowledge. Nat Rev Gastroenterol Hepatol. 2012. 9: 445-53.
35. Hong SM, Park JY, Hruban RH, Goggins M. Molecular signatures of pancreatic cancer. Arch Pathol Lab Med. 2011. 135: 716-27.
36. Klein AP, Brune KA, Petersen GM, Goggins M, Tersmette AC, Offerhaus GJ, et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004. 64: 2634-8.
37. Canto MI, Hruban RH, fishman EK, Kamel IR, Schulick R, Zhang Z, et al. Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. Gastroenterology. 2012. 142: 796-804.
38. Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, et al. Increased prevalence of precursor lesions in familial pancreatic cancer patients. Clin Cancer Res. 2009. 15: 7737-43.
39. Brune K, Abe T, Canto M, O'Malley L, Klein AP, Maitra A, et al. Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol. 2006. 30: 1067-76.
40. Canto MI, Harinck F, Hruban RH, Offerhaus GJ, Poley JW, Kamel I, et al. International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. Gut. 2013. 62: 339-47.
41. Andrén-Sandberg Å. Chap 7: Classification of pancreatitis. In: Löhr M, Andrén-Sandberg Å, editors. Pancreatitis-diagnosis and therapy. Bremen/London/Boston: Uni-Med Verlag AG. 2011. p. 73-81.
42. Sharma S, Green KB. The pancreatic duct and its arteriovenous relationship. An underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens. Am J Surg Pathol. 2004. 28: 613-20.
43. Wachtel MS, Miller EJ. Focal changes of chronic pancreatitis and duct-arteriovenous relationships. Avoiding a diagnostic pitfall. Am J Surg Pathol. 2005. 29: 1521-3.
44. Rebours V, Boutron-Ruault M-C, Schnee M, Férec C, Le Maréchal C, Hentic O, et al. The natural history of hereditary pancreatitis: a national series. Gut. 2009. 58: 97-103.
45. Raghuwansh PS, Chari ST. Autoimmune pancreatitis: an update on classification, diagnosis, natural history and management. Curr Gastroenterol Rep. 2012. 14: 95-105.
46. Chari ST, Klöppel G, Zhang L, Notohara K, Lerch MM, Shimosegawa T, et al. Histopathologic and clinical subtypes of autoimmune pancreatitis: The Honolulu consensus document. Pancreas. 2010. 39: 549-54.
47. Shimosegawa T, Chari ST, Frulloni L, Kamisawa T, Kawa S, Mino-Kenudson M, et al. International consensus diagnostic criteria for autoimmune pancreatitis. Guidelines of the International Association of Pancreatology. Pancreas. 2011. 40: 352-8.
48. Zhang L, Chari S, Smyrk TC, Deshpande V, Klöppel G, Kojima M, et al. Autoimmune pancreatitis (AIP) type 1 and type 2. An international consensus study on histopathological diagnostic criteria. Pancreas. 2011. 40: 1172-9.
49. Deshpande V, Zen Y, Chan JKC, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012. 25: 1181-92.
50. Moon S-H, Kim M-H, Park DH, Song TJ, Eum J, Lee SS, et al. IgG4 immunostaining of duodenal papillary biopsy specimens may be useful for supporting a diagnosis of autoimmune pancreatitis. Gastrointest Endosc. 2010. 71: 960-6.
51. Strehl JD, Hartmann A, Agaimy A. Numerous IgG4-positive plasma cells are ubiquitous in diverse localised non-specific chronic in fl ammatory conditions and need to be distinguished from IgG4-related systemic disorders. J Clin Pathol. 2011. 64: 237-43.
52. Dhall D, Suriawinata AA, Tang LH, Shia J, Klimstra DS. Use of immunohistochemistry for IgG4 in the distinction of autoimmune pancreatitis from peritumoral pancreatitis. Hum Pathol. 2010. 41: 643-52.
53. Yamamoto H, Yamaguchi H, Aishima S, Oda Y, Kohashi K, Oshiro Y, et al. Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study. Am J Surg Pathol. 2009. 33: 1330-40.
54. Mizukami H, Yajima N, Wada R, Matsumoto K, Kojima M, Klöppel G, et al. Pancreatic malignantfibrous histiocytoma, inflamatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis. Virchows Arch. 2006. 448: 552-60.
55. Friedlander J, Quiros JA, Morgan T, Zhang Z, Tian W, Kehr E, et al. Diagnosis of autoimmune pancreatitis vs neoplasms in children with pancreatic mass and biliary obstruction. Clin Gastroenterol Hepatol. 2012. 10: 1051-5.
56. Zhang L, Smyrk TC. Autoimmune pancreatitis and IgG4-related systemic diseases. Int J Clin Exp Pathol. 2010. 3: 491-504.
57. Abraham SC, Leach S, Yeo CJ, Cameron JL, Murakata LA, Boitnott JK, et al. Eosinophilic pancreatitis and increased eosinophils in the pancreas. Am J Surg Pathol. 2003. 27: 334-42.
58. Fujita T, Kojima M, Kato Y, Gotohda N, Takahashi S, Konishi M, et al. Clinical and histopathological study of “follicular cholangitis”. Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. Hepatol Res. 2010. 40: 1239-47.
59. Zen Y, Ishikawa A, Ogiso S, Heaton N, Portmann B. Follicular cholangitis and pancreatitis-clinicopathological features and differential diagnosis of an under-recognized entity. Histopathology. 2012. 60: 261-9.
60. Zuk RJ, Neal JW, Baithun SI. Malakoplakia of the pancreas. Virchows Arch A Pathol Anat Histopathol. 1990. 417: 181-4.
61. Nuciforo PG, Moneghini L, Braidotti P, Castoldi L, De Rai P, Bosari S. Malakoplakia of the pancreas with diffuse lymph-node involvement. Virchows Arch. 2003. 442: 82-5.
62. Lewin DNB. Systemic illnesses involving the GI tract. In: Odze RD, Goldblum JR, Crawford JM, editors. Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders. 2004. p. 73-6, chapter 5.
63. Sobel RA, Ruebner BH. Buerger’s disease involving the celiac artery. Hum Pathol. 1979. 10: 112-5.
64. Haraguchi K, Gunji K, Ito Y, Yokomori N, Kawaguchi A, Ohomori M, et al. Extensive pancreatic necrosis in microscopic polyangiitis. Clin Exp Nephrol. 2005. 9: 326-31.
65. Nie Y, Li W, Tong Z, Wang X, Li J. Acute pancreatitis associated with Henoch-Schönlein purpura. Pancreas. 2011. 40: 315-6.
66. Tada M, Naruse S, Arai A, Sato A, Tanaka K, Piao YS, et al. An autopsy case of systemic vasculitis associated with hepatitis C virus-related mixed cryoglobulinemia presenting severe peripheral neuropathy. Rinsho Shinkeigaku. 2004. 44: 686-90.
67. Bély M, Apáthy Á. Recurrent pancreatic arteritis and vasculogenic relapsing pancreatitis in rheumatoid arthritis-a retrospective clinicopathologic and immunohistochemical study of 161 autopsy patients. Pathol Oncol Res. 2008. 14: 473-80.
68. Kuroda T, Sato H, Hasegawa H, Wada Y, Murakami S, Saeki T, et al. Fatal acute pancreatitis associated with reactive AA amyloidosis in rheumatoid arthritis with end-stage renal disease: a report of three cases. Intern Med. 2011. 50: 739-44.
69. Klimstra D, Longnecker DS. K-ras mutations in pancreatic ductal proliferative lesions. Am J Pathol. 1994. 145: 1547-50.
70. Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001. 25: 579-86.
71. Hruban RH, Takaori K, Klimstra DS, Adsay NV, Albores-Saavedra J, Biankin AV, et al. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004. 28: 977-87.
72. Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron JL, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol. 2003. 16: 902-12.
73. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010. 467: 1114-7.
74. Iacobuzio-Donahue CA. Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project. Gut. 2012. 61: 1085-94.
75. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumors of the digestive system. Lyon: IARC. 2010. p. 280, chapter 12.
76. Albores-Saavedra J, Wu J, Crook T, Amirkhan RH, Jones L, Hruban RH. Intestinal and oncocytic variants of pancreatic intraepithelialneoplasia. A morphological and immunohistochemical study. Ann Diagn Pathol. 2005. 9: 69-76.
77. Albores-Saavedra J, Weimersheimer-Sandoval M, Chable-Montero F, Montante-Montes de Oca D, Hruban RH, Henson DE. The foamy variant of pancreatic intraepithelial neoplasia. Ann Diagn Pathol. 2008. 12: 252-9.
78. Rebours V, Lévy P, Mosnier JF, Scoazec JY, Soubeyrand MS, Fléjou JF, et al. Pathology analysis reveals that dysplastic pancreatic ductal lesions are frequent in patients with hereditary pancreatitis. Clin Gastroenterol Hepatol. 2010. 8: 206-12.
79. Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, et al. Increased prevalence of precursor lesions in familial pancreatic cancer patients. Clin Cancer Res. 2009. 15: 7737-43.
80. Detlefsen S, Sipos B, Feyerabend B, Klöppel G. Pancreaticfibrosis associated with age and ductal papillary hyperplasia. Virchows Arch. 2005. 447: 800-5.
81. Bosetti C, Bertuccio P, Negri E, La Vecchia C, Zeegers MP, Boffetta P. Pancreatic cancer: overview of descriptive epidemiology. Mol Carcinog. 2012. 51: 3-13.
82. Iacobuzio-Donahue CA. Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project. Gut. 2012. 61: 1085-94.
83. Sobin LH, Gospodarowicz MK, Wittekind C. UICC: TNM classification of malignant tumours. 7th ed. Oxford: Wiley-Blackwell. 2009.
84. Hruban RH, Boffetta P, Hiraoka N, Iacobuzio-Donahue C, Kato Y, Kern SE, et al. Ductal adenocarcinoma of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system, World Health Organization Classification of tumours. Lyon: International Agency for Research on Cancer (IARC). 2010. p. 281-91, chapter 12.
85. Kelly PJ, Shinagare S, Sainani N, Hong X, Ferrone C, Yilmaz O, et al. Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma. Am J Surg Pathol. 2012. 36: 696-701.
86. Harsha HC, Kandasamy K, Ranganathan P, Rani S, Ramabadran S, Gollapudi S, et al. A compendium of potential biomarkers of pancreatic cancer. PLoS Med. 2009. 6: e1000046.
87. Dennis JL, Hvidsten TR, Wit EC, Komorowski J, Bell AK, Downie I, et al. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res. 2005. 11: 3766-72.
88. Liu H, Shi J, Anadan V, Wan HL, Diehl D, Blansfield J, et al. Reevaluation and identification of the best immunohistochemical panel (pVHL, maspin, S100P, IMP-3) for ductal adenocarcinoma of the pancreas. Arch Pathol Lab Med. 2012. 136: 601-9.
89. Winter JM, Tang LH, Klimstra DS, Brennan MF, Brody JR, Rocha FG, et al. A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as markers. PLoS One. 2012. 7: e40157.
90. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC cancer staging handbook. 7th ed. New York: Springer. 2010.
91. Björnstedt M, Franzén L, Glaumann H, Nordlinder H, Palmqvist R, Rissler P, Öst Å, Verbeke C. Gastrointestinal pathology-pancreas and peri-ampullary region. Recommendations from the KVAST Study Group of the Swedish Society for Pathology. Available at: http: //svfp.se/node/240. Accessed 19 Oct 2012.
92. The Royal College of Pathologists. Standards and datasets for reporting cancers. Dataset for the histopathological reporting of carcinomas of the pancreas, ampulla of Vater and common bile duct. 2nd ed. London: The Royal College of Pathologists. 2010.
93. Verbeke CS, Knapp J, Gladhaug IP. Tumour growth is more dispersed in pancreatic head cancers than in rectal cancer-implications for resection margin assessment. Histopathology. 2011. 59: 1111-21.
94. Jamieson NB, Foulis AK, Oien KA, Going JJ, Glen P, Dickson EJ, et al. Positive immobilization margins alone do not in fl uence survival following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. Ann Surg. 2010. 251: 1003-10.
95. Sharma S, Green KB. The pancreatic duct and its arteriovenous relationship. An underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens. Am J Surg Pathol. 2004. 28: 613-20.
96. Wachtel MS, Miller EJ. Focal changes of chronic pancreatitis and duct-arteriovenous relationships. Avoiding a diagnostic pitfall. Am J Surg Pathol. 2005. 29: 1521-3.
97. Westgaard A, Schjølberg AR, Cvancarova M, Eide TJ, Clausen OPF, Gladhaug IP. Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. 2009. 54: 337-47.
98. Matsuoka L, Selby R, Genyk Y. The surgical management of pancreatic cancer. Gastroenterol Clin North Am. 2012. 41: 211-21.
99. Verbeke CS, Gladhaug IP. Resection margin involvement and tumour origin in pancreatic head cancer. Br J Surg. 2012. 99: 1036-49.
100. Páez D, Labonte MJ, Lenz H-J. Pancreatic cancer: medical management (novel chemotherapeutics). Gastroenterol Clin North Am. 2012. 41: 189-209.
101. Wilentz RE, Goggings M, Redston M, Marcus VA, Adsay NV, Sohn TA, et al. Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas. A newly described and characterized entity. Am J Pathol. 2000. 156: 1641-51.
102. Chatterjee D, Katz MH, Rashid A, Varadhachary GR, Wolff RA, Wang H, et al. Histologic grading the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma. A predictor for patient outcome. Cancer. 2012. 118: 3182-90.
103. Evans DB, Rich TA, Byrd DR, Cleary KR, Connelly JH, Levin B, et al. Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch Surg. 1992. 127: 1335-9.
104. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system, World Health Organization Classification of tumours. Lyon: IARC. 2010. p. 280, chapter 12.
105. Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, et al. Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. Oncologist. 2011. 16: 1714-20.
106. La Rosa S, Adsay V, Albarello L, Asioli S, Casnedi S, Franzi F, et al. Clinicopathologic study of 62 acinar cell carcinomas of the pancreas: insights into the morphology and immunophenotype and search for prognostic markers. Am J Surg Pathol. 2012. 36: 1782-95.
107. Basturk O, Zamboni G, Klimstra DS, Capelli P, Andea A, Kamel NS, et al. Intraductal and papillary variants of acinar cell carcinomas. A new addition to the challenging differential diagnosis of intraductal neoplasms. Am J Surg Pathol. 2007. 31: 363-70.
108. Toll AD, Mitchell D, Yeo CJ, Hruban RH, Witkiewicz AK. Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature. Int J Surg Pathol. 2011. 19: 795-9.
109. Colombo P, Aizzi C, Roncalli M. Acinar cell cystadenocarcinoma of the pancreas: report of rare case and review of the literature. Hum Pathol. 2004. 35: 1568-71.
110. Glick RD, Pashankar FD, Pappo A, Laquaglia MP. Management of pancreatoblastoma in children and young adults. J Pediatr Hematol Oncol. 2012. 34 Suppl 2: S47-50.
111. Cavallini A, Falconi M, Bortesi L, Crippa S, Barugola G, Butturini G. Pancreatoblastoma in adults: a review of the literature. Pancreatology. 2009. 9: 73-80.
112. Schmidt CM, Matos JM, Bentrem DJ, Talamonti MS, Lillemoe KD, Bilimoria KY. Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma. J Gastrointest Surg. 2008. 12: 2078-86.
113. Bismar TA, Basturk O, Gerald WL, Schwarz K, Adsay NV. Desmoplastic small cell tumor in the pancreas. Am J Surg Pathol. 2004. 28: 808-12.
114. Kosmahl M, Pauser U, Peters K, Sipos B, Luttges J, Kremer B, et al. Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch. 2004. 445: 168-78.
115. Pauser U, da Silva MT, Placke J, Klimstra DS, Klöppel G. Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117). Mod Pathol. 2005. 18: 1211-6.
116. Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, et al. Granular cell tumor of the pancreas: a case report and review of literature. World J Gastrointest Oncol. 2010. 2: 121-4.
117. Yamamoto H, Yamaguchi H, Aishima S, Oda Y, Kohashi K, Oshiro Y, et al. Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study. Am J Surg Pathol. 2009. 33: 1330-40.
118. Zhang H, Jensen MH, Farnell MB, Smyrk TC, Zhang L. Primary leiomyosarcoma of the pancreas: study of 9 cases and review of literature. Am J Surg Pathol. 2010. 34: 1849-56.
119. Lee JY, Seo HI, Park EY, et al. Histologic confirmation of huge pancreatic lipoma: a case report and review of literatures. J Korean Surg Soc. 2011. 81: 427-30.
120. Singhi AD, Hruban RH, Fabre M, Imura J, Schulick R, Wolfgang C, et al. Peripancreatic paraganglioma: a potential diagnostic challenge in cytopathology and surgical pathology. Am J Surg Pathol. 2011. 35: 1498-504.
121. Movahedi-Lankarani S, Hruban RH, Westra WH, Klimstra DS. Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm. Am J Surg Pathol. 2002. 26: 1040-7.
122. Doi H, Ichikawa S, Hiraoka A, Ichiryu M, Nakahara H, Ochi H, et al. Primitive neuroectodermal tumor of the pancreas. Intern Med. 2009. 48: 329-33.
123. Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG. Primary pancreatic cystic neoplasms of the pancreas revisited. Part IV: rare cystic neoplasms. Surg Oncol. 2012. 21: 153-63.
124. Crippa S, Angelini C, Mussi C, Bonardi C, Romano F, Sartori P, et al. Surgical treatment of metastatic tumors to the pancreas: a single center experience and review of the literature. World J Surg. 2006. 30: 1536-42.
125. Adsay NV, Andea A, Basturk O, Kilinc N, Nassar H, Cheng JD. Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature. Virchows Arch. 2004. 444: 527-35.
126. Truong LD, Shen SS. Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med. 2011. 135: 92-109.
127. Park S-Y, Kim B-H, Kim J-H, Lee S, Kang GH. Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma. Arch Pathol Lab Med. 2007. 131: 1561-7.
128. Dennis JL, Hvidsten TR, Wit EC, Komorowski J, Bell AK, Downie I, et al. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res. 2005. 11: 3766-72.
129. Cai YC, Banner B, Glickman J, Odze RD. Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. Hum Pathol. 2001. 32: 1087-93.
130. Ordonez NG. Application of mesothelin immunostaining in tumor diagnosis. Am J Surg Pathol. 2003. 27: 1418-28.
131. Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin. An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 2003. 27: 303-10.
132. Bertin C, Pelletier A-L, Vullierme MP, Bienvenu T, Rebours V, Hentic O, et al. Pancreas divisum is not a cause of pancreatitis by itself but acts as a partner of genetic mutations. Am J Gastroenterol. 2012. 107: 311-7.
133. Kamisawa T, Honda G, Kurata M, Tokura M, Tsuruta K. Pancreatobiliary disorders associated with pancreaticobiliary maljunction. Dig Surg. 2010. 27: 100-4.
134. Muruyama H, Kikuchi M, Imai T, Yamamoto Y, Iwata Y. A case of heterotopic pancreas in lymph node. Virchows Arch A Pathol Anat Histol. 1978. 377: 175-9.
135. Guillou L, Nordback P, Gerber C, Schneider RP. Ductal adenocarcinoma arising in a heterotopic pancreas situated in a hiatal hernia. Arch Pathol Lab Med. 1994. 118: 568-71.
136. Goodarzi M, Rashid A, Maru D. Invasive ductal adenocarcinoma arising from pancreatic heterotopia in rectum: case report and review of literature. Hum Pathol. 2010. 41: 1809-13.
137. St Romain P, Muehlebach G, Damjanov I, Fan F. Adenocarcinoma arising in an ectopic mediastinal pancreas. Ann Diagn Pathol. 2012. 16: 494-7.
138. Landry ML, Sarma DP. Accessory spleen in the head of the pancreas. Hum Pathol. 1989. 20: 497.
139. Ioachim HL, Medeiros LJ. Ioachim’s lymph node pathology. 4th ed. Philadelphia: Lippincott Williams & Wilkins. 2008. p. 283-8.
140. Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, et al. 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery. 2012. 152(3 Suppl 1): S4-12.
141. Lee KS, Sekhar A, Rofsky NM, Pedrosa I. Prevalence of incidental pancreatic cysts in the adult population on MR imaging. Am J Gastroenterol. 2010. 105: 2079-84.
142. Salvia R, Malleo G, Marchegiani G, Pennacchio S, Paiella S, Paini M, et al. Pancreatic resections for cystic neoplasms: from the surgeon’s presumption to the pathologist’s reality. Surgery. 2012. 152(3 Suppl 1): S135-42.
143. Adsay NV, Klimstra DS. Cystic forms of typically solid pancreatic tumors. Semin Diagn Pathol. 2000. 17: 81-8.
144. Lee LY, Hsu HL, Chen HM, Hsueh C. Ductal adenocarcinoma of the pancreas with huge cystic degeneration: a lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma. Int J Surg Pathol. 2003. 11: 235-9.
145. Kosmahl M, Pauser U, Anlauf M, Klöppel G. Pancreatic adenocarcinoma with cystic features: neither rare nor uniform. Mod Pathol. 2005. 18: 1157-64.
146. Kosmahl M, Pauser U, Peters K, Sipos B, Luttges J, Kremer B, et al. Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch. 2004. 445: 168-78.
147. Warshaw AL, Compton CC, Lewandrowski K, Cardenosa G, Mueller PR. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg. 1990. 212: 432-43.
148. Del Chiaro M, Verbeke C, Salvia R, Klöppel G, Werner J, McKay C, Friess H, Manfredi R, van Cutsem E, Löhr M, Segersvard R and the European Study Group on Cystic Tumours of the Pancreas. European experts consensus statement on cystic tumours of the pancreas. Dig Liv Dis. 2013 [Epub ahead of print].
149. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: IARC. 2010. p. 280, chapter 12.
150. Khashab MA, Shin EJ, Amateau S, Canto MI, Hruban RH, fishman EK, et al. Tumor size and location correlate with behavior of pancreatic serous cystic neoplasms. Am J Gastroenterol. 2011. 106: 1521-6.
151. Hashimoto M, Watanabe G, Miura Y, Matsuda M, Takeuchi K, Mori M. Macrocystic type of serous cystadenoma with a communication between the cyst and pancreatic duct. J Gastroenterol Hepatol. 2001. 16: 836-8.
152. Tripodi SA, Civitelli S, Schurfeld K, Cintorino M. Microcystic adenoma of the pancreas (glycogen-rich cystadenoma) with stromal amyloid deposits. Histopathology. 2000. 37: 147-9.
153. Perez-Ordonez B, Naseem A, Lieberman PH, Klimstra DS. Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma? Am J Surg Pathol. 1996. 20: 1401-5.
154. Panarelli NC, Park KJ, Hruban RH, Klimstra DS. Microcystic serous cystadenoma of the pancreas with subtotal cystic degeneration: another neoplastic mimic of pancreatic pseudocyst. Am J Surg Pathol. 2012. 36: 726-31.
155. Blandamura S, Parenti A, Famengo B, Canesso A, Moschino P, Pasquali C, et al. Three cases of pancreatic serous cystadenoma and endocrine tumour. J Clin Pathol. 2007. 60: 278-82.
156. Strobel O, Z’graggen K, Schmitz-Winnenthal FH, Friess H, Kappeler A, Zimmermann A, et al. Risk of malignancy in serous cystic neoplasms of the pancreas. Digestion. 2003. 68: 24-33.
157. Malleo G, Bassi C, Rossini R, Manfredi R, Butturini G, Massignani M, et al. Growth pattern of serous cystic neoplasms of the pancreas: observational study with long-term magnetic resonance surveillance and recommendations for treatment. Gut. 2012. 61: 746-51.
158. Del Chiaro M, Verbeke C, Salvia R, Klöppel G, Werner J, McKay C, Friess H, Manfredi R, van Cutsem E, Löhr M, Segersvard R and the European Study Group on Cystic Tumours of the Pancreas. European experts consensus statement on cystic tumours of the pancreas. Dig Liv Dis. 2013 [Epub ahead of print].
159. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: IARC. 2010. p. 280, chapter 12.
160. Thompson L, Becker R, Przygodzki R, Adair C, Heffess CS. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of lowgrade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol. 1999. 23: 1-16.
161. Baker ML, Seeley ES, Pai R, Suriawinata AA, Mino-Kenudson M, Zamboni G, et al. Invasive mucinous cystic neoplasms of the pancreas. Exp Mol Pathol. 2012. 93: 345-9.
162. Tanaka M, Fernández-Del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012. 12: 183-97.
163. Masia R, Mino-Kenudson M, Warshaw AL, Pitman MB, Misdraji J. Pancreatic mucinous cystic neoplasm of the main pancreatic duct. Arch Pathol Lab Med. 2011. 135: 264-7.
164. Handra-Luca A, Couvelard A, Sauvanet A, Flejou JF, Degott C. Mucinous cystadenoma with mesenchymal overgrowth: a new variant among pancreatic mucinous cystadenomas? Virchows Arch. 2004. 445: 203-5.
165. Wenig BM, Albores-Saavedra J, Buetow PC, Heffess CS. Pancreatic mucinous cystic neoplasm with sarcomatous stroma: a report of three cases. Am J Surg Pathol. 1997. 21: 70-80.
166. Hruban RH, Takaori K, Klimstra DS, Adsay NV, Albores-Saavedra J, Biankin AV, et al. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004. 28: 977-87.
167. Rebours V, Couvelard A, Peyroux JL, Sauvanet A, Hammel P, Ruszniewski P, et al. Familial intraductal papillary mucinous neoplasms of the pancreas. Dig Liver Dis. 2012. 44: 442-6.
168. Tanaka M, Fernández-Del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012. 12: 183-97.
169. Waters JA, Schmidt CM, Pinchot JW, White PB, Cummings OW, Pitt HA, et al. CT vs MRCP: optimal classification of IPMN type and extent. J Gastrointest Surg. 2008. 12: 101-9.
170. Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernández-Del Castillo C. Incidental pancreatic cysts: do we really know what we are watching? Pancreatology. 2010. 10: 144-50.
171. Tanaka M. Controversies in the management of pancreatic IPMN. Nat Rev Gastroenterol Hepatol. 2011. 8: 56-60.
172. Mino-Kenudson M, Fernández-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M, et al. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut. 2011. 60: 1712-20.
173. Zapiach M, Yadav D, Smyrk TC, Fletcher JG, Pearson RK, Clain JE, et al. Calcifying obstructive pancreatitis: a study of intraductal papillary mucinous neoplasm associated with pancreatic calcification. Clin Gastroenterol Hepatol. 2004. 2: 57-63.
174. Longnecker DS, Adsay NV, Fernandez-del Castillo C, Hruban RH, Kasugai T, Klimstra DS, et al. Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreement. Pancreas. 2005. 31: 344-9.
175. Katabi N, Klimstra DS. Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach. J Clin Pathol. 2008. 61: 1303-13.
176. Yamaguchi K, Kanemitsu S, Hatori T, Maguchi H, Shimizu Y, Tada M, et al. Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. Pancreas. 2011. 40: 571-80.
177. Kelly PJ, Shinagare S, Sainani N, Hong X, Ferrone C, Yilmaz O, et al. Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma. Am J Surg Pathol. 2012. 36: 696-701.
178. Katabi N, Torres J, Klimstra DS. Intraductal tubular neoplasms of bile ducts. Am J Surg Pathol. 2012. 36: 1647-55.
179. Yamaguchi H, Shimizu M, Ban S, Koyama I, Hatori T, Fujita I, et al. Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2009. 33: 1164-72.
180. Furukawa T, Hatori T, Fujita I, Yamamoto M, Kobayashi M, Ohike N, et al. Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Gut. 2011. 60: 509-16.
181. Nakata K, Ohuchida K, Aishima S, Sadakari Y, Kayashima T, Miyasaka Y, et al. Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. Pancreas. 2011. 40: 581-7.
182. Yopp AC, Katabi N, Janakos M, Klimstra DS, D'Angelica MI, DeMatteo RP, et al. Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas: a matched control study with conventional pancreatic ductal adenocarcinoma. Ann Surg. 2011. 253: 968-74.
183. Nara S, Shimada K, Kosuge T, Kanai Y, Hiraoka N. Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms. Am J Surg Pathol. 2008. 32: 243-55.
184. Daum O, Sima R, Mukensnabl P, Vanecek T, Brouckova M, Benes Z, et al. Pigmented solid-pseudopapillary neoplasm of the pancreas. Pathol Int. 2005. 55: 280-4.
185. Chen C, Jing W, Gulati P, Vargas H, French SW. Melanocytic differentiation in a solid pseudopapillary tumor of the pancreas. J Gastroenterol. 2004. 39: 579-83.
186. Albores-Saavedra J, Simpson KW, Bilello SJ. The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm. Am J Surg Pathol. 2006. 30: 1237-42.
187. Tang LH, Aydin H, Brennan MF, Klimstra DS. Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol. 2005. 29: 512-9.
188. Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, et al. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol. 2011. 35: 981-8.
189. Gomez P, Yorke R, Ayala AG, Ro JY. Solid-pseudopapillary neoplasm of pancreas with long delayed liver metastasis. Ann Diagn Pathol. 2012. 16: 380-4.
190. Del Chiaro M, Verbeke C, Salvia R, Klöppel G, Werner J, McKay C, Friess H, Manfredi R, van Cutsem E, Löhr M, Segersvard R and the European Study Group on Cystic Tumours of the Pancreas. European experts consensus statement on cystic tumours of the pancreas. Dig Liv Dis. 2013 [Epub ahead of print].
191. Klöppel G. Pseudocysts and other non-neoplastic cysts of the pancreas. Semin Diagn Pathol. 2000. 17: 7-15.
192. Albores-Saavedra J. Acinar cystadenoma of the pancreas: a previously undescribed tumor. Ann Diagn Pathol. 2002. 6: 113-5.
193. Zamboni G, Terris B, Scarpa A, Kosmahl M, Capelli P, Klimstra DS, et al. Acinar cell cystadenoma of the pancreas: a new entity? Am J Surg Pathol. 2002. 26: 698-704.
194. McEvoy MP, Rich B, Klimstra D, Vakiani E, La Quaglia MP. Acinar cell cystadenoma of the pancreas in a 9-year-old boy. J Pediatr Surg. 2010. 45: E7-9.
195. Khor TS, Badizadegan K, Ferrone C, Fernández-Del Castillo C, Desai GS, Saenz A, et al. Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodules. Am J Surg Pathol. 2012. 36: 1579-91.
196. Pesci A, Castelli P, Facci E, Romano L, Zamboni G. Primary retroperitoneal acinar cell cystadenoma. Hum Pathol. 2012. 43: 446-50.
197. Kosmahl M, Egawa N, Schröder S, Carneiro F, Lüttges J, Klöppel G. Mucinous nonneoplastic cyst of the pancreas: a novel nonneoplastic cystic change? Mod Pathol. 2002. 15: 154-8.
198. Cao W, Adley BP, Liao J, Lin X, Talamonti M, Bentrem DJ, et al. Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm. Hum Pathol. 2010. 41: 513-21.
199. Hori S, Nara S, Shimada K, Ojima H, Kanai Y, Hiraoka N. Serous cystic neoplasm in an intrapancreatic accessory spleen. Pathol Int. 2010. 60: 681-4.
200. Othman M, Basturk O, Groisman G, Krasinskas A, Adsay NV. Squamoid cyst of pancreatic ducts: a distinct type of cystic lesion in the pancreas. Am J Surg Pathol. 2007. 31: 291-7.
201. Nagata S, Yamaguchi K, Inoue T, Yamaguchi H, Ito T, Gibo J, et al. Case report: solid pancreatic hamartoma. Pathol Int. 2007. 57: 276-80.
202. Flaherty MJ, Benjamin DR. Multicystic pancreatic hamartoma: a distinctive lesion with immunohistochemical and ultrastructural study. Hum Pathol. 1992. 23: 1309-12.
203. Pauser U, Kosmahl M, Kruslin B, Klimstra DS, Klöppel G. Pancreatic solid and cystic hamartoma in adults: characterization of a new tumorous lesion. Am J Surg Pathol. 2005. 29: 797-800.
204. Bhat NA, Rashid KA, Wani I, Wani S, Syeed A. Hydatid cyst of the pancreas mimicking choledochal cyst. Ann Saudi Med. 2011. 31: 536-8.
205. Klimstra DS, Arnold R, Capela C, Hruban RH, Klöppel G, Komminoth P, et al. Neuroendocrine neoplasms of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system, World Health Organization classification of tumours. Lyon: International Agency for Research on Cancer (IARC). 2010. p. 322-6, chapter 12.
206. Heitz PU, Komminoth P, Perren A, Klimstra DS, Dayal Y, Bordi C, et al. Tumours of the endocrine pancreas. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C, editors. Pathology and genetics. Tumours of endocrine organs, World Health Organization classification of tumours. Lyon: International Agency for Research on Cancer (IARC). 2004. p. 176-208, chapter 4.
207. Anlauf M, Bauersfeld J, Raffel A, Koch CA, Henopp T, Alkatout I, et al. Insulinomatosis. A multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia. Am J Surg Pathol. 2009. 33: 339-46.
208. Verbeke CS. Endocrine tumours of the pancreas. Histopathology. 2010. 56: 669-82. doi: 10.1111/j.1365-2559.2010.03490.x.
209. Yachida S, Vakiani E, White CM, Zhong Y, Saunders T, Morgan R, et al. Small and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am J Surg Pathol. 2012. 36: 173-84.
210. Klöppel G, Rindi G, Perren A, Komminoth P, Klimstra DS. The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement. Virchows Arch. 2010. 456: 595-7.
211. Couvelard A. Neuroendocrine tumours of the pancreas: recent developments in staging and grading. Diagn Pathol. 2012. 18: 1-7.
212. Klöppel G, Couvelard A, Perren A, Komminoth P, McNicol A-M, Nilsson O, et al. ENETS consensus guidelines for the standards of care in neuroendocrine tumors: towards a standardized approach to the diagnosis of gastroenteropancreatic neuroendocrine tumors and their prognostic stratification. Neuroendocrinology. 2009. 90: 162-6.
213. Chan ES, Alexander J, Swanson PE, Jain D, Yeh MM. PDX-1, CDX-2, TTF-1, and CK7: a reliable immunohistochemical panel for pancreatic neuroendocrine neoplasms. Am J Surg Pathol. 2012. 36: 737-43.
214. Rindi G, Klöppel G, Ahlman H, Caplin M, Couvelard A, de Herder WW, et al. TNM staging of foregut (neuro)endocrine tumours: a consensus proposal including a grading system. Virchows Arch. 2006. 449: 395-401.
215. Sobin LH, Gospodarowicz MK, Wittekind C. UICC: TNM classification of malignant tumours. 7th ed. Oxford: Wiley-Blackwell. 2009.
216. Takahashi T, Hatakeyama S, Machida T. Ductal adenocarcinoma of the pancreas with psammomatous calcification: report of a case with immunohistochemical study for bone morphogenetic protein. Pathol Int. 2011. 61: 603-7.
217. Schneider NI, Bauernhofer T, Schöllnast H, Ott A, Langner C. Pancreatic adenocarcinoma with multiple eosinophilic extracellular deposits consistent with noncalcified psammoma bodies. Virchows Arch. 2011. 459: 623-5.
218. Rindi G, Solcia E. Endocrine hyperplasia and dysplasia in the pathogenesis of gastrointestinal and pancreatic endocrine tumors. Gastroenterol Clin North Am. 2007. 36: 851-65.
219. Ouyang D, Dhall D, Yu R. Pathologic pancreatic endocrine cell hyperplasia. World J Gastroenterol. 2011. 17(2): 137-43.
220. Henopp T, Anlauf M, Schmitt A, Schlenger R, Zalatnai A, Couvelard A, et al. Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas. J Clin Endocrinol Metab. 2009. 94: 213-7.
221. Albazaz R, Da Costa PE, Verbeke CS. Pancreatic polypeptide cell hyperplasia of the pancreas. J Clin Pathol. 2006. 59: 1087-90.
222. Hyland C, Kheir SM, Kashlan MB. Frozen section diagnosis of pancreatic carcinoma. A prospective study of 64 cases. Am J Surg Pathol. 1981. 5: 179-91.
223. Matthaei H, Hong SM, Mayo SC, dal Molin M, Olino K, Venkat R, et al. Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not in fl uence outcome in patients with R0 resected pancreatic cancer. Ann Surg Oncol. 2011. 18: 3493-9.
224. Sauvanet A, Couvelard A, Belghiti J. Role of frozen section assessment for intraductal papillary and mucinous tumor of the pancreas. World J Gastrointest Surg. 2010. 2: 352-8.
225. Tanaka M, Fernández-Del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012. 12: 183-97.
226. Del Chiaro M, Verbeke C, Salvia R, Klöppel G, Werner J, McKay C, Friess H, Manfredi R, van Cutsem E, Löhr M, Segersvard R and the European Study Group on Cystic Tumours of the Pancreas. European experts consensus statement on cystic tumours of the pancreas. Dig Liv Dis. 2013 [Epub ahead of print].
227. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumors of the digestive system. Lyon: IARC. 2010. p. 280, chapter 12.